Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAX0_LEIBR

TriTrypDb:

LbrM.20.0620 , LbrM.20.2070 , LbrM.20.2080 , LbrM.20.2090 , LBRM2903_200031400

Length:

1270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HAX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAX0

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	2
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0140657	ATP-dependent activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1039	1043	PF00656	0.659
CLV_C14_Caspase3-7	1136	1140	PF00656	0.743
CLV_C14_Caspase3-7	20	24	PF00656	0.522
CLV_C14_Caspase3-7	202	206	PF00656	0.598
CLV_C14_Caspase3-7	369	373	PF00656	0.764
CLV_C14_Caspase3-7	579	583	PF00656	0.654
CLV_C14_Caspase3-7	691	695	PF00656	0.666
CLV_C14_Caspase3-7	886	890	PF00656	0.678
CLV_NRD_NRD_1	1267	1269	PF00675	0.660
CLV_PCSK_FUR_1	1031	1035	PF00082	0.616

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HAW9	Leishmania braziliensis	80%	100%
A4HAX1	Leishmania braziliensis	75%	82%
A4HW56	Leishmania infantum	33%	100%
A4IA29	Leishmania infantum	58%	70%

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