Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAS1_LEIBR

TriTrypDb:

LbrM.20.1580 , LBRM2903_200026300

Length:

385

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HAS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAS1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0019538	protein metabolic process	3	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0004674	protein serine/threonine kinase activity	4	4
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	23
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.392
CLV_NRD_NRD_1	242	244	PF00675	0.392
CLV_NRD_NRD_1	49	51	PF00675	0.539
CLV_NRD_NRD_1	59	61	PF00675	0.403
CLV_PCSK_KEX2_1	242	244	PF00082	0.392
CLV_PCSK_KEX2_1	49	51	PF00082	0.518
CLV_PCSK_KEX2_1	59	61	PF00082	0.369
CLV_PCSK_PC7_1	238	244	PF00082	0.392
CLV_PCSK_SKI1_1	107	111	PF00082	0.279
CLV_PCSK_SKI1_1	193	197	PF00082	0.284
CLV_PCSK_SKI1_1	259	263	PF00082	0.155
CLV_PCSK_SKI1_1	80	84	PF00082	0.334
CLV_PCSK_SKI1_1	86	90	PF00082	0.320
DOC_CKS1_1	244	249	PF01111	0.279
DOC_CYCLIN_RxL_1	126	136	PF00134	0.234
DOC_MAPK_gen_1	193	202	PF00069	0.246
DOC_MAPK_gen_1	49	55	PF00069	0.456
DOC_MAPK_MEF2A_6	127	135	PF00069	0.270
DOC_PP2B_LxvP_1	367	370	PF13499	0.489
DOC_USP7_MATH_1	20	24	PF00917	0.571
DOC_USP7_MATH_1	78	82	PF00917	0.353
DOC_WW_Pin1_4	232	237	PF00397	0.284
DOC_WW_Pin1_4	243	248	PF00397	0.284
DOC_WW_Pin1_4	320	325	PF00397	0.405
LIG_14-3-3_CanoR_1	107	117	PF00244	0.242
LIG_14-3-3_CanoR_1	242	247	PF00244	0.251
LIG_14-3-3_CanoR_1	314	321	PF00244	0.263
LIG_14-3-3_CanoR_1	97	103	PF00244	0.296
LIG_BRCT_BRCA1_1	270	274	PF00533	0.204
LIG_BRCT_BRCA1_1	314	318	PF00533	0.476
LIG_FHA_1	116	122	PF00498	0.320
LIG_FHA_1	148	154	PF00498	0.360
LIG_FHA_1	203	209	PF00498	0.393
LIG_FHA_1	219	225	PF00498	0.206
LIG_FHA_2	215	221	PF00498	0.371
LIG_FHA_2	244	250	PF00498	0.273
LIG_FHA_2	371	377	PF00498	0.431
LIG_LIR_Apic_2	230	236	PF02991	0.284
LIG_LIR_Gen_1	271	281	PF02991	0.278
LIG_LIR_Gen_1	315	326	PF02991	0.456
LIG_LIR_Gen_1	52	61	PF02991	0.344
LIG_LIR_Nem_3	271	277	PF02991	0.313
LIG_LIR_Nem_3	315	321	PF02991	0.476
LIG_LIR_Nem_3	52	58	PF02991	0.498
LIG_LYPXL_yS_3	287	290	PF13949	0.392
LIG_MYND_1	3	7	PF01753	0.561
LIG_NRBOX	339	345	PF00104	0.285
LIG_PTB_Apo_2	120	127	PF02174	0.261
LIG_PTB_Phospho_1	120	126	PF10480	0.261
LIG_SH2_CRK	244	248	PF00017	0.279
LIG_SH2_GRB2like	137	140	PF00017	0.274
LIG_SH2_NCK_1	244	248	PF00017	0.279
LIG_SH2_STAP1	117	121	PF00017	0.289
LIG_SH2_STAT5	117	120	PF00017	0.323
LIG_SH2_STAT5	160	163	PF00017	0.277
LIG_SH2_STAT5	75	78	PF00017	0.309
LIG_SH3_3	176	182	PF00018	0.384
LIG_SH3_3	45	51	PF00018	0.473
