DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania braziliensis

UniProt:

A4HAV4_LEIBR

TriTrypDb:

LbrM.20.1930 , LBRM2903_200030100

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAV4

Function

Biological processes
Term	Name	Level	Count
GO:0007154	cell communication	2	1
GO:0007267	cell-cell signaling	2	1
GO:0007268	chemical synaptic transmission	6	1
GO:0009987	cellular process	1	1
GO:0023052	signaling	1	1
GO:0098916	anterograde trans-synaptic signaling	5	1
GO:0099536	synaptic signaling	3	1
GO:0099537	trans-synaptic signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0033130	acetylcholine receptor binding	4	1
GO:0043495	protein-membrane adaptor activity	3	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.718
CLV_C14_Caspase3-7	752	756	PF00656	0.440
CLV_NRD_NRD_1	108	110	PF00675	0.735
CLV_NRD_NRD_1	199	201	PF00675	0.529
CLV_NRD_NRD_1	241	243	PF00675	0.649
CLV_NRD_NRD_1	317	319	PF00675	0.629
CLV_NRD_NRD_1	349	351	PF00675	0.544
CLV_NRD_NRD_1	544	546	PF00675	0.538
CLV_NRD_NRD_1	645	647	PF00675	0.335
CLV_NRD_NRD_1	759	761	PF00675	0.436
CLV_PCSK_FUR_1	245	249	PF00082	0.650
CLV_PCSK_KEX2_1	108	110	PF00082	0.735
CLV_PCSK_KEX2_1	199	201	PF00082	0.547
CLV_PCSK_KEX2_1	241	243	PF00082	0.650
CLV_PCSK_KEX2_1	247	249	PF00082	0.651
CLV_PCSK_KEX2_1	431	433	PF00082	0.576
CLV_PCSK_KEX2_1	645	647	PF00082	0.335
CLV_PCSK_KEX2_1	758	760	PF00082	0.351
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.656
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.571
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.354
CLV_PCSK_SKI1_1	173	177	PF00082	0.563
CLV_PCSK_SKI1_1	182	186	PF00082	0.539
CLV_PCSK_SKI1_1	200	204	PF00082	0.530
CLV_PCSK_SKI1_1	222	226	PF00082	0.714
CLV_PCSK_SKI1_1	241	245	PF00082	0.747
CLV_PCSK_SKI1_1	366	370	PF00082	0.583
CLV_PCSK_SKI1_1	631	635	PF00082	0.445
CLV_PCSK_SKI1_1	661	665	PF00082	0.337
CLV_PCSK_SKI1_1	705	709	PF00082	0.349
CLV_PCSK_SKI1_1	710	714	PF00082	0.319
CLV_Separin_Metazoa	212	216	PF03568	0.720
CLV_Separin_Metazoa	219	223	PF03568	0.587
CLV_Separin_Metazoa	405	409	PF03568	0.531
DEG_SPOP_SBC_1	11	15	PF00917	0.788
DEG_SPOP_SBC_1	325	329	PF00917	0.523
DOC_CYCLIN_RxL_1	628	638	PF00134	0.294
DOC_MAPK_gen_1	199	205	PF00069	0.680
DOC_MAPK_gen_1	215	223	PF00069	0.499
DOC_MAPK_gen_1	713	721	PF00069	0.335
DOC_MAPK_MEF2A_6	182	189	PF00069	0.652
DOC_MAPK_NFAT4_5	182	190	PF00069	0.409
DOC_PP2B_LxvP_1	203	206	PF13499	0.686
