Tr-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor Tu GTP binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAV7_LEIBR

TriTrypDb:

LbrM.20.1960 , LBRM2903_200030400

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAV7

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.582
CLV_C14_Caspase3-7	442	446	PF00656	0.529
CLV_C14_Caspase3-7	528	532	PF00656	0.545
CLV_C14_Caspase3-7	760	764	PF00656	0.762
CLV_C14_Caspase3-7	788	792	PF00656	0.547
CLV_NRD_NRD_1	227	229	PF00675	0.563
CLV_NRD_NRD_1	311	313	PF00675	0.565
CLV_NRD_NRD_1	460	462	PF00675	0.282
CLV_NRD_NRD_1	59	61	PF00675	0.669
CLV_PCSK_KEX2_1	227	229	PF00082	0.563
CLV_PCSK_KEX2_1	311	313	PF00082	0.565
CLV_PCSK_KEX2_1	59	61	PF00082	0.669
CLV_PCSK_SKI1_1	258	262	PF00082	0.592
CLV_PCSK_SKI1_1	439	443	PF00082	0.266
CLV_PCSK_SKI1_1	452	456	PF00082	0.207
CLV_PCSK_SKI1_1	773	777	PF00082	0.508
CLV_PCSK_SKI1_1	779	783	PF00082	0.490
DEG_APCC_DBOX_1	596	604	PF00400	0.509
DEG_SCF_FBW7_1	427	434	PF00400	0.470
DEG_SCF_FBW7_1	561	568	PF00400	0.560
DEG_SPOP_SBC_1	408	412	PF00917	0.380
DEG_SPOP_SBC_1	556	560	PF00917	0.564
DOC_CKS1_1	490	495	PF01111	0.537
DOC_CKS1_1	562	567	PF01111	0.560
DOC_CKS1_1	810	815	PF01111	0.379
DOC_CYCLIN_RxL_1	773	785	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.463
DOC_MAPK_gen_1	461	468	PF00069	0.537
DOC_MAPK_gen_1	643	651	PF00069	0.495
DOC_MAPK_gen_1	742	750	PF00069	0.488
DOC_MAPK_HePTP_8	458	470	PF00069	0.537
DOC_MAPK_MEF2A_6	333	341	PF00069	0.457
DOC_MAPK_MEF2A_6	461	470	PF00069	0.537
DOC_PP2B_LxvP_1	108	111	PF13499	0.480
DOC_PP2B_LxvP_1	577	580	PF13499	0.537
DOC_PP2B_LxvP_1	612	615	PF13499	0.616
DOC_PP2B_LxvP_1	76	79	PF13499	0.503
DOC_PP2B_LxvP_1	92	95	PF13499	0.480
DOC_USP7_MATH_1	165	169	PF00917	0.634
DOC_USP7_MATH_1	328	332	PF00917	0.502
DOC_USP7_MATH_1	407	411	PF00917	0.453
DOC_USP7_MATH_1	414	418	PF00917	0.444
DOC_USP7_MATH_1	475	479	PF00917	0.528
DOC_USP7_MATH_1	51	55	PF00917	0.616
DOC_USP7_MATH_1	722	726	PF00917	0.529
DOC_USP7_MATH_1	8	12	PF00917	0.741
DOC_USP7_MATH_1	95	99	PF00917	0.525
DOC_WW_Pin1_4	153	158	PF00397	0.719
DOC_WW_Pin1_4	218	223	PF00397	0.477
DOC_WW_Pin1_4	267	272	PF00397	0.674
DOC_WW_Pin1_4	383	388	PF00397	0.518
DOC_WW_Pin1_4	397	402	PF00397	0.455
DOC_WW_Pin1_4	418	423	PF00397	0.543
DOC_WW_Pin1_4	425	430	PF00397	0.547
DOC_WW_Pin1_4	434	439	PF00397	0.371
DOC_WW_Pin1_4	489	494	PF00397	0.537
DOC_WW_Pin1_4	557	562	PF00397	0.542
DOC_WW_Pin1_4	606	611	PF00397	0.527
DOC_WW_Pin1_4	78	83	PF00397	0.712
DOC_WW_Pin1_4	809	814	PF00397	0.356
DOC_WW_Pin1_4	85	90	PF00397	0.654
LIG_14-3-3_CanoR_1	353	357	PF00244	0.521
LIG_14-3-3_CanoR_1	367	372	PF00244	0.528
LIG_14-3-3_CanoR_1	374	379	PF00244	0.509
LIG_14-3-3_CanoR_1	391	399	PF00244	0.466
