Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA and DNA helicase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4HAX9_LEIBR

TriTrypDb:

LbrM.20.2180 , LBRM2903_200032500

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:0045025	mitochondrial degradosome	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HAX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAX9

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0000963	mitochondrial RNA processing	6	1
GO:0000965	mitochondrial RNA 3'-end processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010467	gene expression	4	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140053	mitochondrial gene expression	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003724	RNA helicase activity	3	13
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	13
GO:0008186	ATP-dependent activity, acting on RNA	2	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0140098	catalytic activity, acting on RNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.265
CLV_MEL_PAP_1	654	660	PF00089	0.224
CLV_NRD_NRD_1	117	119	PF00675	0.411
CLV_NRD_NRD_1	141	143	PF00675	0.288
CLV_NRD_NRD_1	274	276	PF00675	0.426
CLV_NRD_NRD_1	4	6	PF00675	0.530
CLV_NRD_NRD_1	424	426	PF00675	0.380
CLV_NRD_NRD_1	506	508	PF00675	0.478
CLV_NRD_NRD_1	627	629	PF00675	0.457
CLV_NRD_NRD_1	646	648	PF00675	0.235
CLV_PCSK_KEX2_1	140	142	PF00082	0.322
CLV_PCSK_KEX2_1	284	286	PF00082	0.368
CLV_PCSK_KEX2_1	4	6	PF00082	0.532
CLV_PCSK_KEX2_1	627	629	PF00082	0.457
CLV_PCSK_KEX2_1	646	648	PF00082	0.235
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.379
CLV_PCSK_PC7_1	137	143	PF00082	0.359
CLV_PCSK_SKI1_1	142	146	PF00082	0.312
CLV_PCSK_SKI1_1	243	247	PF00082	0.264
CLV_PCSK_SKI1_1	276	280	PF00082	0.281
CLV_PCSK_SKI1_1	316	320	PF00082	0.317
CLV_PCSK_SKI1_1	399	403	PF00082	0.298
CLV_PCSK_SKI1_1	418	422	PF00082	0.273
CLV_PCSK_SKI1_1	467	471	PF00082	0.254
CLV_PCSK_SKI1_1	545	549	PF00082	0.347
CLV_PCSK_SKI1_1	55	59	PF00082	0.508
CLV_PCSK_SKI1_1	565	569	PF00082	0.112
CLV_PCSK_SKI1_1	595	599	PF00082	0.312
CLV_Separin_Metazoa	555	559	PF03568	0.493
DEG_APCC_DBOX_1	274	282	PF00400	0.465
DEG_APCC_DBOX_1	321	329	PF00400	0.377
DEG_SPOP_SBC_1	377	381	PF00917	0.475
DOC_CYCLIN_RxL_1	542	552	PF00134	0.441
DOC_CYCLIN_RxL_1	664	674	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.507
DOC_MAPK_gen_1	186	195	PF00069	0.369
DOC_MAPK_gen_1	275	281	PF00069	0.316
DOC_MAPK_gen_1	284	291	PF00069	0.340
DOC_MAPK_gen_1	315	321	PF00069	0.377
DOC_MAPK_JIP1_4	595	601	PF00069	0.219
DOC_MAPK_MEF2A_6	102	111	PF00069	0.485
DOC_MAPK_MEF2A_6	284	291	PF00069	0.345
DOC_PP1_RVXF_1	416	422	PF00149	0.240
DOC_PP1_RVXF_1	563	569	PF00149	0.404
DOC_PP2B_LxvP_1	246	249	PF13499	0.270
DOC_SPAK_OSR1_1	600	604	PF12202	0.373
DOC_USP7_MATH_1	149	153	PF00917	0.328
DOC_USP7_MATH_1	30	34	PF00917	0.609
DOC_USP7_MATH_1	382	386	PF00917	0.634
DOC_USP7_MATH_1	444	448	PF00917	0.470
DOC_USP7_MATH_1	474	478	PF00917	0.396
DOC_USP7_UBL2_3	119	123	PF12436	0.429
DOC_WW_Pin1_4	15	20	PF00397	0.527
DOC_WW_Pin1_4	28	33	PF00397	0.413
