Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAS8_LEIBR

TriTrypDb:

LbrM.20.1660 , LBRM2903_200027200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.661
CLV_MEL_PAP_1	407	413	PF00089	0.509
CLV_NRD_NRD_1	265	267	PF00675	0.465
CLV_NRD_NRD_1	63	65	PF00675	0.414
CLV_NRD_NRD_1	80	82	PF00675	0.379
CLV_NRD_NRD_1	86	88	PF00675	0.581
CLV_PCSK_FUR_1	61	65	PF00082	0.535
CLV_PCSK_KEX2_1	246	248	PF00082	0.744
CLV_PCSK_KEX2_1	420	422	PF00082	0.648
CLV_PCSK_KEX2_1	425	427	PF00082	0.612
CLV_PCSK_KEX2_1	63	65	PF00082	0.414
CLV_PCSK_KEX2_1	79	81	PF00082	0.394
CLV_PCSK_KEX2_1	86	88	PF00082	0.537
CLV_PCSK_KEX2_1	99	101	PF00082	0.417
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.729
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.494
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.491
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.669
CLV_PCSK_PC7_1	421	427	PF00082	0.378
CLV_PCSK_PC7_1	95	101	PF00082	0.471
CLV_PCSK_SKI1_1	198	202	PF00082	0.411
CLV_PCSK_SKI1_1	256	260	PF00082	0.612
CLV_PCSK_SKI1_1	404	408	PF00082	0.564
DEG_APCC_DBOX_1	186	194	PF00400	0.524
DEG_APCC_DBOX_1	326	334	PF00400	0.499
DEG_APCC_DBOX_1	340	348	PF00400	0.615
DEG_SCF_FBW7_1	470	475	PF00400	0.541
DEG_SPOP_SBC_1	39	43	PF00917	0.401
DEG_SPOP_SBC_1	472	476	PF00917	0.637
DOC_CYCLIN_RxL_1	11	21	PF00134	0.413
DOC_CYCLIN_RxL_1	186	194	PF00134	0.565
DOC_MAPK_FxFP_2	216	219	PF00069	0.535
DOC_MAPK_gen_1	173	181	PF00069	0.493
DOC_MAPK_gen_1	195	205	PF00069	0.449
DOC_MAPK_gen_1	79	85	PF00069	0.532
DOC_MAPK_MEF2A_6	14	22	PF00069	0.640
DOC_PP1_RVXF_1	430	437	PF00149	0.433
DOC_PP2B_LxvP_1	406	409	PF13499	0.656
DOC_PP4_FxxP_1	216	219	PF00568	0.518
DOC_USP7_MATH_1	142	146	PF00917	0.675
DOC_USP7_MATH_1	152	156	PF00917	0.715
DOC_USP7_MATH_1	248	252	PF00917	0.662
DOC_USP7_MATH_1	297	301	PF00917	0.624
DOC_USP7_MATH_1	473	477	PF00917	0.546
DOC_USP7_MATH_2	122	128	PF00917	0.629
DOC_USP7_UBL2_3	197	201	PF12436	0.492
DOC_WW_Pin1_4	128	133	PF00397	0.603
DOC_WW_Pin1_4	228	233	PF00397	0.614
DOC_WW_Pin1_4	468	473	PF00397	0.666
LIG_14-3-3_CanoR_1	353	357	PF00244	0.583
LIG_14-3-3_CanoR_1	410	414	PF00244	0.522
LIG_14-3-3_CanoR_1	464	472	PF00244	0.436
LIG_14-3-3_CanoR_1	87	96	PF00244	0.611
LIG_APCC_ABBA_1	20	25	PF00400	0.599
LIG_BRCT_BRCA1_1	122	126	PF00533	0.479
LIG_BRCT_BRCA1_1	214	218	PF00533	0.427
LIG_Clathr_ClatBox_1	190	194	PF01394	0.579
LIG_FHA_1	105	111	PF00498	0.549
LIG_FHA_1	208	214	PF00498	0.366
LIG_FHA_1	22	28	PF00498	0.587
LIG_FHA_1	66	72	PF00498	0.335
LIG_FHA_2	272	278	PF00498	0.600
LIG_FHA_2	41	47	PF00498	0.564
LIG_LIR_Apic_2	214	219	PF02991	0.483
LIG_LIR_Gen_1	377	386	PF02991	0.609
LIG_LIR_Gen_1	412	419	PF02991	0.613
LIG_LIR_Nem_3	377	381	PF02991	0.653
LIG_LIR_Nem_3	412	416	PF02991	0.619
LIG_MAD2	211	219	PF02301	0.524
LIG_NRBOX	54	60	PF00104	0.403
LIG_PCNA_PIPBox_1	430	439	PF02747	0.504
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.611
LIG_Rb_pABgroove_1	342	350	PF01858	0.539
LIG_SH2_STAP1	318	322	PF00017	0.486
LIG_SH2_STAP1	348	352	PF00017	0.537
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.447
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.620
LIG_SUMO_SIM_par_1	70	75	PF11976	0.553
LIG_TRAF2_1	75	78	PF00917	0.416
LIG_UBA3_1	190	198	PF00899	0.585
LIG_UBA3_1	47	53	PF00899	0.312
