NAD-dependent protein deacylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Silent information regulator 2 related protein 3

Species:

Leishmania braziliensis

UniProt:

A4HAS6_LEIBR

TriTrypDb:

LbrM.20.1640 , LBRM2903_200026900

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HAS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAS6

Function

Biological processes
Term	Name	Level	Count
GO:0006476	protein deacetylation	6	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0035601	protein deacylation	5	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0098732	macromolecule deacylation	5	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0036046	protein demalonylation	6	1
GO:0036047	peptidyl-lysine demalonylation	7	1
GO:0036048	protein desuccinylation	6	1
GO:0036049	peptidyl-lysine desuccinylation	7	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061698	protein deglutarylation	6	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0016740	transferase activity	2	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	11
GO:0019213	deacetylase activity	3	11
GO:0033558	protein lysine deacetylase activity	3	11
GO:0034979	NAD-dependent protein deacetylase activity	4	11
GO:0036054	protein-malonyllysine demalonylase activity	3	11
GO:0036055	protein-succinyllysine desuccinylase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0051287	NAD binding	4	11
GO:0061697	protein-glutaryllysine deglutarylase activity	3	11
GO:0070403	NAD+ binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.465
CLV_NRD_NRD_1	60	62	PF00675	0.210
CLV_PCSK_KEX2_1	59	61	PF00082	0.210
CLV_PCSK_SKI1_1	235	239	PF00082	0.369
CLV_PCSK_SKI1_1	5	9	PF00082	0.413
CLV_PCSK_SKI1_1	61	65	PF00082	0.212
DEG_Nend_UBRbox_1	1	4	PF02207	0.465
DOC_CYCLIN_RxL_1	58	67	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.406
DOC_MAPK_gen_1	59	65	PF00069	0.505
DOC_MAPK_gen_1	69	77	PF00069	0.426
DOC_MAPK_gen_1	85	93	PF00069	0.359
DOC_WW_Pin1_4	38	43	PF00397	0.487
LIG_14-3-3_CanoR_1	103	112	PF00244	0.373
LIG_14-3-3_CanoR_1	120	124	PF00244	0.412
LIG_14-3-3_CanoR_1	5	10	PF00244	0.204
LIG_APCC_ABBA_1	110	115	PF00400	0.410
LIG_APCC_ABBA_1	160	165	PF00400	0.351
LIG_FHA_1	105	111	PF00498	0.410
LIG_FHA_1	122	128	PF00498	0.410
LIG_FHA_1	129	135	PF00498	0.359
LIG_FHA_1	201	207	PF00498	0.284
LIG_FHA_1	86	92	PF00498	0.409
LIG_FHA_2	180	186	PF00498	0.349
LIG_FHA_2	200	206	PF00498	0.351
LIG_FHA_2	21	27	PF00498	0.410
LIG_LIR_Nem_3	174	180	PF02991	0.428
LIG_SH3_3	36	42	PF00018	0.445
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.401
LIG_SUMO_SIM_par_1	88	94	PF11976	0.390
LIG_WRC_WIRS_1	21	26	PF05994	0.410
MOD_CK1_1	16	22	PF00069	0.439
MOD_CK1_1	169	175	PF00069	0.512
MOD_CK1_1	179	185	PF00069	0.423
MOD_CK1_1	212	218	PF00069	0.444
MOD_CK2_1	199	205	PF00069	0.361
MOD_GlcNHglycan	15	18	PF01048	0.239
MOD_GlcNHglycan	182	185	PF01048	0.253
MOD_GlcNHglycan	240	243	PF01048	0.324
MOD_GSK3_1	16	23	PF00069	0.410
MOD_GSK3_1	176	183	PF00069	0.401
MOD_LATS_1	101	107	PF00433	0.410
MOD_N-GLC_1	212	217	PF02516	0.325
MOD_NEK2_1	146	151	PF00069	0.454
MOD_NEK2_1	198	203	PF00069	0.442
MOD_NEK2_1	217	222	PF00069	0.299
MOD_NEK2_1	237	242	PF00069	0.493
MOD_NEK2_1	63	68	PF00069	0.507
MOD_PIKK_1	91	97	PF00454	0.410
MOD_PK_1	166	172	PF00069	0.349
MOD_PKA_2	119	125	PF00069	0.396
MOD_Plk_1	212	218	PF00069	0.328
MOD_Plk_4	166	172	PF00069	0.510
MOD_Plk_4	212	218	PF00069	0.345
MOD_ProDKin_1	38	44	PF00069	0.487
TRG_DiLeu_BaEn_2	172	178	PF01217	0.479
TRG_ER_diArg_1	59	61	PF00400	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFL5	Leptomonas seymouri	74%	98%
A0A1X0P9P3	Trypanosomatidae	66%	100%
A0A3S5IS96	Trypanosoma rangeli	65%	100%
A0A3S7X7Z3	Leishmania donovani	84%	100%
A0QC96	Mycobacterium avium (strain 104)	39%	100%
A0QDH4	Mycobacterium avium (strain 104)	30%	86%
A0R2N3	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	39%	100%
A4IAM7	Leishmania infantum	84%	100%
A8MBU4	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	34%	95%
A8NWP2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	32%	81%
A9A0B2	Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3)	32%	89%
A9SDL4	Physcomitrium patens	39%	75%
A9UVV1	Monosiga brevicollis	29%	79%
B0RM75	Xanthomonas campestris pv. campestris (strain B100)	32%	83%
