Alpha-1,3/1,6-mannosyltransferase ALG2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAV3_LEIBR

TriTrypDb:

LbrM.20.1920 , LBRM2903_200030000

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HAV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAV3

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043413	macromolecule glycosylation	3	11
GO:0044238	primary metabolic process	2	11
GO:0070085	glycosylation	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	11
GO:0003824	catalytic activity	1	11
GO:0004376	glycolipid mannosyltransferase activity	6	11
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	7	11
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	11
GO:0102704	GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity	5	11
GO:0000033	alpha-1,3-mannosyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.475
CLV_MEL_PAP_1	495	501	PF00089	0.322
CLV_NRD_NRD_1	324	326	PF00675	0.221
CLV_PCSK_KEX2_1	510	512	PF00082	0.253
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.220
CLV_PCSK_SKI1_1	126	130	PF00082	0.302
CLV_PCSK_SKI1_1	236	240	PF00082	0.280
CLV_PCSK_SKI1_1	305	309	PF00082	0.379
CLV_PCSK_SKI1_1	392	396	PF00082	0.276
CLV_PCSK_SKI1_1	402	406	PF00082	0.191
CLV_PCSK_SKI1_1	521	525	PF00082	0.348
CLV_PCSK_SKI1_1	80	84	PF00082	0.268
CLV_Separin_Metazoa	77	81	PF03568	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.272
DEG_SCF_FBW7_2	412	419	PF00400	0.411
DOC_CKS1_1	413	418	PF01111	0.411
DOC_CYCLIN_RxL_1	232	243	PF00134	0.477
DOC_MAPK_gen_1	322	331	PF00069	0.417
DOC_MAPK_gen_1	351	358	PF00069	0.506
DOC_MAPK_JIP1_4	352	358	PF00069	0.535
DOC_MAPK_MEF2A_6	325	333	PF00069	0.411
DOC_MAPK_MEF2A_6	351	358	PF00069	0.506
DOC_MAPK_NFAT4_5	326	334	PF00069	0.411
DOC_PIKK_1	368	376	PF02985	0.499
DOC_PP1_RVXF_1	78	84	PF00149	0.490
DOC_PP2B_LxvP_1	384	387	PF13499	0.506
DOC_PP4_FxxP_1	282	285	PF00568	0.448
DOC_PP4_FxxP_1	83	86	PF00568	0.457
DOC_USP7_MATH_1	443	447	PF00917	0.428
DOC_USP7_MATH_1	478	482	PF00917	0.430
DOC_USP7_UBL2_3	270	274	PF12436	0.531
DOC_USP7_UBL2_3	541	545	PF12436	0.733
DOC_WW_Pin1_4	195	200	PF00397	0.323
DOC_WW_Pin1_4	412	417	PF00397	0.411
DOC_WW_Pin1_4	461	466	PF00397	0.469
DOC_WW_Pin1_4	50	55	PF00397	0.503
DOC_WW_Pin1_4	540	545	PF00397	0.541
LIG_14-3-3_CanoR_1	312	318	PF00244	0.358
LIG_14-3-3_CanoR_1	385	394	PF00244	0.462
LIG_14-3-3_CanoR_1	498	502	PF00244	0.588
LIG_APCC_ABBA_1	82	87	PF00400	0.377
LIG_BIR_III_4	63	67	PF00653	0.571
LIG_BRCT_BRCA1_1	124	128	PF00533	0.597
LIG_BRCT_BRCA1_1	245	249	PF00533	0.545
LIG_BRCT_BRCA1_1	313	317	PF00533	0.396
LIG_BRCT_BRCA1_1	526	530	PF00533	0.439
LIG_BRCT_BRCA1_2	526	532	PF00533	0.445
LIG_CaM_IQ_9	503	518	PF13499	0.498
LIG_Clathr_ClatBox_1	339	343	PF01394	0.424
LIG_FHA_1	133	139	PF00498	0.473
