Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAU2_LEIBR

TriTrypDb:

LbrM.20.1800 , LBRM2903_200028600

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	424	426	PF00675	0.521
CLV_NRD_NRD_1	563	565	PF00675	0.515
CLV_PCSK_KEX2_1	36	38	PF00082	0.713
CLV_PCSK_KEX2_1	424	426	PF00082	0.494
CLV_PCSK_KEX2_1	472	474	PF00082	0.393
CLV_PCSK_KEX2_1	567	569	PF00082	0.533
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.713
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.351
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.565
CLV_PCSK_SKI1_1	317	321	PF00082	0.729
CLV_PCSK_SKI1_1	349	353	PF00082	0.577
CLV_PCSK_SKI1_1	396	400	PF00082	0.550
CLV_PCSK_SKI1_1	407	411	PF00082	0.496
CLV_PCSK_SKI1_1	424	428	PF00082	0.430
CLV_PCSK_SKI1_1	45	49	PF00082	0.752
CLV_PCSK_SKI1_1	524	528	PF00082	0.414
CLV_PCSK_SKI1_1	65	69	PF00082	0.605
DEG_APCC_DBOX_1	602	610	PF00400	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.697
DEG_SPOP_SBC_1	306	310	PF00917	0.735
DOC_CDC14_PxL_1	257	265	PF14671	0.603
DOC_CKS1_1	557	562	PF01111	0.275
DOC_CKS1_1	56	61	PF01111	0.679
DOC_CKS1_1	77	82	PF01111	0.396
DOC_CKS1_1	92	97	PF01111	0.534
DOC_CYCLIN_RxL_1	268	279	PF00134	0.318
DOC_CYCLIN_RxL_1	314	322	PF00134	0.729
DOC_CYCLIN_RxL_1	346	353	PF00134	0.609
DOC_MAPK_MEF2A_6	182	190	PF00069	0.466
DOC_MAPK_MEF2A_6	20	27	PF00069	0.510
DOC_MIT_MIM_1	178	186	PF04212	0.481
DOC_PP1_RVXF_1	422	429	PF00149	0.493
DOC_PP2B_LxvP_1	98	101	PF13499	0.499
DOC_PP4_FxxP_1	21	24	PF00568	0.587
DOC_PP4_FxxP_1	538	541	PF00568	0.390
DOC_USP7_MATH_1	103	107	PF00917	0.716
DOC_USP7_MATH_1	109	113	PF00917	0.616
DOC_USP7_MATH_1	168	172	PF00917	0.580
DOC_USP7_MATH_1	255	259	PF00917	0.412
DOC_USP7_MATH_1	306	310	PF00917	0.724
DOC_USP7_MATH_1	342	346	PF00917	0.495
DOC_USP7_MATH_1	347	351	PF00917	0.481
DOC_USP7_MATH_1	382	386	PF00917	0.722
DOC_USP7_MATH_1	563	567	PF00917	0.515
DOC_WW_Pin1_4	142	147	PF00397	0.697
DOC_WW_Pin1_4	366	371	PF00397	0.627
DOC_WW_Pin1_4	390	395	PF00397	0.626
DOC_WW_Pin1_4	52	57	PF00397	0.621
DOC_WW_Pin1_4	556	561	PF00397	0.449
DOC_WW_Pin1_4	58	63	PF00397	0.605
DOC_WW_Pin1_4	76	81	PF00397	0.597
DOC_WW_Pin1_4	91	96	PF00397	0.625
LIG_14-3-3_CanoR_1	122	128	PF00244	0.483
LIG_14-3-3_CanoR_1	173	178	PF00244	0.508
LIG_14-3-3_CanoR_1	37	44	PF00244	0.535
LIG_14-3-3_CanoR_1	467	471	PF00244	0.568
LIG_14-3-3_CanoR_1	498	505	PF00244	0.485
LIG_Actin_WH2_2	508	526	PF00022	0.500
LIG_BRCT_BRCA1_1	135	139	PF00533	0.362
LIG_BRCT_BRCA1_1	473	477	PF00533	0.598
LIG_BRCT_BRCA1_1	81	85	PF00533	0.493
LIG_Clathr_ClatBox_1	545	549	PF01394	0.505
LIG_CtBP_PxDLS_1	24	28	PF00389	0.507
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.581
LIG_FHA_1	174	180	PF00498	0.472
LIG_FHA_1	310	316	PF00498	0.481
