Coiled-coil domain-containing protein 146

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAW2_LEIBR

TriTrypDb:

LbrM.20.2010 , LBRM2903_200030800

Length:

1114

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HAW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.317
CLV_C14_Caspase3-7	754	758	PF00656	0.615
CLV_C14_Caspase3-7	834	838	PF00656	0.466
CLV_MEL_PAP_1	828	834	PF00089	0.524
CLV_NRD_NRD_1	1102	1104	PF00675	0.496
CLV_NRD_NRD_1	135	137	PF00675	0.377
CLV_NRD_NRD_1	288	290	PF00675	0.536
CLV_NRD_NRD_1	393	395	PF00675	0.513
CLV_NRD_NRD_1	443	445	PF00675	0.486
CLV_NRD_NRD_1	486	488	PF00675	0.406
CLV_NRD_NRD_1	575	577	PF00675	0.450
CLV_NRD_NRD_1	594	596	PF00675	0.301
CLV_NRD_NRD_1	611	613	PF00675	0.403
CLV_NRD_NRD_1	65	67	PF00675	0.368
CLV_NRD_NRD_1	914	916	PF00675	0.371
CLV_PCSK_FUR_1	723	727	PF00082	0.440
CLV_PCSK_KEX2_1	106	108	PF00082	0.522
CLV_PCSK_KEX2_1	135	137	PF00082	0.517
CLV_PCSK_KEX2_1	288	290	PF00082	0.386
CLV_PCSK_KEX2_1	380	382	PF00082	0.359
CLV_PCSK_KEX2_1	442	444	PF00082	0.455
CLV_PCSK_KEX2_1	452	454	PF00082	0.417
CLV_PCSK_KEX2_1	486	488	PF00082	0.402
CLV_PCSK_KEX2_1	493	495	PF00082	0.405
CLV_PCSK_KEX2_1	594	596	PF00082	0.410
CLV_PCSK_KEX2_1	611	613	PF00082	0.351
CLV_PCSK_KEX2_1	65	67	PF00082	0.315
CLV_PCSK_KEX2_1	72	74	PF00082	0.375
CLV_PCSK_KEX2_1	725	727	PF00082	0.490
CLV_PCSK_KEX2_1	916	918	PF00082	0.385
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.522
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.386
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.359
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.464
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.439
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.416
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.306
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.490
CLV_PCSK_PC1ET2_1	916	918	PF00082	0.333
CLV_PCSK_PC7_1	489	495	PF00082	0.464
CLV_PCSK_SKI1_1	187	191	PF00082	0.457
CLV_PCSK_SKI1_1	241	245	PF00082	0.485
CLV_PCSK_SKI1_1	289	293	PF00082	0.403
CLV_PCSK_SKI1_1	324	328	PF00082	0.427
CLV_PCSK_SKI1_1	380	384	PF00082	0.598
CLV_PCSK_SKI1_1	402	406	PF00082	0.540
CLV_PCSK_SKI1_1	477	481	PF00082	0.578
CLV_PCSK_SKI1_1	542	546	PF00082	0.383
CLV_PCSK_SKI1_1	587	591	PF00082	0.385
CLV_PCSK_SKI1_1	664	668	PF00082	0.488
DEG_APCC_DBOX_1	288	296	PF00400	0.478
DEG_APCC_DBOX_1	442	450	PF00400	0.514
DEG_SPOP_SBC_1	1042	1046	PF00917	0.742
DEG_SPOP_SBC_1	1050	1054	PF00917	0.692
