WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAW4_LEIBR

TriTrypDb:

LbrM.20.2030 , LBRM2903_200031000

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAW4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0008104	protein localization	4	4
GO:0009966	regulation of signal transduction	4	4
GO:0009967	positive regulation of signal transduction	5	4
GO:0009987	cellular process	1	4
GO:0010646	regulation of cell communication	4	4
GO:0010647	positive regulation of cell communication	5	4
GO:0015031	protein transport	4	4
GO:0023051	regulation of signaling	3	4
GO:0023056	positive regulation of signaling	4	4
GO:0032006	regulation of TOR signaling	6	4
GO:0032008	positive regulation of TOR signaling	7	4
GO:0033036	macromolecule localization	2	4
GO:0045184	establishment of protein localization	3	4
GO:0048518	positive regulation of biological process	3	4
GO:0048522	positive regulation of cellular process	4	4
GO:0048583	regulation of response to stimulus	3	4
GO:0048584	positive regulation of response to stimulus	4	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051641	cellular localization	2	4
GO:0065007	biological regulation	1	4
GO:0070727	cellular macromolecule localization	3	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:1902531	regulation of intracellular signal transduction	5	4
GO:1902533	positive regulation of intracellular signal transduction	6	4
GO:1903432	regulation of TORC1 signaling	7	4
GO:1904263	positive regulation of TORC1 signaling	8	4

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	438	442	PF00656	0.485
CLV_NRD_NRD_1	288	290	PF00675	0.535
CLV_NRD_NRD_1	370	372	PF00675	0.528
CLV_NRD_NRD_1	39	41	PF00675	0.468
CLV_NRD_NRD_1	497	499	PF00675	0.509
CLV_NRD_NRD_1	506	508	PF00675	0.462
CLV_PCSK_FUR_1	285	289	PF00082	0.613
CLV_PCSK_KEX2_1	287	289	PF00082	0.576
CLV_PCSK_KEX2_1	370	372	PF00082	0.436
CLV_PCSK_KEX2_1	497	499	PF00082	0.579
CLV_PCSK_KEX2_1	506	508	PF00082	0.509
CLV_PCSK_SKI1_1	289	293	PF00082	0.401
CLV_PCSK_SKI1_1	351	355	PF00082	0.389
CLV_PCSK_SKI1_1	434	438	PF00082	0.441
CLV_PCSK_SKI1_1	84	88	PF00082	0.278
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DOC_ANK_TNKS_1	217	224	PF00023	0.511
DOC_MAPK_gen_1	285	294	PF00069	0.589
DOC_MAPK_gen_1	497	505	PF00069	0.547
DOC_MAPK_MEF2A_6	351	358	PF00069	0.393
DOC_MAPK_MEF2A_6	497	505	PF00069	0.564
DOC_MAPK_NFAT4_5	351	359	PF00069	0.390
DOC_PP1_RVXF_1	120	127	PF00149	0.630
DOC_PP1_RVXF_1	339	346	PF00149	0.408
DOC_PP1_RVXF_1	423	429	PF00149	0.532
