Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAW3_LEIBR

TriTrypDb:

LbrM.20.2020 , LBRM2903_200030900

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.432
CLV_NRD_NRD_1	14	16	PF00675	0.703
CLV_NRD_NRD_1	279	281	PF00675	0.407
CLV_NRD_NRD_1	346	348	PF00675	0.678
CLV_NRD_NRD_1	88	90	PF00675	0.508
CLV_PCSK_KEX2_1	11	13	PF00082	0.567
CLV_PCSK_KEX2_1	19	21	PF00082	0.567
CLV_PCSK_KEX2_1	279	281	PF00082	0.407
CLV_PCSK_KEX2_1	348	350	PF00082	0.636
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.512
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.490
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.660
CLV_PCSK_PC7_1	15	21	PF00082	0.653
CLV_PCSK_SKI1_1	112	116	PF00082	0.470
CLV_PCSK_SKI1_1	16	20	PF00082	0.703
CLV_PCSK_SKI1_1	342	346	PF00082	0.423
CLV_Separin_Metazoa	107	111	PF03568	0.502
DEG_APCC_DBOX_1	159	167	PF00400	0.337
DEG_SPOP_SBC_1	51	55	PF00917	0.624
DOC_PP1_RVXF_1	162	169	PF00149	0.382
DOC_PP2B_LxvP_1	297	300	PF13499	0.441
DOC_USP7_MATH_1	217	221	PF00917	0.629
DOC_USP7_MATH_1	300	304	PF00917	0.658
DOC_USP7_MATH_1	52	56	PF00917	0.543
DOC_WW_Pin1_4	289	294	PF00397	0.656
LIG_14-3-3_CanoR_1	160	164	PF00244	0.378
LIG_14-3-3_CanoR_1	170	180	PF00244	0.353
LIG_14-3-3_CanoR_1	201	208	PF00244	0.691
LIG_14-3-3_CanoR_1	218	222	PF00244	0.433
LIG_Actin_WH2_2	149	166	PF00022	0.389
LIG_FHA_1	160	166	PF00498	0.402
LIG_FHA_1	182	188	PF00498	0.373
LIG_FHA_1	319	325	PF00498	0.502
LIG_FHA_1	52	58	PF00498	0.683
LIG_FHA_1	76	82	PF00498	0.495
LIG_LIR_Gen_1	305	316	PF02991	0.351
LIG_LIR_Nem_3	305	311	PF02991	0.364
LIG_REV1ctd_RIR_1	150	159	PF16727	0.424
LIG_SH2_GRB2like	308	311	PF00017	0.459
LIG_SH2_STAT5	124	127	PF00017	0.325
LIG_SH2_STAT5	308	311	PF00017	0.459
LIG_SH2_STAT5	315	318	PF00017	0.488
LIG_SUMO_SIM_anti_2	103	111	PF11976	0.361
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.269
LIG_SUMO_SIM_par_1	228	233	PF11976	0.276
LIG_TRAF2_1	66	69	PF00917	0.460
LIG_UBA3_1	229	237	PF00899	0.477
MOD_CK1_1	10	16	PF00069	0.638
MOD_CK1_1	233	239	PF00069	0.252
MOD_CK1_1	289	295	PF00069	0.612
MOD_CK1_1	40	46	PF00069	0.638
MOD_CK1_1	50	56	PF00069	0.646
MOD_CK2_1	113	119	PF00069	0.544
MOD_CK2_1	222	228	PF00069	0.427
MOD_CK2_1	61	67	PF00069	0.538
MOD_CK2_1	81	87	PF00069	0.476
MOD_GlcNHglycan	12	15	PF01048	0.718
MOD_GlcNHglycan	188	191	PF01048	0.460
MOD_GlcNHglycan	203	206	PF01048	0.567
MOD_GlcNHglycan	219	222	PF01048	0.671
MOD_GlcNHglycan	289	292	PF01048	0.654
MOD_GlcNHglycan	302	305	PF01048	0.579
MOD_GlcNHglycan	33	36	PF01048	0.645
MOD_GlcNHglycan	39	42	PF01048	0.678
MOD_GlcNHglycan	49	52	PF01048	0.442
MOD_GlcNHglycan	81	84	PF01048	0.608
MOD_GSK3_1	192	199	PF00069	0.549
MOD_GSK3_1	209	216	PF00069	0.652
MOD_GSK3_1	282	289	PF00069	0.456
MOD_GSK3_1	298	305	PF00069	0.559
MOD_GSK3_1	47	54	PF00069	0.656
MOD_GSK3_1	55	62	PF00069	0.498
MOD_GSK3_1	75	82	PF00069	0.540
MOD_N-GLC_1	353	358	PF02516	0.478
MOD_NEK2_1	113	118	PF00069	0.481
MOD_NEK2_1	125	130	PF00069	0.341
MOD_NEK2_1	181	186	PF00069	0.471
MOD_NEK2_1	197	202	PF00069	0.454
MOD_NEK2_1	211	216	PF00069	0.611
MOD_NEK2_1	230	235	PF00069	0.266
MOD_NEK2_1	286	291	PF00069	0.592
MOD_PKA_1	347	353	PF00069	0.608
MOD_PKA_2	159	165	PF00069	0.428
MOD_PKA_2	171	177	PF00069	0.353
MOD_PKA_2	200	206	PF00069	0.472
MOD_PKA_2	217	223	PF00069	0.428
MOD_PKA_2	318	324	PF00069	0.522
MOD_PKB_1	170	178	PF00069	0.245
MOD_Plk_1	125	131	PF00069	0.370
MOD_Plk_1	209	215	PF00069	0.596
MOD_Plk_1	230	236	PF00069	0.288
MOD_Plk_4	42	48	PF00069	0.476
MOD_ProDKin_1	289	295	PF00069	0.654
TRG_ENDOCYTIC_2	124	127	PF00928	0.419
TRG_ENDOCYTIC_2	308	311	PF00928	0.462
TRG_ENDOCYTIC_2	94	97	PF00928	0.354
TRG_ER_diArg_1	109	112	PF00400	0.531
TRG_ER_diArg_1	170	173	PF00400	0.332
TRG_ER_diArg_1	278	280	PF00400	0.407
TRG_ER_diArg_1	340	343	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC4	Leptomonas seymouri	64%	97%
A0A0S4JWU2	Bodo saltans	32%	100%
A0A1X0P9N6	Trypanosomatidae	47%	100%
A0A3Q8INF5	Leishmania donovani	78%	100%
A0A3R7NT18	Trypanosoma rangeli	44%	100%
A4IA23	Leishmania infantum	78%	100%
C9ZMJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B538	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q2U8	Leishmania major	77%	100%
V5B0E5	Trypanosoma cruzi	51%	97%