CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania braziliensis

UniProt:

A4HAY2_LEIBR

TriTrypDb:

LbrM.20.2210 , LBRM2903_200032700

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 5
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAY2

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.489
CLV_NRD_NRD_1	329	331	PF00675	0.516
CLV_NRD_NRD_1	425	427	PF00675	0.559
CLV_PCSK_KEX2_1	11	13	PF00082	0.489
CLV_PCSK_KEX2_1	329	331	PF00082	0.529
CLV_PCSK_KEX2_1	414	416	PF00082	0.614
CLV_PCSK_KEX2_1	425	427	PF00082	0.548
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.614
CLV_PCSK_SKI1_1	222	226	PF00082	0.448
CLV_PCSK_SKI1_1	307	311	PF00082	0.448
CLV_PCSK_SKI1_1	319	323	PF00082	0.498
DEG_APCC_DBOX_1	216	224	PF00400	0.248
DEG_COP1_1	531	539	PF00400	0.345
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_CKS1_1	258	263	PF01111	0.259
DOC_MAPK_gen_1	11	19	PF00069	0.466
DOC_MAPK_MEF2A_6	11	19	PF00069	0.454
DOC_MAPK_MEF2A_6	180	187	PF00069	0.335
DOC_MAPK_MEF2A_6	297	305	PF00069	0.249
DOC_MAPK_MEF2A_6	319	326	PF00069	0.338
DOC_MAPK_MEF2A_6	512	519	PF00069	0.375
DOC_PP1_RVXF_1	219	226	PF00149	0.248
DOC_PP2B_LxvP_1	3	6	PF13499	0.723
DOC_PP2B_LxvP_1	534	537	PF13499	0.353
DOC_USP7_MATH_1	168	172	PF00917	0.459
DOC_USP7_MATH_1	228	232	PF00917	0.262
DOC_USP7_MATH_1	32	36	PF00917	0.576
DOC_USP7_MATH_1	407	411	PF00917	0.403
DOC_USP7_MATH_1	472	476	PF00917	0.499
DOC_USP7_MATH_1	529	533	PF00917	0.376
DOC_USP7_MATH_1	53	57	PF00917	0.428
DOC_USP7_MATH_1	6	10	PF00917	0.643
DOC_USP7_UBL2_3	205	209	PF12436	0.334
DOC_WW_Pin1_4	257	262	PF00397	0.255
LIG_14-3-3_CanoR_1	573	581	PF00244	0.546
LIG_14-3-3_CanoR_1	584	588	PF00244	0.467
LIG_APCC_ABBA_1	486	491	PF00400	0.391
LIG_BRCT_BRCA1_1	387	391	PF00533	0.342
LIG_BRCT_BRCA1_1	494	498	PF00533	0.303
LIG_BRCT_BRCA1_1	531	535	PF00533	0.392
LIG_Clathr_ClatBox_1	375	379	PF01394	0.287
LIG_Clathr_ClatBox_1	65	69	PF01394	0.447
LIG_Clathr_ClatBox_1	86	90	PF01394	0.534
LIG_EH1_1	369	377	PF00400	0.294
LIG_eIF4E_1	370	376	PF01652	0.292
LIG_eIF4E_1	557	563	PF01652	0.239
LIG_FHA_1	123	129	PF00498	0.310
LIG_FHA_1	276	282	PF00498	0.283
LIG_FHA_1	316	322	PF00498	0.314
LIG_FHA_1	336	342	PF00498	0.162
LIG_FHA_1	497	503	PF00498	0.284
LIG_FHA_1	525	531	PF00498	0.363
LIG_FHA_1	81	87	PF00498	0.300
LIG_FHA_1	89	95	PF00498	0.442
LIG_FHA_2	252	258	PF00498	0.311
LIG_FHA_2	375	381	PF00498	0.283
LIG_GBD_Chelix_1	149	157	PF00786	0.330
LIG_LIR_Gen_1	495	506	PF02991	0.291