LIG_FHA_1	196	202	PF00498	0.380
LIG_FHA_1	249	255	PF00498	0.502
LIG_FHA_1	379	385	PF00498	0.490
LIG_FHA_1	401	407	PF00498	0.392
LIG_FHA_1	504	510	PF00498	0.515
LIG_FHA_2	467	473	PF00498	0.418
LIG_FHA_2	54	60	PF00498	0.646
LIG_LIR_Apic_2	279	285	PF02991	0.455
LIG_LIR_Gen_1	314	323	PF02991	0.502
LIG_LIR_Gen_1	334	342	PF02991	0.337
LIG_LIR_Gen_1	42	51	PF02991	0.544
LIG_LIR_Nem_3	172	176	PF02991	0.205
LIG_LIR_Nem_3	234	238	PF02991	0.504
LIG_LIR_Nem_3	266	271	PF02991	0.503
LIG_LIR_Nem_3	280	286	PF02991	0.406
LIG_LIR_Nem_3	314	320	PF02991	0.502
LIG_LIR_Nem_3	334	339	PF02991	0.337
LIG_LIR_Nem_3	419	424	PF02991	0.434
LIG_LIR_Nem_3	42	47	PF02991	0.535
LIG_LYPXL_S_1	282	286	PF13949	0.249
LIG_LYPXL_yS_3	283	286	PF13949	0.451
LIG_PCNA_PIPBox_1	2	11	PF02747	0.158
LIG_Pex14_1	231	235	PF04695	0.624
LIG_Pex14_2	167	171	PF04695	0.323
LIG_Pex14_2	202	206	PF04695	0.474
LIG_Pex14_2	8	12	PF04695	0.306
LIG_PTB_Apo_2	253	260	PF02174	0.445
LIG_REV1ctd_RIR_1	18	28	PF16727	0.171
LIG_RPA_C_Fungi	474	486	PF08784	0.171
LIG_SH2_CRK	235	239	PF00017	0.278
LIG_SH2_CRK	44	48	PF00017	0.347
LIG_SH2_STAP1	372	376	PF00017	0.307
LIG_SH2_STAP1	483	487	PF00017	0.378
LIG_SH2_STAT3	483	486	PF00017	0.171
LIG_SH2_STAT5	393	396	PF00017	0.365
LIG_SH2_STAT5	414	417	PF00017	0.263
LIG_SH3_3	410	416	PF00018	0.263
LIG_SH3_3	536	542	PF00018	0.385
LIG_SH3_4	541	548	PF00018	0.436
LIG_Sin3_3	335	342	PF02671	0.171
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.371
LIG_SUMO_SIM_par_1	114	119	PF11976	0.325
LIG_SUMO_SIM_par_1	398	408	PF11976	0.193
LIG_TRAF2_2	207	212	PF00917	0.305
LIG_TYR_ITIM	281	286	PF00017	0.297
LIG_UBA3_1	338	346	PF00899	0.214
LIG_WRC_WIRS_1	501	506	PF05994	0.271
MOD_CDK_SPK_2	540	545	PF00069	0.427
MOD_CDK_SPxK_1	412	418	PF00069	0.306
MOD_CDK_SPxxK_3	540	547	PF00069	0.430
MOD_CK1_1	195	201	PF00069	0.171
MOD_CK1_1	257	263	PF00069	0.294
MOD_CK1_1	296	302	PF00069	0.280
MOD_CK1_1	50	56	PF00069	0.386
MOD_CK1_1	500	506	PF00069	0.340
MOD_CK1_1	537	543	PF00069	0.541
MOD_CK2_1	338	344	PF00069	0.430
MOD_CK2_1	395	401	PF00069	0.378
MOD_CK2_1	460	466	PF00069	0.358
MOD_CK2_1	53	59	PF00069	0.585
MOD_Cter_Amidation	349	352	PF01082	0.261
MOD_GlcNHglycan	194	197	PF01048	0.171
MOD_GlcNHglycan	295	298	PF01048	0.418
MOD_GlcNHglycan	300	303	PF01048	0.514
MOD_GlcNHglycan	346	349	PF01048	0.283
MOD_GlcNHglycan	68	72	PF01048	0.546
MOD_GSK3_1	128	135	PF00069	0.352
MOD_GSK3_1	27	34	PF00069	0.423
MOD_GSK3_1	400	407	PF00069	0.233
MOD_GSK3_1	49	56	PF00069	0.617
MOD_N-GLC_1	395	400	PF02516	0.323
MOD_N-GLC_2	192	194	PF02516	0.171
MOD_NEK2_1	156	161	PF00069	0.263
MOD_NEK2_1	201	206	PF00069	0.393
MOD_NEK2_1	249	254	PF00069	0.376
MOD_NEK2_1	298	303	PF00069	0.523
MOD_NEK2_1	429	434	PF00069	0.306
MOD_NEK2_1	47	52	PF00069	0.476