DOC_PP4_FxxP_1	369	372	PF00568	0.446
DOC_USP7_MATH_1	129	133	PF00917	0.489
DOC_WW_Pin1_4	222	227	PF00397	0.755
DOC_WW_Pin1_4	276	281	PF00397	0.623
DOC_WW_Pin1_4	343	348	PF00397	0.423
DOC_WW_Pin1_4	405	410	PF00397	0.533
DOC_WW_Pin1_4	476	481	PF00397	0.783
LIG_14-3-3_CanoR_1	169	177	PF00244	0.441
LIG_14-3-3_CanoR_1	211	216	PF00244	0.649
LIG_14-3-3_CanoR_1	399	409	PF00244	0.448
LIG_14-3-3_CanoR_1	425	429	PF00244	0.477
LIG_14-3-3_CanoR_1	434	444	PF00244	0.411
LIG_14-3-3_CanoR_1	452	458	PF00244	0.353
LIG_14-3-3_CanoR_1	506	514	PF00244	0.513
LIG_APCC_ABBA_1	254	259	PF00400	0.377
LIG_BRCT_BRCA1_1	191	195	PF00533	0.421
LIG_CSL_BTD_1	344	347	PF09270	0.467
LIG_deltaCOP1_diTrp_1	144	150	PF00928	0.497
LIG_FHA_1	128	134	PF00498	0.443
LIG_FHA_1	250	256	PF00498	0.442
LIG_FHA_1	359	365	PF00498	0.518
LIG_FHA_1	413	419	PF00498	0.523
LIG_FHA_1	431	437	PF00498	0.375
LIG_FHA_1	506	512	PF00498	0.608
LIG_FHA_2	139	145	PF00498	0.489
LIG_FHA_2	28	34	PF00498	0.613
LIG_FHA_2	320	326	PF00498	0.356
LIG_FHA_2	436	442	PF00498	0.344
LIG_FHA_2	57	63	PF00498	0.523
LIG_LIR_Apic_2	326	332	PF02991	0.467
LIG_LIR_Apic_2	50	54	PF02991	0.662
LIG_LIR_Gen_1	352	360	PF02991	0.365
LIG_LIR_Gen_1	361	369	PF02991	0.370
LIG_LIR_Gen_1	89	97	PF02991	0.566
LIG_LIR_Nem_3	23	27	PF02991	0.584
LIG_LIR_Nem_3	352	356	PF02991	0.377
LIG_LIR_Nem_3	361	366	PF02991	0.377
LIG_LIR_Nem_3	89	93	PF02991	0.547
LIG_Pex14_1	24	28	PF04695	0.614
LIG_Pex14_1	447	451	PF04695	0.547
LIG_PTB_Apo_2	50	57	PF02174	0.428
LIG_RPA_C_Fungi	463	475	PF08784	0.507
LIG_SH2_CRK	329	333	PF00017	0.594
LIG_SH2_CRK	51	55	PF00017	0.677
LIG_SH2_CRK	514	518	PF00017	0.709
LIG_SH2_GRB2like	51	54	PF00017	0.435
LIG_SH2_SRC	453	456	PF00017	0.514
LIG_SH2_SRC	476	479	PF00017	0.525
LIG_SH2_STAT5	140	143	PF00017	0.508
LIG_SH2_STAT5	155	158	PF00017	0.261
LIG_SH2_STAT5	313	316	PF00017	0.514
LIG_SH2_STAT5	463	466	PF00017	0.740
LIG_SH3_3	413	419	PF00018	0.304
LIG_UBA3_1	76	84	PF00899	0.474
LIG_WRC_WIRS_1	360	365	PF05994	0.269
MOD_CDK_SPK_2	476	481	PF00069	0.524
MOD_CDK_SPxxK_3	222	229	PF00069	0.526
MOD_CK1_1	183	189	PF00069	0.553
MOD_CK1_1	213	219	PF00069	0.700
MOD_CK1_1	225	231	PF00069	0.682
MOD_CK1_1	346	352	PF00069	0.546
MOD_CK1_1	386	392	PF00069	0.501
MOD_CK1_1	401	407	PF00069	0.523
MOD_CK2_1	138	144	PF00069	0.488
MOD_CK2_1	79	85	PF00069	0.290
MOD_CMANNOS	147	150	PF00535	0.396
MOD_GlcNHglycan	191	194	PF01048	0.352
MOD_GlcNHglycan	201	204	PF01048	0.409
MOD_GlcNHglycan	215	218	PF01048	0.701
MOD_GlcNHglycan	273	276	PF01048	0.776
MOD_GlcNHglycan	281	284	PF01048	0.593
