Exocyst complex component Sec10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps52 / Sac2 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HAY3_LEIBR

TriTrypDb:

LbrM.20.2220 , LBRM2903_200032800

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0000938	GARP complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4HAY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006896	Golgi to vacuole transport	5	1
GO:0007034	vacuolar transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0032456	endocytic recycling	5	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.279
CLV_C14_Caspase3-7	364	368	PF00656	0.350
CLV_C14_Caspase3-7	457	461	PF00656	0.266
CLV_NRD_NRD_1	104	106	PF00675	0.282
CLV_NRD_NRD_1	125	127	PF00675	0.355
CLV_NRD_NRD_1	131	133	PF00675	0.264
CLV_NRD_NRD_1	173	175	PF00675	0.392
CLV_NRD_NRD_1	329	331	PF00675	0.460
CLV_NRD_NRD_1	45	47	PF00675	0.406
CLV_NRD_NRD_1	618	620	PF00675	0.442
CLV_NRD_NRD_1	674	676	PF00675	0.555
CLV_NRD_NRD_1	816	818	PF00675	0.492
CLV_NRD_NRD_1	866	868	PF00675	0.426
CLV_PCSK_KEX2_1	131	133	PF00082	0.308
CLV_PCSK_KEX2_1	173	175	PF00082	0.430
CLV_PCSK_KEX2_1	329	331	PF00082	0.460
CLV_PCSK_KEX2_1	45	47	PF00082	0.406
CLV_PCSK_KEX2_1	617	619	PF00082	0.399
CLV_PCSK_KEX2_1	674	676	PF00082	0.555
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.399
CLV_PCSK_PC7_1	169	175	PF00082	0.400
CLV_PCSK_PC7_1	325	331	PF00082	0.553
CLV_PCSK_SKI1_1	210	214	PF00082	0.344
CLV_PCSK_SKI1_1	215	219	PF00082	0.344
CLV_PCSK_SKI1_1	269	273	PF00082	0.270
CLV_PCSK_SKI1_1	339	343	PF00082	0.562
CLV_PCSK_SKI1_1	361	365	PF00082	0.433
CLV_PCSK_SKI1_1	444	448	PF00082	0.341
CLV_PCSK_SKI1_1	505	509	PF00082	0.403
CLV_PCSK_SKI1_1	513	517	PF00082	0.401
CLV_PCSK_SKI1_1	736	740	PF00082	0.312
CLV_Separin_Metazoa	814	818	PF03568	0.459
DEG_SCF_FBW7_1	652	659	PF00400	0.516
DEG_SCF_FBW7_1	778	784	PF00400	0.477
DOC_CDC14_PxL_1	489	497	PF14671	0.452
DOC_CDC14_PxL_1	523	531	PF14671	0.462
DOC_CKS1_1	778	783	PF01111	0.594
DOC_CYCLIN_RxL_1	169	179	PF00134	0.348
DOC_CYCLIN_RxL_1	210	222	PF00134	0.400
DOC_CYCLIN_RxL_1	733	743	PF00134	0.344
DOC_MAPK_gen_1	867	873	PF00069	0.523
DOC_MIT_MIM_1	170	178	PF04212	0.400
DOC_PP1_RVXF_1	171	178	PF00149	0.285
DOC_PP1_RVXF_1	180	187	PF00149	0.282
DOC_PP1_RVXF_1	240	247	PF00149	0.203
DOC_PP1_RVXF_1	672	679	PF00149	0.509
DOC_PP2B_LxvP_1	900	903	PF13499	0.332
DOC_PP4_FxxP_1	246	249	PF00568	0.203
