Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HAR5_LEIBR

TriTrypDb:

LbrM.20.1520 , LBRM2903_200025500

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005938	cell cortex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.721
CLV_C14_Caspase3-7	34	38	PF00656	0.763
CLV_C14_Caspase3-7	556	560	PF00656	0.625
CLV_NRD_NRD_1	12	14	PF00675	0.595
CLV_NRD_NRD_1	290	292	PF00675	0.611
CLV_NRD_NRD_1	297	299	PF00675	0.512
CLV_NRD_NRD_1	346	348	PF00675	0.529
CLV_NRD_NRD_1	476	478	PF00675	0.687
CLV_NRD_NRD_1	548	550	PF00675	0.584
CLV_NRD_NRD_1	57	59	PF00675	0.702
CLV_NRD_NRD_1	606	608	PF00675	0.737
CLV_NRD_NRD_1	612	614	PF00675	0.675
CLV_PCSK_KEX2_1	12	14	PF00082	0.595
CLV_PCSK_KEX2_1	290	292	PF00082	0.605
CLV_PCSK_KEX2_1	297	299	PF00082	0.514
CLV_PCSK_KEX2_1	346	348	PF00082	0.547
CLV_PCSK_KEX2_1	476	478	PF00082	0.561
CLV_PCSK_KEX2_1	56	58	PF00082	0.699
CLV_PCSK_KEX2_1	583	585	PF00082	0.816
CLV_PCSK_KEX2_1	606	608	PF00082	0.811
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.699
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.654
CLV_PCSK_SKI1_1	240	244	PF00082	0.553
CLV_PCSK_SKI1_1	298	302	PF00082	0.556
CLV_PCSK_SKI1_1	394	398	PF00082	0.623
CLV_PCSK_SKI1_1	513	517	PF00082	0.587
CLV_PCSK_SKI1_1	64	68	PF00082	0.733
DEG_Kelch_Keap1_1	14	19	PF01344	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DEG_SPOP_SBC_1	112	116	PF00917	0.654
DEG_SPOP_SBC_1	201	205	PF00917	0.671
DOC_CKS1_1	293	298	PF01111	0.530
DOC_CYCLIN_RxL_1	261	272	PF00134	0.449
DOC_MAPK_gen_1	152	160	PF00069	0.517
DOC_MAPK_gen_1	549	555	PF00069	0.600
DOC_PP1_RVXF_1	259	266	PF00149	0.538
DOC_PP4_FxxP_1	126	129	PF00568	0.582
DOC_PP4_FxxP_1	475	478	PF00568	0.779
DOC_USP7_MATH_1	138	142	PF00917	0.456
DOC_USP7_MATH_1	31	35	PF00917	0.628
DOC_USP7_MATH_1	372	376	PF00917	0.392
DOC_USP7_MATH_1	406	410	PF00917	0.474
DOC_USP7_MATH_1	420	424	PF00917	0.426
DOC_USP7_MATH_1	582	586	PF00917	0.828
DOC_WW_Pin1_4	292	297	PF00397	0.534
DOC_WW_Pin1_4	302	307	PF00397	0.499
DOC_WW_Pin1_4	400	405	PF00397	0.456
DOC_WW_Pin1_4	453	458	PF00397	0.520
DOC_WW_Pin1_4	500	505	PF00397	0.796
LIG_14-3-3_CanoR_1	12	21	PF00244	0.688
LIG_14-3-3_CanoR_1	240	245	PF00244	0.544
LIG_14-3-3_CanoR_1	290	296	PF00244	0.589
LIG_14-3-3_CanoR_1	297	303	PF00244	0.512
LIG_14-3-3_CanoR_1	32	40	PF00244	0.433
LIG_14-3-3_CanoR_1	64	74	PF00244	0.695
LIG_BIR_III_2	570	574	PF00653	0.768
LIG_Clathr_ClatBox_1	317	321	PF01394	0.523
