C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil and C2 domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HAX2_LEIBR

TriTrypDb:

LbrM.20.2110 , LBRM2903_200031700

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0044297	cell body	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAX2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.570
CLV_C14_Caspase3-7	573	577	PF00656	0.586
CLV_NRD_NRD_1	155	157	PF00675	0.450
CLV_NRD_NRD_1	227	229	PF00675	0.376
CLV_NRD_NRD_1	294	296	PF00675	0.585
CLV_NRD_NRD_1	524	526	PF00675	0.542
CLV_NRD_NRD_1	578	580	PF00675	0.650
CLV_NRD_NRD_1	592	594	PF00675	0.556
CLV_NRD_NRD_1	619	621	PF00675	0.659
CLV_NRD_NRD_1	632	634	PF00675	0.590
CLV_NRD_NRD_1	638	640	PF00675	0.702
CLV_NRD_NRD_1	668	670	PF00675	0.638
CLV_NRD_NRD_1	810	812	PF00675	0.445
CLV_NRD_NRD_1	95	97	PF00675	0.517
CLV_PCSK_KEX2_1	122	124	PF00082	0.630
CLV_PCSK_KEX2_1	157	159	PF00082	0.568
CLV_PCSK_KEX2_1	192	194	PF00082	0.614
CLV_PCSK_KEX2_1	294	296	PF00082	0.618
CLV_PCSK_KEX2_1	498	500	PF00082	0.607
CLV_PCSK_KEX2_1	524	526	PF00082	0.521
CLV_PCSK_KEX2_1	618	620	PF00082	0.606
CLV_PCSK_KEX2_1	667	669	PF00082	0.645
CLV_PCSK_KEX2_1	810	812	PF00082	0.446
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.630
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.582
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.614
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.607
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.582
CLV_PCSK_PC7_1	663	669	PF00082	0.688
CLV_PCSK_SKI1_1	11	15	PF00082	0.579
CLV_PCSK_SKI1_1	167	171	PF00082	0.606
CLV_PCSK_SKI1_1	228	232	PF00082	0.581
CLV_PCSK_SKI1_1	3	7	PF00082	0.657
CLV_PCSK_SKI1_1	32	36	PF00082	0.509
CLV_PCSK_SKI1_1	361	365	PF00082	0.352
CLV_PCSK_SKI1_1	524	528	PF00082	0.579
CLV_PCSK_SKI1_1	583	587	PF00082	0.666
CLV_PCSK_SKI1_1	633	637	PF00082	0.617
CLV_PCSK_SKI1_1	713	717	PF00082	0.516
CLV_PCSK_SKI1_1	726	730	PF00082	0.426
CLV_PCSK_SKI1_1	97	101	PF00082	0.500
CLV_Separin_Metazoa	504	508	PF03568	0.543
DOC_CKS1_1	198	203	PF01111	0.507
DOC_CYCLIN_RxL_1	504	515	PF00134	0.585
DOC_MAPK_gen_1	667	676	PF00069	0.555
DOC_MAPK_gen_1	729	738	PF00069	0.560
DOC_MAPK_gen_1	807	817	PF00069	0.437
DOC_MAPK_MEF2A_6	810	819	PF00069	0.395
DOC_PP1_RVXF_1	505	512	PF00149	0.556
DOC_USP7_MATH_1	317	321	PF00917	0.697
DOC_USP7_MATH_1	662	666	PF00917	0.697
DOC_USP7_UBL2_3	236	240	PF12436	0.594
DOC_USP7_UBL2_3	315	319	PF12436	0.474
DOC_USP7_UBL2_3	452	456	PF12436	0.571
DOC_USP7_UBL2_3	67	71	PF12436	0.681
DOC_WW_Pin1_4	197	202	PF00397	0.595
DOC_WW_Pin1_4	644	649	PF00397	0.733
DOC_WW_Pin1_4	651	656	PF00397	0.623
DOC_WW_Pin1_4	658	663	PF00397	0.600
DOC_WW_Pin1_4	667	672	PF00397	0.674
LIG_14-3-3_CanoR_1	252	260	PF00244	0.436
LIG_14-3-3_CanoR_1	295	305	PF00244	0.656
LIG_14-3-3_CanoR_1	390	395	PF00244	0.694
LIG_14-3-3_CanoR_1	583	592	PF00244	0.629
LIG_14-3-3_CanoR_1	65	70	PF00244	0.433
LIG_14-3-3_CanoR_1	653	659	PF00244	0.805
LIG_14-3-3_CanoR_1	713	718	PF00244	0.602
LIG_14-3-3_CanoR_1	733	737	PF00244	0.309
LIG_14-3-3_CanoR_1	839	843	PF00244	0.347
LIG_14-3-3_CanoR_1	96	106	PF00244	0.545