DOC_USP7_MATH_1	27	31	PF00917	0.520
DOC_USP7_MATH_1	291	295	PF00917	0.562
DOC_USP7_MATH_1	349	353	PF00917	0.648
DOC_USP7_MATH_1	539	543	PF00917	0.466
DOC_USP7_MATH_1	656	660	PF00917	0.715
DOC_USP7_MATH_1	680	684	PF00917	0.616
DOC_USP7_MATH_1	71	75	PF00917	0.360
DOC_USP7_MATH_1	734	738	PF00917	0.471
DOC_USP7_MATH_1	757	761	PF00917	0.538
DOC_USP7_UBL2_3	203	207	PF12436	0.400
DOC_WW_Pin1_4	619	624	PF00397	0.428
DOC_WW_Pin1_4	652	657	PF00397	0.709
DOC_WW_Pin1_4	660	665	PF00397	0.700
DOC_WW_Pin1_4	686	691	PF00397	0.762
DOC_WW_Pin1_4	767	772	PF00397	0.647
DOC_WW_Pin1_4	777	782	PF00397	0.627
LIG_14-3-3_CanoR_1	194	202	PF00244	0.336
LIG_14-3-3_CanoR_1	261	268	PF00244	0.348
LIG_14-3-3_CanoR_1	332	341	PF00244	0.503
LIG_14-3-3_CanoR_1	361	366	PF00244	0.439
LIG_14-3-3_CanoR_1	509	513	PF00244	0.412
LIG_14-3-3_CanoR_1	530	535	PF00244	0.429
LIG_14-3-3_CanoR_1	582	586	PF00244	0.500
LIG_14-3-3_CanoR_1	703	708	PF00244	0.375
LIG_14-3-3_CanoR_1	867	872	PF00244	0.384
LIG_Actin_WH2_2	493	511	PF00022	0.450
LIG_Actin_WH2_2	566	584	PF00022	0.262
LIG_AP2alpha_2	595	597	PF02296	0.277
LIG_APCC_ABBA_1	54	59	PF00400	0.379
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BRCT_BRCA1_1	235	239	PF00533	0.400
LIG_BRCT_BRCA1_1	582	586	PF00533	0.394
LIG_BRCT_BRCA1_1	855	859	PF00533	0.323
LIG_Clathr_ClatBox_1	15	19	PF01394	0.374
LIG_Clathr_ClatBox_1	739	743	PF01394	0.306
LIG_eIF4E_1	267	273	PF01652	0.203
LIG_FHA_1	211	217	PF00498	0.344
LIG_FHA_1	352	358	PF00498	0.587
LIG_FHA_1	454	460	PF00498	0.476
LIG_FHA_1	467	473	PF00498	0.309
LIG_FHA_1	526	532	PF00498	0.414
LIG_FHA_1	576	582	PF00498	0.449
LIG_FHA_1	744	750	PF00498	0.472
LIG_FHA_1	8	14	PF00498	0.606
LIG_FHA_1	850	856	PF00498	0.287
LIG_FHA_1	889	895	PF00498	0.469
LIG_FHA_2	216	222	PF00498	0.448
LIG_FHA_2	362	368	PF00498	0.364
LIG_FHA_2	435	441	PF00498	0.494
LIG_FHA_2	485	491	PF00498	0.478
LIG_FHA_2	512	518	PF00498	0.411
LIG_FHA_2	609	615	PF00498	0.317
LIG_FHA_2	638	644	PF00498	0.418
LIG_FHA_2	859	865	PF00498	0.423
LIG_GBD_Chelix_1	854	862	PF00786	0.265
LIG_Integrin_isoDGR_2	672	674	PF01839	0.515
LIG_LIR_Gen_1	140	149	PF02991	0.285
LIG_LIR_Gen_1	150	155	PF02991	0.286
LIG_LIR_Gen_1	397	408	PF02991	0.393
LIG_LIR_Gen_1	632	639	PF02991	0.462
LIG_LIR_Gen_1	856	865	PF02991	0.328
LIG_LIR_LC3C_4	851	855	PF02991	0.340
LIG_LIR_Nem_3	140	145	PF02991	0.285
LIG_LIR_Nem_3	149	154	PF02991	0.286
LIG_LIR_Nem_3	256	262	PF02991	0.296