LIG_LIR_Gen_1	521	530	PF02991	0.298
LIG_LIR_Gen_1	555	563	PF02991	0.349
LIG_LIR_Gen_1	60	68	PF02991	0.348
LIG_LIR_LC3C_4	499	502	PF02991	0.360
LIG_LIR_Nem_3	367	372	PF02991	0.335
LIG_LIR_Nem_3	388	394	PF02991	0.352
LIG_LIR_Nem_3	495	501	PF02991	0.287
LIG_LIR_Nem_3	521	525	PF02991	0.299
LIG_LIR_Nem_3	60	65	PF02991	0.351
LIG_PCNA_yPIPBox_3	116	127	PF02747	0.448
LIG_PDZ_Class_3	585	590	PF00595	0.540
LIG_Pex14_2	188	192	PF04695	0.300
LIG_Pex14_2	535	539	PF04695	0.344
LIG_Pex14_2	75	79	PF04695	0.316
LIG_SH2_SRC	394	397	PF00017	0.298
LIG_SH2_STAP1	108	112	PF00017	0.473
LIG_SH2_STAT5	346	349	PF00017	0.303
LIG_SH2_STAT5	557	560	PF00017	0.382
LIG_SH3_3	192	198	PF00018	0.348
LIG_SH3_3	255	261	PF00018	0.246
LIG_SH3_3	466	472	PF00018	0.342
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.324
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.309
LIG_SUMO_SIM_anti_2	352	359	PF11976	0.299
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.280
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.380
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.448
LIG_SUMO_SIM_par_1	263	269	PF11976	0.258
LIG_SUMO_SIM_par_1	498	503	PF11976	0.294
LIG_SUMO_SIM_par_1	513	518	PF11976	0.371
LIG_SUMO_SIM_par_1	64	70	PF11976	0.336
LIG_SUMO_SIM_par_1	90	95	PF11976	0.448
LIG_WRC_WIRS_1	157	162	PF05994	0.195
LIG_WRC_WIRS_1	536	541	PF05994	0.321
MOD_CK1_1	231	237	PF00069	0.415
MOD_CK1_1	410	416	PF00069	0.419
MOD_CK1_1	421	427	PF00069	0.410
MOD_CK1_1	496	502	PF00069	0.370
MOD_CK1_1	569	575	PF00069	0.488
MOD_CK2_1	251	257	PF00069	0.392
MOD_CK2_1	441	447	PF00069	0.373
MOD_CK2_1	97	103	PF00069	0.440
MOD_Cter_Amidation	9	12	PF01082	0.485
MOD_GlcNHglycan	170	173	PF01048	0.253
MOD_GlcNHglycan	180	183	PF01048	0.287
MOD_GlcNHglycan	230	233	PF01048	0.577
MOD_GlcNHglycan	34	37	PF01048	0.618
MOD_GlcNHglycan	451	456	PF01048	0.631
MOD_GlcNHglycan	502	505	PF01048	0.547
MOD_GlcNHglycan	576	579	PF01048	0.684
MOD_GlcNHglycan	59	62	PF01048	0.625
MOD_GlcNHglycan	8	11	PF01048	0.358
MOD_GlcNHglycan	99	102	PF01048	0.248
MOD_GSK3_1	148	155	PF00069	0.300
MOD_GSK3_1	335	342	PF00069	0.304
MOD_GSK3_1	417	424	PF00069	0.405
MOD_GSK3_1	492	499	PF00069	0.305
MOD_GSK3_1	520	527	PF00069	0.386
MOD_GSK3_1	53	60	PF00069	0.459
MOD_GSK3_1	568	575	PF00069	0.471
MOD_N-GLC_1	407	412	PF02516	0.675
MOD_N-GLC_1	41	46	PF02516	0.711
MOD_NEK2_1	122	127	PF00069	0.293
MOD_NEK2_1	132	137	PF00069	0.275
MOD_NEK2_1	441	446	PF00069	0.321
MOD_NEK2_1	500	505	PF00069	0.320
