Membrane magnesium transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAU4_LEIBR

TriTrypDb:

LbrM.20.1820 , LBRM2903_200028800

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HAU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAU4

Function

Biological processes
Term	Name	Level	Count
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.440
CLV_PCSK_SKI1_1	124	128	PF00082	0.507
DOC_USP7_MATH_1	32	36	PF00917	0.385
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_eIF4E_1	9	15	PF01652	0.404
LIG_FHA_1	14	20	PF00498	0.193
LIG_FHA_1	51	57	PF00498	0.246
LIG_FHA_1	86	92	PF00498	0.645
LIG_FHA_2	40	46	PF00498	0.376
LIG_LIR_Nem_3	5	9	PF02991	0.337
LIG_LIR_Nem_3	88	93	PF02991	0.558
LIG_SH2_CRK	9	13	PF00017	0.414
LIG_SH2_GRB2like	93	96	PF00017	0.639
LIG_SH2_SRC	38	41	PF00017	0.377
LIG_SH2_STAP1	93	97	PF00017	0.580
LIG_SH2_STAT3	93	96	PF00017	0.639
LIG_SH2_STAT5	38	41	PF00017	0.314
LIG_SH2_STAT5	6	9	PF00017	0.349
LIG_SH2_STAT5	90	93	PF00017	0.618
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.335
LIG_SUMO_SIM_par_1	11	16	PF11976	0.288
LIG_SUMO_SIM_par_1	56	61	PF11976	0.404
LIG_TYR_ITIM	7	12	PF00017	0.350
MOD_CK2_1	21	27	PF00069	0.349
MOD_CK2_1	39	45	PF00069	0.304
MOD_GlcNHglycan	98	101	PF01048	0.484
MOD_GSK3_1	45	52	PF00069	0.314
MOD_NEK2_1	13	18	PF00069	0.256
MOD_NEK2_1	21	26	PF00069	0.285
MOD_PKA_2	108	114	PF00069	0.615
MOD_Plk_4	122	128	PF00069	0.567
MOD_Plk_4	45	51	PF00069	0.389
MOD_SUMO_rev_2	117	126	PF00179	0.705
TRG_ENDOCYTIC_2	9	12	PF00928	0.308
TRG_ER_diLys_1	129	132	PF00400	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ3	Leptomonas seymouri	61%	100%
A0A0S4JQP5	Bodo saltans	36%	100%
A0A1X0PAH4	Trypanosomatidae	35%	92%
A0A3S5H7W9	Leishmania donovani	77%	100%
A0A3S5ISH1	Trypanosoma rangeli	38%	92%
A4IA11	Leishmania infantum	77%	100%
C9ZMM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9B518	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q2W8	Leishmania major	75%	100%