LIG_LIR_Nem_3	397	403	PF02991	0.384
LIG_LIR_Nem_3	541	547	PF02991	0.546
LIG_LIR_Nem_3	591	597	PF02991	0.465
LIG_LIR_Nem_3	632	638	PF02991	0.448
LIG_LIR_Nem_3	640	644	PF02991	0.506
LIG_LIR_Nem_3	732	738	PF02991	0.513
LIG_LIR_Nem_3	856	862	PF02991	0.546
LIG_LRP6_Inhibitor_1	188	194	PF00058	0.400
LIG_MAD2	215	223	PF02301	0.400
LIG_NRBOX	896	902	PF00104	0.393
LIG_PCNA_yPIPBox_3	717	725	PF02747	0.498
LIG_Pex14_1	398	402	PF04695	0.328
LIG_Pex14_2	239	243	PF04695	0.400
LIG_Pex14_2	402	406	PF04695	0.432
LIG_Pex14_2	419	423	PF04695	0.263
LIG_Pex14_2	597	601	PF04695	0.251
LIG_PTB_Apo_2	547	554	PF02174	0.489
LIG_PTB_Phospho_1	547	553	PF10480	0.495
LIG_SH2_CRK	142	146	PF00017	0.308
LIG_SH2_CRK	635	639	PF00017	0.256
LIG_SH2_GRB2like	575	578	PF00017	0.436
LIG_SH2_SRC	711	714	PF00017	0.480
LIG_SH2_STAP1	635	639	PF00017	0.370
LIG_SH2_STAT3	247	250	PF00017	0.203
LIG_SH2_STAT3	262	265	PF00017	0.368
LIG_SH2_STAT3	267	270	PF00017	0.319
LIG_SH2_STAT3	707	710	PF00017	0.338
LIG_SH2_STAT5	164	167	PF00017	0.284
LIG_SH2_STAT5	267	270	PF00017	0.321
LIG_SH2_STAT5	43	46	PF00017	0.536
LIG_SH2_STAT5	553	556	PF00017	0.410
LIG_SH2_STAT5	575	578	PF00017	0.464
LIG_SH2_STAT5	635	638	PF00017	0.355
LIG_SH2_STAT5	711	714	PF00017	0.454
LIG_SH3_1	776	782	PF00018	0.493
LIG_SH3_2	771	776	PF14604	0.526
LIG_SH3_3	285	291	PF00018	0.527
LIG_SH3_3	304	310	PF00018	0.609
LIG_SH3_3	317	323	PF00018	0.541
LIG_SH3_3	590	596	PF00018	0.333
LIG_SH3_3	658	664	PF00018	0.700
LIG_SH3_3	768	774	PF00018	0.707
LIG_SH3_3	775	781	PF00018	0.721
LIG_Sin3_3	443	450	PF02671	0.455
LIG_SUMO_SIM_anti_2	460	467	PF11976	0.403
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.377
LIG_SUMO_SIM_par_1	215	222	PF11976	0.399
LIG_SUMO_SIM_par_1	492	498	PF11976	0.351
LIG_SUMO_SIM_par_1	737	744	PF11976	0.549
LIG_SUMO_SIM_par_1	851	856	PF11976	0.270
LIG_TRAF2_1	232	235	PF00917	0.429
LIG_TRAF2_1	294	297	PF00917	0.515
LIG_TRAF2_1	726	729	PF00917	0.317
LIG_UBA3_1	609	617	PF00899	0.392
LIG_WRC_WIRS_1	100	105	PF05994	0.355
LIG_WRC_WIRS_1	598	603	PF05994	0.446
MOD_CK1_1	156	162	PF00069	0.463
MOD_CK1_1	279	285	PF00069	0.360
MOD_CK1_1	35	41	PF00069	0.426
MOD_CK1_1	511	517	PF00069	0.453
MOD_CK1_1	648	654	PF00069	0.674
MOD_CK1_1	657	663	PF00069	0.729
MOD_CK1_1	756	762	PF00069	0.484
MOD_CK1_1	807	813	PF00069	0.336
MOD_CK1_1	829	835	PF00069	0.667
MOD_CK1_1	860	866	PF00069	0.421
MOD_CK1_1	889	895	PF00069	0.421
MOD_CK2_1	156	162	PF00069	0.351