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.312
LIG_TRAF2_1	373	376	PF00917	0.431
LIG_UBA3_1	277	286	PF00899	0.392
LIG_WRC_WIRS_1	224	229	PF05994	0.279
MOD_CDC14_SPxK_1	235	238	PF00782	0.284
MOD_CDK_SPxK_1	232	238	PF00069	0.284
MOD_CDK_SPxxK_3	320	327	PF00069	0.257
MOD_CK1_1	218	224	PF00069	0.268
MOD_CK1_1	245	251	PF00069	0.277
MOD_CK1_1	365	371	PF00069	0.706
MOD_CK2_1	214	220	PF00069	0.344
MOD_CK2_1	313	319	PF00069	0.315
MOD_CK2_1	370	376	PF00069	0.681
MOD_Cter_Amidation	240	243	PF01082	0.392
MOD_GlcNHglycan	15	18	PF01048	0.588
MOD_GlcNHglycan	217	220	PF01048	0.292
MOD_GlcNHglycan	315	318	PF01048	0.377
MOD_GSK3_1	111	118	PF00069	0.305
MOD_GSK3_1	173	180	PF00069	0.340
MOD_GSK3_1	214	221	PF00069	0.307
MOD_GSK3_1	223	230	PF00069	0.277
MOD_GSK3_1	245	252	PF00069	0.260
MOD_GSK3_1	358	365	PF00069	0.656
MOD_GSK3_1	371	378	PF00069	0.698
MOD_GSK3_1	74	81	PF00069	0.396
MOD_GSK3_1	86	93	PF00069	0.348
MOD_NEK2_1	201	206	PF00069	0.321
MOD_NEK2_1	227	232	PF00069	0.256
MOD_NEK2_1	290	295	PF00069	0.346
MOD_NEK2_1	302	307	PF00069	0.289
MOD_NEK2_2	78	83	PF00069	0.437
MOD_PIKK_1	160	166	PF00454	0.313
MOD_PIKK_1	293	299	PF00454	0.275
MOD_PIKK_1	65	71	PF00454	0.263
MOD_PKA_1	242	248	PF00069	0.392
MOD_PKA_1	86	92	PF00069	0.392
MOD_PKA_2	242	248	PF00069	0.393
MOD_PKA_2	313	319	PF00069	0.284
MOD_PKA_2	370	376	PF00069	0.462
MOD_PKA_2	98	104	PF00069	0.328
MOD_Plk_1	115	121	PF00069	0.340
MOD_Plk_1	353	359	PF00069	0.527
MOD_Plk_1	362	368	PF00069	0.641
MOD_Plk_1	78	84	PF00069	0.305
MOD_Plk_2-3	280	286	PF00069	0.392
MOD_Plk_4	223	229	PF00069	0.261
MOD_Plk_4	78	84	PF00069	0.437
MOD_ProDKin_1	232	238	PF00069	0.284
MOD_ProDKin_1	243	249	PF00069	0.284
MOD_ProDKin_1	320	326	PF00069	0.405
TRG_AP2beta_CARGO_1	52	62	PF09066	0.345
TRG_DiLeu_BaEn_1	336	341	PF01217	0.462
TRG_DiLeu_BaEn_2	297	303	PF01217	0.293
TRG_ENDOCYTIC_2	122	125	PF00928	0.304
TRG_ENDOCYTIC_2	287	290	PF00928	0.348
TRG_ER_diArg_1	126	129	PF00400	0.234
TRG_ER_diArg_1	242	244	PF00400	0.392
TRG_ER_diArg_1	48	50	PF00400	0.509
TRG_ER_diArg_1	58	60	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	28%	69%
A0A0N0P3N5	Leptomonas seymouri	27%	90%
A0A0N0P3Q8	Leptomonas seymouri	35%	100%
A0A0N0P6T0	Leptomonas seymouri	24%	70%
A0A0N0P787	Leptomonas seymouri	27%	100%
A0A0N0P8X6	Leptomonas seymouri	79%	99%
A0A0N1HVN6	Leptomonas seymouri	29%	100%
A0A0N1HWQ2	Leptomonas seymouri	25%	100%
A0A0N1HY86	Leptomonas seymouri	28%	74%
A0A0N1I0B6	Leptomonas seymouri	32%	72%
A0A0N1IIF9	Leptomonas seymouri	23%	100%
A0A0N1IM47	Leptomonas seymouri	24%	100%
A0A0N1PC31	Leptomonas seymouri	30%	99%
A0A0N1PD05	Leptomonas seymouri	26%	86%