LIG_14-3-3_CanoR_1	439	444	PF00244	0.492
LIG_14-3-3_CanoR_1	50	56	PF00244	0.656
LIG_14-3-3_CanoR_1	597	607	PF00244	0.510
LIG_14-3-3_CanoR_1	74	79	PF00244	0.647
LIG_14-3-3_CanoR_1	749	754	PF00244	0.321
LIG_14-3-3_CanoR_1	806	811	PF00244	0.558
LIG_Actin_WH2_2	14	32	PF00022	0.486
LIG_APCC_ABBA_1	480	485	PF00400	0.533
LIG_BIR_III_4	160	164	PF00653	0.497
LIG_BIR_III_4	445	449	PF00653	0.537
LIG_BRCT_BRCA1_1	321	325	PF00533	0.422
LIG_FHA_1	340	346	PF00498	0.488
LIG_FHA_1	366	372	PF00498	0.449
LIG_FHA_1	472	478	PF00498	0.537
LIG_FHA_1	490	496	PF00498	0.537
LIG_FHA_1	557	563	PF00498	0.547
LIG_FHA_1	688	694	PF00498	0.395
LIG_FHA_1	721	727	PF00498	0.356
LIG_FHA_2	257	263	PF00498	0.550
LIG_FHA_2	276	282	PF00498	0.562
LIG_FHA_2	294	300	PF00498	0.643
LIG_FHA_2	440	446	PF00498	0.498
LIG_FHA_2	497	503	PF00498	0.457
LIG_FHA_2	558	564	PF00498	0.477
LIG_FHA_2	98	104	PF00498	0.489
LIG_GSK3_LRP6_1	606	611	PF00069	0.666
LIG_Integrin_isoDGR_2	662	664	PF01839	0.304
LIG_Integrin_RGD_1	158	160	PF01839	0.500
LIG_LIR_Apic_2	654	659	PF02991	0.486
LIG_LIR_Gen_1	16	26	PF02991	0.492
LIG_LIR_Gen_1	190	199	PF02991	0.444
LIG_LIR_Gen_1	270	280	PF02991	0.731
LIG_LIR_Gen_1	373	382	PF02991	0.477
LIG_LIR_Gen_1	464	472	PF02991	0.516
LIG_LIR_Gen_1	481	490	PF02991	0.488
LIG_LIR_Gen_1	492	498	PF02991	0.488
LIG_LIR_Nem_3	16	21	PF02991	0.490
LIG_LIR_Nem_3	190	195	PF02991	0.442
LIG_LIR_Nem_3	270	275	PF02991	0.732
LIG_LIR_Nem_3	373	379	PF02991	0.477
LIG_LIR_Nem_3	464	468	PF02991	0.471
LIG_LIR_Nem_3	481	486	PF02991	0.477
LIG_LIR_Nem_3	492	497	PF02991	0.458
LIG_MYND_1	610	614	PF01753	0.690
LIG_PDZ_Class_2	811	816	PF00595	0.602
LIG_Rb_LxCxE_1	299	316	PF01857	0.455
LIG_SH2_CRK	166	170	PF00017	0.704
LIG_SH2_CRK	272	276	PF00017	0.760
LIG_SH2_CRK	666	670	PF00017	0.493
LIG_SH2_NCK_1	272	276	PF00017	0.507
LIG_SH2_PTP2	465	468	PF00017	0.537
LIG_SH2_PTP2	656	659	PF00017	0.476
LIG_SH2_SRC	483	486	PF00017	0.533
LIG_SH2_STAP1	22	26	PF00017	0.480
LIG_SH2_STAP1	666	670	PF00017	0.454
LIG_SH2_STAP1	740	744	PF00017	0.455
LIG_SH2_STAT3	286	289	PF00017	0.501
LIG_SH2_STAT5	465	468	PF00017	0.537
LIG_SH2_STAT5	539	542	PF00017	0.537
LIG_SH2_STAT5	598	601	PF00017	0.560
LIG_SH2_STAT5	656	659	PF00017	0.476
LIG_SH2_STAT5	740	743	PF00017	0.426
LIG_SH3_1	140	146	PF00018	0.761
LIG_SH3_3	140	146	PF00018	0.764
LIG_SH3_3	379	385	PF00018	0.398
LIG_SH3_3	416	422	PF00018	0.565
LIG_SH3_3	426	432	PF00018	0.521
LIG_SH3_3	559	565	PF00018	0.408
LIG_SH3_3	604	610	PF00018	0.501
LIG_SH3_3	642	648	PF00018	0.278
LIG_SH3_3	707	713	PF00018	0.521
LIG_SH3_3	750	756	PF00018	0.557
LIG_SH3_3	76	82	PF00018	0.755
LIG_SH3_3	807	813	PF00018	0.467
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.509
LIG_SUMO_SIM_anti_2	723	728	PF11976	0.292