MOD_CK2_1	215	221	PF00069	0.401
MOD_CK2_1	229	235	PF00069	0.249
MOD_CK2_1	291	297	PF00069	0.487
MOD_CK2_1	3	9	PF00069	0.617
MOD_CK2_1	349	355	PF00069	0.627
MOD_CK2_1	434	440	PF00069	0.447
MOD_CK2_1	449	455	PF00069	0.339
MOD_CK2_1	511	517	PF00069	0.523
MOD_CK2_1	637	643	PF00069	0.428
MOD_CK2_1	686	692	PF00069	0.818
MOD_CK2_1	84	90	PF00069	0.257
MOD_CK2_1	858	864	PF00069	0.536
MOD_Cter_Amidation	672	675	PF01082	0.514
MOD_GlcNHglycan	1	4	PF01048	0.677
MOD_GlcNHglycan	142	145	PF01048	0.338
MOD_GlcNHglycan	178	181	PF01048	0.335
MOD_GlcNHglycan	186	189	PF01048	0.285
MOD_GlcNHglycan	234	238	PF01048	0.407
MOD_GlcNHglycan	280	284	PF01048	0.406
MOD_GlcNHglycan	293	296	PF01048	0.485
MOD_GlcNHglycan	437	440	PF01048	0.513
MOD_GlcNHglycan	497	500	PF01048	0.347
MOD_GlcNHglycan	51	54	PF01048	0.496
MOD_GlcNHglycan	541	544	PF01048	0.370
MOD_GlcNHglycan	647	650	PF01048	0.548
MOD_GlcNHglycan	652	655	PF01048	0.650
MOD_GlcNHglycan	656	659	PF01048	0.681
MOD_GlcNHglycan	669	672	PF01048	0.805
MOD_GlcNHglycan	755	758	PF01048	0.532
MOD_GlcNHglycan	759	762	PF01048	0.581
MOD_GlcNHglycan	831	834	PF01048	0.732
MOD_GlcNHglycan	85	89	PF01048	0.313
MOD_GlcNHglycan	855	858	PF01048	0.266
MOD_GlcNHglycan	877	880	PF01048	0.510
MOD_GSK3_1	229	236	PF00069	0.422
MOD_GSK3_1	3	10	PF00069	0.627
MOD_GSK3_1	32	39	PF00069	0.614
MOD_GSK3_1	339	346	PF00069	0.712
MOD_GSK3_1	349	356	PF00069	0.519
MOD_GSK3_1	361	368	PF00069	0.364
MOD_GSK3_1	449	456	PF00069	0.483
MOD_GSK3_1	525	532	PF00069	0.386
MOD_GSK3_1	577	584	PF00069	0.404
MOD_GSK3_1	629	636	PF00069	0.401
MOD_GSK3_1	648	655	PF00069	0.639
MOD_GSK3_1	656	663	PF00069	0.705
MOD_GSK3_1	753	760	PF00069	0.517
MOD_GSK3_1	777	784	PF00069	0.646
MOD_GSK3_1	800	807	PF00069	0.504
MOD_GSK3_1	820	827	PF00069	0.536
MOD_GSK3_1	829	836	PF00069	0.709
MOD_GSK3_1	849	856	PF00069	0.448
MOD_GSK3_1	882	889	PF00069	0.473
MOD_LATS_1	337	343	PF00433	0.572
MOD_N-GLC_1	156	161	PF02516	0.484
MOD_N-GLC_1	460	465	PF02516	0.251
MOD_N-GLC_1	767	772	PF02516	0.722
MOD_N-GLC_1	829	834	PF02516	0.648
MOD_N-GLC_1	889	894	PF02516	0.387
MOD_N-GLC_2	411	413	PF02516	0.368
MOD_NEK2_1	184	189	PF00069	0.300
MOD_NEK2_1	233	238	PF00069	0.332
MOD_NEK2_1	263	268	PF00069	0.425
MOD_NEK2_1	365	370	PF00069	0.443
MOD_NEK2_1	495	500	PF00069	0.328
MOD_NEK2_1	501	506	PF00069	0.337
MOD_NEK2_1	508	513	PF00069	0.346
MOD_NEK2_1	529	534	PF00069	0.327
MOD_NEK2_1	581	586	PF00069	0.482
MOD_NEK2_1	597	602	PF00069	0.228
