TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 8

Species:

Leishmania braziliensis

UniProt:

A4HAX4_LEIBR

TriTrypDb:

LbrM.20.2130 , LBRM2903_200032000

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.442
CLV_C14_Caspase3-7	165	169	PF00656	0.358
CLV_NRD_NRD_1	117	119	PF00675	0.409
CLV_NRD_NRD_1	208	210	PF00675	0.519
CLV_NRD_NRD_1	223	225	PF00675	0.395
CLV_NRD_NRD_1	381	383	PF00675	0.508
CLV_NRD_NRD_1	519	521	PF00675	0.367
CLV_PCSK_KEX2_1	117	119	PF00082	0.409
CLV_PCSK_KEX2_1	381	383	PF00082	0.483
CLV_PCSK_KEX2_1	519	521	PF00082	0.384
CLV_PCSK_SKI1_1	224	228	PF00082	0.471
CLV_PCSK_SKI1_1	259	263	PF00082	0.609
CLV_PCSK_SKI1_1	381	385	PF00082	0.608
CLV_PCSK_SKI1_1	445	449	PF00082	0.408
DEG_APCC_DBOX_1	223	231	PF00400	0.343
DEG_APCC_KENBOX_2	383	387	PF00400	0.663
DEG_APCC_KENBOX_2	398	402	PF00400	0.570
DOC_MAPK_gen_1	147	155	PF00069	0.548
DOC_MAPK_MEF2A_6	497	506	PF00069	0.402
DOC_MAPK_MEF2A_6	94	102	PF00069	0.370
DOC_PIKK_1	168	176	PF02985	0.350
DOC_PP1_RVXF_1	469	475	PF00149	0.448
DOC_USP7_MATH_1	294	298	PF00917	0.714
DOC_USP7_MATH_1	439	443	PF00917	0.460
DOC_USP7_MATH_1	490	494	PF00917	0.415
DOC_USP7_MATH_1	495	499	PF00917	0.372
DOC_USP7_UBL2_3	154	158	PF12436	0.579
DOC_WW_Pin1_4	290	295	PF00397	0.656
LIG_14-3-3_CanoR_1	391	395	PF00244	0.671
LIG_14-3-3_CanoR_1	406	416	PF00244	0.530
LIG_14-3-3_CanoR_1	459	463	PF00244	0.403
LIG_14-3-3_CanoR_1	514	523	PF00244	0.375
LIG_14-3-3_CanoR_1	70	74	PF00244	0.305
LIG_BRCT_BRCA1_1	17	21	PF00533	0.582
LIG_BRCT_BRCA1_1	303	307	PF00533	0.492
LIG_BRCT_BRCA1_2	303	309	PF00533	0.388
LIG_CaM_IQ_9	249	264	PF13499	0.463
LIG_FHA_1	362	368	PF00498	0.516
LIG_FHA_1	407	413	PF00498	0.543
LIG_FHA_1	462	468	PF00498	0.292
LIG_FHA_1	99	105	PF00498	0.350
LIG_FHA_2	103	109	PF00498	0.522
LIG_FHA_2	18	24	PF00498	0.465
LIG_FHA_2	433	439	PF00498	0.431
LIG_Integrin_RGD_1	166	168	PF01839	0.513
LIG_LIR_Gen_1	304	314	PF02991	0.455
LIG_LIR_Gen_1	8	14	PF02991	0.631
LIG_LIR_Gen_1	97	104	PF02991	0.346
LIG_LIR_Nem_3	126	131	PF02991	0.514
LIG_LIR_Nem_3	304	310	PF02991	0.465
LIG_LIR_Nem_3	427	433	PF02991	0.433
LIG_LIR_Nem_3	56	61	PF02991	0.377
LIG_LIR_Nem_3	8	13	PF02991	0.610
LIG_LIR_Nem_3	97	102	PF02991	0.346
LIG_NRBOX	337	343	PF00104	0.516
LIG_PCNA_PIPBox_1	92	101	PF02747	0.507
LIG_PCNA_yPIPBox_3	262	276	PF02747	0.560
LIG_Pex14_2	124	128	PF04695	0.514
LIG_PTB_Apo_2	87	94	PF02174	0.287
LIG_Rb_pABgroove_1	503	511	PF01858	0.294
LIG_SH2_GRB2like	430	433	PF00017	0.441
LIG_SH2_STAP1	408	412	PF00017	0.407
LIG_SH2_STAP1	430	434	PF00017	0.399
LIG_SH2_STAP1	75	79	PF00017	0.336
LIG_SH2_STAT5	275	278	PF00017	0.540
LIG_SH2_STAT5	408	411	PF00017	0.540
LIG_SH2_STAT5	433	436	PF00017	0.533
LIG_SH2_STAT5	99	102	PF00017	0.341
LIG_SH3_3	29	35	PF00018	0.697
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.631
LIG_SUMO_SIM_par_1	297	302	PF11976	0.552
LIG_SUMO_SIM_par_1	359	364	PF11976	0.338
LIG_TRAF2_1	111	114	PF00917	0.575
LIG_TRAF2_1	182	185	PF00917	0.554
LIG_TRAF2_1	20	23	PF00917	0.469
LIG_UBA3_1	198	204	PF00899	0.525