A0A0S4IHW4	Bodo saltans	30%	86%
A0A0S4IKC2	Bodo saltans	28%	100%
A0A0S4IKH2	Bodo saltans	27%	78%
A0A0S4IMB7	Bodo saltans	25%	87%
A0A0S4IQX7	Bodo saltans	29%	100%
A0A0S4IRZ7	Bodo saltans	26%	78%
A0A0S4IX86	Bodo saltans	28%	90%
A0A0S4J3Y5	Bodo saltans	28%	90%
A0A0S4J444	Bodo saltans	47%	96%
A0A0S4J4X4	Bodo saltans	29%	100%
A0A0S4J6L4	Bodo saltans	29%	100%
A0A0S4J9Q7	Bodo saltans	29%	85%
A0A0S4J9Y8	Bodo saltans	27%	72%
A0A0S4JA09	Bodo saltans	28%	93%
A0A0S4JBR3	Bodo saltans	25%	100%
A0A0S4JCG2	Bodo saltans	27%	86%
A0A0S4JER5	Bodo saltans	27%	85%
A0A0S4JHA7	Bodo saltans	27%	84%
A0A0S4JK24	Bodo saltans	28%	89%
A0A0S4JNA1	Bodo saltans	28%	78%
A0A0S4JUJ2	Bodo saltans	27%	100%
A0A0S4JUT0	Bodo saltans	32%	72%
A0A0S4KHR9	Bodo saltans	35%	100%
A0A0S4KN74	Bodo saltans	27%	100%
A0A1X0NFW4	Trypanosomatidae	27%	81%
A0A1X0NIA0	Trypanosomatidae	28%	90%
A0A1X0NIX2	Trypanosomatidae	26%	88%
A0A1X0NKA1	Trypanosomatidae	25%	87%
A0A1X0NM94	Trypanosomatidae	26%	76%
A0A1X0NNE5	Trypanosomatidae	30%	76%
A0A1X0NRZ9	Trypanosomatidae	28%	100%
A0A1X0NTP1	Trypanosomatidae	32%	66%
A0A1X0NUQ4	Trypanosomatidae	27%	100%
A0A1X0NW24	Trypanosomatidae	38%	100%
A0A1X0NWB9	Trypanosomatidae	28%	80%
A0A1X0NWR7	Trypanosomatidae	30%	75%
A0A1X0NY93	Trypanosomatidae	26%	98%
A0A1X0NYK8	Trypanosomatidae	24%	100%
A0A1X0NYS1	Trypanosomatidae	28%	75%
A0A1X0P4Z7	Trypanosomatidae	29%	69%
A0A1X0P527	Trypanosomatidae	26%	87%
A0A1X0P6F5	Trypanosomatidae	27%	100%
A0A1X0P6V1	Trypanosomatidae	24%	100%
A0A1X0P735	Trypanosomatidae	25%	100%
A0A1X0P8A0	Trypanosomatidae	28%	100%
A0A1X0P8F7	Trypanosomatidae	24%	89%
A0A1X0P919	Trypanosomatidae	32%	100%
A0A1X0P935	Trypanosomatidae	31%	100%
A0A1X0P9C4	Trypanosomatidae	28%	77%
A0A1X0PAW2	Trypanosomatidae	61%	100%
A0A3Q8IEH3	Leishmania donovani	25%	100%
A0A3Q8IFK8	Leishmania donovani	28%	87%
A0A3Q8IFW0	Leishmania donovani	26%	90%
A0A3Q8IHH8	Leishmania donovani	28%	77%
A0A3Q8IIG1	Leishmania donovani	26%	100%
A0A3Q8IIH5	Leishmania donovani	29%	69%
A0A3Q8IND3	Leishmania donovani	34%	73%
A0A3Q8INQ4	Leishmania donovani	30%	99%
A0A3Q8IRT6	Leishmania donovani	26%	75%
A0A3R7K109	Trypanosoma rangeli	28%	81%
A0A3R7KMF0	Trypanosoma rangeli	57%	100%
A0A3R7KRP1	Trypanosoma rangeli	28%	81%
A0A3R7M1U6	Trypanosoma rangeli	31%	100%
A0A3R7M819	Trypanosoma rangeli	36%	100%
A0A3R7MKG5	Trypanosoma rangeli	27%	88%
A0A3R7MKJ1	Trypanosoma rangeli	30%	71%
A0A3R7N4D8	Trypanosoma rangeli	27%	95%
A0A3R7NKI8	Trypanosoma rangeli	26%	100%
A0A3R7RIN5	Trypanosoma rangeli	28%	77%
A0A3R7RLL1	Trypanosoma rangeli	28%	89%
A0A3S5H4Z4	Leishmania donovani	24%	73%
