Dynamin-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynamin family, putative

Species:

Leishmania braziliensis

UniProt:

A4HAT9_LEIBR

TriTrypDb:

LbrM.20.1770 , LBRM2903_200028300

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HAT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAT9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0005525	GTP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0019001	guanyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032561	guanyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.300
CLV_C14_Caspase3-7	422	426	PF00656	0.622
CLV_NRD_NRD_1	176	178	PF00675	0.298
CLV_NRD_NRD_1	27	29	PF00675	0.414
CLV_NRD_NRD_1	303	305	PF00675	0.316
CLV_NRD_NRD_1	310	312	PF00675	0.314
CLV_PCSK_KEX2_1	176	178	PF00082	0.271
CLV_PCSK_KEX2_1	27	29	PF00082	0.504
CLV_PCSK_KEX2_1	303	305	PF00082	0.334
CLV_PCSK_KEX2_1	310	312	PF00082	0.317
CLV_PCSK_KEX2_1	390	392	PF00082	0.334
CLV_PCSK_KEX2_1	68	70	PF00082	0.347
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.334
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.347
CLV_PCSK_SKI1_1	210	214	PF00082	0.287
CLV_PCSK_SKI1_1	303	307	PF00082	0.337
CLV_PCSK_SKI1_1	371	375	PF00082	0.321
CLV_PCSK_SKI1_1	395	399	PF00082	0.337
CLV_Separin_Metazoa	238	242	PF03568	0.367
CLV_Separin_Metazoa	258	262	PF03568	0.193
DEG_APCC_DBOX_1	325	333	PF00400	0.340
DEG_APCC_DBOX_1	370	378	PF00400	0.373
DEG_Nend_Nbox_1	1	3	PF02207	0.432
DEG_ODPH_VHL_1	149	160	PF01847	0.314
DOC_AGCK_PIF_2	175	180	PF00069	0.153
DOC_CKS1_1	161	166	PF01111	0.289
DOC_CKS1_1	480	485	PF01111	0.587
DOC_MAPK_DCC_7	255	264	PF00069	0.425
DOC_MAPK_gen_1	176	183	PF00069	0.322
DOC_MAPK_gen_1	310	318	PF00069	0.327
DOC_MAPK_gen_1	326	333	PF00069	0.320
DOC_MAPK_gen_1	387	396	PF00069	0.303
DOC_MAPK_gen_1	421	429	PF00069	0.541
DOC_MAPK_gen_1	66	74	PF00069	0.360
DOC_MAPK_MEF2A_6	255	264	PF00069	0.425
DOC_MAPK_MEF2A_6	310	319	PF00069	0.319
DOC_MAPK_MEF2A_6	326	333	PF00069	0.319
DOC_MAPK_MEF2A_6	66	74	PF00069	0.428
DOC_PP1_RVXF_1	154	161	PF00149	0.412
DOC_PP4_FxxP_1	74	77	PF00568	0.233
DOC_USP7_MATH_1	271	275	PF00917	0.538
DOC_USP7_MATH_1	297	301	PF00917	0.377
DOC_USP7_MATH_1	474	478	PF00917	0.583
DOC_USP7_MATH_1	513	517	PF00917	0.725
DOC_USP7_MATH_1	80	84	PF00917	0.235
DOC_USP7_UBL2_3	335	339	PF12436	0.320
DOC_WW_Pin1_4	160	165	PF00397	0.292
DOC_WW_Pin1_4	453	458	PF00397	0.740
DOC_WW_Pin1_4	464	469	PF00397	0.732
DOC_WW_Pin1_4	479	484	PF00397	0.642
LIG_14-3-3_CanoR_1	132	141	PF00244	0.319
LIG_14-3-3_CanoR_1	156	161	PF00244	0.373
LIG_14-3-3_CanoR_1	255	259	PF00244	0.416
LIG_14-3-3_CanoR_1	261	271	PF00244	0.346
LIG_14-3-3_CanoR_1	303	309	PF00244	0.286
LIG_14-3-3_CanoR_1	356	365	PF00244	0.348
LIG_14-3-3_CanoR_1	6	13	PF00244	0.625
LIG_14-3-3_CanoR_1	69	75	PF00244	0.358
LIG_Actin_WH2_2	141	158	PF00022	0.343
LIG_AP2alpha_1	137	141	PF02296	0.343
LIG_APCC_ABBA_1	108	113	PF00400	0.259
LIG_BRCT_BRCA1_1	156	160	PF00533	0.389
LIG_BRCT_BRCA1_1	378	382	PF00533	0.371
LIG_CaM_NSCaTE_8	25	32	PF13499	0.403
LIG_FHA_1	161	167	PF00498	0.281
LIG_FHA_1	293	299	PF00498	0.356
LIG_FHA_1	39	45	PF00498	0.424
LIG_FHA_1	517	523	PF00498	0.552
LIG_FHA_2	199	205	PF00498	0.284
LIG_LIR_Apic_2	265	271	PF02991	0.377
LIG_LIR_Apic_2	73	77	PF02991	0.233
LIG_LIR_Gen_1	103	111	PF02991	0.292
LIG_LIR_Gen_1	139	149	PF02991	0.319
LIG_LIR_Gen_1	179	188	PF02991	0.314
LIG_LIR_Gen_1	276	284	PF02991	0.436
LIG_LIR_Gen_1	287	298	PF02991	0.434
LIG_LIR_Gen_1	344	354	PF02991	0.278
LIG_LIR_Gen_1	52	61	PF02991	0.431
LIG_LIR_Nem_3	103	109	PF02991	0.279
LIG_LIR_Nem_3	139	144	PF02991	0.281
LIG_LIR_Nem_3	172	178	PF02991	0.299
LIG_LIR_Nem_3	179	183	PF02991	0.301
LIG_LIR_Nem_3	192	198	PF02991	0.281
LIG_LIR_Nem_3	245	250	PF02991	0.413
LIG_LIR_Nem_3	276	281	PF02991	0.424
LIG_LIR_Nem_3	287	293	PF02991	0.422
LIG_LIR_Nem_3	340	346	PF02991	0.308
LIG_LIR_Nem_3	379	385	PF02991	0.364
LIG_LIR_Nem_3	52	56	PF02991	0.453
LIG_LIR_Nem_3	83	88	PF02991	0.282
LIG_LRP6_Inhibitor_1	429	435	PF00058	0.349
LIG_Pex14_1	268	272	PF04695	0.394
LIG_Pex14_2	137	141	PF04695	0.292
LIG_Pex14_2	56	60	PF04695	0.319
LIG_Pex14_2	74	78	PF04695	0.291
LIG_Rb_pABgroove_1	192	200	PF01858	0.233
LIG_SH2_CRK	243	247	PF00017	0.351
LIG_SH2_PTP2	180	183	PF00017	0.330
LIG_SH2_SRC	178	181	PF00017	0.344
LIG_SH2_STAP1	290	294	PF00017	0.477
LIG_SH2_STAP1	346	350	PF00017	0.360
LIG_SH2_STAP1	40	44	PF00017	0.416
LIG_SH2_STAP1	51	55	PF00017	0.338
LIG_SH2_STAT3	88	91	PF00017	0.319
LIG_SH2_STAT5	180	183	PF00017	0.308
LIG_SH2_STAT5	263	266	PF00017	0.338
LIG_SH2_STAT5	40	43	PF00017	0.304
LIG_SH2_STAT5	433	436	PF00017	0.379
LIG_SH2_STAT5	88	91	PF00017	0.300
LIG_SH2_STAT5	94	97	PF00017	0.280
LIG_SH3_3	145	151	PF00018	0.347
LIG_SH3_3	158	164	PF00018	0.290
LIG_SH3_3	291	297	PF00018	0.468
LIG_SH3_3	477	483	PF00018	0.733
LIG_SH3_3	52	58	PF00018	0.359
LIG_TRAF2_2	297	302	PF00917	0.365
LIG_TYR_ITIM	288	293	PF00017	0.467
LIG_UBA3_1	408	413	PF00899	0.469
LIG_WRC_WIRS_1	264	269	PF05994	0.356
LIG_WRC_WIRS_1	71	76	PF05994	0.233
LIG_WW_3	258	262	PF00397	0.370
LIG_WW_3	456	460	PF00397	0.444
MOD_CDC14_SPxK_1	456	459	PF00782	0.442
MOD_CDK_SPxK_1	453	459	PF00069	0.443
MOD_CK1_1	400	406	PF00069	0.207
MOD_CK1_1	478	484	PF00069	0.606
MOD_CK1_1	5	11	PF00069	0.504
MOD_CK1_1	507	513	PF00069	0.593
MOD_CK1_1	515	521	PF00069	0.540
MOD_CK2_1	39	45	PF00069	0.413
MOD_GlcNHglycan	126	129	PF01048	0.400
MOD_GlcNHglycan	273	276	PF01048	0.254
MOD_GlcNHglycan	359	362	PF01048	0.314
MOD_GlcNHglycan	507	510	PF01048	0.730
MOD_GlcNHglycan	515	518	PF01048	0.758
MOD_GlcNHglycan	78	81	PF01048	0.284
MOD_GSK3_1	100	107	PF00069	0.292
MOD_GSK3_1	156	163	PF00069	0.309
MOD_GSK3_1	2	9	PF00069	0.530
MOD_GSK3_1	242	249	PF00069	0.324
MOD_GSK3_1	474	481	PF00069	0.684
MOD_GSK3_1	504	511	PF00069	0.737
MOD_GSK3_1	512	519	PF00069	0.655
MOD_GSK3_1	76	83	PF00069	0.284
MOD_N-GLC_1	9	14	PF02516	0.534
MOD_NEK2_1	124	129	PF00069	0.354
MOD_NEK2_1	154	159	PF00069	0.284
MOD_NEK2_1	2	7	PF00069	0.513
MOD_NEK2_1	246	251	PF00069	0.416
MOD_NEK2_1	262	267	PF00069	0.397
MOD_NEK2_1	292	297	PF00069	0.425
MOD_NEK2_1	39	44	PF00069	0.410
MOD_NEK2_1	527	532	PF00069	0.670
MOD_NEK2_1	61	66	PF00069	0.259
MOD_PIKK_1	112	118	PF00454	0.153
MOD_PIKK_1	132	138	PF00454	0.371
MOD_PIKK_1	482	488	PF00454	0.612
MOD_PK_1	230	236	PF00069	0.325
MOD_PK_1	304	310	PF00069	0.231
MOD_PKA_1	303	309	PF00069	0.412
MOD_PKA_2	254	260	PF00069	0.441
MOD_PKA_2	303	309	PF00069	0.306
MOD_PKA_2	5	11	PF00069	0.475
MOD_PKA_2	56	62	PF00069	0.300
MOD_Plk_1	29	35	PF00069	0.476
MOD_Plk_1	413	419	PF00069	0.635
MOD_Plk_1	9	15	PF00069	0.494
MOD_Plk_4	156	162	PF00069	0.285
MOD_Plk_4	242	248	PF00069	0.405
MOD_Plk_4	263	269	PF00069	0.363
MOD_Plk_4	304	310	PF00069	0.306
MOD_Plk_4	345	351	PF00069	0.446
MOD_Plk_4	488	494	PF00069	0.598
MOD_Plk_4	533	539	PF00069	0.623
MOD_Plk_4	56	62	PF00069	0.308
MOD_Plk_4	70	76	PF00069	0.285
MOD_Plk_4	81	87	PF00069	0.300
MOD_ProDKin_1	160	166	PF00069	0.292
MOD_ProDKin_1	453	459	PF00069	0.743
MOD_ProDKin_1	464	470	PF00069	0.691
MOD_ProDKin_1	479	485	PF00069	0.637
TRG_DiLeu_BaEn_1	189	194	PF01217	0.300
TRG_DiLeu_BaEn_1	284	289	PF01217	0.342
TRG_DiLeu_BaEn_3	344	350	PF01217	0.279
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.251
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.441
TRG_ENDOCYTIC_2	178	181	PF00928	0.296
TRG_ENDOCYTIC_2	243	246	PF00928	0.354
TRG_ENDOCYTIC_2	247	250	PF00928	0.359
TRG_ENDOCYTIC_2	278	281	PF00928	0.517
TRG_ENDOCYTIC_2	290	293	PF00928	0.469
TRG_ENDOCYTIC_2	346	349	PF00928	0.337
TRG_ENDOCYTIC_2	53	56	PF00928	0.259
TRG_ER_diArg_1	175	177	PF00400	0.260
TRG_ER_diArg_1	27	29	PF00400	0.480
TRG_ER_diArg_1	303	305	PF00400	0.344
TRG_ER_diArg_1	309	311	PF00400	0.333
TRG_ER_diArg_1	325	328	PF00400	0.304
TRG_NES_CRM1_1	286	302	PF08389	0.400
TRG_NES_CRM1_1	525	541	PF08389	0.669
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.159

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	48%	91%
A0A0N0P9A4	Leptomonas seymouri	75%	99%
A0A0S4KGM0	Bodo saltans	48%	89%
A0A1X0P6D7	Trypanosomatidae	51%	99%
A0A1X0P9Q8	Trypanosomatidae	64%	98%
A0A3R7LDF3	Trypanosoma rangeli	46%	100%
A0A3S7WV81	Leishmania donovani	46%	86%
A0A3S7X801	Leishmania donovani	78%	100%
A0A422P0G8	Trypanosoma rangeli	62%	100%
A4H9Y5	Leishmania braziliensis	44%	100%
A4HY50	Leishmania infantum	46%	86%
A4IA07	Leishmania infantum	78%	100%
B3LF48	Arabidopsis thaliana	37%	100%
C9ZMM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	87%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	87%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q2X3	Leishmania major	77%	100%
Q4QDJ3	Leishmania major	42%	100%
Q4V8H8	Rattus norvegicus	34%	100%
Q5E9R3	Bos taurus	33%	100%
Q5RBP4	Pongo abelii	34%	100%
Q641Z6	Rattus norvegicus	34%	100%
Q8BH64	Mus musculus	34%	100%
Q8R491	Rattus norvegicus	33%	100%
Q94CF0	Arabidopsis thaliana	37%	100%
Q9EQP2	Mus musculus	33%	100%
Q9H223	Homo sapiens	33%	100%
Q9H4M9	Homo sapiens	34%	100%
Q9NZN3	Homo sapiens	33%	100%
Q9NZN4	Homo sapiens	34%	100%
Q9QXY6	Mus musculus	33%	100%
Q9WVK4	Mus musculus	34%	100%
V5BSA9	Trypanosoma cruzi	49%	100%
V5DGT0	Trypanosoma cruzi	62%	99%