MOD_GlcNHglycan	297	301	PF01048	0.310
MOD_GlcNHglycan	333	336	PF01048	0.589
MOD_GlcNHglycan	348	351	PF01048	0.528
MOD_GlcNHglycan	388	391	PF01048	0.707
MOD_GlcNHglycan	400	403	PF01048	0.565
MOD_GSK3_1	181	188	PF00069	0.437
MOD_GSK3_1	189	196	PF00069	0.359
MOD_GSK3_1	271	278	PF00069	0.745
MOD_GSK3_1	315	322	PF00069	0.519
MOD_GSK3_1	345	352	PF00069	0.504
MOD_GSK3_1	401	408	PF00069	0.582
MOD_GSK3_1	424	431	PF00069	0.477
MOD_GSK3_1	435	442	PF00069	0.411
MOD_GSK3_1	501	508	PF00069	0.502
MOD_N-GLC_1	193	198	PF02516	0.526
MOD_N-GLC_1	35	40	PF02516	0.655
MOD_N-GLC_1	428	433	PF02516	0.484
MOD_N-GLC_2	72	74	PF02516	0.561
MOD_NEK2_1	249	254	PF00069	0.350
MOD_NEK2_1	27	32	PF00069	0.625
MOD_NEK2_1	34	39	PF00069	0.614
MOD_NEK2_1	358	363	PF00069	0.514
MOD_NEK2_1	435	440	PF00069	0.529
MOD_NEK2_2	453	458	PF00069	0.386
MOD_PIKK_1	315	321	PF00454	0.556
MOD_PIKK_1	6	12	PF00454	0.776
MOD_PIKK_1	88	94	PF00454	0.500
MOD_PKA_1	506	512	PF00069	0.524
MOD_PKA_2	168	174	PF00069	0.434
MOD_PKA_2	181	187	PF00069	0.440
MOD_PKA_2	210	216	PF00069	0.654
MOD_PKA_2	271	277	PF00069	0.527
MOD_PKA_2	398	404	PF00069	0.495
MOD_PKA_2	424	430	PF00069	0.322
MOD_PKA_2	505	511	PF00069	0.634
MOD_Plk_1	143	149	PF00069	0.463
MOD_Plk_1	193	199	PF00069	0.522
MOD_Plk_1	319	325	PF00069	0.610
MOD_Plk_1	383	389	PF00069	0.491
MOD_Plk_1	440	446	PF00069	0.536
MOD_Plk_1	486	492	PF00069	0.695
MOD_Plk_1	61	67	PF00069	0.589
MOD_Plk_4	129	135	PF00069	0.445
MOD_Plk_4	243	249	PF00069	0.544
MOD_Plk_4	308	314	PF00069	0.477
MOD_Plk_4	359	365	PF00069	0.320
MOD_Plk_4	47	53	PF00069	0.630
MOD_Plk_4	61	67	PF00069	0.444
MOD_ProDKin_1	222	228	PF00069	0.756
MOD_ProDKin_1	276	282	PF00069	0.621
MOD_ProDKin_1	343	349	PF00069	0.433
MOD_ProDKin_1	405	411	PF00069	0.529
MOD_ProDKin_1	476	482	PF00069	0.781
MOD_SUMO_rev_2	240	245	PF00179	0.642
TRG_DiLeu_BaEn_1	298	303	PF01217	0.421
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.653
TRG_ENDOCYTIC_2	514	517	PF00928	0.708
TRG_ER_diArg_1	285	288	PF00400	0.665
TRG_ER_diArg_1	369	371	PF00400	0.474
TRG_ER_diArg_1	497	499	PF00400	0.607
TRG_ER_diArg_1	505	507	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3R7	Leptomonas seymouri	58%	87%
A0A1X0P9T6	Trypanosomatidae	33%	100%
A0A3Q8IHB0	Leishmania donovani	79%	97%
A0A3R7N181	Trypanosoma rangeli	33%	100%
A4IA24	Leishmania infantum	79%	97%
C9ZMJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B539	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
Q4Q2U7	Leishmania major	78%	100%
V5BFU9	Trypanosoma cruzi	33%	100%