MOD_NEK2_2	217	222	PF00069	0.456
MOD_NEK2_2	478	483	PF00069	0.171
MOD_PIKK_1	31	37	PF00454	0.260
MOD_PIKK_1	386	392	PF00454	0.371
MOD_PIKK_1	453	459	PF00454	0.171
MOD_PIKK_1	503	509	PF00454	0.352
MOD_PK_1	106	112	PF00069	0.394
MOD_PKA_2	27	33	PF00069	0.453
MOD_PKA_2	311	317	PF00069	0.171
MOD_PKA_2	478	484	PF00069	0.447
MOD_PKA_2	497	503	PF00069	0.489
MOD_Plk_1	242	248	PF00069	0.519
MOD_Plk_1	400	406	PF00069	0.303
MOD_Plk_2-3	466	472	PF00069	0.332
MOD_Plk_2-3	72	78	PF00069	0.299
MOD_Plk_4	145	151	PF00069	0.364
MOD_Plk_4	249	255	PF00069	0.307
MOD_Plk_4	313	319	PF00069	0.306
MOD_Plk_4	400	406	PF00069	0.332
MOD_Plk_4	478	484	PF00069	0.314
MOD_ProDKin_1	195	201	PF00069	0.323
MOD_ProDKin_1	412	418	PF00069	0.245
MOD_ProDKin_1	461	467	PF00069	0.326
MOD_ProDKin_1	50	56	PF00069	0.386
MOD_ProDKin_1	540	546	PF00069	0.428
MOD_SUMO_for_1	531	534	PF00179	0.571
MOD_SUMO_rev_2	300	310	PF00179	0.393
MOD_SUMO_rev_2	341	348	PF00179	0.385
MOD_SUMO_rev_2	398	404	PF00179	0.381
MOD_SUMO_rev_2	518	524	PF00179	0.436
TRG_DiLeu_BaEn_1	334	339	PF01217	0.378
TRG_DiLeu_BaEn_1	401	406	PF01217	0.323
TRG_DiLeu_BaEn_1	408	413	PF01217	0.323
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.343
TRG_ENDOCYTIC_2	203	206	PF00928	0.290
TRG_ENDOCYTIC_2	235	238	PF00928	0.318
TRG_ENDOCYTIC_2	283	286	PF00928	0.301
TRG_ENDOCYTIC_2	44	47	PF00928	0.426
TRG_ENDOCYTIC_2	48	51	PF00928	0.414
TRG_ER_diArg_1	23	26	PF00400	0.454
TRG_ER_diArg_1	492	495	PF00400	0.387
TRG_ER_diArg_1	513	516	PF00400	0.406
TRG_ER_diLys_1	545	549	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8W1	Leptomonas seymouri	64%	97%
A0A0S4INF7	Bodo saltans	47%	100%
A0A1X0P9N2	Trypanosomatidae	46%	100%
A0A3Q8IEF0	Leishmania donovani	83%	100%
A0A3R7N194	Trypanosoma rangeli	45%	100%
A4IA00	Leishmania infantum	83%	100%
C9ZML3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B528	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O94738	Rhizomucor pusillus	38%	100%
P43636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q08B22	Xenopus laevis	26%	100%
Q2TAA5	Homo sapiens	24%	100%
Q3TZM9	Mus musculus	26%	100%
Q4Q2V8	Leishmania major	82%	100%
Q59LF2	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	100%
Q6BVA4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	35%	100%
Q6C3V7	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CWQ0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	100%
Q6FJJ9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	100%
Q755C1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%
Q7KWM5	Dictyostelium discoideum	35%	100%
Q7ZW24	Danio rerio	25%	100%
Q8X0H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q96WW6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q9DBE8	Mus musculus	36%	100%
Q9H553	Homo sapiens	36%	100%