B4EVF5	Proteus mirabilis (strain HI4320)	58%	85%
B5YJW3	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	36%	95%
C1DBX3	Laribacter hongkongensis (strain HLHK9)	31%	98%
C6A243	Thermococcus sibiricus (strain DSM 12597 / MM 739)	38%	95%
C9ZMP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E1BRE2	Gallus gallus	37%	79%
E2RDZ6	Canis lupus familiaris	37%	78%
E9B500	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9GD30	Daphnia pulex	35%	89%
F4P804	Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)	27%	80%
F7D4X9	Monodelphis domestica	34%	77%
F7DKV7	Xenopus tropicalis	37%	79%
F7EZ75	Macaca mulatta	36%	78%
O07595	Bacillus subtilis (strain 168)	34%	98%
O25849	Helicobacter pylori (strain ATCC 700392 / 26695)	44%	100%
O28597	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	41%	99%
O30124	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	38%	96%
O58669	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	40%	98%
O67919	Aquifex aeolicus (strain VF5)	43%	100%
P0A2F2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	56%	89%
P0A2F3	Salmonella typhi	56%	89%
P0CS88	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	69%
P53686	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	68%
P66814	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	100%
P66815	Staphylococcus aureus (strain Mu50 / ATCC 700699)	35%	100%
P66816	Staphylococcus aureus (strain N315)	35%	100%
P75960	Escherichia coli (strain K12)	57%	87%
P9WGG2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	100%
P9WGG3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	100%
Q1JQC6	Bos taurus	27%	77%
Q20480	Caenorhabditis elegans	27%	85%
Q20481	Caenorhabditis elegans	28%	85%
Q3ZBQ0	Bos taurus	37%	78%
Q4JBN2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	96%
Q4Q2Y6	Leishmania major	82%	100%
Q4UZX0	Xanthomonas campestris pv. campestris (strain 8004)	33%	83%
Q53700	Staphylococcus aureus (strain NCTC 8325 / PS 47)	36%	100%
Q55DB0	Dictyostelium discoideum	25%	71%
Q584D5	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	62%	100%
Q5AI90	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	79%
Q5AW69	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	67%
Q5HE07	Staphylococcus aureus (strain COL)	35%	100%
Q5HM33	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	34%	99%
Q5HU51	Campylobacter jejuni (strain RM1221)	39%	100%
Q5HZN8	Xenopus laevis	37%	79%
Q5JG47	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	42%	95%
Q5KZE8	Geobacillus kaustophilus (strain HTA426)	33%	98%
Q5L014	Geobacillus kaustophilus (strain HTA426)	36%	100%
Q5R6G3	Pongo abelii	36%	78%
Q5RBF1	Pongo abelii	26%	69%
Q5RJQ4	Rattus norvegicus	27%	69%
Q5SIH7	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	40%	96%
Q5V4Q5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	30%	93%
Q5WKC8	Alkalihalobacillus clausii (strain KSM-K16)	36%	100%
Q607X6	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	35%	95%
Q639M6	Bacillus cereus (strain ZK / E33L)	34%	99%
Q669P6	Yersinia pseudotuberculosis serotype I (strain IP32953)	57%	87%
Q67KQ0	Symbiobacterium thermophilum (strain T / IAM 14863)	34%	97%
Q68F47	Xenopus laevis	37%	79%
Q68FX9	Rattus norvegicus	35%	78%
Q6A5T5	Cutibacterium acnes (strain DSM 16379 / KPA171202)	35%	100%
Q6DHI5	Danio rerio	36%	80%
Q6G7B7	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GEN2	Staphylococcus aureus (strain MRSA252)	35%	100%
Q6HH09	Bacillus thuringiensis subsp. konkukian (strain 97-27)	35%	99%
Q6MJJ2	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	51%	100%
Q6N6U0	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	33%	96%
Q71W25	Listeria monocytogenes serotype 4b (strain F2365)	33%	100%
Q72IV5	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	39%	96%
Q72RR0	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	36%	99%
Q735N7	Bacillus cereus (strain ATCC 10987 / NRS 248)	35%	100%
Q73KE1	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	35%	97%
Q73WM7	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	39%	100%
Q7MKT7	Vibrio vulnificus (strain YJ016)	56%	99%
Q7P1B9	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	36%	100%
Q7UFQ9	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	49%	100%
Q7VIN2	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	41%	95%
