LeishMANIAdb
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DUF4456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4456 domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HAU7_LEIBR
TriTrypDb:
LbrM.20.1850 , LBRM2903_200029100
Length:
189

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAU7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 64 66 PF00675 0.610
CLV_PCSK_KEX2_1 64 66 PF00082 0.446
CLV_PCSK_PC7_1 60 66 PF00082 0.434
DEG_Nend_Nbox_1 1 3 PF02207 0.532
DEG_SIAH_1 104 112 PF03145 0.535
DOC_MAPK_gen_1 82 91 PF00069 0.754
DOC_USP7_MATH_1 121 125 PF00917 0.695
DOC_USP7_MATH_1 51 55 PF00917 0.547
DOC_USP7_MATH_1 74 78 PF00917 0.710
DOC_USP7_MATH_1 9 13 PF00917 0.610
DOC_WW_Pin1_4 67 72 PF00397 0.522
LIG_14-3-3_CanoR_1 104 110 PF00244 0.614
LIG_14-3-3_CanoR_1 21 25 PF00244 0.370
LIG_FHA_1 145 151 PF00498 0.390
LIG_FHA_1 54 60 PF00498 0.454
LIG_FHA_1 86 92 PF00498 0.746
LIG_FHA_1 96 102 PF00498 0.574
LIG_FHA_2 170 176 PF00498 0.587
LIG_LIR_Nem_3 175 179 PF02991 0.576
LIG_MYND_1 185 189 PF01753 0.518
LIG_SH2_NCK_1 182 186 PF00017 0.709
LIG_SH2_SRC 182 185 PF00017 0.495
LIG_SH2_STAP1 79 83 PF00017 0.682
LIG_SH3_3 68 74 PF00018 0.744
LIG_SUMO_SIM_anti_2 87 93 PF11976 0.741
LIG_TRAF2_1 39 42 PF00917 0.488
MOD_CK1_1 34 40 PF00069 0.388
MOD_CK2_1 51 57 PF00069 0.385
MOD_CK2_1 67 73 PF00069 0.502
MOD_GlcNHglycan 105 108 PF01048 0.536
MOD_GSK3_1 16 23 PF00069 0.387
MOD_N-GLC_1 67 72 PF02516 0.522
MOD_NEK2_1 174 179 PF00069 0.657
MOD_NEK2_1 20 25 PF00069 0.443
MOD_PIKK_1 34 40 PF00454 0.388
MOD_PKA_2 103 109 PF00069 0.530
MOD_PKA_2 20 26 PF00069 0.374
MOD_PKA_2 31 37 PF00069 0.649
MOD_Plk_1 174 180 PF00069 0.733
MOD_Plk_4 144 150 PF00069 0.590
MOD_Plk_4 20 26 PF00069 0.374
MOD_Plk_4 31 37 PF00069 0.529
MOD_Plk_4 87 93 PF00069 0.681
MOD_ProDKin_1 67 73 PF00069 0.524
MOD_SUMO_for_1 39 42 PF00179 0.370
MOD_SUMO_rev_2 52 56 PF00179 0.384
TRG_DiLeu_BaEn_4 41 47 PF01217 0.377
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.468

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IC33 Leptomonas seymouri 34% 100%
A0A3Q8IHA0 Leishmania donovani 60% 92%
A4IA14 Leishmania infantum 59% 92%
E9B521 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 92%
Q4Q2W5 Leishmania major 56% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS