Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HAT2_LEIBR

TriTrypDb:

LbrM.20.1700 , LBRM2903_200027600

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAT2

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.530
CLV_PCSK_SKI1_1	290	294	PF00082	0.581
CLV_PCSK_SKI1_1	341	345	PF00082	0.490
CLV_PCSK_SKI1_1	398	402	PF00082	0.472
DEG_APCC_DBOX_1	332	340	PF00400	0.365
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DOC_CKS1_1	3	8	PF01111	0.406
DOC_CYCLIN_RxL_1	189	199	PF00134	0.276
DOC_MAPK_DCC_7	175	184	PF00069	0.391
DOC_MAPK_gen_1	165	172	PF00069	0.380
DOC_MAPK_gen_1	175	184	PF00069	0.357
DOC_MAPK_gen_1	190	198	PF00069	0.496
DOC_MAPK_gen_1	317	327	PF00069	0.461
DOC_MAPK_gen_1	341	351	PF00069	0.519
DOC_MAPK_HePTP_8	172	184	PF00069	0.278
DOC_MAPK_MEF2A_6	165	174	PF00069	0.559
DOC_MAPK_MEF2A_6	175	184	PF00069	0.319
DOC_MAPK_MEF2A_6	190	198	PF00069	0.425
DOC_MAPK_MEF2A_6	290	298	PF00069	0.575
DOC_MAPK_MEF2A_6	344	351	PF00069	0.488
DOC_PP4_FxxP_1	311	314	PF00568	0.386
DOC_PP4_FxxP_1	58	61	PF00568	0.338
DOC_USP7_MATH_1	133	137	PF00917	0.375
DOC_USP7_UBL2_3	268	272	PF12436	0.706
DOC_WW_Pin1_4	160	165	PF00397	0.298
DOC_WW_Pin1_4	185	190	PF00397	0.401
DOC_WW_Pin1_4	2	7	PF00397	0.483
DOC_WW_Pin1_4	223	228	PF00397	0.447
DOC_WW_Pin1_4	301	306	PF00397	0.454
DOC_WW_Pin1_4	320	325	PF00397	0.553
LIG_14-3-3_CanoR_1	2	6	PF00244	0.599
LIG_14-3-3_CanoR_1	290	295	PF00244	0.669
LIG_14-3-3_CanoR_1	93	101	PF00244	0.204
LIG_Actin_WH2_2	210	226	PF00022	0.435
LIG_BRCT_BRCA1_1	24	28	PF00533	0.443
LIG_Clathr_ClatBox_1	348	352	PF01394	0.380
LIG_Clathr_ClatBox_1	425	429	PF01394	0.290
LIG_FHA_1	291	297	PF00498	0.545
LIG_FHA_1	302	308	PF00498	0.469
LIG_FHA_1	314	320	PF00498	0.485
LIG_FHA_1	381	387	PF00498	0.442
LIG_FHA_2	149	155	PF00498	0.526
LIG_FHA_2	224	230	PF00498	0.433
LIG_HP1_1	53	57	PF01393	0.425
LIG_LIR_Apic_2	309	314	PF02991	0.429
LIG_LIR_Gen_1	234	240	PF02991	0.485
LIG_LIR_Gen_1	247	256	PF02991	0.387
LIG_LIR_Gen_1	72	80	PF02991	0.323
LIG_LIR_Nem_3	234	239	PF02991	0.484
LIG_LIR_Nem_3	247	251	PF02991	0.494
LIG_LIR_Nem_3	72	76	PF02991	0.323
LIG_NRBOX	11	17	PF00104	0.552
LIG_PCNA_yPIPBox_3	216	224	PF02747	0.377
LIG_Pex14_2	58	62	PF04695	0.338
LIG_Pex14_2	69	73	PF04695	0.338
LIG_SH2_NCK_1	225	229	PF00017	0.545
LIG_SH2_NCK_1	248	252	PF00017	0.356
LIG_SH2_STAP1	248	252	PF00017	0.381
LIG_SH2_STAT3	125	128	PF00017	0.425
LIG_SH2_STAT5	225	228	PF00017	0.554
LIG_SH2_STAT5	303	306	PF00017	0.552
LIG_SH2_STAT5	342	345	PF00017	0.476
LIG_SH3_3	23	29	PF00018	0.487
LIG_SH3_3	291	297	PF00018	0.492
LIG_SUMO_SIM_anti_2	383	390	PF11976	0.498
LIG_SUMO_SIM_par_1	180	186	PF11976	0.389
LIG_SUMO_SIM_par_1	371	377	PF11976	0.402
LIG_SUMO_SIM_par_1	424	429	PF11976	0.460
LIG_TRAF2_1	152	155	PF00917	0.332
LIG_TYR_ITIM	246	251	PF00017	0.373
LIG_UBA3_1	167	175	PF00899	0.417
LIG_UBA3_1	181	190	PF00899	0.498
