CBFD_NFYB_HMF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAU8_LEIBR

TriTrypDb:

LbrM.20.1870 , LBRM2903_200029400

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAU8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0046982	protein heterodimerization activity	4	8
GO:0046983	protein dimerization activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.716
CLV_C14_Caspase3-7	161	165	PF00656	0.643
CLV_MEL_PAP_1	252	258	PF00089	0.442
CLV_NRD_NRD_1	235	237	PF00675	0.291
CLV_NRD_NRD_1	292	294	PF00675	0.555
CLV_NRD_NRD_1	308	310	PF00675	0.520
CLV_NRD_NRD_1	347	349	PF00675	0.493
CLV_PCSK_KEX2_1	235	237	PF00082	0.292
CLV_PCSK_KEX2_1	299	301	PF00082	0.675
CLV_PCSK_KEX2_1	308	310	PF00082	0.583
CLV_PCSK_KEX2_1	347	349	PF00082	0.648
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.602
CLV_PCSK_PC7_1	231	237	PF00082	0.238
CLV_PCSK_SKI1_1	194	198	PF00082	0.263
CLV_PCSK_SKI1_1	231	235	PF00082	0.274
CLV_PCSK_SKI1_1	239	243	PF00082	0.257
CLV_PCSK_SKI1_1	36	40	PF00082	0.625
DEG_SPOP_SBC_1	267	271	PF00917	0.567
DEG_SPOP_SBC_1	46	50	PF00917	0.675
DOC_CYCLIN_RxL_1	190	200	PF00134	0.302
DOC_MAPK_gen_1	192	199	PF00069	0.481
DOC_USP7_MATH_1	111	115	PF00917	0.635
DOC_USP7_MATH_1	267	271	PF00917	0.524
DOC_USP7_MATH_1	276	280	PF00917	0.569
DOC_USP7_MATH_1	292	296	PF00917	0.539
DOC_USP7_MATH_1	319	323	PF00917	0.537
DOC_USP7_MATH_1	330	334	PF00917	0.623
DOC_USP7_MATH_1	46	50	PF00917	0.697
DOC_USP7_MATH_1	71	75	PF00917	0.713
DOC_USP7_MATH_1	81	85	PF00917	0.612
DOC_USP7_UBL2_3	194	198	PF12436	0.506
DOC_WW_Pin1_4	288	293	PF00397	0.585
DOC_WW_Pin1_4	323	328	PF00397	0.673
DOC_WW_Pin1_4	42	47	PF00397	0.687
LIG_14-3-3_CanoR_1	104	110	PF00244	0.619
LIG_14-3-3_CanoR_1	236	242	PF00244	0.466
LIG_14-3-3_CanoR_1	255	259	PF00244	0.323
LIG_14-3-3_CanoR_1	308	315	PF00244	0.694
LIG_14-3-3_CanoR_1	36	41	PF00244	0.655
LIG_AP2alpha_2	130	132	PF02296	0.573
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_Clathr_ClatBox_1	196	200	PF01394	0.405
LIG_FHA_1	161	167	PF00498	0.513
LIG_FHA_1	220	226	PF00498	0.517
LIG_FHA_1	324	330	PF00498	0.600
LIG_FHA_2	125	131	PF00498	0.587
LIG_FHA_2	132	138	PF00498	0.618
LIG_FHA_2	16	22	PF00498	0.528
LIG_FHA_2	240	246	PF00498	0.508
LIG_FHA_2	59	65	PF00498	0.538
LIG_LIR_Apic_2	31	35	PF02991	0.614
LIG_LIR_Gen_1	240	250	PF02991	0.466
LIG_LIR_Gen_1	254	264	PF02991	0.378
LIG_LIR_LC3C_4	222	227	PF02991	0.405
LIG_LIR_Nem_3	240	246	PF02991	0.487
LIG_LIR_Nem_3	254	259	PF02991	0.432
LIG_PDZ_Class_2	360	365	PF00595	0.542
LIG_SH2_GRB2like	184	187	PF00017	0.535
LIG_SH2_NCK_1	243	247	PF00017	0.477
LIG_SH2_SRC	184	187	PF00017	0.535
LIG_SH2_SRC	243	246	PF00017	0.463
LIG_SH2_SRC	40	43	PF00017	0.614
LIG_SH2_STAP1	12	16	PF00017	0.582