DOC_WW_Pin1_4	373	378	PF00397	0.554
DOC_WW_Pin1_4	388	393	PF00397	0.513
DOC_WW_Pin1_4	620	625	PF00397	0.620
LIG_14-3-3_CanoR_1	275	279	PF00244	0.468
LIG_14-3-3_CanoR_1	383	389	PF00244	0.485
LIG_14-3-3_CanoR_1	418	427	PF00244	0.311
LIG_14-3-3_CanoR_1	460	464	PF00244	0.364
LIG_14-3-3_CanoR_1	657	663	PF00244	0.404
LIG_Actin_WH2_2	536	551	PF00022	0.415
LIG_APCC_ABBA_1	495	500	PF00400	0.471
LIG_BRCT_BRCA1_1	446	450	PF00533	0.481
LIG_BRCT_BRCA1_1	534	538	PF00533	0.368
LIG_BRCT_BRCA1_1	654	658	PF00533	0.480
LIG_BRCT_BRCA1_2	654	660	PF00533	0.513
LIG_Clathr_ClatBox_1	278	282	PF01394	0.337
LIG_deltaCOP1_diTrp_1	236	241	PF00928	0.291
LIG_deltaCOP1_diTrp_1	86	93	PF00928	0.499
LIG_eIF4E_1	133	139	PF01652	0.387
LIG_FHA_1	240	246	PF00498	0.264
LIG_FHA_1	396	402	PF00498	0.376
LIG_FHA_1	403	409	PF00498	0.262
LIG_FHA_1	489	495	PF00498	0.324
LIG_FHA_2	51	57	PF00498	0.428
LIG_FHA_2	531	537	PF00498	0.262
LIG_FHA_2	637	643	PF00498	0.347
LIG_FHA_2	659	665	PF00498	0.493
LIG_Integrin_RGD_1	614	616	PF01839	0.359
LIG_LIR_Apic_2	167	173	PF02991	0.286
LIG_LIR_Gen_1	308	318	PF02991	0.403
LIG_LIR_Gen_1	520	530	PF02991	0.425
LIG_LIR_Gen_1	649	658	PF02991	0.404
LIG_LIR_Nem_3	179	185	PF02991	0.357
LIG_LIR_Nem_3	308	313	PF02991	0.387
LIG_LIR_Nem_3	520	524	PF02991	0.392
LIG_LIR_Nem_3	649	654	PF02991	0.404
LIG_NRBOX	549	555	PF00104	0.184
LIG_PCNA_yPIPBox_3	351	360	PF02747	0.469
LIG_Pex14_1	89	93	PF04695	0.475
LIG_Pex14_2	658	662	PF04695	0.404
LIG_SH2_CRK	170	174	PF00017	0.264
LIG_SH2_STAT5	170	173	PF00017	0.256
LIG_SH2_STAT5	359	362	PF00017	0.484
LIG_SH2_STAT5	570	573	PF00017	0.424
LIG_SH2_STAT5	651	654	PF00017	0.408
LIG_SH3_3	386	392	PF00018	0.474
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.359
LIG_SUMO_SIM_anti_2	277	282	PF11976	0.228
LIG_SUMO_SIM_par_1	277	282	PF11976	0.356
LIG_SUMO_SIM_par_1	317	323	PF11976	0.370
LIG_SUMO_SIM_par_1	431	437	PF11976	0.271
LIG_TRAF2_1	617	620	PF00917	0.431
LIG_UBA3_1	497	505	PF00899	0.407
MOD_CDK_SPK_2	378	383	PF00069	0.503
MOD_CDK_SPxxK_3	620	627	PF00069	0.634
MOD_CK1_1	152	158	PF00069	0.323
MOD_CK1_1	294	300	PF00069	0.421
MOD_CK1_1	31	37	PF00069	0.569
MOD_CK1_1	361	367	PF00069	0.323
MOD_CK1_1	376	382	PF00069	0.749
MOD_CK1_1	384	390	PF00069	0.720
MOD_CK1_1	510	516	PF00069	0.576
MOD_CK1_1	574	580	PF00069	0.292
MOD_CK1_1	98	104	PF00069	0.521
MOD_CK2_1	311	317	PF00069	0.368
MOD_CK2_1	387	393	PF00069	0.626
MOD_CK2_1	50	56	PF00069	0.357
MOD_CK2_1	517	523	PF00069	0.570
MOD_CK2_1	530	536	PF00069	0.507
MOD_CK2_1	630	636	PF00069	0.483
MOD_CK2_1	658	664	PF00069	0.420
MOD_CMANNOS	653	656	PF00535	0.281
MOD_DYRK1A_RPxSP_1	388	392	PF00069	0.471
MOD_GlcNHglycan	151	154	PF01048	0.319
MOD_GlcNHglycan	166	169	PF01048	0.281
MOD_GlcNHglycan	25	28	PF01048	0.526
MOD_GlcNHglycan	333	336	PF01048	0.359
MOD_GlcNHglycan	34	37	PF01048	0.539
MOD_GlcNHglycan	360	363	PF01048	0.380
MOD_GlcNHglycan	446	449	PF01048	0.491
MOD_GlcNHglycan	472	475	PF01048	0.453
MOD_GlcNHglycan	476	479	PF01048	0.498
MOD_GlcNHglycan	50	53	PF01048	0.265
MOD_GlcNHglycan	575	579	PF01048	0.317