LIG_UBA3_1	360	367	PF00899	0.408
MOD_CDC14_SPxK_1	163	166	PF00782	0.302
MOD_CDK_SPK_2	160	165	PF00069	0.298
MOD_CDK_SPK_2	185	190	PF00069	0.427
MOD_CDK_SPK_2	301	306	PF00069	0.511
MOD_CDK_SPxK_1	160	166	PF00069	0.299
MOD_CDK_SPxxK_3	185	192	PF00069	0.427
MOD_CK1_1	118	124	PF00069	0.425
MOD_CK1_1	145	151	PF00069	0.452
MOD_CK1_1	183	189	PF00069	0.377
MOD_CK1_1	247	253	PF00069	0.460
MOD_CK1_1	264	270	PF00069	0.675
MOD_CK1_1	34	40	PF00069	0.448
MOD_CK1_1	4	10	PF00069	0.688
MOD_CK2_1	140	146	PF00069	0.401
MOD_CK2_1	148	154	PF00069	0.454
MOD_CK2_1	223	229	PF00069	0.419
MOD_CK2_1	326	332	PF00069	0.500
MOD_CK2_1	371	377	PF00069	0.599
MOD_CK2_1	378	384	PF00069	0.557
MOD_CK2_1	403	409	PF00069	0.297
MOD_GlcNHglycan	113	116	PF01048	0.477
MOD_GlcNHglycan	120	123	PF01048	0.375
MOD_GlcNHglycan	198	201	PF01048	0.358
MOD_GlcNHglycan	264	267	PF01048	0.618
MOD_GlcNHglycan	33	36	PF01048	0.389
MOD_GlcNHglycan	6	9	PF01048	0.550
MOD_GSK3_1	111	118	PF00069	0.417
MOD_GSK3_1	141	148	PF00069	0.434
MOD_GSK3_1	262	269	PF00069	0.646
MOD_GSK3_1	30	37	PF00069	0.539
MOD_GSK3_1	378	385	PF00069	0.560
MOD_N-GLC_1	244	249	PF02516	0.321
MOD_N-GLC_2	261	263	PF02516	0.317
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	196	201	PF00069	0.408
MOD_NEK2_1	212	217	PF00069	0.348
MOD_NEK2_1	270	275	PF00069	0.477
MOD_NEK2_1	351	356	PF00069	0.449
MOD_NEK2_1	382	387	PF00069	0.500
MOD_NEK2_1	389	394	PF00069	0.442
MOD_NEK2_1	39	44	PF00069	0.309
MOD_NEK2_1	47	52	PF00069	0.282
MOD_PIKK_1	212	218	PF00454	0.446
MOD_PIKK_1	306	312	PF00454	0.429
MOD_PIKK_1	351	357	PF00454	0.425
MOD_PKA_2	1	7	PF00069	0.646
MOD_PKA_2	389	395	PF00069	0.424
MOD_PKA_2	92	98	PF00069	0.204
MOD_Plk_1	244	250	PF00069	0.527
MOD_Plk_4	133	139	PF00069	0.377
MOD_Plk_4	180	186	PF00069	0.374
MOD_Plk_4	266	272	PF00069	0.655
MOD_Plk_4	382	388	PF00069	0.561
MOD_ProDKin_1	160	166	PF00069	0.299
MOD_ProDKin_1	185	191	PF00069	0.395
MOD_ProDKin_1	2	8	PF00069	0.483
MOD_ProDKin_1	223	229	PF00069	0.454
MOD_ProDKin_1	301	307	PF00069	0.448
MOD_ProDKin_1	320	326	PF00069	0.545
MOD_SUMO_rev_2	154	159	PF00179	0.319
MOD_SUMO_rev_2	273	283	PF00179	0.585
TRG_DiLeu_BaEn_1	234	239	PF01217	0.393
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.415
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.644
TRG_ENDOCYTIC_2	248	251	PF00928	0.384
TRG_ENDOCYTIC_2	399	402	PF00928	0.412
TRG_NES_CRM1_1	358	371	PF08389	0.442
TRG_NLS_MonoExtN_4	314	321	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y0	Leptomonas seymouri	53%	95%
A0A0S4J6N7	Bodo saltans	36%	99%
A0A1X0PAY2	Trypanosomatidae	39%	100%
A0A3Q8IL31	Leishmania donovani	75%	100%
A4I9Z2	Leishmania infantum	75%	100%
C9ZMN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AY45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B506	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q2Y0	Leishmania major	74%	100%
V5BFX1	Trypanosoma cruzi	38%	98%