MOD_NEK2_1	629	634	PF00069	0.473
MOD_NEK2_1	753	758	PF00069	0.566
MOD_NEK2_1	789	794	PF00069	0.445
MOD_NEK2_1	824	829	PF00069	0.627
MOD_NEK2_1	853	858	PF00069	0.462
MOD_PIKK_1	261	267	PF00454	0.454
MOD_PIKK_1	32	38	PF00454	0.616
MOD_PIKK_1	332	338	PF00454	0.524
MOD_PIKK_1	711	717	PF00454	0.486
MOD_PIKK_1	800	806	PF00454	0.436
MOD_PK_1	330	336	PF00069	0.510
MOD_PK_1	867	873	PF00069	0.265
MOD_PKA_1	867	873	PF00069	0.324
MOD_PKA_2	508	514	PF00069	0.408
MOD_PKA_2	529	535	PF00069	0.422
MOD_PKA_2	581	587	PF00069	0.526
MOD_PKB_1	330	338	PF00069	0.517
MOD_Plk_1	156	162	PF00069	0.448
MOD_Plk_1	279	285	PF00069	0.360
MOD_Plk_1	330	336	PF00069	0.410
MOD_Plk_1	454	460	PF00069	0.417
MOD_Plk_1	743	749	PF00069	0.394
MOD_Plk_1	790	796	PF00069	0.366
MOD_Plk_1	848	854	PF00069	0.470
MOD_Plk_1	889	895	PF00069	0.392
MOD_Plk_4	263	269	PF00069	0.434
MOD_Plk_4	454	460	PF00069	0.366
MOD_Plk_4	503	509	PF00069	0.362
MOD_Plk_4	581	587	PF00069	0.528
MOD_Plk_4	597	603	PF00069	0.432
MOD_Plk_4	608	614	PF00069	0.322
MOD_Plk_4	633	639	PF00069	0.434
MOD_Plk_4	734	740	PF00069	0.399
MOD_Plk_4	790	796	PF00069	0.570
MOD_Plk_4	849	855	PF00069	0.422
MOD_Plk_4	867	873	PF00069	0.360
MOD_Plk_4	889	895	PF00069	0.418
MOD_ProDKin_1	619	625	PF00069	0.425
MOD_ProDKin_1	652	658	PF00069	0.711
MOD_ProDKin_1	660	666	PF00069	0.699
MOD_ProDKin_1	686	692	PF00069	0.764
MOD_ProDKin_1	767	773	PF00069	0.648
MOD_ProDKin_1	777	783	PF00069	0.627
TRG_DiLeu_BaEn_1	20	25	PF01217	0.447
TRG_DiLeu_BaEn_1	355	360	PF01217	0.500
TRG_DiLeu_BaEn_1	849	854	PF01217	0.373
TRG_DiLeu_BaEn_1	896	901	PF01217	0.339
TRG_DiLeu_BaEn_1	9	14	PF01217	0.604
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.331
TRG_DiLeu_LyEn_5	355	360	PF01217	0.500
TRG_DiLeu_LyEn_5	896	901	PF01217	0.302
TRG_ENDOCYTIC_2	142	145	PF00928	0.324
TRG_ENDOCYTIC_2	635	638	PF00928	0.373
TRG_ENDOCYTIC_2	83	86	PF00928	0.296
TRG_ER_diArg_1	173	175	PF00400	0.428
TRG_ER_diArg_1	44	46	PF00400	0.403
TRG_ER_diArg_1	674	676	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	674	679	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P609	Leptomonas seymouri	64%	100%
A0A0S4JX74	Bodo saltans	33%	100%
A0A1X0PA29	Trypanosomatidae	36%	100%
A0A3Q8IHM2	Leishmania donovani	77%	100%
A0A422NRZ3	Trypanosoma rangeli	36%	100%
A4IA42	Leishmania infantum	77%	100%
E9B556	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4Q2S9	Leishmania major	79%	100%