LIG_UBA3_1	226	234	PF00899	0.440
LIG_UBA3_1	247	256	PF00899	0.480
LIG_UBA3_1	276	281	PF00899	0.512
LIG_WRC_WIRS_1	2	7	PF05994	0.435
LIG_WRC_WIRS_1	99	104	PF05994	0.342
MOD_CDK_SPK_2	290	295	PF00069	0.684
MOD_CK1_1	392	398	PF00069	0.581
MOD_CK1_1	47	53	PF00069	0.424
MOD_CK1_1	476	482	PF00069	0.350
MOD_CK1_1	9	15	PF00069	0.632
MOD_CK2_1	102	108	PF00069	0.501
MOD_CK2_1	17	23	PF00069	0.465
MOD_CK2_1	390	396	PF00069	0.530
MOD_CK2_1	407	413	PF00069	0.468
MOD_CK2_1	432	438	PF00069	0.411
MOD_CK2_1	490	496	PF00069	0.598
MOD_GlcNHglycan	17	20	PF01048	0.698
MOD_GlcNHglycan	290	293	PF01048	0.655
MOD_GlcNHglycan	498	501	PF01048	0.496
MOD_GSK3_1	1	8	PF00069	0.555
MOD_GSK3_1	279	286	PF00069	0.468
MOD_GSK3_1	290	297	PF00069	0.598
MOD_GSK3_1	366	373	PF00069	0.543
MOD_GSK3_1	424	431	PF00069	0.390
MOD_GSK3_1	458	465	PF00069	0.428
MOD_GSK3_1	510	517	PF00069	0.380
MOD_GSK3_1	57	64	PF00069	0.410
MOD_GSK3_1	94	101	PF00069	0.376
MOD_N-GLC_1	288	293	PF02516	0.617
MOD_N-GLC_1	30	35	PF02516	0.653
MOD_N-GLC_1	400	405	PF02516	0.448
MOD_N-GLC_1	439	444	PF02516	0.319
MOD_NEK2_1	389	394	PF00069	0.676
MOD_NEK2_1	415	420	PF00069	0.530
MOD_NEK2_1	462	467	PF00069	0.466
MOD_NEK2_1	5	10	PF00069	0.591
MOD_NEK2_1	508	513	PF00069	0.400
MOD_NEK2_1	533	538	PF00069	0.394
MOD_NEK2_1	61	66	PF00069	0.321
MOD_NEK2_1	69	74	PF00069	0.346
MOD_NEK2_1	98	103	PF00069	0.340
MOD_PIKK_1	108	114	PF00454	0.579
MOD_PIKK_1	279	285	PF00454	0.551
MOD_PIKK_1	321	327	PF00454	0.441
MOD_PIKK_1	361	367	PF00454	0.566
MOD_PK_1	463	469	PF00069	0.515
MOD_PKA_2	294	300	PF00069	0.691
MOD_PKA_2	336	342	PF00069	0.459
MOD_PKA_2	370	376	PF00069	0.491
MOD_PKA_2	390	396	PF00069	0.477
MOD_PKA_2	458	464	PF00069	0.445
MOD_PKA_2	47	53	PF00069	0.392
MOD_PKA_2	476	482	PF00069	0.445
MOD_PKA_2	69	75	PF00069	0.306
MOD_Plk_1	30	36	PF00069	0.457
MOD_Plk_1	400	406	PF00069	0.436
MOD_Plk_1	5	11	PF00069	0.665
MOD_Plk_1	75	81	PF00069	0.441
MOD_Plk_4	294	300	PF00069	0.698
MOD_Plk_4	400	406	PF00069	0.436
MOD_Plk_4	57	63	PF00069	0.487
MOD_Plk_4	6	12	PF00069	0.586
MOD_Plk_4	69	75	PF00069	0.356
MOD_Plk_4	94	100	PF00069	0.380
MOD_ProDKin_1	290	296	PF00069	0.659
MOD_SUMO_for_1	230	233	PF00179	0.474
MOD_SUMO_rev_2	150	155	PF00179	0.476
MOD_SUMO_rev_2	165	173	PF00179	0.549
MOD_SUMO_rev_2	452	458	PF00179	0.457
MOD_SUMO_rev_2	54	61	PF00179	0.409
TRG_DiLeu_BaEn_1	222	227	PF01217	0.502
TRG_DiLeu_BaEn_1	306	311	PF01217	0.446
TRG_DiLeu_BaEn_1	444	449	PF01217	0.401
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.299
TRG_ENDOCYTIC_2	99	102	PF00928	0.341
TRG_ER_diArg_1	117	119	PF00400	0.409
TRG_ER_diArg_1	284	287	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P612	Leptomonas seymouri	69%	98%
A0A1X0P9R7	Trypanosomatidae	47%	96%
A0A3S7X860	Leishmania donovani	84%	100%
A0A422N8F5	Trypanosoma rangeli	46%	96%
A4IA33	Leishmania infantum	84%	100%
C9ZMJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
E9B548	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2T8	Leishmania major	86%	100%
V5BUY7	Trypanosoma cruzi	46%	96%