Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAR4_LEIBR

TriTrypDb:

LbrM.20.1510 , LBRM2903_200025400

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.565
CLV_NRD_NRD_1	90	92	PF00675	0.448
CLV_PCSK_KEX2_1	19	21	PF00082	0.565
CLV_PCSK_KEX2_1	90	92	PF00082	0.450
CLV_PCSK_SKI1_1	153	157	PF00082	0.663
CLV_PCSK_SKI1_1	37	41	PF00082	0.610
CLV_PCSK_SKI1_1	84	88	PF00082	0.515
CLV_Separin_Metazoa	113	117	PF03568	0.588
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_CYCLIN_RxL_1	81	89	PF00134	0.607
DOC_PP1_RVXF_1	126	133	PF00149	0.546
DOC_USP7_MATH_1	52	56	PF00917	0.810
DOC_USP7_MATH_1	57	61	PF00917	0.720
DOC_WW_Pin1_4	158	163	PF00397	0.525
LIG_14-3-3_CanoR_1	116	122	PF00244	0.604
LIG_14-3-3_CanoR_1	6	14	PF00244	0.598
LIG_14-3-3_CanoR_1	90	100	PF00244	0.689
LIG_BRCT_BRCA1_1	135	139	PF00533	0.513
LIG_BRCT_BRCA1_1	144	148	PF00533	0.364
LIG_BRCT_BRCA1_1	9	13	PF00533	0.606
LIG_CSL_BTD_1	159	162	PF09270	0.527
LIG_deltaCOP1_diTrp_1	121	126	PF00928	0.633
LIG_deltaCOP1_diTrp_1	157	163	PF00928	0.414
LIG_FHA_1	31	37	PF00498	0.663
LIG_FHA_1	38	44	PF00498	0.623
LIG_FHA_2	108	114	PF00498	0.765
LIG_FHA_2	118	124	PF00498	0.601
LIG_LIR_Gen_1	121	132	PF02991	0.624
LIG_LIR_Gen_1	141	152	PF02991	0.183
LIG_LIR_Nem_3	121	127	PF02991	0.628
LIG_LIR_Nem_3	141	147	PF02991	0.183
LIG_LIR_Nem_3	157	163	PF02991	0.512
LIG_MLH1_MIPbox_1	144	148	PF16413	0.261
LIG_SH2_STAP1	144	148	PF00017	0.377
LIG_SH2_STAT5	146	149	PF00017	0.477
LIG_SH2_STAT5	154	157	PF00017	0.422
LIG_SH3_1	156	162	PF00018	0.528
LIG_SH3_3	156	162	PF00018	0.498
LIG_TRAF2_1	64	67	PF00917	0.745
MOD_CK1_1	93	99	PF00069	0.730
MOD_CK2_1	107	113	PF00069	0.713
MOD_CK2_1	117	123	PF00069	0.610
MOD_CK2_1	91	97	PF00069	0.680
MOD_Cter_Amidation	17	20	PF01082	0.426
MOD_GlcNHglycan	20	23	PF01048	0.569
MOD_GlcNHglycan	48	51	PF01048	0.557
MOD_GlcNHglycan	9	12	PF01048	0.495
MOD_GSK3_1	134	141	PF00069	0.416
MOD_GSK3_1	14	21	PF00069	0.753
MOD_GSK3_1	37	44	PF00069	0.668
MOD_GSK3_1	52	59	PF00069	0.802
MOD_GSK3_1	86	93	PF00069	0.643
MOD_LATS_1	54	60	PF00433	0.746
MOD_LATS_1	63	69	PF00433	0.710
MOD_NEK2_1	100	105	PF00069	0.573
MOD_NEK2_1	13	18	PF00069	0.712
MOD_NEK2_1	133	138	PF00069	0.397
MOD_NEK2_1	139	144	PF00069	0.366
MOD_NEK2_1	7	12	PF00069	0.658
MOD_NEK2_1	86	91	PF00069	0.696
MOD_PKA_1	90	96	PF00069	0.679
MOD_PKA_2	18	24	PF00069	0.735
MOD_PKA_2	5	11	PF00069	0.636
MOD_PKA_2	90	96	PF00069	0.679
MOD_Plk_1	57	63	PF00069	0.833
MOD_Plk_4	139	145	PF00069	0.411
MOD_ProDKin_1	158	164	PF00069	0.529
MOD_SUMO_for_1	155	158	PF00179	0.527
MOD_SUMO_for_1	64	67	PF00179	0.720
TRG_ENDOCYTIC_2	144	147	PF00928	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P996	Leptomonas seymouri	56%	100%
A0A3Q8INA7	Leishmania donovani	67%	100%
A4I9X8	Leishmania infantum	68%	100%
E9B4Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q300	Leishmania major	65%	98%