DEG_SPOP_SBC_1	1058	1062	PF00917	0.641
DOC_CKS1_1	1037	1042	PF01111	0.625
DOC_CYCLIN_RxL_1	224	234	PF00134	0.563
DOC_CYCLIN_RxL_1	399	407	PF00134	0.620
DOC_CYCLIN_RxL_1	472	483	PF00134	0.486
DOC_CYCLIN_RxL_1	814	826	PF00134	0.459
DOC_CYCLIN_yClb5_NLxxxL_5	806	815	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	966	972	PF00134	0.661
DOC_MAPK_gen_1	135	142	PF00069	0.393
DOC_MAPK_gen_1	224	231	PF00069	0.509
DOC_MAPK_gen_1	339	348	PF00069	0.547
DOC_MAPK_gen_1	493	501	PF00069	0.563
DOC_MAPK_gen_1	723	731	PF00069	0.662
DOC_MAPK_gen_1	75	83	PF00069	0.493
DOC_MAPK_gen_1	814	822	PF00069	0.384
DOC_MAPK_MEF2A_6	122	130	PF00069	0.419
DOC_MAPK_MEF2A_6	686	694	PF00069	0.561
DOC_MAPK_MEF2A_6	723	731	PF00069	0.662
DOC_MAPK_MEF2A_6	800	808	PF00069	0.414
DOC_MAPK_MEF2A_6	977	984	PF00069	0.615
DOC_PP1_RVXF_1	400	407	PF00149	0.474
DOC_PP2B_LxvP_1	729	732	PF13499	0.567
DOC_PP2B_LxvP_1	964	967	PF13499	0.560
DOC_USP7_MATH_1	1019	1023	PF00917	0.751
DOC_USP7_MATH_1	1024	1028	PF00917	0.736
DOC_USP7_MATH_1	1051	1055	PF00917	0.708
DOC_USP7_MATH_1	1058	1062	PF00917	0.747
DOC_USP7_MATH_1	582	586	PF00917	0.530
DOC_USP7_MATH_1	685	689	PF00917	0.555
DOC_USP7_MATH_1	738	742	PF00917	0.609
DOC_USP7_MATH_1	761	765	PF00917	0.671
DOC_USP7_MATH_1	775	779	PF00917	0.598
DOC_USP7_MATH_1	8	12	PF00917	0.717
DOC_USP7_MATH_1	852	856	PF00917	0.458
DOC_USP7_MATH_1	975	979	PF00917	0.696
DOC_USP7_MATH_1	991	995	PF00917	0.747
DOC_USP7_UBL2_3	412	416	PF12436	0.602
DOC_USP7_UBL2_3	493	497	PF12436	0.517
DOC_USP7_UBL2_3	50	54	PF12436	0.378
DOC_USP7_UBL2_3	531	535	PF12436	0.451
DOC_USP7_UBL2_3	577	581	PF12436	0.429
DOC_USP7_UBL2_3	814	818	PF12436	0.505
DOC_WW_Pin1_4	1036	1041	PF00397	0.743
DOC_WW_Pin1_4	12	17	PF00397	0.545
DOC_WW_Pin1_4	976	981	PF00397	0.515
DOC_WW_Pin1_4	983	988	PF00397	0.554
LIG_14-3-3_CanoR_1	1035	1040	PF00244	0.480
LIG_14-3-3_CanoR_1	1088	1094	PF00244	0.519
LIG_14-3-3_CanoR_1	1099	1106	PF00244	0.446
LIG_14-3-3_CanoR_1	122	126	PF00244	0.360
LIG_14-3-3_CanoR_1	306	313	PF00244	0.575
LIG_14-3-3_CanoR_1	466	470	PF00244	0.520
LIG_14-3-3_CanoR_1	611	615	PF00244	0.553
LIG_14-3-3_CanoR_1	763	769	PF00244	0.457
LIG_14-3-3_CanoR_1	87	92	PF00244	0.462
LIG_Actin_WH2_2	56	74	PF00022	0.365
LIG_BRCT_BRCA1_1	410	414	PF00533	0.629
LIG_BRCT_BRCA1_1	764	768	PF00533	0.461
LIG_BRCT_BRCA1_2	410	416	PF00533	0.559
LIG_FHA_1	25	31	PF00498	0.462
LIG_FHA_1	320	326	PF00498	0.443
LIG_FHA_1	381	387	PF00498	0.548
LIG_FHA_1	399	405	PF00498	0.461
LIG_FHA_1	429	435	PF00498	0.601
