AP complex subunit sigma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

clathrin coat assembly protein AP17, putative

Species:

Leishmania braziliensis

UniProt:

A4HAU5_LEIBR

TriTrypDb:

LbrM.20.1830 , LBRM2903_200028900

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	10
GO:0030122	AP-2 adaptor complex	4	10
GO:0030131	clathrin adaptor complex	4	10
GO:0032991	protein-containing complex	1	10
GO:0098796	membrane protein complex	2	10
GO:0098797	plasma membrane protein complex	3	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAU5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006897	endocytosis	5	10
GO:0006898	receptor-mediated endocytosis	6	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0072583	clathrin-dependent endocytosis	7	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030276	clathrin binding	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0035615	clathrin adaptor activity	4	10
GO:0060090	molecular adaptor activity	1	10
GO:0140312	cargo adaptor activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	60	62	PF00675	0.313
CLV_PCSK_KEX2_1	32	34	PF00082	0.337
CLV_PCSK_KEX2_1	60	62	PF00082	0.313
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.337
CLV_PCSK_SKI1_1	15	19	PF00082	0.313
CLV_PCSK_SKI1_1	53	57	PF00082	0.201
DEG_Nend_Nbox_1	1	3	PF02207	0.412
DOC_MAPK_gen_1	15	23	PF00069	0.412
DOC_MAPK_gen_1	60	67	PF00069	0.302
DOC_MAPK_MEF2A_6	96	105	PF00069	0.337
DOC_PP4_FxxP_1	19	22	PF00568	0.337
LIG_Clathr_ClatBox_1	78	82	PF01394	0.313
LIG_eIF4E_1	52	58	PF01652	0.360
LIG_FHA_1	45	51	PF00498	0.387
LIG_IRF3_LxIS_1	135	141	PF10401	0.412
LIG_KLC1_Yacidic_2	77	82	PF13176	0.313
LIG_LIR_Gen_1	77	88	PF02991	0.313
LIG_LIR_Nem_3	47	52	PF02991	0.319
LIG_LIR_Nem_3	77	83	PF02991	0.313
LIG_LIR_Nem_3	92	98	PF02991	0.313
LIG_NRBOX	82	88	PF00104	0.412
LIG_PCNA_yPIPBox_3	10	20	PF02747	0.201
LIG_Pex3_1	83	94	PF04882	0.412
LIG_REV1ctd_RIR_1	92	100	PF16727	0.337
LIG_SH2_CRK	62	66	PF00017	0.340
LIG_SH2_PTP2	20	23	PF00017	0.412
LIG_SH2_PTP2	80	83	PF00017	0.412
LIG_SH2_SRC	20	23	PF00017	0.375
LIG_SH2_STAT5	20	23	PF00017	0.313
LIG_SH2_STAT5	80	83	PF00017	0.305
LIG_SH3_3	123	129	PF00018	0.369
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.313
LIG_SUMO_SIM_par_1	86	92	PF11976	0.313
LIG_TYR_ITIM	50	55	PF00017	0.406
LIG_TYR_ITIM	78	83	PF00017	0.412
MOD_GSK3_1	44	51	PF00069	0.337
MOD_NEK2_1	11	16	PF00069	0.283
MOD_NEK2_1	138	143	PF00069	0.447
MOD_PKA_2	44	50	PF00069	0.309
MOD_SUMO_rev_2	51	58	PF00179	0.201
TRG_DiLeu_BaEn_1	74	79	PF01217	0.343
TRG_DiLeu_BaEn_1	82	87	PF01217	0.278
TRG_ENDOCYTIC_2	111	114	PF00928	0.218
TRG_ENDOCYTIC_2	20	23	PF00928	0.412
TRG_ENDOCYTIC_2	52	55	PF00928	0.330
TRG_ENDOCYTIC_2	62	65	PF00928	0.265
TRG_ENDOCYTIC_2	80	83	PF00928	0.253
TRG_ER_diArg_1	59	61	PF00400	0.313
TRG_NES_CRM1_1	102	116	PF08389	0.369
TRG_NES_CRM1_1	77	92	PF08389	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V4	Leptomonas seymouri	37%	86%
A0A0N1I965	Leptomonas seymouri	45%	87%
A0A0N1PDE8	Leptomonas seymouri	35%	89%
A0A0N1PDX0	Leptomonas seymouri	85%	100%