DOC_PP4_FxxP_1	771	774	PF00568	0.558
DOC_PP4_FxxP_1	94	97	PF00568	0.744
DOC_USP7_MATH_1	117	121	PF00917	0.665
DOC_USP7_MATH_1	151	155	PF00917	0.702
DOC_USP7_MATH_1	272	276	PF00917	0.708
DOC_USP7_MATH_1	282	286	PF00917	0.603
DOC_USP7_MATH_1	306	310	PF00917	0.632
DOC_USP7_MATH_1	317	321	PF00917	0.603
DOC_USP7_MATH_1	420	424	PF00917	0.512
DOC_USP7_UBL2_3	637	641	PF12436	0.529
DOC_WW_Pin1_4	123	128	PF00397	0.671
DOC_WW_Pin1_4	16	21	PF00397	0.767
DOC_WW_Pin1_4	270	275	PF00397	0.742
DOC_WW_Pin1_4	332	337	PF00397	0.554
DOC_WW_Pin1_4	37	42	PF00397	0.797
DOC_WW_Pin1_4	437	442	PF00397	0.555
DOC_WW_Pin1_4	519	524	PF00397	0.437
DOC_WW_Pin1_4	78	83	PF00397	0.660
LIG_14-3-3_CanoR_1	318	325	PF00244	0.735
LIG_14-3-3_CanoR_1	419	427	PF00244	0.522
LIG_14-3-3_CanoR_1	493	500	PF00244	0.511
LIG_14-3-3_CanoR_1	527	535	PF00244	0.467
LIG_14-3-3_CanoR_1	70	74	PF00244	0.547
LIG_14-3-3_CanoR_1	705	714	PF00244	0.354
LIG_Actin_WH2_2	163	178	PF00022	0.691
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_FHA_1	286	292	PF00498	0.588
LIG_FHA_1	363	369	PF00498	0.455
LIG_FHA_1	590	596	PF00498	0.402
LIG_FHA_1	628	634	PF00498	0.385
LIG_FHA_1	7	13	PF00498	0.533
LIG_FHA_1	72	78	PF00498	0.787
LIG_FHA_2	424	430	PF00498	0.365
LIG_FHA_2	438	444	PF00498	0.569
LIG_FHA_2	670	676	PF00498	0.572
LIG_FHA_2	704	710	PF00498	0.415
LIG_FHA_2	750	756	PF00498	0.335
LIG_FHA_2	762	768	PF00498	0.461
LIG_LIR_Apic_2	769	774	PF02991	0.546
LIG_LIR_Apic_2	91	97	PF02991	0.742
LIG_LIR_Gen_1	536	544	PF02991	0.407
LIG_LIR_Gen_1	655	663	PF02991	0.447
LIG_LIR_Nem_3	100	106	PF02991	0.757
LIG_LIR_Nem_3	476	482	PF02991	0.427
LIG_LIR_Nem_3	536	541	PF02991	0.404
LIG_LIR_Nem_3	589	593	PF02991	0.556
LIG_LIR_Nem_3	638	643	PF02991	0.508
LIG_LIR_Nem_3	655	660	PF02991	0.447
LIG_LIR_Nem_3	696	701	PF02991	0.342
LIG_LIR_Nem_3	740	746	PF02991	0.335
LIG_PCNA_yPIPBox_3	287	301	PF02747	0.465
LIG_PCNA_yPIPBox_3	601	612	PF02747	0.488
LIG_PTB_Apo_2	351	358	PF02174	0.579
LIG_PTB_Phospho_1	351	357	PF10480	0.577
LIG_RPA_C_Fungi	540	552	PF08784	0.294
LIG_SH2_CRK	479	483	PF00017	0.521
LIG_SH2_GRB2like	352	355	PF00017	0.589
LIG_SH2_NCK_1	352	356	PF00017	0.485
LIG_SH2_SRC	352	355	PF00017	0.557
LIG_SH2_STAP1	364	368	PF00017	0.433
LIG_SH2_STAP1	591	595	PF00017	0.390
LIG_SH2_STAP1	643	647	PF00017	0.335
LIG_SH2_STAP1	762	766	PF00017	0.420
LIG_SH2_STAT3	391	394	PF00017	0.575
LIG_SH2_STAT3	697	700	PF00017	0.354
LIG_SH2_STAT5	357	360	PF00017	0.411