LIG_FHA_1	528	534	PF00498	0.557
LIG_FHA_1	637	643	PF00498	0.343
LIG_FHA_1	706	712	PF00498	0.513
LIG_FHA_1	744	750	PF00498	0.468
LIG_FHA_1	841	847	PF00498	0.387
LIG_FHA_2	189	195	PF00498	0.452
LIG_FHA_2	242	248	PF00498	0.353
LIG_FHA_2	295	301	PF00498	0.448
LIG_FHA_2	543	549	PF00498	0.361
LIG_FHA_2	604	610	PF00498	0.420
LIG_FHA_2	622	628	PF00498	0.382
LIG_FHA_2	737	743	PF00498	0.512
LIG_FHA_2	752	758	PF00498	0.683
LIG_FHA_2	88	94	PF00498	0.542
LIG_FHA_2	931	937	PF00498	0.483
LIG_LIR_Gen_1	121	131	PF02991	0.279
LIG_LIR_Gen_1	26	36	PF02991	0.469
LIG_LIR_Gen_1	269	278	PF02991	0.437
LIG_LIR_Gen_1	500	510	PF02991	0.394
LIG_LIR_Gen_1	791	799	PF02991	0.501
LIG_LIR_Nem_3	121	126	PF02991	0.280
LIG_LIR_Nem_3	26	32	PF02991	0.469
LIG_LIR_Nem_3	269	274	PF02991	0.442
LIG_LIR_Nem_3	500	505	PF02991	0.391
LIG_LIR_Nem_3	791	797	PF02991	0.459
LIG_LIR_Nem_3	90	94	PF02991	0.296
LIG_NRBOX	31	37	PF00104	0.298
LIG_RPA_C_Fungi	61	73	PF08784	0.285
LIG_RPA_C_Fungi	636	648	PF08784	0.477
LIG_SH2_CRK	123	127	PF00017	0.277
LIG_SH2_PTP2	794	797	PF00017	0.555
LIG_SH2_STAP1	614	618	PF00017	0.464
LIG_SH2_STAT3	48	51	PF00017	0.304
LIG_SH2_STAT3	957	960	PF00017	0.619
LIG_SH2_STAT5	29	32	PF00017	0.564
LIG_SH2_STAT5	48	51	PF00017	0.255
LIG_SH2_STAT5	794	797	PF00017	0.555
LIG_SH2_STAT5	89	92	PF00017	0.461
LIG_SH2_STAT5	957	960	PF00017	0.583
LIG_SH3_2	718	723	PF14604	0.499
LIG_SH3_2	972	977	PF14604	0.590
LIG_SH3_3	715	721	PF00018	0.496
LIG_SH3_3	732	738	PF00018	0.469
LIG_SH3_3	784	790	PF00018	0.561
LIG_SH3_3	966	972	PF00018	0.552
LIG_SH3_CIN85_PxpxPR_1	1000	1005	PF14604	0.585
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.371
LIG_SUMO_SIM_anti_2	624	630	PF11976	0.296
LIG_SxIP_EBH_1	1056	1070	PF03271	0.462
LIG_TRAF2_1	1093	1096	PF00917	0.477
LIG_TRAF2_1	149	152	PF00917	0.407
LIG_TRAF2_1	15	18	PF00917	0.456
LIG_TRAF2_1	245	248	PF00917	0.505
LIG_TRAF2_1	308	311	PF00917	0.566
LIG_TRAF2_1	364	367	PF00917	0.437
LIG_TRAF2_1	461	464	PF00917	0.507
LIG_TRAF2_1	790	793	PF00917	0.421
LIG_TRAF2_1	933	936	PF00917	0.390
LIG_UBA3_1	347	355	PF00899	0.344
LIG_WRC_WIRS_1	88	93	PF05994	0.460
MOD_CDK_SPK_2	983	988	PF00069	0.462
MOD_CK1_1	1018	1024	PF00069	0.731
MOD_CK1_1	1029	1035	PF00069	0.660
MOD_CK1_1	1044	1050	PF00069	0.697
MOD_CK1_1	1062	1068	PF00069	0.763
MOD_CK1_1	1069	1075	PF00069	0.541
MOD_CK1_1	12	18	PF00069	0.651
MOD_CK1_1	161	167	PF00069	0.471
MOD_CK1_1	457	463	PF00069	0.575
MOD_CK1_1	743	749	PF00069	0.533
MOD_CK1_1	764	770	PF00069	0.700
MOD_CK1_1	978	984	PF00069	0.676