A0A0S4J0F7	Bodo saltans	36%	86%
A0A0S4J161	Bodo saltans	50%	85%
A0A0S4JQI5	Bodo saltans	66%	99%
A0A1X0NVQ0	Trypanosomatidae	38%	87%
A0A1X0P093	Trypanosomatidae	44%	86%
A0A1X0P9M2	Trypanosomatidae	70%	100%
A0A3Q8IMU4	Leishmania donovani	37%	86%
A0A3Q8INE3	Leishmania donovani	94%	100%
A0A3R7MTZ7	Trypanosoma rangeli	65%	100%
A0A3R7N944	Trypanosoma rangeli	35%	87%
A0A3R7NTN2	Trypanosoma rangeli	31%	76%
A0A3S7X2E9	Leishmania donovani	43%	87%
A0A422N1J3	Trypanosoma rangeli	43%	86%
A4HDI7	Leishmania braziliensis	37%	86%
A4HHF6	Leishmania braziliensis	45%	87%
A4I4K2	Leishmania infantum	43%	87%
A4IA12	Leishmania infantum	94%	100%
B0G185	Dictyostelium discoideum	46%	93%
C9ZL88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	90%
C9ZWF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	87%
D0A005	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	81%
E9AE03	Leishmania major	43%	100%
E9AH61	Leishmania infantum	37%	86%
E9ALS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	91%
E9AWZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
E9B519	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O23685	Arabidopsis thaliana	47%	88%
O50016	Zea mays	55%	100%
O82201	Arabidopsis thaliana	41%	100%
P35181	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	92%
P47064	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	74%
P53680	Homo sapiens	52%	100%
P56377	Homo sapiens	42%	91%
P59780	Homo sapiens	39%	74%
P61966	Homo sapiens	41%	91%
P61967	Mus musculus	41%	91%
P62743	Mus musculus	52%	100%
P62744	Rattus norvegicus	52%	100%
Q00381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	97%
Q09905	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	87%
Q17QC5	Bos taurus	52%	100%
Q1JQ98	Bos taurus	41%	91%
Q1JQA3	Bos taurus	39%	74%
Q2YDH6	Bos taurus	43%	74%
Q3ZBB6	Bos taurus	42%	99%
Q3ZBS3	Bos taurus	42%	89%
Q4ICG5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	53%	100%
Q4Q2W7	Leishmania major	93%	100%
Q4QAH7	Leishmania major	37%	100%
Q4WS49	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	53%	99%
Q54H39	Dictyostelium discoideum	53%	100%
Q54NZ4	Dictyostelium discoideum	42%	100%
Q54WW3	Dictyostelium discoideum	39%	92%
Q553S2	Dictyostelium discoideum	41%	84%
Q59QC5	Candida albicans (strain SC5314 / ATCC MYA-2876)	38%	82%
Q5BFF8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	53%	99%
Q5R940	Pongo abelii	52%	100%
Q5RDP9	Pongo abelii	39%	74%
Q75F71	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	77%
Q7SAQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	100%
Q7TN05	Mus musculus	45%	93%
Q84WL9	Arabidopsis thaliana	55%	100%
Q8BSZ2	Mus musculus	39%	74%
Q8LEZ8	Arabidopsis thaliana	45%	89%
Q8VZ37	Arabidopsis thaliana	37%	86%
Q92572	Homo sapiens	43%	74%
Q96PC3	Homo sapiens	47%	93%
Q9DB50	Mus musculus	42%	89%
Q9DCR2	Mus musculus	43%	74%
Q9P7N2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	88%
Q9WVL1	Mus musculus	44%	99%
Q9Y587	Homo sapiens	43%	99%
Q9Y7L6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
V5DBK5	Trypanosoma cruzi	37%	87%