LIG_FHA_1	114	120	PF00498	0.613
LIG_FHA_1	223	229	PF00498	0.567
LIG_FHA_1	252	258	PF00498	0.586
LIG_FHA_1	446	452	PF00498	0.538
LIG_FHA_1	550	556	PF00498	0.827
LIG_FHA_1	60	66	PF00498	0.689
LIG_FHA_2	1	7	PF00498	0.749
LIG_FHA_2	186	192	PF00498	0.517
LIG_FHA_2	39	45	PF00498	0.754
LIG_FHA_2	515	521	PF00498	0.698
LIG_FHA_2	65	71	PF00498	0.468
LIG_GBD_Chelix_1	433	441	PF00786	0.336
LIG_LIR_Gen_1	181	191	PF02991	0.448
LIG_LIR_Gen_1	19	29	PF02991	0.569
LIG_LIR_Nem_3	181	187	PF02991	0.440
LIG_LIR_Nem_3	272	277	PF02991	0.459
LIG_LIR_Nem_3	401	405	PF02991	0.373
LIG_LIR_Nem_3	469	475	PF02991	0.646
LIG_LIR_Nem_3	6	11	PF02991	0.688
LIG_PCNA_PIPBox_1	352	361	PF02747	0.585
LIG_SH2_CRK	135	139	PF00017	0.474
LIG_SH2_NCK_1	135	139	PF00017	0.474
LIG_SH2_STAP1	468	472	PF00017	0.590
LIG_SH2_STAT3	359	362	PF00017	0.554
LIG_SH2_STAT5	131	134	PF00017	0.653
LIG_SH2_STAT5	327	330	PF00017	0.339
LIG_SH2_STAT5	350	353	PF00017	0.499
LIG_SH2_STAT5	359	362	PF00017	0.456
LIG_SH2_STAT5	426	429	PF00017	0.521
LIG_SH2_STAT5	468	471	PF00017	0.620
LIG_SH3_2	91	96	PF14604	0.544
LIG_SH3_3	163	169	PF00018	0.516
LIG_SH3_3	203	209	PF00018	0.525
LIG_SH3_3	290	296	PF00018	0.628
LIG_SH3_3	570	576	PF00018	0.656
LIG_SH3_3	88	94	PF00018	0.722
LIG_SH3_4	348	355	PF00018	0.595
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.517
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.693
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.652
LIG_SUMO_SIM_par_1	316	321	PF11976	0.528
LIG_SUMO_SIM_par_1	551	557	PF11976	0.604
LIG_SxIP_EBH_1	251	264	PF03271	0.482
LIG_SxIP_EBH_1	397	411	PF03271	0.425
LIG_TRAF2_1	67	70	PF00917	0.467
LIG_WRC_WIRS_1	157	162	PF05994	0.470
LIG_WRC_WIRS_1	399	404	PF05994	0.403
MOD_CAAXbox	622	625	PF01239	0.708
MOD_CDK_SPK_2	292	297	PF00069	0.534
MOD_CDK_SPxK_1	292	298	PF00069	0.534
MOD_CDK_SPxxK_3	302	309	PF00069	0.532
MOD_CK1_1	113	119	PF00069	0.635
MOD_CK1_1	143	149	PF00069	0.444
MOD_CK1_1	202	208	PF00069	0.674
MOD_CK1_1	248	254	PF00069	0.584
MOD_CK1_1	38	44	PF00069	0.611
MOD_CK1_1	384	390	PF00069	0.472
MOD_CK1_1	500	506	PF00069	0.765
MOD_CK1_1	509	515	PF00069	0.730
MOD_CK1_1	530	536	PF00069	0.719
MOD_CK2_1	13	19	PF00069	0.697
MOD_CK2_1	186	192	PF00069	0.552
MOD_CK2_1	38	44	PF00069	0.673
MOD_CK2_1	64	70	PF00069	0.596
MOD_Cter_Amidation	53	56	PF01082	0.645
MOD_GlcNHglycan	161	164	PF01048	0.668
MOD_GlcNHglycan	195	198	PF01048	0.472
MOD_GlcNHglycan	247	250	PF01048	0.621
MOD_GlcNHglycan	311	314	PF01048	0.481
