Putative acyl-CoA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAX7_LEIBR

TriTrypDb:

LbrM.20.2160 , LBRM2903_200032300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAX7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	10
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0008289	lipid binding	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0033218	amide binding	2	10
GO:0036094	small molecule binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0120227	acyl-CoA binding	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:1901567	fatty acid derivative binding	3	10
GO:1901681	sulfur compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.206
CLV_NRD_NRD_1	53	55	PF00675	0.260
CLV_PCSK_SKI1_1	33	37	PF00082	0.254
CLV_PCSK_SKI1_1	71	75	PF00082	0.408
DOC_PP2B_LxvP_1	20	23	PF13499	0.417
DOC_USP7_UBL2_3	39	43	PF12436	0.471
DOC_USP7_UBL2_3	79	83	PF12436	0.470
DOC_USP7_UBL2_3	84	88	PF12436	0.614
DOC_WW_Pin1_4	82	87	PF00397	0.384
LIG_14-3-3_CanoR_1	33	42	PF00244	0.377
LIG_14-3-3_CanoR_1	54	62	PF00244	0.238
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_FHA_1	46	52	PF00498	0.206
LIG_FHA_2	64	70	PF00498	0.327
LIG_LIR_Gen_1	7	13	PF02991	0.303
LIG_LIR_Nem_3	57	62	PF02991	0.370
LIG_LIR_Nem_3	7	12	PF02991	0.444
LIG_PDZ_Class_1	84	89	PF00595	0.550
LIG_SH2_CRK	9	13	PF00017	0.362
LIG_SH2_STAP1	9	13	PF00017	0.411
MOD_CDC14_SPxK_1	85	88	PF00782	0.430
MOD_CDK_SPxK_1	82	88	PF00069	0.397
MOD_CK1_1	18	24	PF00069	0.356
MOD_CMANNOS	56	59	PF00535	0.374
MOD_GlcNHglycan	1	4	PF01048	0.614
MOD_GSK3_1	7	14	PF00069	0.427
MOD_NEK2_2	38	43	PF00069	0.420
MOD_PIKK_1	33	39	PF00454	0.245
MOD_PIKK_1	63	69	PF00454	0.313
MOD_PKA_1	54	60	PF00069	0.206
MOD_PKA_2	7	13	PF00069	0.383
MOD_ProDKin_1	82	88	PF00069	0.397
TRG_ENDOCYTIC_2	62	65	PF00928	0.342
TRG_ENDOCYTIC_2	9	12	PF00928	0.347
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.459
TRG_PTS1	86	89	PF00515	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P610	Leptomonas seymouri	66%	100%
A0A0S4JQG1	Bodo saltans	37%	99%
A0A3Q8II94	Leishmania donovani	76%	100%
A4IA36	Leishmania infantum	76%	100%
C9ZM63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	96%
E9B551	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
P0C8L7	Hypsibius exemplaris	32%	100%
Q4Q2T5	Leishmania major	74%	100%
Q9MZG3	Bos taurus	26%	100%
V5DM18	Trypanosoma cruzi	37%	96%