Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAS3_LEIBR

TriTrypDb:

LbrM.20.1610 , LBRM2903_200026600

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.687
CLV_NRD_NRD_1	172	174	PF00675	0.387
CLV_NRD_NRD_1	280	282	PF00675	0.451
CLV_NRD_NRD_1	295	297	PF00675	0.416
CLV_NRD_NRD_1	53	55	PF00675	0.381
CLV_PCSK_FUR_1	299	303	PF00082	0.551
CLV_PCSK_FUR_1	51	55	PF00082	0.374
CLV_PCSK_KEX2_1	172	174	PF00082	0.372
CLV_PCSK_KEX2_1	280	282	PF00082	0.450
CLV_PCSK_KEX2_1	295	297	PF00082	0.441
CLV_PCSK_KEX2_1	301	303	PF00082	0.450
CLV_PCSK_KEX2_1	53	55	PF00082	0.381
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.492
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.523
CLV_PCSK_SKI1_1	201	205	PF00082	0.444
CLV_PCSK_SKI1_1	282	286	PF00082	0.366
DOC_MAPK_FxFP_2	123	126	PF00069	0.378
DOC_MAPK_gen_1	172	179	PF00069	0.571
DOC_MAPK_gen_1	215	223	PF00069	0.705
DOC_MAPK_gen_1	280	286	PF00069	0.579
DOC_MAPK_MEF2A_6	172	179	PF00069	0.597
DOC_PP1_RVXF_1	88	94	PF00149	0.360
DOC_PP4_FxxP_1	123	126	PF00568	0.378
DOC_USP7_UBL2_3	297	301	PF12436	0.721
DOC_WW_Pin1_4	190	195	PF00397	0.628
DOC_WW_Pin1_4	239	244	PF00397	0.680
LIG_14-3-3_CanoR_1	13	20	PF00244	0.680
LIG_14-3-3_CanoR_1	94	100	PF00244	0.296
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.640
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_deltaCOP1_diTrp_1	247	255	PF00928	0.624
LIG_deltaCOP1_diTrp_1	49	56	PF00928	0.570
LIG_FHA_1	21	27	PF00498	0.647
LIG_FHA_1	218	224	PF00498	0.563
LIG_FHA_1	240	246	PF00498	0.682
LIG_FHA_2	228	234	PF00498	0.688
LIG_FHA_2	261	267	PF00498	0.651
LIG_FHA_2	6	12	PF00498	0.657
LIG_LIR_Apic_2	121	126	PF02991	0.497
LIG_LIR_Gen_1	106	115	PF02991	0.352
LIG_LIR_Gen_1	24	35	PF02991	0.640
LIG_LIR_Gen_1	244	252	PF02991	0.631
LIG_LIR_Gen_1	96	105	PF02991	0.355
LIG_LIR_Nem_3	106	112	PF02991	0.352
LIG_LIR_Nem_3	121	127	PF02991	0.496
LIG_LIR_Nem_3	24	30	PF02991	0.553
LIG_LIR_Nem_3	244	249	PF02991	0.628
LIG_LIR_Nem_3	253	257	PF02991	0.494
LIG_LIR_Nem_3	64	69	PF02991	0.363
LIG_LIR_Nem_3	96	102	PF02991	0.347
LIG_LYPXL_yS_3	125	128	PF13949	0.335
LIG_MYND_1	194	198	PF01753	0.643
LIG_Pex14_1	52	56	PF04695	0.653
LIG_Pex14_2	151	155	PF04695	0.408
LIG_Pex14_2	251	255	PF04695	0.617
LIG_Pex14_2	72	76	PF04695	0.447
LIG_SH2_CRK	27	31	PF00017	0.551
LIG_SH2_CRK	66	70	PF00017	0.377
LIG_SH2_GRB2like	205	208	PF00017	0.675
LIG_SH2_STAP1	95	99	PF00017	0.313
LIG_SH2_STAT5	27	30	PF00017	0.691
LIG_SH2_STAT5	47	50	PF00017	0.581
LIG_SH2_STAT5	85	88	PF00017	0.357
LIG_SH2_STAT5	95	98	PF00017	0.276
LIG_SH3_3	246	252	PF00018	0.628
LIG_SUMO_SIM_par_1	135	141	PF11976	0.355
LIG_SUMO_SIM_par_1	219	224	PF11976	0.655
LIG_TRAF2_1	209	212	PF00917	0.653
LIG_TRAF2_1	263	266	PF00917	0.649
MOD_CK1_1	138	144	PF00069	0.622
MOD_CK1_1	18	24	PF00069	0.723
MOD_CK1_1	239	245	PF00069	0.708
MOD_CK2_1	18	24	PF00069	0.670
MOD_CK2_1	260	266	PF00069	0.651
MOD_CK2_1	76	82	PF00069	0.395
MOD_GlcNHglycan	106	109	PF01048	0.447
MOD_GlcNHglycan	17	20	PF01048	0.586
MOD_GSK3_1	138	145	PF00069	0.486
MOD_GSK3_1	14	21	PF00069	0.684
MOD_GSK3_1	217	224	PF00069	0.739
MOD_N-GLC_1	239	244	PF02516	0.480
MOD_NEK2_1	104	109	PF00069	0.354
MOD_NEK2_1	14	19	PF00069	0.678
MOD_NEK2_1	56	61	PF00069	0.482
MOD_NEK2_1	76	81	PF00069	0.209
MOD_PIKK_1	138	144	PF00454	0.456
MOD_PKA_2	217	223	PF00069	0.562
MOD_PKA_2	76	82	PF00069	0.388
MOD_PKA_2	93	99	PF00069	0.217
MOD_Plk_1	227	233	PF00069	0.688
MOD_Plk_4	165	171	PF00069	0.489
MOD_Plk_4	233	239	PF00069	0.724
MOD_Plk_4	56	62	PF00069	0.436
MOD_ProDKin_1	190	196	PF00069	0.621
MOD_ProDKin_1	239	245	PF00069	0.680
TRG_DiLeu_BaEn_1	265	270	PF01217	0.691
TRG_DiLeu_BaEn_1	289	294	PF01217	0.682
TRG_DiLeu_BaEn_4	265	271	PF01217	0.720
TRG_ENDOCYTIC_2	124	127	PF00928	0.337
TRG_ENDOCYTIC_2	200	203	PF00928	0.652
TRG_ENDOCYTIC_2	27	30	PF00928	0.632
TRG_ENDOCYTIC_2	66	69	PF00928	0.353
TRG_ENDOCYTIC_2	89	92	PF00928	0.357
TRG_ER_diArg_1	52	54	PF00400	0.573
TRG_NLS_Bipartite_1	280	300	PF00514	0.717
TRG_NLS_MonoExtC_3	294	299	PF00514	0.719
TRG_NLS_MonoExtN_4	295	300	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X7	Leptomonas seymouri	85%	100%
A0A0S4J844	Bodo saltans	53%	96%
A0A1X0P9K7	Trypanosomatidae	65%	100%
A0A3Q8II60	Leishmania donovani	89%	100%
A4IAM4	Leishmania infantum	89%	100%
C9ZMP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B4Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2Y9	Leishmania major	89%	100%
V5BQ04	Trypanosoma cruzi	67%	100%