Q7VX46	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	33%	89%
Q7WLE5	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	33%	89%
Q81BT4	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	35%	99%
Q81NT6	Bacillus anthracis	35%	100%
Q839C6	Enterococcus faecalis (strain ATCC 700802 / V583)	32%	100%
Q83RR8	Shigella flexneri	56%	89%
Q87PH8	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	58%	100%
Q87W79	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	36%	95%
Q882K4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	25%	86%
Q885X7	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	29%	98%
Q88A13	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	35%	100%
Q88BY5	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	37%	93%
Q88ZA0	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	32%	100%
Q899G3	Clostridium tetani (strain Massachusetts / E88)	33%	98%
Q89EA6	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	33%	89%
Q89LY4	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	33%	96%
Q8A3H9	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	47%	100%
Q8CJM9	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	32%	100%
Q8CNF4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	34%	99%
Q8D9J9	Vibrio vulnificus (strain CMCP6)	56%	99%
Q8EFN2	Shewanella oneidensis (strain MR-1)	52%	100%
Q8ELR0	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	36%	100%
Q8F3Z6	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	36%	99%
Q8FIM4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	57%	89%
Q8FRV5	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	37%	96%
Q8FUC8	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	27%	86%
Q8IE47	Plasmodium falciparum (isolate 3D7)	28%	89%
Q8IRR5	Drosophila melanogaster	30%	78%
Q8K2C6	Mus musculus	37%	78%
Q8NSM4	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	37%	94%
Q8NVC8	Staphylococcus aureus (strain MW2)	36%	100%
Q8PDM9	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	33%	83%
Q8PQK3	Xanthomonas axonopodis pv. citri (strain 306)	33%	83%
Q8R104	Mus musculus	30%	73%
Q8R216	Mus musculus	29%	73%
Q8R984	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	38%	97%
Q8R9N6	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	44%	100%
Q8REC3	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	34%	96%
Q8TWG0	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	38%	97%
Q8U1Q1	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	40%	97%
Q8X8E0	Escherichia coli O157:H7	57%	89%
Q8XNS6	Clostridium perfringens (strain 13 / Type A)	35%	100%
Q8Y015	Ralstonia solanacearum (strain GMI1000)	39%	99%
Q8Y3U2	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	34%	100%
Q8ZFR1	Yersinia pestis	57%	87%
Q8ZT00	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	39%	98%
Q8ZU41	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	36%	96%
Q927A7	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	34%	100%
Q974M6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	97%
Q97MB4	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	33%	99%
Q97VX5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	36%	98%
Q9A2S6	Caulobacter vibrioides (strain ATCC 19089 / CB15)	52%	100%
Q9CBW6	Mycobacterium leprae (strain TN)	40%	100%
Q9CM50	Pasteurella multocida (strain Pm70)	59%	100%
Q9I4E1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	95%
Q9I4L0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	38%	97%
Q9I7I7	Drosophila melanogaster	32%	68%
Q9JN05	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	40%	100%
Q9KEE5	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	37%	100%
Q9KRX4	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	54%	99%
Q9NXA8	Homo sapiens	36%	78%
Q9RL35	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	81%
Q9RYD4	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	43%	99%
Q9UZE7	Pyrococcus abyssi (strain GE5 / Orsay)	40%	97%
Q9WYW0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	35%	99%
Q9Y6E7	Homo sapiens	30%	77%
Q9YB13	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	46%	99%
Q9ZAB8	Aggregatibacter actinomycetemcomitans	48%	100%
Q9ZJW8	Helicobacter pylori (strain J99 / ATCC 700824)	49%	100%
V5BKJ7	Trypanosoma cruzi	66%	100%