Nicotiana lesion-inducing like

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAS5_LEIBR

TriTrypDb:

LbrM.20.1630 , LBRM2903_200026800

Length:

156

Annotations

LeishMANIAdb annotations

A protein family with Prokaryotic affinities. Might be a subunit for some uncharacterized complex

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HAS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.516
CLV_NRD_NRD_1	152	154	PF00675	0.502
CLV_PCSK_FUR_1	136	140	PF00082	0.530
CLV_PCSK_KEX2_1	138	140	PF00082	0.511
CLV_PCSK_SKI1_1	3	7	PF00082	0.412
CLV_PCSK_SKI1_1	81	85	PF00082	0.276
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DOC_MAPK_MEF2A_6	62	71	PF00069	0.412
DOC_MAPK_MEF2A_6	7	16	PF00069	0.501
DOC_USP7_MATH_1	27	31	PF00917	0.462
DOC_WW_Pin1_4	25	30	PF00397	0.439
DOC_WW_Pin1_4	50	55	PF00397	0.496
LIG_14-3-3_CanoR_1	81	87	PF00244	0.537
LIG_eIF4E_1	8	14	PF01652	0.413
LIG_FHA_1	18	24	PF00498	0.383
LIG_FHA_1	62	68	PF00498	0.347
LIG_FHA_1	7	13	PF00498	0.494
LIG_LIR_Apic_2	102	106	PF02991	0.453
LIG_LIR_Gen_1	55	61	PF02991	0.286
LIG_LIR_Gen_1	72	79	PF02991	0.274
LIG_LIR_Gen_1	82	92	PF02991	0.299
LIG_LIR_Nem_3	55	60	PF02991	0.421
LIG_LIR_Nem_3	72	77	PF02991	0.274
LIG_LIR_Nem_3	82	87	PF02991	0.299
LIG_NRBOX	1	7	PF00104	0.646
LIG_NRBOX	72	78	PF00104	0.344
LIG_SH2_CRK	103	107	PF00017	0.350
LIG_SH2_CRK	8	12	PF00017	0.358
LIG_SH2_PTP2	57	60	PF00017	0.337
LIG_SH2_SRC	103	106	PF00017	0.351
LIG_SH2_STAT5	100	103	PF00017	0.517
LIG_SH2_STAT5	140	143	PF00017	0.573
LIG_SH2_STAT5	57	60	PF00017	0.287
LIG_SH2_STAT5	8	11	PF00017	0.344
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.358
LIG_SUMO_SIM_par_1	104	111	PF11976	0.435
LIG_TYR_ITIM	6	11	PF00017	0.487
LIG_WRC_WIRS_1	83	88	PF05994	0.443
MOD_CK1_1	82	88	PF00069	0.400
MOD_CK2_1	50	56	PF00069	0.476
MOD_GlcNHglycan	130	133	PF01048	0.331
MOD_GlcNHglycan	20	23	PF01048	0.355
MOD_GSK3_1	130	137	PF00069	0.534
MOD_GSK3_1	48	55	PF00069	0.456
MOD_N-GLC_1	119	124	PF02516	0.376
MOD_NEK2_1	128	133	PF00069	0.461
MOD_NEK2_1	18	23	PF00069	0.349
MOD_NEK2_1	36	41	PF00069	0.309
MOD_NEK2_1	48	53	PF00069	0.413
MOD_NEK2_1	6	11	PF00069	0.516
MOD_NEK2_1	92	97	PF00069	0.385
MOD_PIKK_1	138	144	PF00454	0.641
MOD_PK_1	119	125	PF00069	0.298
MOD_PKA_1	138	144	PF00069	0.641
MOD_PKA_2	138	144	PF00069	0.691
MOD_PKA_2	6	12	PF00069	0.497
MOD_PKA_2	61	67	PF00069	0.256
MOD_PKB_1	136	144	PF00069	0.639
MOD_Plk_1	119	125	PF00069	0.378
MOD_ProDKin_1	25	31	PF00069	0.439
MOD_ProDKin_1	50	56	PF00069	0.497
TRG_DiLeu_BaEn_1	56	61	PF01217	0.283
TRG_ENDOCYTIC_2	57	60	PF00928	0.276
TRG_ENDOCYTIC_2	8	11	PF00928	0.344
TRG_ER_diArg_1	136	139	PF00400	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P4	Leptomonas seymouri	61%	100%
A0A0S4JBG1	Bodo saltans	42%	93%
A0A1X0P9I8	Trypanosomatidae	48%	100%
A0A3S7X803	Leishmania donovani	73%	100%
A0A422NY54	Trypanosoma rangeli	48%	99%
A4IAM6	Leishmania infantum	73%	100%
C9ZMP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9B4Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2Y7	Leishmania major	71%	100%
V5BQ15	Trypanosoma cruzi	47%	99%