Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAR8_LEIBR

TriTrypDb:

LbrM.20.1550 , LBRM2903_200025900

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.799
CLV_C14_Caspase3-7	268	272	PF00656	0.662
CLV_NRD_NRD_1	191	193	PF00675	0.729
CLV_NRD_NRD_1	204	206	PF00675	0.671
CLV_PCSK_KEX2_1	191	193	PF00082	0.696
CLV_PCSK_KEX2_1	204	206	PF00082	0.671
CLV_PCSK_KEX2_1	291	293	PF00082	0.670
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.670
DOC_CKS1_1	127	132	PF01111	0.739
DOC_CKS1_1	45	50	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.458
DOC_MAPK_gen_1	291	298	PF00069	0.453
DOC_MAPK_MEF2A_6	291	298	PF00069	0.652
DOC_PP2B_LxvP_1	5	8	PF13499	0.480
DOC_PP4_FxxP_1	45	48	PF00568	0.630
DOC_USP7_MATH_1	241	245	PF00917	0.599
DOC_USP7_MATH_1	265	269	PF00917	0.505
DOC_USP7_MATH_1	48	52	PF00917	0.642
DOC_USP7_MATH_1	71	75	PF00917	0.477
DOC_USP7_UBL2_3	12	16	PF12436	0.544
DOC_WW_Pin1_4	126	131	PF00397	0.728
DOC_WW_Pin1_4	211	216	PF00397	0.561
DOC_WW_Pin1_4	242	247	PF00397	0.646
DOC_WW_Pin1_4	283	288	PF00397	0.643
DOC_WW_Pin1_4	44	49	PF00397	0.602
LIG_14-3-3_CanoR_1	62	68	PF00244	0.554
LIG_14-3-3_CterR_2	305	309	PF00244	0.423
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BIR_III_4	157	161	PF00653	0.587
LIG_BIR_III_4	198	202	PF00653	0.545
LIG_BRCT_BRCA1_1	22	26	PF00533	0.572
LIG_FHA_1	118	124	PF00498	0.587
LIG_FHA_1	265	271	PF00498	0.601
LIG_FHA_1	274	280	PF00498	0.543
LIG_FHA_1	33	39	PF00498	0.433
LIG_FHA_1	58	64	PF00498	0.592
LIG_FHA_2	23	29	PF00498	0.605
LIG_FHA_2	35	41	PF00498	0.413
LIG_FHA_2	45	51	PF00498	0.528
LIG_LIR_Apic_2	193	197	PF02991	0.698
LIG_LIR_Apic_2	43	48	PF02991	0.629
LIG_LIR_Gen_1	118	128	PF02991	0.670
LIG_LIR_Gen_1	23	33	PF02991	0.527
LIG_LIR_Nem_3	118	124	PF02991	0.669
LIG_LIR_Nem_3	211	216	PF02991	0.528
LIG_LIR_Nem_3	23	29	PF02991	0.530
LIG_PDZ_Class_2	304	309	PF00595	0.616
LIG_Pex14_2	45	49	PF04695	0.631
LIG_PTAP_UEV_1	129	134	PF05743	0.626
LIG_SH2_CRK	121	125	PF00017	0.678
LIG_SH2_NCK_1	121	125	PF00017	0.678
LIG_SH2_NCK_1	194	198	PF00017	0.659
LIG_SH2_NCK_1	234	238	PF00017	0.482
LIG_SH2_SRC	269	272	PF00017	0.662
LIG_SH2_STAP1	121	125	PF00017	0.639
LIG_SH2_STAP1	266	270	PF00017	0.624
LIG_SH2_STAT5	20	23	PF00017	0.686
LIG_SH2_STAT5	266	269	PF00017	0.585
LIG_SH3_1	194	200	PF00018	0.681
LIG_SH3_3	127	133	PF00018	0.739
LIG_SH3_3	194	200	PF00018	0.575
LIG_SH3_3	281	287	PF00018	0.567
LIG_SH3_3	291	297	PF00018	0.622
LIG_SH3_3	65	71	PF00018	0.602