A0A3S5IRC3	Trypanosoma rangeli	32%	100%
A0A3S7WUE7	Leishmania donovani	30%	70%
A0A3S7WUX5	Leishmania donovani	23%	100%
A0A3S7WYP4	Leishmania donovani	35%	100%
A0A3S7X123	Leishmania donovani	28%	100%
A0A3S7X2W3	Leishmania donovani	26%	100%
A0A3S7X2W9	Leishmania donovani	24%	100%
A0A3S7X6T8	Leishmania donovani	26%	86%
A0A3S7X7D5	Leishmania donovani	27%	100%
A0A3S7X7Y2	Leishmania donovani	88%	100%
A0A422N3Y6	Trypanosoma rangeli	28%	87%
A0A422N701	Trypanosoma rangeli	28%	86%
A0A422NFN4	Trypanosoma rangeli	32%	76%
A0A422NH41	Trypanosoma rangeli	24%	67%
A0A422NU88	Trypanosoma rangeli	30%	70%
A0A422NUF0	Trypanosoma rangeli	25%	96%
A0A422P0N6	Trypanosoma rangeli	30%	100%
A0A422P1R5	Trypanosoma rangeli	25%	100%
A0A422P270	Trypanosoma rangeli	25%	87%
A0A422P292	Trypanosoma rangeli	28%	100%
A0A422P4L8	Trypanosoma rangeli	27%	90%
A0A422P4V9	Trypanosoma rangeli	24%	84%
A0A8I3S724	Canis lupus familiaris	29%	95%
A2BD05	Sus scrofa	28%	100%
A4H3C7	Leishmania braziliensis	26%	73%
A4H7W1	Leishmania braziliensis	29%	70%
A4H9H4	Leishmania braziliensis	23%	100%
A4HAC8	Leishmania braziliensis	26%	100%
A4HDJ5	Leishmania braziliensis	28%	71%
A4HDU3	Leishmania braziliensis	36%	100%
A4HED7	Leishmania braziliensis	29%	100%
A4HG92	Leishmania braziliensis	24%	100%
A4HHN1	Leishmania braziliensis	26%	100%
A4HHQ5	Leishmania braziliensis	28%	76%
A4HHS9	Leishmania braziliensis	24%	100%
A4HI35	Leishmania braziliensis	26%	75%
A4HJT5	Leishmania braziliensis	29%	87%
A4HJW2	Leishmania braziliensis	26%	90%
A4HLR0	Leishmania braziliensis	27%	86%
A4HNI1	Leishmania braziliensis	26%	81%
A4HNU6	Leishmania braziliensis	34%	73%
A4HRM6	Leishmania infantum	24%	73%
A4HW88	Leishmania infantum	29%	69%
A4HX71	Leishmania infantum	30%	70%
A4HXU0	Leishmania infantum	23%	100%
A4I140	Leishmania infantum	35%	100%
A4I1T4	Leishmania infantum	30%	99%
A4I3C6	Leishmania infantum	25%	100%
A4I435	Leishmania infantum	26%	100%
A4I4U6	Leishmania infantum	26%	100%
A4I4X0	Leishmania infantum	28%	77%
A4I4Y0	Leishmania infantum	24%	100%
A4I5B1	Leishmania infantum	26%	75%
A4I7A1	Leishmania infantum	28%	87%
A4I7C4	Leishmania infantum	27%	90%
A4I960	Leishmania infantum	26%	86%
A4I9H1	Leishmania infantum	27%	100%
A4I9Y5	Leishmania infantum	88%	100%
A4ICP8	Leishmania infantum	34%	73%
A4IGM9	Xenopus tropicalis	26%	100%
A4K2M3	Papio anubis	28%	79%
A4K2P5	Colobus guereza	28%	79%
A4K2Q5	Otolemur garnettii	28%	79%
A4K2S1	Lemur catta	28%	79%
A4K2T0	Macaca mulatta	28%	79%
A4K2W5	Aotus nancymaae	28%	79%
A4K2Y1	Chlorocebus aethiops	28%	79%
A5GFW1	Sus scrofa	30%	96%
A8WXF6	Caenorhabditis briggsae	29%	72%
A8XJW8	Caenorhabditis briggsae	30%	78%