LIG_Actin_WH2_2	152	169	PF00022	0.574
LIG_Actin_WH2_2	216	233	PF00022	0.529
LIG_Actin_WH2_2	454	471	PF00022	0.550
LIG_Actin_WH2_2	544	561	PF00022	0.499
LIG_Actin_WH2_2	695	712	PF00022	0.510
LIG_Actin_WH2_2	82	98	PF00022	0.583
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	75	79	PF00533	0.460
LIG_BRCT_BRCA1_1	772	776	PF00533	0.533
LIG_EH1_1	699	707	PF00400	0.283
LIG_FAT_LD_1	502	510	PF03623	0.389
LIG_FHA_1	386	392	PF00498	0.497
LIG_FHA_1	559	565	PF00498	0.553
LIG_FHA_1	630	636	PF00498	0.642
LIG_FHA_1	73	79	PF00498	0.481
LIG_FHA_1	760	766	PF00498	0.371
LIG_FHA_2	245	251	PF00498	0.582
LIG_FHA_2	362	368	PF00498	0.510
LIG_FHA_2	829	835	PF00498	0.512
LIG_FHA_2	98	104	PF00498	0.613
LIG_Integrin_isoDGR_2	711	713	PF01839	0.522
LIG_LIR_Gen_1	270	280	PF02991	0.519
LIG_LIR_Gen_1	840	849	PF02991	0.421
LIG_LIR_Nem_3	746	752	PF02991	0.387
LIG_LIR_Nem_3	787	792	PF02991	0.460
LIG_LIR_Nem_3	840	845	PF02991	0.417
LIG_PCNA_yPIPBox_3	177	188	PF02747	0.563
LIG_Pex14_1	326	330	PF04695	0.588
LIG_Pex14_2	745	749	PF04695	0.374
LIG_SH2_CRK	789	793	PF00017	0.527
LIG_SH2_NCK_1	330	334	PF00017	0.614
LIG_SH2_STAP1	454	458	PF00017	0.502
LIG_SH2_STAT3	454	457	PF00017	0.571
LIG_SH2_STAT3	752	755	PF00017	0.420
LIG_SH2_STAT5	550	553	PF00017	0.361
LIG_SH2_STAT5	752	755	PF00017	0.422
LIG_SH3_3	207	213	PF00018	0.691
LIG_SH3_3	642	648	PF00018	0.783
LIG_SH3_3	798	804	PF00018	0.517
LIG_SH3_4	315	322	PF00018	0.460
LIG_SUMO_SIM_anti_2	701	707	PF11976	0.303
LIG_SUMO_SIM_par_1	627	632	PF11976	0.382
LIG_SUMO_SIM_par_1	701	707	PF11976	0.402
LIG_TRAF2_1	438	441	PF00917	0.514
LIG_TRAF2_1	501	504	PF00917	0.583
LIG_TRAF2_1	830	833	PF00917	0.592
LIG_TYR_ITSM	785	792	PF00017	0.300
LIG_UBA3_1	272	277	PF00899	0.629
LIG_UBA3_1	419	423	PF00899	0.406
LIG_UBA3_1	722	729	PF00899	0.447
MOD_CDK_SPK_2	658	663	PF00069	0.681
MOD_CDK_SPxxK_3	197	204	PF00069	0.601
MOD_CK1_1	383	389	PF00069	0.610
MOD_CK1_1	393	399	PF00069	0.668
MOD_CK1_1	401	407	PF00069	0.706
MOD_CK1_1	651	657	PF00069	0.702
MOD_CK1_1	677	683	PF00069	0.644
MOD_CK1_1	73	79	PF00069	0.610
MOD_CK1_1	784	790	PF00069	0.491
MOD_CK2_1	107	113	PF00069	0.444
MOD_CK2_1	126	132	PF00069	0.582
MOD_CK2_1	15	21	PF00069	0.618
MOD_CK2_1	165	171	PF00069	0.635
MOD_CK2_1	244	250	PF00069	0.589
MOD_CK2_1	361	367	PF00069	0.378
MOD_CK2_1	435	441	PF00069	0.571
MOD_CK2_1	498	504	PF00069	0.597
MOD_CK2_1	512	518	PF00069	0.572
MOD_CK2_1	549	555	PF00069	0.567
MOD_CK2_1	680	686	PF00069	0.713
MOD_CK2_1	724	730	PF00069	0.415
MOD_CK2_1	828	834	PF00069	0.516
MOD_CK2_1	838	844	PF00069	0.464
MOD_CK2_1	849	855	PF00069	0.289
MOD_CK2_1	95	101	PF00069	0.618
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.639
MOD_GlcNHglycan	167	170	PF01048	0.607
MOD_GlcNHglycan	298	301	PF01048	0.692
MOD_GlcNHglycan	437	440	PF01048	0.620
MOD_GlcNHglycan	610	613	PF01048	0.533
MOD_GlcNHglycan	650	653	PF01048	0.620
MOD_GlcNHglycan	664	667	PF01048	0.716
MOD_GlcNHglycan	689	692	PF01048	0.700
MOD_GlcNHglycan	850	854	PF01048	0.527
MOD_GSK3_1	385	392	PF00069	0.750
MOD_GSK3_1	394	401	PF00069	0.678
MOD_GSK3_1	549	556	PF00069	0.566
MOD_GSK3_1	629	636	PF00069	0.536
