Protein phosphatase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAV5_LEIBR

TriTrypDb:

LbrM.20.1940 , LBRM2903_200030200

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.570
CLV_NRD_NRD_1	173	175	PF00675	0.512
CLV_NRD_NRD_1	180	182	PF00675	0.640
CLV_NRD_NRD_1	31	33	PF00675	0.498
CLV_PCSK_KEX2_1	182	184	PF00082	0.643
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.668
CLV_PCSK_SKI1_1	33	37	PF00082	0.484
DEG_SCF_FBW7_1	16	21	PF00400	0.409
DEG_SPOP_SBC_1	115	119	PF00917	0.639
DOC_ANK_TNKS_1	145	152	PF00023	0.484
DOC_CKS1_1	15	20	PF01111	0.507
DOC_MAPK_MEF2A_6	80	89	PF00069	0.429
DOC_PP4_FxxP_1	100	103	PF00568	0.614
DOC_PP4_FxxP_1	147	150	PF00568	0.460
DOC_PP4_FxxP_1	15	18	PF00568	0.541
DOC_PP4_FxxP_1	91	94	PF00568	0.453
DOC_SPAK_OSR1_1	146	150	PF12202	0.484
DOC_USP7_MATH_1	10	14	PF00917	0.609
DOC_USP7_MATH_1	115	119	PF00917	0.659
DOC_USP7_MATH_1	18	22	PF00917	0.481
DOC_USP7_UBL2_3	175	179	PF12436	0.533
DOC_WW_Pin1_4	127	132	PF00397	0.602
DOC_WW_Pin1_4	14	19	PF00397	0.507
DOC_WW_Pin1_4	72	77	PF00397	0.488
LIG_14-3-3_CanoR_1	11	16	PF00244	0.531
LIG_14-3-3_CanoR_1	32	40	PF00244	0.539
LIG_14-3-3_CterR_2	185	188	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_eIF4E_1	59	65	PF01652	0.456
LIG_FHA_1	103	109	PF00498	0.668
LIG_FHA_2	15	21	PF00498	0.473
LIG_FHA_2	165	171	PF00498	0.580
LIG_LIR_Apic_2	13	18	PF02991	0.445
LIG_LIR_Apic_2	90	94	PF02991	0.382
LIG_LIR_Apic_2	97	103	PF02991	0.523
LIG_LIR_Gen_1	20	29	PF02991	0.517
LIG_LIR_Nem_3	20	25	PF02991	0.396
LIG_SH2_CRK	79	83	PF00017	0.468
LIG_SH2_STAT5	22	25	PF00017	0.475
LIG_SH2_STAT5	59	62	PF00017	0.469
MOD_CK1_1	111	117	PF00069	0.638
MOD_CK1_1	119	125	PF00069	0.646
MOD_CK1_1	14	20	PF00069	0.383
MOD_CK1_1	27	33	PF00069	0.515
MOD_CK1_1	98	104	PF00069	0.557
MOD_CK2_1	121	127	PF00069	0.730
MOD_CK2_1	14	20	PF00069	0.514
MOD_GlcNHglycan	27	30	PF01048	0.470
MOD_GlcNHglycan	97	100	PF01048	0.514
MOD_GSK3_1	10	17	PF00069	0.527
MOD_GSK3_1	111	118	PF00069	0.600
MOD_GSK3_1	119	126	PF00069	0.669
MOD_GSK3_1	129	136	PF00069	0.623
MOD_GSK3_1	98	105	PF00069	0.482
MOD_N-GLC_1	11	16	PF02516	0.531
MOD_N-GLC_1	72	77	PF02516	0.612
MOD_NEK2_1	108	113	PF00069	0.555
MOD_NEK2_1	25	30	PF00069	0.465
MOD_NEK2_1	35	40	PF00069	0.446
MOD_NEK2_1	83	88	PF00069	0.462
MOD_PIKK_1	119	125	PF00454	0.516
MOD_PKA_2	10	16	PF00069	0.489
MOD_PKA_2	57	63	PF00069	0.446
MOD_PKA_2	69	75	PF00069	0.444
MOD_Plk_1	11	17	PF00069	0.521
MOD_Plk_4	18	24	PF00069	0.550
MOD_Plk_4	35	41	PF00069	0.307
MOD_ProDKin_1	127	133	PF00069	0.601
MOD_ProDKin_1	14	20	PF00069	0.501
MOD_ProDKin_1	72	78	PF00069	0.486
TRG_ENDOCYTIC_2	22	25	PF00928	0.399
TRG_ENDOCYTIC_2	81	84	PF00928	0.546
TRG_ER_diArg_1	180	183	PF00400	0.615
TRG_NLS_MonoExtC_3	180	185	PF00514	0.655
TRG_NLS_MonoExtN_4	179	186	PF00514	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I235	Leptomonas seymouri	72%	100%
A0A0S4INZ5	Bodo saltans	40%	94%
A0A1X0P9P7	Trypanosomatidae	60%	100%
A0A3R7KWP6	Trypanosoma rangeli	52%	100%
A0A3S7X7Y8	Leishmania donovani	85%	100%
A4IA02	Leishmania infantum	87%	100%
C9ZMK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B530	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2V6	Leishmania major	87%	100%