A9RWC9	Physcomitrium patens	34%	100%
A9S5R3	Physcomitrium patens	34%	100%
A9SR33	Physcomitrium patens	33%	100%
B0LT89	Rattus norvegicus	28%	89%
B0XPE4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	31%	77%
C6K3W8	Leptomonas seymouri	25%	73%
C9ZIZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	85%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
C9ZKX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	77%
C9ZLJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	84%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	71%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZWG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	98%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A0D3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A2M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A2R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0AA64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	67%
D3ZBE5	Rattus norvegicus	29%	100%
D3ZHP7	Rattus norvegicus	28%	82%
D7UQM5	Patiria pectinifera	29%	95%
E9ACW6	Leishmania major	28%	100%
E9ACW7	Leishmania major	26%	69%
E9AEB9	Leishmania major	28%	77%
E9AED4	Leishmania major	25%	100%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	77%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9APY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	69%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	73%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	79%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	75%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	87%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	90%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	86%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
G4N6Z6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	32%	73%
G4NEB8	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	93%
G5EDF7	Caenorhabditis elegans	26%	100%
G5EDT6	Caenorhabditis elegans	26%	89%
G5EFM9	Caenorhabditis elegans	31%	100%
G5EFU0	Caenorhabditis elegans	27%	74%
J9W0G9	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	27%	67%
O00506	Homo sapiens	28%	90%
O09110	Mus musculus	32%	100%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O14305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	82%
O14733	Homo sapiens	27%	92%
O14965	Homo sapiens	29%	96%
O23304	Arabidopsis thaliana	26%	79%
O54748	Rattus norvegicus	29%	78%
O55099	Rattus norvegicus	28%	100%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O61122	Dictyostelium discoideum	29%	81%
O61125	Dictyostelium discoideum	29%	84%
