Branched-chain-amino-acid transaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminotransferase class IV, putative

Species:

Leishmania braziliensis

UniProt:

A4HAV2_LEIBR

TriTrypDb:

LbrM.20.1910 , LBRM2903_200029900

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HAV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAV2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008483	transaminase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016769	transferase activity, transferring nitrogenous groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.575
CLV_NRD_NRD_1	9	11	PF00675	0.430
CLV_PCSK_KEX2_1	9	11	PF00082	0.403
CLV_PCSK_SKI1_1	124	128	PF00082	0.286
CLV_PCSK_SKI1_1	272	276	PF00082	0.307
CLV_PCSK_SKI1_1	84	88	PF00082	0.360
DEG_Nend_UBRbox_2	1	3	PF02207	0.481
DOC_CYCLIN_RxL_1	81	92	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.379
DOC_MAPK_gen_1	66	74	PF00069	0.483
DOC_MAPK_gen_1	81	90	PF00069	0.483
DOC_MAPK_MEF2A_6	328	335	PF00069	0.424
DOC_MAPK_MEF2A_6	81	90	PF00069	0.379
DOC_PP1_RVXF_1	125	132	PF00149	0.434
DOC_PP2B_LxvP_1	145	148	PF13499	0.379
DOC_PP2B_LxvP_1	88	91	PF13499	0.501
DOC_USP7_MATH_1	135	139	PF00917	0.423
DOC_USP7_MATH_1	154	158	PF00917	0.521
DOC_USP7_MATH_1	159	163	PF00917	0.542
DOC_USP7_MATH_1	219	223	PF00917	0.444
DOC_USP7_MATH_1	291	295	PF00917	0.537
DOC_USP7_MATH_1	41	45	PF00917	0.425
DOC_USP7_UBL2_3	268	272	PF12436	0.537
DOC_WW_Pin1_4	283	288	PF00397	0.465
LIG_14-3-3_CanoR_1	81	87	PF00244	0.501
LIG_Actin_WH2_2	257	274	PF00022	0.537
LIG_APCC_ABBA_1	295	300	PF00400	0.371
LIG_BIR_III_2	53	57	PF00653	0.491
LIG_BRCT_BRCA1_1	16	20	PF00533	0.432
LIG_FHA_1	142	148	PF00498	0.472
LIG_FHA_1	85	91	PF00498	0.490
LIG_FHA_2	268	274	PF00498	0.560
LIG_LIR_Apic_2	214	219	PF02991	0.482
LIG_LIR_Gen_1	17	27	PF02991	0.412
LIG_LIR_Nem_3	17	23	PF02991	0.376
LIG_LIR_Nem_3	251	256	PF02991	0.535
LIG_PCNA_yPIPBox_3	124	132	PF02747	0.537
LIG_Pex14_2	20	24	PF04695	0.370
LIG_SH2_CRK	253	257	PF00017	0.483
LIG_SH2_CRK	58	62	PF00017	0.384
LIG_SH2_SRC	110	113	PF00017	0.539
LIG_SH2_SRC	117	120	PF00017	0.553
LIG_SH2_SRC	307	310	PF00017	0.488
LIG_SH2_STAP1	204	208	PF00017	0.537
LIG_SH2_STAP1	307	311	PF00017	0.503
LIG_SH2_STAP1	78	82	PF00017	0.469
LIG_SH2_STAT3	226	229	PF00017	0.537
LIG_SH2_STAT5	110	113	PF00017	0.486
LIG_SH2_STAT5	117	120	PF00017	0.483
LIG_SH2_STAT5	197	200	PF00017	0.556
LIG_SH2_STAT5	216	219	PF00017	0.464
LIG_SH2_STAT5	226	229	PF00017	0.425
LIG_SH2_STAT5	281	284	PF00017	0.560
LIG_SH2_STAT5	347	350	PF00017	0.468
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.458
LIG_SUMO_SIM_par_1	10	15	PF11976	0.244
LIG_SUMO_SIM_par_1	205	211	PF11976	0.458
LIG_SUMO_SIM_par_1	33	40	PF11976	0.425
LIG_SUMO_SIM_par_1	85	92	PF11976	0.379
LIG_TRAF2_1	238	241	PF00917	0.476
LIG_UBA3_1	243	250	PF00899	0.559
LIG_WRC_WIRS_1	24	29	PF05994	0.445
MOD_CK1_1	231	237	PF00069	0.554
MOD_CK2_1	235	241	PF00069	0.490
MOD_CK2_1	74	80	PF00069	0.565
MOD_GlcNHglycan	237	240	PF01048	0.319
MOD_GlcNHglycan	29	33	PF01048	0.440
MOD_GlcNHglycan	95	98	PF01048	0.179
MOD_GSK3_1	127	134	PF00069	0.440
MOD_GSK3_1	231	238	PF00069	0.507
MOD_GSK3_1	36	43	PF00069	0.314
MOD_GSK3_1	89	96	PF00069	0.471
MOD_GSK3_1	98	105	PF00069	0.499
MOD_NEK2_1	102	107	PF00069	0.465
MOD_NEK2_1	153	158	PF00069	0.483
MOD_NEK2_1	314	319	PF00069	0.550
MOD_NEK2_1	339	344	PF00069	0.248
MOD_NEK2_1	74	79	PF00069	0.522
MOD_NEK2_1	82	87	PF00069	0.455
MOD_NEK2_2	159	164	PF00069	0.510
MOD_NEK2_2	267	272	PF00069	0.496
MOD_Plk_4	127	133	PF00069	0.489
MOD_Plk_4	159	165	PF00069	0.461
MOD_Plk_4	231	237	PF00069	0.515
MOD_Plk_4	276	282	PF00069	0.564
MOD_Plk_4	285	291	PF00069	0.518
MOD_Plk_4	98	104	PF00069	0.549
MOD_ProDKin_1	283	289	PF00069	0.465
MOD_SUMO_for_1	37	40	PF00179	0.270
MOD_SUMO_rev_2	273	280	PF00179	0.483
MOD_SUMO_rev_2	320	329	PF00179	0.470
TRG_DiLeu_BaEn_1	240	245	PF01217	0.476
TRG_DiLeu_BaEn_1	98	103	PF01217	0.448
TRG_ENDOCYTIC_2	204	207	PF00928	0.512
TRG_ENDOCYTIC_2	253	256	PF00928	0.537
TRG_ENDOCYTIC_2	58	61	PF00928	0.333
TRG_ENDOCYTIC_2	62	65	PF00928	0.425
TRG_ER_diArg_1	65	68	PF00400	0.479
TRG_ER_diArg_1	8	10	PF00400	0.462
TRG_NES_CRM1_1	2	15	PF08389	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK5	Leptomonas seymouri	62%	100%
A0A0S4INR1	Bodo saltans	27%	83%
A0A1X0PAI4	Trypanosomatidae	38%	93%
A0A3Q8IUN5	Leishmania donovani	82%	92%
A0A3R7NT31	Trypanosoma rangeli	36%	95%
A4I9Z9	Leishmania infantum	83%	92%
C9ZML4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
E9B527	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	84%
Q4Q2V9	Leishmania major	83%	100%
V5B0F3	Trypanosoma cruzi	32%	75%