MOD_CK2_1	105	111	PF00069	0.360
MOD_CK2_1	12	18	PF00069	0.703
MOD_CK2_1	188	194	PF00069	0.398
MOD_CK2_1	217	223	PF00069	0.539
MOD_CK2_1	241	247	PF00069	0.565
MOD_CK2_1	263	269	PF00069	0.494
MOD_CK2_1	294	300	PF00069	0.435
MOD_CK2_1	305	311	PF00069	0.441
MOD_CK2_1	346	352	PF00069	0.503
MOD_CK2_1	361	367	PF00069	0.390
MOD_CK2_1	457	463	PF00069	0.575
MOD_CK2_1	582	588	PF00069	0.458
MOD_CK2_1	621	627	PF00069	0.474
MOD_CK2_1	685	691	PF00069	0.558
MOD_CK2_1	736	742	PF00069	0.490
MOD_CK2_1	76	82	PF00069	0.428
MOD_CK2_1	864	870	PF00069	0.361
MOD_CK2_1	930	936	PF00069	0.490
MOD_GlcNHglycan	1017	1020	PF01048	0.731
MOD_GlcNHglycan	1026	1029	PF01048	0.734
MOD_GlcNHglycan	11	14	PF01048	0.729
MOD_GlcNHglycan	250	253	PF01048	0.499
MOD_GlcNHglycan	459	462	PF01048	0.572
MOD_GlcNHglycan	778	781	PF01048	0.588
MOD_GSK3_1	1011	1018	PF00069	0.689
MOD_GSK3_1	1058	1065	PF00069	0.742
MOD_GSK3_1	291	298	PF00069	0.452
MOD_GSK3_1	302	309	PF00069	0.462
MOD_GSK3_1	394	401	PF00069	0.571
MOD_GSK3_1	511	518	PF00069	0.387
MOD_GSK3_1	538	545	PF00069	0.417
MOD_GSK3_1	736	743	PF00069	0.525
MOD_GSK3_1	8	15	PF00069	0.719
MOD_LATS_1	1086	1092	PF00433	0.479
MOD_N-GLC_1	1088	1093	PF02516	0.483
MOD_N-GLC_1	295	300	PF02516	0.435
MOD_N-GLC_1	621	626	PF02516	0.441
MOD_NEK2_1	1017	1022	PF00069	0.746
MOD_NEK2_1	1043	1048	PF00069	0.742
MOD_NEK2_1	105	110	PF00069	0.409
MOD_NEK2_1	1059	1064	PF00069	0.622
MOD_NEK2_1	1098	1103	PF00069	0.600
MOD_NEK2_1	204	209	PF00069	0.531
MOD_NEK2_1	319	324	PF00069	0.398
MOD_NEK2_1	610	615	PF00069	0.514
MOD_NEK2_1	692	697	PF00069	0.492
MOD_NEK2_1	762	767	PF00069	0.611
MOD_NEK2_1	864	869	PF00069	0.360
MOD_NEK2_1	874	879	PF00069	0.361
MOD_NEK2_1	945	950	PF00069	0.746
MOD_NEK2_2	277	282	PF00069	0.320
MOD_NEK2_2	853	858	PF00069	0.447
MOD_NEK2_2	869	874	PF00069	0.277
MOD_PIKK_1	1098	1104	PF00454	0.489
MOD_PIKK_1	306	312	PF00454	0.500
MOD_PIKK_1	511	517	PF00454	0.417
MOD_PIKK_1	650	656	PF00454	0.502
MOD_PIKK_1	685	691	PF00454	0.543
MOD_PIKK_1	705	711	PF00454	0.306
MOD_PIKK_1	740	746	PF00454	0.508
MOD_PIKK_1	749	755	PF00454	0.564
MOD_PKA_1	380	386	PF00069	0.343
MOD_PKA_1	394	400	PF00069	0.337
MOD_PKA_1	493	499	PF00069	0.546
MOD_PKA_2	1069	1075	PF00069	0.510
MOD_PKA_2	1087	1093	PF00069	0.523
MOD_PKA_2	1098	1104	PF00069	0.494
MOD_PKA_2	121	127	PF00069	0.376
MOD_PKA_2	263	269	PF00069	0.461
MOD_PKA_2	305	311	PF00069	0.532
MOD_PKA_2	380	386	PF00069	0.505
MOD_PKA_2	425	431	PF00069	0.505
MOD_PKA_2	457	463	PF00069	0.529