O64629	Arabidopsis thaliana	29%	100%
O70126	Mus musculus	29%	100%
O75914	Homo sapiens	29%	69%
O77708	Oryctolagus cuniculus	27%	72%
O80396	Arabidopsis thaliana	34%	74%
O80397	Arabidopsis thaliana	31%	100%
O88445	Mus musculus	27%	100%
O88643	Mus musculus	30%	71%
O95747	Homo sapiens	26%	73%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	97%
P06784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	75%
P08413	Rattus norvegicus	27%	71%
P10506	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P11275	Rattus norvegicus	28%	81%
P11730	Rattus norvegicus	27%	73%
P11798	Mus musculus	28%	81%
P15791	Rattus norvegicus	27%	72%
P22517	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	86%
P23443	Homo sapiens	28%	73%
P28178	Dictyostelium discoideum	27%	80%
P28652	Mus musculus	27%	71%
P29678	Oryctolagus cuniculus	29%	98%
P31938	Mus musculus	29%	98%
P32490	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	76%
P32491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	76%
P35465	Rattus norvegicus	30%	71%
P36506	Rattus norvegicus	29%	96%
P36507	Homo sapiens	28%	96%
P42818	Arabidopsis thaliana	27%	83%
P45985	Homo sapiens	28%	96%
P46734	Homo sapiens	32%	100%
P47809	Mus musculus	28%	97%
P52564	Homo sapiens	30%	100%
P54644	Dictyostelium discoideum	26%	87%
P54666	Trypanosoma brucei brucei	29%	100%
P59241	Rattus norvegicus	29%	97%
P59895	Rattus norvegicus	28%	100%
P67998	Oryctolagus cuniculus	28%	73%
P67999	Rattus norvegicus	28%	73%
P70236	Mus musculus	30%	100%
P97477	Mus musculus	29%	97%
Q01986	Rattus norvegicus	29%	98%
Q02750	Homo sapiens	29%	98%
Q05116	Xenopus laevis	28%	97%
Q07192	Xenopus laevis	29%	86%
Q08942	Trypanosoma brucei brucei	27%	89%
Q08E52	Bos taurus	30%	71%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	84%
Q0PKV7	Leishmania mexicana	34%	73%
Q0VD22	Bos taurus	26%	79%
Q10664	Caenorhabditis elegans	27%	99%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	88%
Q13043	Homo sapiens	28%	79%
Q13153	Homo sapiens	30%	71%
Q13163	Homo sapiens	31%	86%
Q13177	Homo sapiens	29%	73%
Q13188	Homo sapiens	30%	78%
Q13555	Homo sapiens	27%	69%
Q17850	Caenorhabditis elegans	25%	67%
Q1HG70	Canis lupus familiaris	29%	96%
Q1PFH8	Arabidopsis thaliana	27%	70%
Q21307	Caenorhabditis elegans	29%	100%
Q24324	Drosophila melanogaster	30%	97%
Q29502	Oryctolagus cuniculus	29%	73%
Q2QY37	Oryza sativa subsp. japonica	29%	71%
Q2RAV0	Oryza sativa subsp. japonica	29%	71%
Q2TA06	Bos taurus	29%	96%
Q38868	Arabidopsis thaliana	28%	71%
Q39030	Arabidopsis thaliana	26%	82%
Q3E9C0	Arabidopsis thaliana	28%	74%
Q3SWY6	Bos taurus	28%	90%
Q3U3Q1	Mus musculus	27%	82%
Q4KSH7	Rattus norvegicus	27%	92%