LIG_WRC_WIRS_1	213	218	PF05994	0.426
MOD_CDC14_SPxK_1	131	134	PF00782	0.472
MOD_CDK_SPxK_1	128	134	PF00069	0.516
MOD_CK1_1	104	110	PF00069	0.581
MOD_CK1_1	228	234	PF00069	0.595
MOD_CK1_1	304	310	PF00069	0.569
MOD_CK1_1	325	331	PF00069	0.644
MOD_CK1_1	88	94	PF00069	0.623
MOD_CK2_1	299	305	PF00069	0.459
MOD_CK2_1	352	358	PF00069	0.675
MOD_CK2_1	40	46	PF00069	0.576
MOD_CK2_1	72	78	PF00069	0.495
MOD_GlcNHglycan	110	113	PF01048	0.642
MOD_GlcNHglycan	140	143	PF01048	0.711
MOD_GlcNHglycan	154	157	PF01048	0.673
MOD_GlcNHglycan	227	230	PF01048	0.627
MOD_GlcNHglycan	236	239	PF01048	0.586
MOD_GlcNHglycan	241	244	PF01048	0.481
MOD_GlcNHglycan	287	290	PF01048	0.530
MOD_GlcNHglycan	305	309	PF01048	0.623
MOD_GlcNHglycan	377	381	PF01048	0.528
MOD_GlcNHglycan	451	454	PF01048	0.684
MOD_GlcNHglycan	475	478	PF01048	0.639
MOD_GlcNHglycan	7	10	PF01048	0.632
MOD_GlcNHglycan	87	90	PF01048	0.560
MOD_GSK3_1	100	107	PF00069	0.619
MOD_GSK3_1	120	127	PF00069	0.677
MOD_GSK3_1	138	145	PF00069	0.675
MOD_GSK3_1	147	154	PF00069	0.642
MOD_GSK3_1	159	166	PF00069	0.500
MOD_GSK3_1	234	241	PF00069	0.625
MOD_GSK3_1	248	255	PF00069	0.714
MOD_GSK3_1	297	304	PF00069	0.636
MOD_GSK3_1	468	475	PF00069	0.616
MOD_GSK3_1	85	92	PF00069	0.582
MOD_LATS_1	98	104	PF00433	0.467
MOD_N-GLC_1	108	113	PF02516	0.777
MOD_N-GLC_1	271	276	PF02516	0.555
MOD_N-GLC_1	322	327	PF02516	0.389
MOD_NEK2_1	115	120	PF00069	0.677
MOD_NEK2_1	16	21	PF00069	0.558
MOD_NEK2_1	225	230	PF00069	0.674
MOD_NEK2_1	234	239	PF00069	0.669
MOD_NEK2_1	298	303	PF00069	0.609
MOD_NEK2_1	65	70	PF00069	0.522
MOD_NEK2_1	85	90	PF00069	0.384
MOD_PIKK_1	110	116	PF00454	0.440
MOD_PIKK_1	246	252	PF00454	0.515
MOD_PIKK_1	389	395	PF00454	0.576
MOD_PIKK_1	437	443	PF00454	0.409
MOD_PIKK_1	451	457	PF00454	0.639
MOD_PIKK_1	72	78	PF00454	0.560
MOD_PIKK_1	90	96	PF00454	0.590
MOD_PKA_1	246	252	PF00069	0.483
MOD_PKA_2	104	110	PF00069	0.558
MOD_PKA_2	124	130	PF00069	0.694
MOD_PKA_2	246	252	PF00069	0.594
MOD_PKA_2	285	291	PF00069	0.507
MOD_PKA_2	340	346	PF00069	0.637
MOD_PKA_2	352	358	PF00069	0.599
MOD_PKA_2	368	374	PF00069	0.577
MOD_PKA_2	409	415	PF00069	0.498
MOD_PKA_2	85	91	PF00069	0.600
MOD_PKB_1	254	262	PF00069	0.481
MOD_Plk_1	256	262	PF00069	0.635
MOD_Plk_1	376	382	PF00069	0.487
MOD_Plk_2-3	163	169	PF00069	0.536
MOD_Plk_4	368	374	PF00069	0.528
MOD_Plk_4	479	485	PF00069	0.658
MOD_ProDKin_1	128	134	PF00069	0.604
MOD_ProDKin_1	228	234	PF00069	0.620
MOD_ProDKin_1	468	474	PF00069	0.668
MOD_SUMO_rev_2	194	203	PF00179	0.615
MOD_SUMO_rev_2	354	361	PF00179	0.569
MOD_SUMO_rev_2	412	422	PF00179	0.530
TRG_DiLeu_BaEn_1	54	59	PF01217	0.531
TRG_ER_diArg_1	61	64	PF00400	0.428
TRG_ER_diArg_1	79	81	PF00400	0.385
TRG_ER_diArg_1	85	87	PF00400	0.606
TRG_NES_CRM1_1	11	25	PF08389	0.620
TRG_NES_CRM1_1	428	442	PF08389	0.454
TRG_NES_CRM1_1	45	60	PF08389	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED0	Leptomonas seymouri	57%	100%
A0A0S4J9S2	Bodo saltans	26%	98%
A0A1X0P9K0	Trypanosomatidae	30%	100%
A0A3Q8INC5	Leishmania donovani	75%	100%
A0A422NY19	Trypanosoma rangeli	30%	100%
A4I9Y8	Leishmania infantum	75%	100%
C9ZMP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B502	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q2Y4	Leishmania major	75%	100%
V5BPZ9	Trypanosoma cruzi	29%	97%