LIG_SUMO_SIM_par_1	183	188	PF11976	0.645
LIG_SUMO_SIM_par_1	34	40	PF11976	0.552
LIG_TRAF2_1	106	109	PF00917	0.562
LIG_TRAF2_1	113	116	PF00917	0.504
LIG_TYR_ITIM	123	128	PF00017	0.689
LIG_TYR_ITSM	117	124	PF00017	0.724
LIG_WRC_WIRS_1	99	104	PF05994	0.539
MOD_CDC14_SPxK_1	214	217	PF00782	0.557
MOD_CDK_SPxK_1	211	217	PF00069	0.559
MOD_CK1_1	211	217	PF00069	0.552
MOD_CK1_1	242	248	PF00069	0.633
MOD_CK1_1	286	292	PF00069	0.661
MOD_CK1_1	34	40	PF00069	0.610
MOD_CK1_1	79	85	PF00069	0.570
MOD_CK2_1	160	166	PF00069	0.419
MOD_CK2_1	22	28	PF00069	0.683
MOD_CK2_1	279	285	PF00069	0.597
MOD_CK2_1	296	302	PF00069	0.491
MOD_CK2_1	44	50	PF00069	0.606
MOD_GlcNHglycan	102	105	PF01048	0.547
MOD_GlcNHglycan	154	157	PF01048	0.715
MOD_GlcNHglycan	241	244	PF01048	0.676
MOD_GlcNHglycan	50	53	PF01048	0.610
MOD_GSK3_1	148	155	PF00069	0.582
MOD_GSK3_1	160	167	PF00069	0.428
MOD_GSK3_1	226	233	PF00069	0.629
MOD_GSK3_1	235	242	PF00069	0.582
MOD_GSK3_1	245	252	PF00069	0.544
MOD_GSK3_1	265	272	PF00069	0.597
MOD_GSK3_1	279	286	PF00069	0.613
MOD_GSK3_1	44	51	PF00069	0.522
MOD_GSK3_1	91	98	PF00069	0.753
MOD_LATS_1	303	309	PF00433	0.411
MOD_N-GLC_1	152	157	PF02516	0.648
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	185	190	PF00069	0.652
MOD_NEK2_1	21	26	PF00069	0.684
MOD_NEK2_1	230	235	PF00069	0.576
MOD_PIKK_1	185	191	PF00454	0.701
MOD_PIKK_1	208	214	PF00454	0.629
MOD_PKA_2	57	63	PF00069	0.539
MOD_Plk_1	117	123	PF00069	0.589
MOD_Plk_1	79	85	PF00069	0.592
MOD_Plk_1	95	101	PF00069	0.775
MOD_Plk_2-3	221	227	PF00069	0.451
MOD_Plk_4	1	7	PF00069	0.626
MOD_Plk_4	22	28	PF00069	0.691
MOD_Plk_4	265	271	PF00069	0.683
MOD_Plk_4	279	285	PF00069	0.631
MOD_ProDKin_1	126	132	PF00069	0.728
MOD_ProDKin_1	211	217	PF00069	0.559
MOD_ProDKin_1	242	248	PF00069	0.648
MOD_ProDKin_1	283	289	PF00069	0.641
MOD_ProDKin_1	44	50	PF00069	0.605
MOD_SUMO_for_1	83	86	PF00179	0.711
MOD_SUMO_rev_2	219	229	PF00179	0.660
TRG_ENDOCYTIC_2	121	124	PF00928	0.679
TRG_ENDOCYTIC_2	125	128	PF00928	0.693
TRG_ER_diArg_1	203	205	PF00400	0.666
TRG_ER_diArg_1	55	58	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I215	Leptomonas seymouri	51%	100%
A0A1X0P9H8	Trypanosomatidae	35%	100%
A0A3S5IS94	Trypanosoma rangeli	31%	100%
A0A3S7X7Y3	Leishmania donovani	76%	98%
A4I9Y3	Leishmania infantum	76%	98%
C9ZMQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B4Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q2Z5	Leishmania major	73%	100%
V5BT40	Trypanosoma cruzi	28%	96%