Q4Q1Z0	Leishmania major	33%	75%
Q4Q2Z2	Leishmania major	87%	100%
Q4Q3Y9	Leishmania major	25%	86%
Q4Q5T9	Leishmania major	26%	90%
Q4Q5W2	Leishmania major	29%	87%
Q4Q7M5	Leishmania major	26%	75%
Q4Q8T4	Leishmania major	28%	100%
Q4Q9K2	Leishmania major	30%	100%
Q4QA98	Leishmania major	34%	100%
Q4QDX7	Leishmania major	23%	100%
Q4QEJ2	Leishmania major	30%	70%
Q4QFJ2	Leishmania major	29%	69%
Q4WJJ0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	77%
Q54CY9	Dictyostelium discoideum	28%	100%
Q54JG7	Dictyostelium discoideum	29%	79%
Q54PB4	Dictyostelium discoideum	27%	80%
Q54PX0	Dictyostelium discoideum	30%	78%
Q54WX4	Dictyostelium discoideum	26%	100%
Q54XL6	Dictyostelium discoideum	28%	67%
Q54Y26	Dictyostelium discoideum	25%	73%
Q556S2	Dictyostelium discoideum	26%	75%
Q55BN8	Dictyostelium discoideum	27%	92%
Q55GV3	Dictyostelium discoideum	29%	81%
Q5BKK4	Xenopus tropicalis	25%	92%
Q5E9L6	Bos taurus	28%	79%
Q5E9X2	Bos taurus	30%	100%
Q5QN75	Oryza sativa subsp. japonica	32%	100%
Q5R495	Pongo abelii	28%	73%
Q5R7A7	Pongo abelii	25%	78%
Q5RCC4	Pongo abelii	28%	81%
Q5VQQ5	Oryza sativa subsp. japonica	29%	75%
Q5ZJK4	Gallus gallus	28%	79%
Q5ZKI0	Gallus gallus	28%	80%
Q61036	Mus musculus	29%	69%
Q61RA2	Caenorhabditis briggsae	28%	78%
Q61XD3	Caenorhabditis briggsae	25%	100%
Q62829	Rattus norvegicus	29%	71%
Q62862	Rattus norvegicus	31%	86%
Q63932	Mus musculus	29%	96%
Q63980	Cricetulus griseus	29%	98%
Q64303	Rattus norvegicus	30%	73%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	93%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
Q6DE08	Xenopus laevis	26%	100%
Q6DEH3	Danio rerio	27%	78%
Q6DGS3	Danio rerio	27%	69%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6GLY8	Xenopus laevis	24%	89%
Q6GPL3	Xenopus laevis	26%	100%
Q6GPN6	Xenopus laevis	25%	89%
Q6IP06	Xenopus laevis	30%	78%
Q6IP76	Xenopus laevis	25%	79%
Q6NW76	Danio rerio	28%	100%
Q6P3Q4	Xenopus tropicalis	31%	79%
Q6PA14	Xenopus laevis	31%	79%
Q6PHR2	Homo sapiens	26%	82%
Q6TJY3	Bos taurus	28%	73%
Q6YY75	Oryza sativa subsp. japonica	29%	72%
Q6Z2M9	Oryza sativa subsp. japonica	28%	74%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7TSE6	Mus musculus	26%	83%
Q7YQL3	Pongo pygmaeus	29%	69%
Q7YQL4	Pan troglodytes	29%	69%
Q7YRC6	Bos taurus	28%	100%
Q7ZUQ3	Danio rerio	29%	78%
Q802A6	Squalus acanthias	29%	78%
Q863I2	Sus scrofa	26%	73%
Q8AXB4	Xenopus laevis	29%	68%
Q8BGW6	Mus musculus	26%	97%
Q8BSK8	Mus musculus	28%	73%
Q8CE90	Mus musculus	27%	72%
Q8CIN4	Mus musculus	30%	73%
Q8MYF1	Dictyostelium discoideum	29%	84%
Q8QZV4	Mus musculus	28%	79%
Q8R4V0	Rattus norvegicus	27%	78%
