Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAW8_LEIBR

TriTrypDb:

LbrM.20.2070 , LBRM2903_200031400

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.707
CLV_C14_Caspase3-7	41	45	PF00656	0.516
CLV_C14_Caspase3-7	562	566	PF00656	0.503
CLV_C14_Caspase3-7	846	850	PF00656	0.499
CLV_C14_Caspase3-7	912	916	PF00656	0.510
CLV_MEL_PAP_1	494	500	PF00089	0.573
CLV_NRD_NRD_1	1007	1009	PF00675	0.654
CLV_NRD_NRD_1	1022	1024	PF00675	0.550
CLV_NRD_NRD_1	452	454	PF00675	0.527
CLV_NRD_NRD_1	476	478	PF00675	0.495
CLV_NRD_NRD_1	736	738	PF00675	0.532
CLV_NRD_NRD_1	821	823	PF00675	0.522
CLV_NRD_NRD_1	993	995	PF00675	0.530
CLV_PCSK_FUR_1	327	331	PF00082	0.505
CLV_PCSK_FUR_1	477	481	PF00082	0.502
CLV_PCSK_KEX2_1	1022	1024	PF00082	0.588
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.544
CLV_PCSK_KEX2_1	270	272	PF00082	0.506
CLV_PCSK_KEX2_1	329	331	PF00082	0.509
CLV_PCSK_KEX2_1	35	37	PF00082	0.556
CLV_PCSK_KEX2_1	452	454	PF00082	0.527
CLV_PCSK_KEX2_1	479	481	PF00082	0.499
CLV_PCSK_KEX2_1	736	738	PF00082	0.532
CLV_PCSK_KEX2_1	821	823	PF00082	0.522
CLV_PCSK_PC1ET2_1	1026	1028	PF00082	0.583
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.506
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.484
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.556
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.477
CLV_PCSK_PC7_1	1022	1028	PF00082	0.496
CLV_PCSK_PC7_1	448	454	PF00082	0.455
CLV_PCSK_SKI1_1	1022	1026	PF00082	0.491
CLV_PCSK_SKI1_1	454	458	PF00082	0.447
CLV_PCSK_SKI1_1	518	522	PF00082	0.562
CLV_PCSK_SKI1_1	691	695	PF00082	0.675
CLV_PCSK_SKI1_1	718	722	PF00082	0.500
CLV_PCSK_SKI1_1	801	805	PF00082	0.554
DEG_APCC_DBOX_1	1049	1057	PF00400	0.519
DEG_APCC_DBOX_1	517	525	PF00400	0.579
DEG_APCC_KENBOX_2	682	686	PF00400	0.485
DOC_ANK_TNKS_1	362	369	PF00023	0.542
DOC_CYCLIN_yClb5_NLxxxL_5	1013	1021	PF00134	0.456
DOC_MAPK_gen_1	749	758	PF00069	0.513
DOC_MAPK_MEF2A_6	518	526	PF00069	0.550
DOC_MAPK_MEF2A_6	751	760	PF00069	0.511
DOC_USP7_MATH_1	2	6	PF00917	0.688
DOC_USP7_MATH_1	510	514	PF00917	0.560
DOC_USP7_MATH_1	747	751	PF00917	0.498
DOC_USP7_MATH_1	762	766	PF00917	0.679
DOC_USP7_MATH_1	930	934	PF00917	0.563
DOC_USP7_UBL2_3	1005	1009	PF12436	0.495
DOC_WW_Pin1_4	35	40	PF00397	0.529
LIG_14-3-3_CanoR_1	439	445	PF00244	0.496
LIG_14-3-3_CanoR_1	453	462	PF00244	0.419
LIG_14-3-3_CanoR_1	497	503	PF00244	0.581
LIG_Actin_WH2_1	972	989	PF00022	0.475
LIG_Actin_WH2_2	725	742	PF00022	0.492
LIG_Actin_WH2_2	871	887	PF00022	0.470
LIG_Actin_WH2_2	973	989	PF00022	0.496
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_4	338	342	PF00653	0.555
LIG_BIR_III_4	390	394	PF00653	0.491
LIG_FAT_LD_1	571	579	PF03623	0.469
LIG_FHA_1	340	346	PF00498	0.576
LIG_FHA_1	383	389	PF00498	0.553
LIG_FHA_1	535	541	PF00498	0.481
LIG_FHA_1	633	639	PF00498	0.477
LIG_FHA_2	36	42	PF00498	0.523
LIG_FHA_2	372	378	PF00498	0.529
LIG_FHA_2	659	665	PF00498	0.498
LIG_FHA_2	719	725	PF00498	0.518
LIG_FHA_2	844	850	PF00498	0.495
LIG_LIR_Apic_2	23	27	PF02991	0.787
LIG_LIR_Gen_1	565	575	PF02991	0.718
LIG_LIR_Gen_1	660	669	PF02991	0.522
LIG_LIR_Gen_1	778	788	PF02991	0.549
LIG_LIR_Nem_3	23	29	PF02991	0.535
LIG_LIR_Nem_3	565	571	PF02991	0.490
LIG_LIR_Nem_3	660	665	PF02991	0.521
LIG_LIR_Nem_3	778	784	PF02991	0.543
LIG_LYPXL_yS_3	26	29	PF13949	0.533
LIG_MYND_3	343	347	PF01753	0.558
LIG_NRBOX	1020	1026	PF00104	0.485