MOD_GlcNHglycan	33	36	PF01048	0.545
MOD_GlcNHglycan	363	366	PF01048	0.456
MOD_GlcNHglycan	386	389	PF01048	0.447
MOD_GlcNHglycan	489	492	PF01048	0.750
MOD_GlcNHglycan	529	532	PF01048	0.701
MOD_GSK3_1	140	147	PF00069	0.451
MOD_GSK3_1	236	243	PF00069	0.493
MOD_GSK3_1	253	260	PF00069	0.509
MOD_GSK3_1	279	286	PF00069	0.513
MOD_GSK3_1	298	305	PF00069	0.565
MOD_GSK3_1	31	38	PF00069	0.575
MOD_GSK3_1	598	605	PF00069	0.808
MOD_N-GLC_1	13	18	PF02516	0.479
MOD_N-GLC_1	144	149	PF02516	0.587
MOD_N-GLC_1	251	256	PF02516	0.499
MOD_N-GLC_1	384	389	PF02516	0.428
MOD_N-GLC_1	437	442	PF02516	0.608
MOD_N-GLC_1	527	532	PF02516	0.783
MOD_N-GLC_1	535	540	PF02516	0.803
MOD_NEK2_1	140	145	PF00069	0.447
MOD_NEK2_1	199	204	PF00069	0.658
MOD_NEK2_1	437	442	PF00069	0.594
MOD_NEK2_1	506	511	PF00069	0.607
MOD_NEK2_1	524	529	PF00069	0.594
MOD_NEK2_2	144	149	PF00069	0.533
MOD_NEK2_2	420	425	PF00069	0.411
MOD_PIKK_1	104	110	PF00454	0.531
MOD_PIKK_1	576	582	PF00454	0.820
MOD_PIKK_1	614	620	PF00454	0.619
MOD_PKA_1	12	18	PF00069	0.603
MOD_PKA_1	549	555	PF00069	0.600
MOD_PKA_1	607	613	PF00069	0.712
MOD_PKA_2	12	18	PF00069	0.644
MOD_PKA_2	151	157	PF00069	0.512
MOD_PKA_2	31	37	PF00069	0.618
MOD_Plk_1	144	150	PF00069	0.585
MOD_Plk_1	279	285	PF00069	0.371
MOD_Plk_1	437	443	PF00069	0.590
MOD_Plk_2-3	466	472	PF00069	0.574
MOD_Plk_2-3	479	485	PF00069	0.695
MOD_Plk_4	21	27	PF00069	0.644
MOD_Plk_4	222	228	PF00069	0.544
MOD_Plk_4	279	285	PF00069	0.480
MOD_Plk_4	420	426	PF00069	0.412
MOD_Plk_4	549	555	PF00069	0.608
MOD_ProDKin_1	292	298	PF00069	0.534
MOD_ProDKin_1	302	308	PF00069	0.496
MOD_ProDKin_1	400	406	PF00069	0.461
MOD_ProDKin_1	453	459	PF00069	0.527
MOD_ProDKin_1	500	506	PF00069	0.797
MOD_SUMO_for_1	531	534	PF00179	0.578
TRG_ENDOCYTIC_2	274	277	PF00928	0.441
TRG_ER_diArg_1	11	13	PF00400	0.665
TRG_ER_diArg_1	172	175	PF00400	0.495
TRG_ER_diArg_1	296	298	PF00400	0.528
TRG_ER_diArg_1	475	477	PF00400	0.561
TRG_NES_CRM1_1	431	446	PF08389	0.343
TRG_NLS_MonoExtN_4	606	611	PF00514	0.785
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG4	Leptomonas seymouri	64%	100%
A0A1X0PAD3	Trypanosomatidae	58%	100%
A0A3Q8IH78	Leishmania donovani	74%	99%
A0A422NXS0	Trypanosoma rangeli	54%	100%
A4I9X9	Leishmania infantum	74%	99%
C9ZMQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B4Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4Q2Z9	Leishmania major	75%	100%
V5BIX4	Trypanosoma cruzi	58%	100%