Q8RXG3	Arabidopsis thaliana	31%	100%
Q8RXT4	Arabidopsis thaliana	29%	69%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8TDX7	Homo sapiens	29%	100%
Q8WU08	Homo sapiens	26%	97%
Q90891	Gallus gallus	29%	97%
Q91447	Serinus canaria	28%	99%
Q91819	Xenopus laevis	29%	94%
Q91820	Xenopus laevis	29%	95%
Q923T9	Mus musculus	27%	73%
Q93VK0	Arabidopsis thaliana	27%	100%
Q94A06	Arabidopsis thaliana	32%	100%
Q96BR1	Homo sapiens	25%	78%
Q96GD4	Homo sapiens	29%	100%
Q99JT2	Mus musculus	27%	93%
Q99KH8	Mus musculus	28%	89%
Q9BYT3	Homo sapiens	27%	75%
Q9C6P3	Arabidopsis thaliana	28%	74%
Q9DGE0	Danio rerio	27%	100%
Q9ERE3	Mus musculus	26%	78%
Q9ES70	Mus musculus	28%	100%
Q9ES74	Mus musculus	29%	100%
Q9FJV0	Arabidopsis thaliana	31%	100%
Q9FMP5	Arabidopsis thaliana	28%	73%
Q9FX43	Arabidopsis thaliana	30%	100%
Q9GM70	Oryctolagus cuniculus	27%	97%
Q9GRT1	Leishmania mexicana	35%	100%
Q9HBY8	Homo sapiens	26%	100%
Q9HC98	Homo sapiens	28%	100%
Q9JI10	Mus musculus	29%	77%
Q9JI11	Mus musculus	28%	79%
Q9JJX8	Mus musculus	29%	93%
Q9LP51	Arabidopsis thaliana	26%	74%
Q9LPQ3	Arabidopsis thaliana	32%	100%
Q9LQM8	Arabidopsis thaliana	29%	100%
Q9LT35	Arabidopsis thaliana	27%	93%
Q9M0T3	Arabidopsis thaliana	30%	69%
Q9M8J5	Arabidopsis thaliana	31%	100%
Q9N0X0	Sus scrofa	28%	100%
Q9N2N1	Leishmania major	25%	100%
Q9NB31	Caenorhabditis elegans	30%	77%
Q9NY57	Homo sapiens	28%	93%
Q9P289	Homo sapiens	27%	93%
Q9P7J8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	68%
Q9R0A5	Mus musculus	27%	75%
Q9S7U9	Arabidopsis thaliana	33%	100%
Q9U2H1	Caenorhabditis elegans	28%	100%
Q9UEE5	Homo sapiens	27%	93%
Q9UQB9	Homo sapiens	29%	100%
Q9UQM7	Homo sapiens	28%	81%
Q9WVS7	Mus musculus	32%	86%
Q9XT09	Pan troglodytes	29%	98%
Q9Y077	Leishmania major	26%	100%
Q9Y2H1	Homo sapiens	27%	83%
Q9Y6E0	Homo sapiens	28%	87%
Q9Y884	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9Z2W1	Mus musculus	28%	90%
Q9ZSA4	Arabidopsis thaliana	29%	79%
V5B141	Trypanosoma cruzi	28%	81%
V5B871	Trypanosoma cruzi	26%	90%
V5B9R6	Trypanosoma cruzi	37%	100%
V5BC28	Trypanosoma cruzi	26%	77%
V5BFI8	Trypanosoma cruzi	29%	87%
V5BG98	Trypanosoma cruzi	25%	100%
V5BKJ3	Trypanosoma cruzi	56%	100%
V5BP88	Trypanosoma cruzi	25%	83%
V5BQF4	Trypanosoma cruzi	33%	100%
V5BR65	Trypanosoma cruzi	24%	96%
V5BV49	Trypanosoma cruzi	28%	100%
V5BWC2	Trypanosoma cruzi	25%	100%
V5BX61	Trypanosoma cruzi	31%	100%
V5C224	Trypanosoma cruzi	28%	77%
V5C234	Trypanosoma cruzi	27%	71%
V5D579	Trypanosoma cruzi	26%	90%
V5D9M1	Trypanosoma cruzi	28%	100%
V5DC40	Trypanosoma cruzi	29%	71%
V5DPP5	Trypanosoma cruzi	28%	89%
V5DUH0	Trypanosoma cruzi	30%	70%