LIG_NRBOX	570	576	PF00104	0.468
LIG_NRBOX	803	809	PF00104	0.475
LIG_NRBOX	862	868	PF00104	0.461
LIG_PCNA_yPIPBox_3	1013	1025	PF02747	0.483
LIG_PCNA_yPIPBox_3	757	771	PF02747	0.474
LIG_RPA_C_Fungi	616	628	PF08784	0.462
LIG_SH2_CRK	24	28	PF00017	0.537
LIG_SH2_CRK	781	785	PF00017	0.525
LIG_SH2_STAP1	33	37	PF00017	0.550
LIG_SH2_STAP1	371	375	PF00017	0.539
LIG_SH2_STAT5	379	382	PF00017	0.481
LIG_SH3_3	506	512	PF00018	0.599
LIG_SUMO_SIM_anti_2	630	636	PF11976	0.475
LIG_TRAF2_1	374	377	PF00917	0.522
LIG_TRAF2_1	577	580	PF00917	0.475
LIG_TRAF2_1	59	62	PF00917	0.485
LIG_TRAF2_1	620	623	PF00917	0.494
LIG_TRAF2_2	362	367	PF00917	0.573
LIG_UBA3_1	770	777	PF00899	0.516
LIG_WRC_WIRS_1	659	664	PF05994	0.497
MOD_CDK_SPK_2	35	40	PF00069	0.529
MOD_CK1_1	10	16	PF00069	0.537
MOD_CK1_1	1035	1041	PF00069	0.545
MOD_CK1_1	750	756	PF00069	0.635
MOD_CK1_1	933	939	PF00069	0.577
MOD_CK1_1	963	969	PF00069	0.533
MOD_CK2_1	371	377	PF00069	0.535
MOD_CK2_1	566	572	PF00069	0.696
MOD_CK2_1	658	664	PF00069	0.498
MOD_CK2_1	718	724	PF00069	0.502
MOD_CK2_1	941	947	PF00069	0.468
MOD_GlcNHglycan	1034	1037	PF01048	0.596
MOD_GlcNHglycan	1041	1044	PF01048	0.563
MOD_GlcNHglycan	170	175	PF01048	0.779
MOD_GlcNHglycan	240	245	PF01048	0.521
MOD_GlcNHglycan	440	443	PF01048	0.719
MOD_GlcNHglycan	481	484	PF01048	0.562
MOD_GlcNHglycan	542	546	PF01048	0.490
MOD_GlcNHglycan	691	694	PF01048	0.507
MOD_GlcNHglycan	921	926	PF01048	0.666
MOD_GlcNHglycan	934	938	PF01048	0.613
MOD_GSK3_1	1035	1042	PF00069	0.542
MOD_GSK3_1	555	562	PF00069	0.659
MOD_GSK3_1	907	914	PF00069	0.633
MOD_N-GLC_1	1011	1016	PF02516	0.484
MOD_N-GLC_1	793	798	PF02516	0.521
MOD_NEK2_1	1025	1030	PF00069	0.697
MOD_NEK2_1	1039	1044	PF00069	0.514
MOD_NEK2_1	437	442	PF00069	0.473
MOD_NEK2_1	578	583	PF00069	0.459
MOD_NEK2_1	694	699	PF00069	0.547
MOD_PIKK_1	534	540	PF00454	0.482
MOD_PKA_1	479	485	PF00069	0.475
MOD_PKA_2	438	444	PF00069	0.738
MOD_PKA_2	479	485	PF00069	0.550
MOD_PKA_2	750	756	PF00069	0.655
MOD_PKA_2	930	936	PF00069	0.593
MOD_PKB_1	841	849	PF00069	0.494
MOD_PKB_1	939	947	PF00069	0.471
MOD_Plk_1	541	547	PF00069	0.489
MOD_Plk_1	921	927	PF00069	0.500
MOD_Plk_1	933	939	PF00069	0.444
MOD_Plk_4	510	516	PF00069	0.648
MOD_Plk_4	960	966	PF00069	0.507
MOD_ProDKin_1	35	41	PF00069	0.527
MOD_SUMO_for_1	411	414	PF00179	0.441
MOD_SUMO_for_1	59	62	PF00179	0.460
MOD_SUMO_for_1	657	660	PF00179	0.523
MOD_SUMO_rev_2	1047	1056	PF00179	0.520
MOD_SUMO_rev_2	168	174	PF00179	0.542
MOD_SUMO_rev_2	238	244	PF00179	0.530
MOD_SUMO_rev_2	769	778	PF00179	0.488
MOD_SUMO_rev_2	901	910	PF00179	0.489
TRG_DiLeu_BaEn_1	405	410	PF01217	0.473
TRG_DiLeu_BaEn_1	517	522	PF01217	0.811
TRG_DiLeu_BaEn_3	921	927	PF01217	0.500
TRG_DiLeu_BaEn_4	622	628	PF01217	0.481
TRG_DiLeu_BaLyEn_6	1020	1025	PF01217	0.482
TRG_DiLeu_BaLyEn_6	803	808	PF01217	0.480
TRG_ENDOCYTIC_2	26	29	PF00928	0.533
TRG_ENDOCYTIC_2	781	784	PF00928	0.525
TRG_ER_diArg_1	1021	1023	PF00400	0.592
TRG_ER_diArg_1	735	737	PF00400	0.468
TRG_ER_diArg_1	938	941	PF00400	0.513
TRG_NES_CRM1_1	408	422	PF08389	0.472
TRG_NLS_Bipartite_1	994	1012	PF00514	0.459
TRG_NLS_MonoCore_2	476	481	PF00514	0.475
TRG_NLS_MonoExtC_3	993	999	PF00514	0.461
TRG_NLS_MonoExtN_4	1005	1012	PF00514	0.463
TRG_NLS_MonoExtN_4	474	481	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	806	811	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AHT7	Leishmania infantum	74%	100%