LIG_FHA_1	320	326	PF00498	0.429
LIG_FHA_1	442	448	PF00498	0.390
LIG_FHA_1	463	469	PF00498	0.321
LIG_FHA_1	494	500	PF00498	0.514
LIG_FHA_1	610	616	PF00498	0.411
LIG_FHA_2	155	161	PF00498	0.756
LIG_FHA_2	173	179	PF00498	0.504
LIG_FHA_2	199	205	PF00498	0.629
LIG_FHA_2	59	65	PF00498	0.546
LIG_LIR_Apic_2	90	95	PF02991	0.469
LIG_LIR_Gen_1	178	188	PF02991	0.378
LIG_LIR_Gen_1	243	252	PF02991	0.584
LIG_LIR_Gen_1	358	368	PF02991	0.627
LIG_LIR_Gen_1	549	558	PF02991	0.479
LIG_LIR_Gen_1	569	578	PF02991	0.194
LIG_LIR_Gen_1	592	602	PF02991	0.412
LIG_LIR_Nem_3	178	183	PF02991	0.376
LIG_LIR_Nem_3	243	247	PF02991	0.546
LIG_LIR_Nem_3	358	363	PF02991	0.578
LIG_LIR_Nem_3	403	409	PF02991	0.559
LIG_LIR_Nem_3	534	540	PF02991	0.357
LIG_LIR_Nem_3	549	553	PF02991	0.445
LIG_LIR_Nem_3	569	574	PF02991	0.193
LIG_LIR_Nem_3	592	598	PF02991	0.425
LIG_PCNA_yPIPBox_3	519	528	PF02747	0.279
LIG_Pex14_1	282	286	PF04695	0.582
LIG_Pex14_1	414	418	PF04695	0.587
LIG_PTB_Apo_2	544	551	PF02174	0.502
LIG_Rb_pABgroove_1	346	354	PF01858	0.607
LIG_SH2_CRK	418	422	PF00017	0.534
LIG_SH2_CRK	571	575	PF00017	0.489
LIG_SH2_CRK	92	96	PF00017	0.482
LIG_SH2_NCK_1	92	96	PF00017	0.482
LIG_SH2_SRC	140	143	PF00017	0.367
LIG_SH2_STAT3	74	77	PF00017	0.606
LIG_SH2_STAT5	140	143	PF00017	0.549
LIG_SH2_STAT5	180	183	PF00017	0.367
LIG_SH2_STAT5	265	268	PF00017	0.398
LIG_SH2_STAT5	571	574	PF00017	0.274
LIG_SH3_3	391	397	PF00018	0.639
LIG_SH3_3	53	59	PF00018	0.758
LIG_SUMO_SIM_par_1	23	29	PF11976	0.509
LIG_SUMO_SIM_par_1	397	403	PF11976	0.504
LIG_TRAF2_1	61	64	PF00917	0.472
LIG_WRC_WIRS_1	241	246	PF05994	0.599
MOD_CDC14_SPxK_1	145	148	PF00782	0.492
MOD_CDK_SPxK_1	142	148	PF00069	0.459
MOD_CDK_SPxK_1	390	396	PF00069	0.459
MOD_CDK_SPxxK_3	366	373	PF00069	0.625
MOD_CDK_SPxxK_3	58	65	PF00069	0.480
MOD_CK1_1	309	315	PF00069	0.748
MOD_CK1_1	369	375	PF00069	0.603
MOD_CK1_1	38	44	PF00069	0.776
MOD_CK1_1	385	391	PF00069	0.651
MOD_CK1_1	452	458	PF00069	0.548
MOD_CK1_1	501	507	PF00069	0.496
MOD_CK1_1	513	519	PF00069	0.342
MOD_CK1_1	55	61	PF00069	0.666
MOD_CK2_1	172	178	PF00069	0.494
MOD_CK2_1	202	208	PF00069	0.517
MOD_CK2_1	213	219	PF00069	0.323
MOD_CK2_1	310	316	PF00069	0.625
MOD_CK2_1	484	490	PF00069	0.581
MOD_CK2_1	563	569	PF00069	0.501
MOD_CK2_1	58	64	PF00069	0.682
MOD_CMANNOS	463	466	PF00535	0.530
MOD_Cter_Amidation	34	37	PF01082	0.713
MOD_GlcNHglycan	107	110	PF01048	0.611
MOD_GlcNHglycan	135	139	PF01048	0.533
MOD_GlcNHglycan	170	173	PF01048	0.535
MOD_GlcNHglycan	256	260	PF01048	0.518
MOD_GlcNHglycan	385	388	PF01048	0.726
MOD_GlcNHglycan	389	392	PF01048	0.688
MOD_GlcNHglycan	40	43	PF01048	0.643
MOD_GlcNHglycan	45	48	PF01048	0.584
MOD_GlcNHglycan	451	454	PF01048	0.628
MOD_GlcNHglycan	473	476	PF01048	0.549
MOD_GlcNHglycan	485	489	PF01048	0.554
