Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAW1_LEIBR

TriTrypDb:

LbrM.20.2000 , LBRM2903_200030700

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.615
CLV_C14_Caspase3-7	348	352	PF00656	0.538
CLV_NRD_NRD_1	287	289	PF00675	0.592
CLV_NRD_NRD_1	333	335	PF00675	0.645
CLV_PCSK_KEX2_1	333	335	PF00082	0.630
DEG_Nend_UBRbox_1	1	4	PF02207	0.512
DEG_SPOP_SBC_1	314	318	PF00917	0.532
DOC_CDC14_PxL_1	241	249	PF14671	0.538
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.504
DOC_MAPK_gen_1	122	130	PF00069	0.551
DOC_PP1_RVXF_1	372	378	PF00149	0.439
DOC_SPAK_OSR1_1	2	6	PF12202	0.602
DOC_USP7_MATH_1	131	135	PF00917	0.751
DOC_USP7_MATH_1	145	149	PF00917	0.499
DOC_USP7_MATH_1	223	227	PF00917	0.674
DOC_USP7_MATH_1	273	277	PF00917	0.598
DOC_USP7_MATH_1	296	300	PF00917	0.606
DOC_USP7_MATH_1	314	318	PF00917	0.536
DOC_USP7_MATH_1	42	46	PF00917	0.617
DOC_USP7_MATH_1	64	68	PF00917	0.719
DOC_WW_Pin1_4	101	106	PF00397	0.476
DOC_WW_Pin1_4	321	326	PF00397	0.482
LIG_14-3-3_CanoR_1	133	143	PF00244	0.657
LIG_14-3-3_CanoR_1	235	241	PF00244	0.543
LIG_14-3-3_CanoR_1	315	323	PF00244	0.610
LIG_14-3-3_CanoR_1	366	375	PF00244	0.542
LIG_APCC_ABBA_1	383	388	PF00400	0.466
LIG_BIR_III_2	111	115	PF00653	0.468
LIG_BIR_III_2	201	205	PF00653	0.629
LIG_BIR_III_4	351	355	PF00653	0.495
LIG_BRCT_BRCA1_1	160	164	PF00533	0.601
LIG_Clathr_ClatBox_1	247	251	PF01394	0.539
LIG_eIF4E_1	79	85	PF01652	0.518
LIG_FHA_1	102	108	PF00498	0.590
LIG_FHA_1	167	173	PF00498	0.588
LIG_FHA_1	176	182	PF00498	0.552
LIG_FHA_1	213	219	PF00498	0.732
LIG_FHA_1	49	55	PF00498	0.602
LIG_FHA_1	79	85	PF00498	0.518
LIG_FHA_2	258	264	PF00498	0.546
LIG_LIR_Gen_1	161	172	PF02991	0.616
LIG_LIR_Nem_3	161	167	PF02991	0.613
LIG_LIR_Nem_3	324	329	PF02991	0.559
LIG_Pex14_1	156	160	PF04695	0.523
LIG_RPA_C_Fungi	329	341	PF08784	0.473
LIG_SH2_SRC	329	332	PF00017	0.473
LIG_SH2_STAP1	108	112	PF00017	0.521
LIG_SH2_STAP1	160	164	PF00017	0.657
LIG_SH2_STAT5	108	111	PF00017	0.525
LIG_SH2_STAT5	192	195	PF00017	0.576
LIG_SH3_3	239	245	PF00018	0.541
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.534
LIG_SUMO_SIM_par_1	81	88	PF11976	0.520
LIG_TRAF2_1	136	139	PF00917	0.656
MOD_CK1_1	134	140	PF00069	0.618
MOD_CK1_1	20	26	PF00069	0.639
MOD_CK1_1	227	233	PF00069	0.503
MOD_CK1_1	276	282	PF00069	0.639
MOD_CK1_1	373	379	PF00069	0.490
MOD_CK1_1	78	84	PF00069	0.514
MOD_CK1_1	97	103	PF00069	0.420
MOD_CK2_1	132	138	PF00069	0.671
MOD_CK2_1	145	151	PF00069	0.484
MOD_CK2_1	257	263	PF00069	0.553
MOD_CK2_1	373	379	PF00069	0.594
MOD_GlcNHglycan	115	118	PF01048	0.620
MOD_GlcNHglycan	134	137	PF01048	0.463
MOD_GlcNHglycan	24	28	PF01048	0.619
MOD_GlcNHglycan	253	256	PF01048	0.532
MOD_GlcNHglycan	275	278	PF01048	0.576
MOD_GlcNHglycan	298	301	PF01048	0.720
MOD_GlcNHglycan	379	382	PF01048	0.580
MOD_GSK3_1	158	165	PF00069	0.608
MOD_GSK3_1	16	23	PF00069	0.641
MOD_GSK3_1	223	230	PF00069	0.609
MOD_GSK3_1	236	243	PF00069	0.517
MOD_GSK3_1	272	279	PF00069	0.543
MOD_GSK3_1	366	373	PF00069	0.513
MOD_GSK3_1	54	61	PF00069	0.668
MOD_GSK3_1	90	97	PF00069	0.487
MOD_NEK2_1	250	255	PF00069	0.526
MOD_NEK2_1	290	295	PF00069	0.542
MOD_NEK2_1	377	382	PF00069	0.490
MOD_PK_1	334	340	PF00069	0.487
MOD_PKA_1	288	294	PF00069	0.608
MOD_PKA_2	132	138	PF00069	0.671
MOD_PKA_2	162	168	PF00069	0.617
MOD_PKA_2	204	210	PF00069	0.732
MOD_PKA_2	314	320	PF00069	0.624
MOD_PKA_2	352	358	PF00069	0.563
MOD_PKA_2	373	379	PF00069	0.594
MOD_Plk_1	223	229	PF00069	0.540
MOD_Plk_1	23	29	PF00069	0.643
MOD_Plk_1	360	366	PF00069	0.497
MOD_Plk_1	65	71	PF00069	0.564
MOD_Plk_2-3	360	366	PF00069	0.497
MOD_Plk_4	236	242	PF00069	0.537
MOD_ProDKin_1	101	107	PF00069	0.476
MOD_ProDKin_1	321	327	PF00069	0.477
MOD_SUMO_rev_2	116	124	PF00179	0.528
TRG_DiLeu_BaEn_4	138	144	PF01217	0.648
TRG_ER_diArg_1	69	72	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMR5	Leptomonas seymouri	36%	100%
A0A3S5H7X0	Leishmania donovani	68%	96%
A4IA21	Leishmania infantum	67%	96%
E9B536	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q2V0	Leishmania major	61%	93%