LIG_SH2_STAP1	243	247	PF00017	0.463
LIG_SH2_STAT5	184	187	PF00017	0.644
LIG_SH2_STAT5	32	35	PF00017	0.585
LIG_SH3_3	259	265	PF00018	0.460
LIG_SH3_3	65	71	PF00018	0.521
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.461
LIG_SUMO_SIM_anti_2	224	229	PF11976	0.459
LIG_TRAF2_1	61	64	PF00917	0.677
LIG_TYR_ITIM	241	246	PF00017	0.463
MOD_CDK_SPK_2	288	293	PF00069	0.621
MOD_CDK_SPxK_1	288	294	PF00069	0.504
MOD_CK1_1	113	119	PF00069	0.640
MOD_CK1_1	176	182	PF00069	0.454
MOD_CK1_1	2	8	PF00069	0.468
MOD_CK1_1	204	210	PF00069	0.468
MOD_CK1_1	219	225	PF00069	0.371
MOD_CK1_1	269	275	PF00069	0.514
MOD_CK1_1	288	294	PF00069	0.667
MOD_CK1_1	295	301	PF00069	0.615
MOD_CK1_1	45	51	PF00069	0.644
MOD_CK2_1	2	8	PF00069	0.550
MOD_CK2_1	319	325	PF00069	0.553
MOD_CK2_1	58	64	PF00069	0.546
MOD_GlcNHglycan	1	4	PF01048	0.637
MOD_GlcNHglycan	113	116	PF01048	0.660
MOD_GlcNHglycan	170	173	PF01048	0.728
MOD_GlcNHglycan	175	178	PF01048	0.639
MOD_GlcNHglycan	211	214	PF01048	0.317
MOD_GlcNHglycan	271	274	PF01048	0.488
MOD_GlcNHglycan	287	290	PF01048	0.757
MOD_GlcNHglycan	309	312	PF01048	0.595
MOD_GlcNHglycan	42	45	PF01048	0.573
MOD_GlcNHglycan	73	76	PF01048	0.746
MOD_GlcNHglycan	83	86	PF01048	0.588
MOD_GSK3_1	160	167	PF00069	0.765
MOD_GSK3_1	200	207	PF00069	0.506
MOD_GSK3_1	281	288	PF00069	0.684
MOD_GSK3_1	319	326	PF00069	0.669
MOD_GSK3_1	328	335	PF00069	0.653
MOD_GSK3_1	36	43	PF00069	0.601
MOD_GSK3_1	45	52	PF00069	0.648
MOD_GSK3_1	8	15	PF00069	0.609
MOD_LATS_1	237	243	PF00433	0.517
MOD_N-GLC_1	76	81	PF02516	0.516
MOD_NEK2_1	110	115	PF00069	0.564
MOD_NEK2_1	166	171	PF00069	0.511
MOD_NEK2_1	199	204	PF00069	0.407
MOD_NEK2_1	47	52	PF00069	0.771
MOD_PIKK_1	164	170	PF00454	0.513
MOD_PIKK_1	328	334	PF00454	0.516
MOD_PIKK_1	76	82	PF00454	0.670
MOD_PKA_1	293	299	PF00069	0.516
MOD_PKA_2	103	109	PF00069	0.659
MOD_PKA_2	237	243	PF00069	0.456
MOD_PKA_2	254	260	PF00069	0.348
MOD_PKA_2	292	298	PF00069	0.531
MOD_PKA_2	307	313	PF00069	0.715
MOD_PKA_2	81	87	PF00069	0.593
MOD_Plk_1	12	18	PF00069	0.564
MOD_Plk_2-3	8	14	PF00069	0.483
MOD_Plk_4	201	207	PF00069	0.508
MOD_Plk_4	216	222	PF00069	0.417
MOD_Plk_4	28	34	PF00069	0.651
MOD_ProDKin_1	288	294	PF00069	0.588
MOD_ProDKin_1	323	329	PF00069	0.674
MOD_ProDKin_1	42	48	PF00069	0.692
MOD_SUMO_for_1	197	200	PF00179	0.506
TRG_DiLeu_BaEn_1	216	221	PF01217	0.463
TRG_ENDOCYTIC_2	243	246	PF00928	0.463
TRG_ER_diArg_1	235	238	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A7	Leptomonas seymouri	42%	100%
A0A3S7X811	Leishmania donovani	70%	100%
A0A422P0E4	Trypanosoma rangeli	31%	100%
A4IA16	Leishmania infantum	70%	100%
E9B523	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2W3	Leishmania major	72%	100%