MOD_NEK2_1	57	62	PF00069	0.400
MOD_NEK2_2	537	542	PF00069	0.292
MOD_PKA_2	572	578	PF00069	0.562
MOD_PKA_2	583	589	PF00069	0.328
MOD_Plk_1	104	110	PF00069	0.452
MOD_Plk_1	251	257	PF00069	0.306
MOD_Plk_1	275	281	PF00069	0.259
MOD_Plk_1	407	413	PF00069	0.440
MOD_Plk_1	451	457	PF00069	0.380
MOD_Plk_1	461	467	PF00069	0.358
MOD_Plk_1	53	59	PF00069	0.371
MOD_Plk_1	545	551	PF00069	0.306
MOD_Plk_2-3	90	96	PF00069	0.438
MOD_Plk_2-3	99	105	PF00069	0.438
MOD_Plk_4	122	128	PF00069	0.300
MOD_Plk_4	132	138	PF00069	0.300
MOD_Plk_4	148	154	PF00069	0.300
MOD_Plk_4	15	21	PF00069	0.366
MOD_Plk_4	197	203	PF00069	0.287
MOD_Plk_4	251	257	PF00069	0.306
MOD_Plk_4	462	468	PF00069	0.373
MOD_Plk_4	493	499	PF00069	0.383
MOD_Plk_4	545	551	PF00069	0.303
MOD_Plk_4	61	67	PF00069	0.335
MOD_ProDKin_1	257	263	PF00069	0.255
MOD_SUMO_rev_2	216	223	PF00179	0.248
MOD_SUMO_rev_2	336	341	PF00179	0.289
MOD_SUMO_rev_2	367	375	PF00179	0.310
TRG_DiLeu_BaEn_1	219	224	PF01217	0.248
TRG_DiLeu_BaEn_1	277	282	PF01217	0.259
TRG_DiLeu_BaEn_1	371	376	PF01217	0.283
TRG_ENDOCYTIC_2	369	372	PF00928	0.324
TRG_ENDOCYTIC_2	557	560	PF00928	0.334
TRG_ER_diArg_1	425	427	PF00400	0.351
TRG_ER_diArg_1	467	470	PF00400	0.419
TRG_NES_CRM1_1	257	272	PF08389	0.289
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	33%	71%
A0A0N1PDI6	Leptomonas seymouri	88%	98%
A0A0S4JSF9	Bodo saltans	69%	100%
A0A131MCZ8	Caenorhabditis elegans	30%	74%
A0A1X0P6Q5	Trypanosomatidae	31%	79%
A0A1X0PAL3	Trypanosomatidae	70%	100%
A0A3Q8IC75	Leishmania donovani	25%	100%
A0A3Q8IL77	Leishmania donovani	90%	97%
A0A3Q8ITK0	Leishmania donovani	23%	100%
A0A422NS01	Trypanosoma rangeli	70%	100%
A0JPA0	Xenopus tropicalis	36%	77%
A3QM97	Caenorhabditis elegans	31%	73%
A4HIN7	Leishmania braziliensis	22%	100%
A4HKU5	Leishmania braziliensis	23%	100%
A4I5Y4	Leishmania infantum	25%	100%
A4I8C4	Leishmania infantum	23%	100%
A4IA41	Leishmania infantum	90%	97%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
P0C588	Rattus norvegicus	35%	76%
Q12296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	84%
Q32NY4	Mus musculus	29%	83%
Q3TWN3	Mus musculus	35%	67%
Q4Q2T0	Leishmania major	90%	100%
Q4Q4X2	Leishmania major	21%	100%
Q4Q6Y7	Leishmania major	24%	100%
Q4QE29	Leishmania major	32%	100%
Q5U2P1	Rattus norvegicus	35%	67%
Q69ZF7	Mus musculus	36%	77%
Q6P4Q7	Homo sapiens	36%	76%
Q8NE01	Homo sapiens	28%	83%
Q9GYL2	Caenorhabditis elegans	30%	77%
Q9H8M5	Homo sapiens	35%	67%
V5BKR5	Trypanosoma cruzi	71%	100%