MOD_PKA_2	465	471	PF00069	0.555
MOD_PKA_2	493	499	PF00069	0.411
MOD_PKA_2	610	616	PF00069	0.578
MOD_PKA_2	762	768	PF00069	0.470
MOD_PKA_2	776	782	PF00069	0.457
MOD_PKA_2	930	936	PF00069	0.462
MOD_PKB_1	85	93	PF00069	0.550
MOD_Plk_1	295	301	PF00069	0.435
MOD_Plk_1	361	367	PF00069	0.500
MOD_Plk_1	428	434	PF00069	0.566
MOD_Plk_1	542	548	PF00069	0.457
MOD_Plk_1	559	565	PF00069	0.580
MOD_Plk_1	603	609	PF00069	0.508
MOD_Plk_1	692	698	PF00069	0.493
MOD_Plk_1	816	822	PF00069	0.349
MOD_Plk_1	840	846	PF00069	0.415
MOD_Plk_1	869	875	PF00069	0.365
MOD_Plk_1	937	943	PF00069	0.677
MOD_Plk_2-3	361	367	PF00069	0.541
MOD_Plk_4	1026	1032	PF00069	0.658
MOD_Plk_4	1077	1083	PF00069	0.482
MOD_Plk_4	121	127	PF00069	0.361
MOD_Plk_4	816	822	PF00069	0.288
MOD_Plk_4	869	875	PF00069	0.365
MOD_ProDKin_1	1036	1042	PF00069	0.738
MOD_ProDKin_1	12	18	PF00069	0.542
MOD_ProDKin_1	976	982	PF00069	0.517
MOD_ProDKin_1	983	989	PF00069	0.554
MOD_SUMO_for_1	505	508	PF00179	0.396
MOD_SUMO_rev_2	242	251	PF00179	0.451
MOD_SUMO_rev_2	584	591	PF00179	0.532
MOD_SUMO_rev_2	712	721	PF00179	0.621
TRG_DiLeu_BaEn_1	315	320	PF01217	0.486
TRG_DiLeu_BaEn_1	367	372	PF01217	0.553
TRG_DiLeu_BaEn_1	528	533	PF01217	0.518
TRG_DiLeu_BaEn_4	792	798	PF01217	0.391
TRG_DiLeu_BaEn_4	823	829	PF01217	0.389
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.403
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.427
TRG_ENDOCYTIC_2	123	126	PF00928	0.277
TRG_ENDOCYTIC_2	271	274	PF00928	0.328
TRG_ENDOCYTIC_2	29	32	PF00928	0.443
TRG_ENDOCYTIC_2	794	797	PF00928	0.521
TRG_ENDOCYTIC_2	970	973	PF00928	0.527
TRG_ER_diArg_1	154	157	PF00400	0.461
TRG_ER_diArg_1	486	489	PF00400	0.344
TRG_ER_diArg_1	593	595	PF00400	0.405
TRG_ER_diArg_1	610	612	PF00400	0.391
TRG_ER_diArg_1	64	66	PF00400	0.500
TRG_ER_diArg_1	77	80	PF00400	0.421
TRG_ER_diArg_1	85	88	PF00400	0.529
TRG_NES_CRM1_1	490	503	PF08389	0.343
TRG_NES_CRM1_1	536	550	PF08389	0.447
TRG_NES_CRM1_1	560	571	PF08389	0.428
TRG_NLS_Bipartite_1	275	292	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC41	Leptomonas seymouri	65%	96%
A0A0S4JNC8	Bodo saltans	41%	100%
A0A1X0P9Q4	Trypanosomatidae	45%	100%
A0A3S7X809	Leishmania donovani	82%	100%
A0A422P0B4	Trypanosoma rangeli	44%	100%
A4IA22	Leishmania infantum	82%	100%
C9ZMK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B537	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2U9	Leishmania major	80%	100%
Q66H60	Rattus norvegicus	22%	100%
Q8IYE0	Homo sapiens	20%	100%
V5DGR4	Trypanosoma cruzi	45%	100%