Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HAY5_LEIBR

TriTrypDb:

LbrM.20.2240 , LBRM2903_200033000

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HAY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.577
CLV_NRD_NRD_1	278	280	PF00675	0.526
CLV_NRD_NRD_1	415	417	PF00675	0.730
CLV_NRD_NRD_1	470	472	PF00675	0.478
CLV_NRD_NRD_1	517	519	PF00675	0.589
CLV_PCSK_KEX2_1	278	280	PF00082	0.643
CLV_PCSK_KEX2_1	470	472	PF00082	0.478
CLV_PCSK_KEX2_1	517	519	PF00082	0.589
CLV_PCSK_SKI1_1	199	203	PF00082	0.562
CLV_PCSK_SKI1_1	27	31	PF00082	0.565
CLV_PCSK_SKI1_1	426	430	PF00082	0.646
CLV_PCSK_SKI1_1	470	474	PF00082	0.507
DEG_APCC_DBOX_1	39	47	PF00400	0.527
DEG_APCC_DBOX_1	425	433	PF00400	0.650
DOC_CKS1_1	64	69	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.536
DOC_MAPK_gen_1	228	236	PF00069	0.429
DOC_MAPK_gen_1	416	424	PF00069	0.700
DOC_MAPK_gen_1	445	455	PF00069	0.642
DOC_MAPK_MEF2A_6	448	457	PF00069	0.671
DOC_MAPK_MEF2A_6	56	64	PF00069	0.570
DOC_USP7_MATH_1	2	6	PF00917	0.586
DOC_USP7_MATH_1	335	339	PF00917	0.744
DOC_USP7_MATH_1	340	344	PF00917	0.742
DOC_USP7_MATH_1	349	353	PF00917	0.680
DOC_USP7_MATH_1	451	455	PF00917	0.589
DOC_USP7_MATH_1	525	529	PF00917	0.512
DOC_WW_Pin1_4	295	300	PF00397	0.783
DOC_WW_Pin1_4	322	327	PF00397	0.756
DOC_WW_Pin1_4	355	360	PF00397	0.627
DOC_WW_Pin1_4	372	377	PF00397	0.518
DOC_WW_Pin1_4	63	68	PF00397	0.561
DOC_WW_Pin1_4	93	98	PF00397	0.720
DOC_WW_Pin1_4	99	104	PF00397	0.708
LIG_14-3-3_CanoR_1	228	236	PF00244	0.430
LIG_14-3-3_CanoR_1	250	255	PF00244	0.468
LIG_14-3-3_CanoR_1	27	34	PF00244	0.630
LIG_14-3-3_CanoR_1	364	372	PF00244	0.537
LIG_14-3-3_CanoR_1	374	380	PF00244	0.426
LIG_14-3-3_CanoR_1	470	479	PF00244	0.459
LIG_APCC_ABBA_1	453	458	PF00400	0.666
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_4	315	319	PF00653	0.554
LIG_BIR_III_4	91	95	PF00653	0.504
LIG_BRCT_BRCA1_1	453	457	PF00533	0.568
LIG_CSL_BTD_1	535	538	PF09270	0.424
LIG_EH1_1	43	51	PF00400	0.574
LIG_eIF4E_1	44	50	PF01652	0.485
LIG_FHA_1	119	125	PF00498	0.487
LIG_FHA_1	184	190	PF00498	0.477
LIG_FHA_1	229	235	PF00498	0.407
LIG_FHA_1	325	331	PF00498	0.553
LIG_FHA_1	351	357	PF00498	0.685
LIG_FHA_1	387	393	PF00498	0.545
LIG_FHA_1	460	466	PF00498	0.740
LIG_FHA_1	484	490	PF00498	0.450
LIG_FHA_1	530	536	PF00498	0.471
LIG_FHA_1	73	79	PF00498	0.637
LIG_FHA_2	159	165	PF00498	0.449
LIG_FHA_2	195	201	PF00498	0.648
LIG_FHA_2	326	332	PF00498	0.824
LIG_FHA_2	364	370	PF00498	0.629
LIG_FHA_2	46	52	PF00498	0.566
LIG_FHA_2	471	477	PF00498	0.481
LIG_FHA_2	64	70	PF00498	0.622
LIG_FHA_2	84	90	PF00498	0.383
LIG_HCF-1_HBM_1	246	249	PF13415	0.584
LIG_LIR_Gen_1	89	97	PF02991	0.506
LIG_LIR_Nem_3	89	93	PF02991	0.650
LIG_MLH1_MIPbox_1	453	457	PF16413	0.568
LIG_PDZ_Class_2	536	541	PF00595	0.344
LIG_Pex14_2	379	383	PF04695	0.573
LIG_RPA_C_Fungi	503	515	PF08784	0.354
LIG_SH2_CRK	90	94	PF00017	0.752
LIG_SH2_GRB2like	183	186	PF00017	0.449
LIG_SH2_NCK_1	256	260	PF00017	0.591
LIG_SH2_NCK_1	90	94	PF00017	0.714
LIG_SH2_SRC	256	259	PF00017	0.523
LIG_SH2_STAP1	183	187	PF00017	0.449
LIG_SH2_STAT5	151	154	PF00017	0.557
LIG_SH2_STAT5	205	208	PF00017	0.499
LIG_SH2_STAT5	423	426	PF00017	0.624
LIG_SH3_3	293	299	PF00018	0.756
LIG_SH3_3	462	468	PF00018	0.689
LIG_SUMO_SIM_par_1	270	276	PF11976	0.449