LIG_SUMO_SIM_anti_2	90	98	PF11976	0.731
LIG_SUMO_SIM_par_1	494	499	PF11976	0.536
LIG_SUMO_SIM_par_1	722	728	PF11976	0.287
LIG_SUMO_SIM_par_1	90	98	PF11976	0.720
LIG_TRAF2_1	757	760	PF00917	0.723
LIG_TYR_ITIM	164	169	PF00017	0.675
LIG_UBA3_1	454	462	PF00899	0.537
LIG_WRC_WIRS_1	15	20	PF05994	0.499
MOD_CDK_SPK_2	153	158	PF00069	0.506
MOD_CDK_SPK_2	397	402	PF00069	0.560
MOD_CDK_SPK_2	434	439	PF00069	0.537
MOD_CDK_SPxxK_3	267	274	PF00069	0.761
MOD_CK1_1	11	17	PF00069	0.612
MOD_CK1_1	131	137	PF00069	0.740
MOD_CK1_1	147	153	PF00069	0.779
MOD_CK1_1	233	239	PF00069	0.396
MOD_CK1_1	331	337	PF00069	0.491
MOD_CK1_1	370	376	PF00069	0.483
MOD_CK1_1	412	418	PF00069	0.572
MOD_CK1_1	437	443	PF00069	0.511
MOD_CK1_1	478	484	PF00069	0.560
MOD_CK1_1	613	619	PF00069	0.657
MOD_CK1_1	725	731	PF00069	0.554
MOD_CK1_1	762	768	PF00069	0.697
MOD_CK1_1	809	815	PF00069	0.370
MOD_CK1_1	97	103	PF00069	0.748
MOD_CK2_1	275	281	PF00069	0.756
MOD_CK2_1	293	299	PF00069	0.418
MOD_CK2_1	557	563	PF00069	0.411
MOD_CK2_1	754	760	PF00069	0.666
MOD_CK2_1	97	103	PF00069	0.553
MOD_DYRK1A_RPxSP_1	267	271	PF00069	0.507
MOD_GlcNHglycan	121	124	PF01048	0.672
MOD_GlcNHglycan	146	149	PF01048	0.765
MOD_GlcNHglycan	186	190	PF01048	0.368
MOD_GlcNHglycan	222	225	PF01048	0.432
MOD_GlcNHglycan	315	318	PF01048	0.561
MOD_GlcNHglycan	330	333	PF01048	0.246
MOD_GlcNHglycan	393	396	PF01048	0.299
MOD_GlcNHglycan	536	539	PF01048	0.277
MOD_GlcNHglycan	572	575	PF01048	0.240
MOD_GlcNHglycan	628	631	PF01048	0.467
MOD_GlcNHglycan	76	79	PF01048	0.503
MOD_GlcNHglycan	787	790	PF01048	0.547
MOD_GlcNHglycan	9	13	PF01048	0.690
MOD_GSK3_1	119	126	PF00069	0.681
MOD_GSK3_1	13	20	PF00069	0.651
MOD_GSK3_1	144	151	PF00069	0.688
MOD_GSK3_1	214	221	PF00069	0.558
MOD_GSK3_1	256	263	PF00069	0.413
MOD_GSK3_1	328	335	PF00069	0.471
MOD_GSK3_1	362	369	PF00069	0.458
MOD_GSK3_1	370	377	PF00069	0.461
MOD_GSK3_1	393	400	PF00069	0.501
MOD_GSK3_1	408	415	PF00069	0.501
MOD_GSK3_1	427	434	PF00069	0.439
MOD_GSK3_1	471	478	PF00069	0.542
MOD_GSK3_1	557	564	PF00069	0.515
MOD_GSK3_1	606	613	PF00069	0.621
MOD_GSK3_1	74	81	PF00069	0.640
MOD_GSK3_1	751	758	PF00069	0.558
MOD_GSK3_1	759	766	PF00069	0.683
MOD_GSK3_1	805	812	PF00069	0.573
MOD_N-GLC_1	230	235	PF02516	0.550
MOD_N-GLC_1	275	280	PF02516	0.502
MOD_NEK2_1	13	18	PF00069	0.635
MOD_NEK2_1	136	141	PF00069	0.760
MOD_NEK2_1	230	235	PF00069	0.478
MOD_NEK2_1	246	251	PF00069	0.448
MOD_NEK2_1	340	345	PF00069	0.554
MOD_NEK2_1	534	539	PF00069	0.434
MOD_NEK2_1	582	587	PF00069	0.457
MOD_NEK2_1	626	631	PF00069	0.401
MOD_NEK2_1	720	725	PF00069	0.460
MOD_NEK2_1	727	732	PF00069	0.483
MOD_NEK2_2	51	56	PF00069	0.615
MOD_PIKK_1	194	200	PF00454	0.424
MOD_PIKK_1	39	45	PF00454	0.687