LIG_SH2_STAT5	364	367	PF00017	0.404
LIG_SH2_STAT5	534	537	PF00017	0.372
LIG_SH2_STAT5	540	543	PF00017	0.402
LIG_SH2_STAT5	591	594	PF00017	0.405
LIG_SH2_STAT5	609	612	PF00017	0.368
LIG_SH2_STAT5	698	701	PF00017	0.358
LIG_SH3_3	268	274	PF00018	0.769
LIG_SH3_3	52	58	PF00018	0.663
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.681
LIG_SUMO_SIM_anti_2	401	408	PF11976	0.525
LIG_SUMO_SIM_par_1	186	192	PF11976	0.431
LIG_SUMO_SIM_par_1	287	292	PF11976	0.456
LIG_SUMO_SIM_par_1	630	636	PF11976	0.415
LIG_TYR_ITIM	714	719	PF00017	0.354
LIG_WRC_WIRS_1	128	133	PF05994	0.543
MOD_CDK_SPK_2	437	442	PF00069	0.616
MOD_CDK_SPxxK_3	437	444	PF00069	0.544
MOD_CK1_1	14	20	PF00069	0.728
MOD_CK1_1	154	160	PF00069	0.677
MOD_CK1_1	259	265	PF00069	0.680
MOD_CK1_1	270	276	PF00069	0.679
MOD_CK1_1	285	291	PF00069	0.515
MOD_CK1_1	320	326	PF00069	0.612
MOD_CK1_1	328	334	PF00069	0.587
MOD_CK1_1	423	429	PF00069	0.548
MOD_CK1_1	44	50	PF00069	0.816
MOD_CK1_1	496	502	PF00069	0.518
MOD_CK1_1	517	523	PF00069	0.473
MOD_CK2_1	166	172	PF00069	0.657
MOD_CK2_1	302	308	PF00069	0.622
MOD_CK2_1	455	461	PF00069	0.396
MOD_CK2_1	496	502	PF00069	0.550
MOD_CK2_1	533	539	PF00069	0.386
MOD_CK2_1	669	675	PF00069	0.378
MOD_CK2_1	703	709	PF00069	0.361
MOD_GlcNHglycan	1	4	PF01048	0.759
MOD_GlcNHglycan	113	116	PF01048	0.745
MOD_GlcNHglycan	14	17	PF01048	0.749
MOD_GlcNHglycan	142	145	PF01048	0.779
MOD_GlcNHglycan	153	156	PF01048	0.718
MOD_GlcNHglycan	252	255	PF01048	0.759
MOD_GlcNHglycan	261	264	PF01048	0.804
MOD_GlcNHglycan	304	307	PF01048	0.629
MOD_GlcNHglycan	319	322	PF01048	0.505
MOD_GlcNHglycan	328	331	PF01048	0.627
MOD_GlcNHglycan	386	389	PF01048	0.404
MOD_GlcNHglycan	422	425	PF01048	0.499
MOD_GlcNHglycan	457	460	PF01048	0.424
MOD_GlcNHglycan	495	498	PF01048	0.516
MOD_GlcNHglycan	535	538	PF01048	0.411
MOD_GlcNHglycan	66	69	PF01048	0.672
MOD_GlcNHglycan	779	782	PF01048	0.612
MOD_GlcNHglycan	783	786	PF01048	0.614
MOD_GSK3_1	104	111	PF00069	0.714
MOD_GSK3_1	123	130	PF00069	0.580
MOD_GSK3_1	140	147	PF00069	0.658
MOD_GSK3_1	164	171	PF00069	0.553
MOD_GSK3_1	252	259	PF00069	0.623
MOD_GSK3_1	302	309	PF00069	0.644
MOD_GSK3_1	320	327	PF00069	0.587
MOD_GSK3_1	328	335	PF00069	0.626
MOD_GSK3_1	37	44	PF00069	0.805
MOD_GSK3_1	370	377	PF00069	0.372
MOD_GSK3_1	46	53	PF00069	0.810
MOD_GSK3_1	6	13	PF00069	0.715
MOD_GSK3_1	701	708	PF00069	0.354
MOD_GSK3_1	749	756	PF00069	0.273
MOD_GSK3_1	775	782	PF00069	0.683