LIG_TRAF2_1	162	165	PF00917	0.449
LIG_UBA3_1	49	56	PF00899	0.472
LIG_WW_3	358	362	PF00397	0.735
LIG_WW_3	467	471	PF00397	0.645
MOD_CDC14_SPxK_1	358	361	PF00782	0.500
MOD_CDK_SPxK_1	355	361	PF00069	0.514
MOD_CK1_1	350	356	PF00069	0.711
MOD_CK1_1	375	381	PF00069	0.479
MOD_CK1_1	409	415	PF00069	0.701
MOD_CK1_1	5	11	PF00069	0.628
MOD_CK1_1	528	534	PF00069	0.511
MOD_CK1_1	63	69	PF00069	0.645
MOD_CK2_1	127	133	PF00069	0.449
MOD_CK2_1	158	164	PF00069	0.430
MOD_CK2_1	325	331	PF00069	0.767
MOD_CK2_1	363	369	PF00069	0.547
MOD_Cter_Amidation	414	417	PF01082	0.734
MOD_GlcNHglycan	15	18	PF01048	0.502
MOD_GlcNHglycan	152	155	PF01048	0.576
MOD_GlcNHglycan	179	182	PF01048	0.335
MOD_GlcNHglycan	212	215	PF01048	0.441
MOD_GlcNHglycan	3	7	PF01048	0.612
MOD_GlcNHglycan	337	341	PF01048	0.725
MOD_GlcNHglycan	349	352	PF01048	0.654
MOD_GlcNHglycan	395	398	PF01048	0.461
MOD_GlcNHglycan	408	411	PF01048	0.501
MOD_GlcNHglycan	440	443	PF01048	0.458
MOD_GlcNHglycan	494	499	PF01048	0.610
MOD_GlcNHglycan	527	530	PF01048	0.412
MOD_GSK3_1	179	186	PF00069	0.327
MOD_GSK3_1	224	231	PF00069	0.405
MOD_GSK3_1	283	290	PF00069	0.655
MOD_GSK3_1	321	328	PF00069	0.723
MOD_GSK3_1	336	343	PF00069	0.694
MOD_GSK3_1	347	354	PF00069	0.511
MOD_GSK3_1	382	389	PF00069	0.585
MOD_GSK3_1	490	497	PF00069	0.491
MOD_GSK3_1	525	532	PF00069	0.370
MOD_N-GLC_1	287	292	PF02516	0.806
MOD_N-GLC_1	406	411	PF02516	0.582
MOD_NEK2_1	136	141	PF00069	0.400
MOD_NEK2_1	210	215	PF00069	0.399
MOD_NEK2_1	265	270	PF00069	0.516
MOD_NEK2_1	284	289	PF00069	0.484
MOD_NEK2_1	34	39	PF00069	0.578
MOD_NEK2_1	347	352	PF00069	0.780
MOD_NEK2_1	477	482	PF00069	0.499
MOD_NEK2_2	183	188	PF00069	0.449
MOD_NEK2_2	451	456	PF00069	0.605
MOD_NEK2_2	529	534	PF00069	0.407
MOD_PIKK_1	257	263	PF00454	0.464
MOD_PKA_1	470	476	PF00069	0.493
MOD_PKA_2	335	341	PF00069	0.758
MOD_PKA_2	363	369	PF00069	0.596
MOD_PKA_2	470	476	PF00069	0.470
MOD_PKA_2	509	515	PF00069	0.549
MOD_PKA_2	516	522	PF00069	0.584
MOD_Plk_1	183	189	PF00069	0.388
MOD_Plk_1	336	342	PF00069	0.687
MOD_Plk_1	34	40	PF00069	0.508
MOD_Plk_1	406	412	PF00069	0.635
MOD_Plk_1	451	457	PF00069	0.602
MOD_Plk_1	529	535	PF00069	0.390
MOD_Plk_4	217	223	PF00069	0.456
MOD_Plk_4	270	276	PF00069	0.515
MOD_Plk_4	34	40	PF00069	0.589
MOD_Plk_4	418	424	PF00069	0.583
MOD_Plk_4	45	51	PF00069	0.579
MOD_Plk_4	451	457	PF00069	0.638
MOD_ProDKin_1	295	301	PF00069	0.783
MOD_ProDKin_1	322	328	PF00069	0.757
MOD_ProDKin_1	355	361	PF00069	0.621
MOD_ProDKin_1	372	378	PF00069	0.512
MOD_ProDKin_1	63	69	PF00069	0.560
MOD_ProDKin_1	93	99	PF00069	0.720
TRG_DiLeu_BaEn_1	474	479	PF01217	0.472
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.449
TRG_ENDOCYTIC_2	90	93	PF00928	0.736
TRG_ER_diArg_1	277	279	PF00400	0.615
TRG_ER_diArg_1	469	471	PF00400	0.524
TRG_ER_diArg_1	516	518	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E9	Leptomonas seymouri	65%	95%
A0A0S4JQH6	Bodo saltans	33%	100%
A0A1X0P9Q5	Trypanosomatidae	42%	100%
A0A3Q8IUQ4	Leishmania donovani	85%	99%
A0A3R7L5W7	Trypanosoma rangeli	40%	100%
A4IA44	Leishmania infantum	85%	99%
C9ZM56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B558	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2S7	Leishmania major	85%	100%
V5BKS0	Trypanosoma cruzi	42%	100%