MOD_GlcNHglycan	512	515	PF01048	0.607
MOD_GSK3_1	105	112	PF00069	0.587
MOD_GSK3_1	140	147	PF00069	0.523
MOD_GSK3_1	168	175	PF00069	0.518
MOD_GSK3_1	194	201	PF00069	0.354
MOD_GSK3_1	202	209	PF00069	0.511
MOD_GSK3_1	251	258	PF00069	0.606
MOD_GSK3_1	305	312	PF00069	0.745
MOD_GSK3_1	31	38	PF00069	0.703
MOD_GSK3_1	315	322	PF00069	0.648
MOD_GSK3_1	383	390	PF00069	0.707
MOD_GSK3_1	438	445	PF00069	0.550
MOD_GSK3_1	45	52	PF00069	0.550
MOD_GSK3_1	462	469	PF00069	0.442
MOD_GSK3_1	589	596	PF00069	0.332
MOD_GSK3_1	75	82	PF00069	0.559
MOD_N-GLC_1	29	34	PF02516	0.527
MOD_N-GLC_1	75	80	PF02516	0.428
MOD_N-GLC_2	458	460	PF02516	0.323
MOD_N-GLC_2	500	502	PF02516	0.425
MOD_NEK2_1	134	139	PF00069	0.469
MOD_NEK2_1	141	146	PF00069	0.583
MOD_NEK2_1	232	237	PF00069	0.416
MOD_NEK2_1	240	245	PF00069	0.442
MOD_NEK2_1	31	36	PF00069	0.667
MOD_NEK2_1	315	320	PF00069	0.696
MOD_NEK2_1	462	467	PF00069	0.346
MOD_NEK2_1	492	497	PF00069	0.649
MOD_NEK2_1	581	586	PF00069	0.494
MOD_NEK2_2	347	352	PF00069	0.589
MOD_PIKK_1	109	115	PF00454	0.395
MOD_PIKK_1	198	204	PF00454	0.550
MOD_PIKK_1	330	336	PF00454	0.661
MOD_PIKK_1	438	444	PF00454	0.333
MOD_PKA_2	172	178	PF00069	0.533
MOD_PKA_2	38	44	PF00069	0.666
MOD_PKA_2	466	472	PF00069	0.526
MOD_PKA_2	563	569	PF00069	0.501
MOD_Plk_1	191	197	PF00069	0.414
MOD_Plk_1	218	224	PF00069	0.462
MOD_Plk_1	232	238	PF00069	0.346
MOD_Plk_1	245	251	PF00069	0.504
MOD_Plk_1	315	321	PF00069	0.726
MOD_Plk_1	492	498	PF00069	0.533
MOD_Plk_1	548	554	PF00069	0.432
MOD_Plk_2-3	400	406	PF00069	0.582
MOD_Plk_4	123	129	PF00069	0.350
MOD_Plk_4	218	224	PF00069	0.498
MOD_Plk_4	232	238	PF00069	0.468
MOD_Plk_4	79	85	PF00069	0.611
MOD_ProDKin_1	142	148	PF00069	0.706
MOD_ProDKin_1	366	372	PF00069	0.624
MOD_ProDKin_1	390	396	PF00069	0.611
MOD_ProDKin_1	52	58	PF00069	0.617
MOD_ProDKin_1	556	562	PF00069	0.448
MOD_ProDKin_1	76	82	PF00069	0.604
MOD_ProDKin_1	91	97	PF00069	0.635
MOD_SUMO_rev_2	400	409	PF00179	0.584
TRG_DiLeu_BaEn_4	63	69	PF01217	0.450
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.512
TRG_ENDOCYTIC_2	180	183	PF00928	0.367
TRG_ENDOCYTIC_2	418	421	PF00928	0.525
TRG_ENDOCYTIC_2	571	574	PF00928	0.523
TRG_ER_diArg_1	423	425	PF00400	0.490
TRG_NES_CRM1_1	123	135	PF08389	0.530
TRG_NES_CRM1_1	178	192	PF08389	0.392
TRG_NES_CRM1_1	429	442	PF08389	0.296
TRG_NLS_MonoExtC_3	563	568	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH4	Leptomonas seymouri	45%	95%
A0A1X0P9M0	Trypanosomatidae	27%	100%
A0A3Q8IFL4	Leishmania donovani	75%	100%
A0A422P0J6	Trypanosoma rangeli	28%	100%
C9ZMM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AHT6	Leishmania infantum	75%	100%
E9B516	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q2X0	Leishmania major	73%	100%
V5BKG8	Trypanosoma cruzi	26%	100%