MOD_N-GLC_1	151	156	PF02516	0.787
MOD_N-GLC_1	259	264	PF02516	0.792
MOD_N-GLC_1	336	341	PF02516	0.564
MOD_N-GLC_1	384	389	PF02516	0.394
MOD_N-GLC_1	45	50	PF02516	0.670
MOD_N-GLC_2	397	399	PF02516	0.506
MOD_NEK2_1	166	171	PF00069	0.599
MOD_NEK2_1	175	180	PF00069	0.458
MOD_NEK2_1	189	194	PF00069	0.473
MOD_NEK2_1	45	50	PF00069	0.559
MOD_NEK2_1	486	491	PF00069	0.434
MOD_NEK2_1	516	521	PF00069	0.542
MOD_NEK2_1	533	538	PF00069	0.253
MOD_NEK2_1	701	706	PF00069	0.335
MOD_NEK2_1	753	758	PF00069	0.469
MOD_NEK2_1	777	782	PF00069	0.667
MOD_PIKK_1	118	124	PF00454	0.802
MOD_PIKK_1	189	195	PF00454	0.559
MOD_PIKK_1	252	258	PF00454	0.769
MOD_PKA_1	108	114	PF00069	0.703
MOD_PKA_2	108	114	PF00069	0.575
MOD_PKA_2	147	153	PF00069	0.760
MOD_PKA_2	317	323	PF00069	0.714
MOD_PKA_2	325	331	PF00069	0.704
MOD_PKA_2	443	449	PF00069	0.593
MOD_PKA_2	69	75	PF00069	0.547
MOD_PKA_2	769	775	PF00069	0.534
MOD_Plk_1	41	47	PF00069	0.802
MOD_Plk_1	50	56	PF00069	0.599
MOD_Plk_1	717	723	PF00069	0.327
MOD_Plk_4	285	291	PF00069	0.525
MOD_Plk_4	629	635	PF00069	0.288
MOD_Plk_4	749	755	PF00069	0.323
MOD_ProDKin_1	123	129	PF00069	0.667
MOD_ProDKin_1	16	22	PF00069	0.770
MOD_ProDKin_1	270	276	PF00069	0.736
MOD_ProDKin_1	332	338	PF00069	0.547
MOD_ProDKin_1	37	43	PF00069	0.798
MOD_ProDKin_1	437	443	PF00069	0.564
MOD_ProDKin_1	519	525	PF00069	0.427
MOD_ProDKin_1	78	84	PF00069	0.658
MOD_SUMO_for_1	264	267	PF00179	0.806
MOD_SUMO_for_1	97	100	PF00179	0.742
MOD_SUMO_rev_2	423	433	PF00179	0.305
MOD_SUMO_rev_2	709	714	PF00179	0.341
MOD_SUMO_rev_2	735	743	PF00179	0.357
MOD_SUMO_rev_2	761	766	PF00179	0.362
TRG_ENDOCYTIC_2	479	482	PF00928	0.508
TRG_ENDOCYTIC_2	590	593	PF00928	0.549
TRG_ENDOCYTIC_2	698	701	PF00928	0.338
TRG_ENDOCYTIC_2	716	719	PF00928	0.378
TRG_ER_diArg_1	108	110	PF00400	0.784
TRG_ER_diArg_1	241	243	PF00400	0.669
TRG_ER_diArg_1	492	495	PF00400	0.402
TRG_ER_diArg_1	645	648	PF00400	0.335
TRG_ER_diArg_1	792	795	PF00400	0.731
TRG_NES_CRM1_1	398	410	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	674	679	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH1	Leptomonas seymouri	62%	100%
A0A1X0P9Z7	Trypanosomatidae	51%	100%
A0A3S7X821	Leishmania donovani	81%	100%
A0A422P0G2	Trypanosoma rangeli	48%	100%
A4IA01	Leishmania infantum	81%	100%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B529	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2V7	Leishmania major	80%	100%
V5BKG1	Trypanosoma cruzi	49%	100%