MOD_GSK3_1	640	647	PF00069	0.690
MOD_GSK3_1	654	661	PF00069	0.625
MOD_GSK3_1	677	684	PF00069	0.647
MOD_GSK3_1	824	831	PF00069	0.579
MOD_LATS_1	105	111	PF00433	0.388
MOD_LATS_1	63	69	PF00433	0.425
MOD_N-GLC_1	260	265	PF02516	0.481
MOD_N-GLC_1	648	653	PF02516	0.550
MOD_NEK2_1	145	150	PF00069	0.535
MOD_NEK2_1	698	703	PF00069	0.349
MOD_NEK2_1	745	750	PF00069	0.359
MOD_NEK2_1	849	854	PF00069	0.388
MOD_NEK2_1	95	100	PF00069	0.518
MOD_NEK2_2	310	315	PF00069	0.500
MOD_NEK2_2	732	737	PF00069	0.399
MOD_PIKK_1	409	415	PF00454	0.667
MOD_PK_1	107	113	PF00069	0.392
MOD_PK_1	329	335	PF00069	0.616
MOD_PK_1	390	396	PF00069	0.705
MOD_PK_1	498	504	PF00069	0.597
MOD_PK_1	724	730	PF00069	0.415
MOD_PKA_1	294	300	PF00069	0.619
MOD_PKA_1	498	504	PF00069	0.597
MOD_PKA_1	633	639	PF00069	0.559
MOD_PKA_2	113	119	PF00069	0.626
MOD_PKA_2	139	145	PF00069	0.465
MOD_PKA_2	294	300	PF00069	0.629
MOD_PKA_2	389	395	PF00069	0.712
MOD_PKA_2	404	410	PF00069	0.725
MOD_PKA_2	492	498	PF00069	0.608
MOD_PKA_2	558	564	PF00069	0.436
MOD_PKA_2	662	668	PF00069	0.709
MOD_PKA_2	681	687	PF00069	0.725
MOD_PKA_2	732	738	PF00069	0.313
MOD_PKA_2	838	844	PF00069	0.348
MOD_PKA_2	95	101	PF00069	0.518
MOD_Plk_1	162	168	PF00069	0.616
MOD_Plk_1	509	515	PF00069	0.381
MOD_Plk_1	677	683	PF00069	0.706
MOD_Plk_1	745	751	PF00069	0.384
MOD_Plk_1	837	843	PF00069	0.437
MOD_Plk_2-3	126	132	PF00069	0.465
MOD_Plk_2-3	838	844	PF00069	0.348
MOD_Plk_4	303	309	PF00069	0.585
MOD_Plk_4	480	486	PF00069	0.688
MOD_Plk_4	738	744	PF00069	0.412
MOD_Plk_4	745	751	PF00069	0.364
MOD_Plk_4	784	790	PF00069	0.440
MOD_ProDKin_1	197	203	PF00069	0.599
MOD_ProDKin_1	644	650	PF00069	0.736
MOD_ProDKin_1	651	657	PF00069	0.623
MOD_ProDKin_1	658	664	PF00069	0.600
MOD_ProDKin_1	667	673	PF00069	0.672
MOD_SUMO_for_1	219	222	PF00179	0.612
MOD_SUMO_rev_2	137	145	PF00179	0.588
MOD_SUMO_rev_2	221	230	PF00179	0.373
MOD_SUMO_rev_2	33	41	PF00179	0.494
MOD_SUMO_rev_2	353	363	PF00179	0.588
MOD_SUMO_rev_2	428	436	PF00179	0.532
MOD_SUMO_rev_2	438	445	PF00179	0.606
MOD_SUMO_rev_2	552	558	PF00179	0.617
MOD_SUMO_rev_2	567	574	PF00179	0.431
TRG_DiLeu_BaEn_1	504	509	PF01217	0.590
TRG_DiLeu_BaEn_1	84	89	PF01217	0.482
TRG_DiLeu_BaEn_4	221	227	PF01217	0.605
TRG_DiLeu_LyEn_5	504	509	PF01217	0.590
TRG_ENDOCYTIC_2	330	333	PF00928	0.576
TRG_ENDOCYTIC_2	789	792	PF00928	0.522
TRG_ER_diArg_1	155	158	PF00400	0.449
TRG_ER_diArg_1	523	525	PF00400	0.562
TRG_ER_diArg_1	619	621	PF00400	0.668
TRG_ER_diArg_1	667	669	PF00400	0.685
TRG_ER_diArg_1	793	796	PF00400	0.410
TRG_NES_CRM1_1	26	40	PF08389	0.362
TRG_NLS_Bipartite_1	579	597	PF00514	0.554
TRG_NLS_MonoExtC_3	592	598	PF00514	0.597
TRG_NLS_MonoExtN_4	591	597	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	427	432	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I241	Leptomonas seymouri	58%	100%
A0A1X0P9P4	Trypanosomatidae	34%	95%
A0A3Q8IEG3	Leishmania donovani	80%	100%
A0A3R7KUQ1	Trypanosoma rangeli	35%	93%
A4IA30	Leishmania infantum	80%	100%
C9ZMJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9B545	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2U1	Leishmania major	80%	100%