MOD_GlcNHglycan	632	635	PF01048	0.592
MOD_GSK3_1	28	35	PF00069	0.631
MOD_GSK3_1	358	365	PF00069	0.388
MOD_GSK3_1	373	380	PF00069	0.479
MOD_GSK3_1	384	391	PF00069	0.529
MOD_GSK3_1	470	477	PF00069	0.298
MOD_GSK3_1	513	520	PF00069	0.517
MOD_GSK3_1	528	535	PF00069	0.346
MOD_GSK3_1	573	580	PF00069	0.256
MOD_GSK3_1	94	101	PF00069	0.554
MOD_LATS_1	465	471	PF00433	0.255
MOD_N-GLC_1	94	99	PF02516	0.520
MOD_NEK2_1	450	455	PF00069	0.493
MOD_NEK2_1	528	533	PF00069	0.357
MOD_NEK2_1	573	578	PF00069	0.256
MOD_NEK2_1	658	663	PF00069	0.241
MOD_NEK2_1	671	676	PF00069	0.241
MOD_PIKK_1	176	182	PF00454	0.343
MOD_PIKK_1	382	388	PF00454	0.695
MOD_PKA_1	507	513	PF00069	0.404
MOD_PKA_2	274	280	PF00069	0.460
MOD_PKA_2	382	388	PF00069	0.607
MOD_PKA_2	459	465	PF00069	0.331
MOD_Plk_1	436	442	PF00069	0.255
MOD_Plk_1	558	564	PF00069	0.338
MOD_Plk_2-3	636	642	PF00069	0.373
MOD_Plk_4	274	280	PF00069	0.363
MOD_Plk_4	459	465	PF00069	0.455
MOD_Plk_4	517	523	PF00069	0.387
MOD_Plk_4	658	664	PF00069	0.274
MOD_ProDKin_1	15	21	PF00069	0.529
MOD_ProDKin_1	28	34	PF00069	0.404
MOD_ProDKin_1	373	379	PF00069	0.561
MOD_ProDKin_1	388	394	PF00069	0.506
MOD_ProDKin_1	620	626	PF00069	0.616
MOD_SUMO_rev_2	277	286	PF00179	0.407
MOD_SUMO_rev_2	664	674	PF00179	0.317
TRG_DiLeu_BaEn_1	274	279	PF01217	0.371
TRG_DiLeu_BaEn_1	282	287	PF01217	0.358
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.286
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.489
TRG_ENDOCYTIC_2	337	340	PF00928	0.339
TRG_ENDOCYTIC_2	570	573	PF00928	0.269
TRG_ENDOCYTIC_2	651	654	PF00928	0.267
TRG_ER_diArg_1	139	142	PF00400	0.325
TRG_ER_diArg_1	163	166	PF00400	0.363
TRG_ER_diArg_1	3	5	PF00400	0.532
TRG_ER_diArg_1	627	629	PF00400	0.539
TRG_ER_diArg_1	645	647	PF00400	0.379
TRG_NES_CRM1_1	213	227	PF08389	0.218
TRG_NES_CRM1_1	552	564	PF08389	0.243
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL37	Leptomonas seymouri	65%	98%
A0A0S4JQD9	Bodo saltans	43%	100%
A0A0S4JTX4	Bodo saltans	43%	100%
A0A1X0PB30	Trypanosomatidae	54%	100%
A0A3R7MLZ5	Trypanosoma rangeli	53%	100%
A0A3S5H7X1	Leishmania donovani	83%	100%
A4IA38	Leishmania infantum	83%	100%
A4IG62	Danio rerio	31%	90%
C9ZM61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B553	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F4KFV7	Arabidopsis thaliana	32%	88%
O74727	Saccharomyces paradoxus	29%	93%
O94445	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P32580	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	93%
Q01IJ3	Oryza sativa subsp. indica	31%	93%
Q10D00	Oryza sativa subsp. japonica	33%	100%
Q17828	Caenorhabditis elegans	33%	95%
Q295E6	Drosophila pseudoobscura pseudoobscura	35%	90%
Q4Q2T3	Leishmania major	84%	100%
Q59TB2	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	95%
Q5EBA1	Rattus norvegicus	33%	88%
Q5ZJT0	Gallus gallus	32%	86%
Q61SU7	Caenorhabditis briggsae	33%	95%
Q7X745	Oryza sativa subsp. japonica	31%	93%
Q80YD1	Mus musculus	33%	88%
Q8IYB8	Homo sapiens	33%	87%
Q9SMX1	Arabidopsis thaliana	31%	100%
Q9VN03	Drosophila melanogaster	33%	90%
V5DLS8	Trypanosoma cruzi	53%	100%