MOD_PIKK_1	393	399	PF00454	0.392
MOD_PIKK_1	725	731	PF00454	0.489
MOD_PK_1	749	755	PF00069	0.330
MOD_PK_1	806	812	PF00069	0.456
MOD_PKA_2	182	188	PF00069	0.406
MOD_PKA_2	201	207	PF00069	0.509
MOD_PKA_2	352	358	PF00069	0.521
MOD_PKA_2	366	372	PF00069	0.531
MOD_PKA_2	748	754	PF00069	0.338
MOD_PKA_2	805	811	PF00069	0.520
MOD_Plk_1	230	236	PF00069	0.472
MOD_Plk_1	246	252	PF00069	0.441
MOD_Plk_1	319	325	PF00069	0.508
MOD_Plk_1	478	484	PF00069	0.484
MOD_Plk_1	687	693	PF00069	0.409
MOD_Plk_1	95	101	PF00069	0.482
MOD_Plk_4	165	171	PF00069	0.556
MOD_Plk_4	17	23	PF00069	0.672
MOD_Plk_4	233	239	PF00069	0.410
MOD_Plk_4	246	252	PF00069	0.452
MOD_Plk_4	332	338	PF00069	0.457
MOD_Plk_4	352	358	PF00069	0.324
MOD_Plk_4	450	456	PF00069	0.517
MOD_Plk_4	478	484	PF00069	0.522
MOD_Plk_4	529	535	PF00069	0.542
MOD_Plk_4	722	728	PF00069	0.539
MOD_Plk_4	806	812	PF00069	0.442
MOD_Plk_4	87	93	PF00069	0.708
MOD_ProDKin_1	153	159	PF00069	0.715
MOD_ProDKin_1	218	224	PF00069	0.470
MOD_ProDKin_1	267	273	PF00069	0.673
MOD_ProDKin_1	383	389	PF00069	0.518
MOD_ProDKin_1	397	403	PF00069	0.455
MOD_ProDKin_1	418	424	PF00069	0.543
MOD_ProDKin_1	425	431	PF00069	0.547
MOD_ProDKin_1	434	440	PF00069	0.371
MOD_ProDKin_1	489	495	PF00069	0.537
MOD_ProDKin_1	557	563	PF00069	0.542
MOD_ProDKin_1	606	612	PF00069	0.533
MOD_ProDKin_1	78	84	PF00069	0.709
MOD_ProDKin_1	809	815	PF00069	0.370
MOD_ProDKin_1	85	91	PF00069	0.656
TRG_DiLeu_BaEn_1	508	513	PF01217	0.537
TRG_DiLeu_BaEn_4	103	109	PF01217	0.496
TRG_DiLeu_BaEn_4	24	30	PF01217	0.492
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.741
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.685
TRG_ENDOCYTIC_2	166	169	PF00928	0.710
TRG_ENDOCYTIC_2	272	275	PF00928	0.761
TRG_ENDOCYTIC_2	465	468	PF00928	0.509
TRG_ENDOCYTIC_2	483	486	PF00928	0.457
TRG_ENDOCYTIC_2	666	669	PF00928	0.459
TRG_ER_diArg_1	226	228	PF00400	0.557
TRG_ER_diArg_1	545	548	PF00400	0.537
TRG_ER_diArg_1	576	579	PF00400	0.537
TRG_ER_diArg_1	59	61	PF00400	0.647
TRG_NES_CRM1_1	235	247	PF08389	0.426
TRG_NES_CRM1_1	508	521	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y7	Leptomonas seymouri	65%	97%
A0A0S4JNB2	Bodo saltans	34%	100%
A0A1X0PAM4	Trypanosomatidae	40%	100%
A0A3R7MTY6	Trypanosoma rangeli	39%	100%
A0A3S7X814	Leishmania donovani	79%	93%
A4IA17	Leishmania infantum	79%	93%
C9ZMK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D2XV59	Rattus norvegicus	26%	100%
E9B532	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	93%
O00178	Homo sapiens	26%	100%
O08582	Mus musculus	26%	100%
Q3UJK4	Mus musculus	26%	100%
Q4Q2V4	Leishmania major	77%	100%
Q58DC5	Bos taurus	26%	100%
Q5R8Q7	Pongo abelii	26%	100%
Q5XGS8	Xenopus laevis	25%	100%
Q9BX10	Homo sapiens	26%	100%