Putative pyroglutamyl-peptidase I (PGP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyroglutamyl-peptidase I, putative

Species:

Leishmania braziliensis

UniProt:

A4HAR3_LEIBR

TriTrypDb:

LbrM.20.1500 , LBRM2903_200025300

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAR3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008242	omega peptidase activity	4	1
GO:0016920	pyroglutamyl-peptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	38	40	PF00082	0.437
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.437
CLV_PCSK_SKI1_1	82	86	PF00082	0.419
DOC_CYCLIN_RxL_1	213	222	PF00134	0.328
DOC_MAPK_HePTP_8	73	85	PF00069	0.249
DOC_MAPK_MEF2A_6	5	12	PF00069	0.399
DOC_MAPK_MEF2A_6	76	85	PF00069	0.298
DOC_PP2B_LxvP_1	124	127	PF13499	0.249
DOC_PP2B_PxIxI_1	254	260	PF00149	0.293
DOC_PP4_FxxP_1	194	197	PF00568	0.548
DOC_USP7_MATH_1	182	186	PF00917	0.604
DOC_WW_Pin1_4	142	147	PF00397	0.574
LIG_14-3-3_CanoR_1	47	53	PF00244	0.522
LIG_APCC_ABBA_1	88	93	PF00400	0.477
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BRCT_BRCA1_1	144	148	PF00533	0.355
LIG_FHA_1	121	127	PF00498	0.269
LIG_FHA_1	129	135	PF00498	0.403
LIG_FHA_1	18	24	PF00498	0.464
LIG_FHA_1	223	229	PF00498	0.499
LIG_FHA_1	92	98	PF00498	0.477
LIG_FHA_2	241	247	PF00498	0.565
LIG_LIR_Gen_1	107	115	PF02991	0.477
LIG_LIR_Gen_1	145	155	PF02991	0.538
LIG_LIR_Gen_1	45	55	PF02991	0.461
LIG_LIR_Nem_3	107	112	PF02991	0.486
LIG_LIR_Nem_3	13	18	PF02991	0.338
LIG_LIR_Nem_3	145	151	PF02991	0.537
LIG_LIR_Nem_3	45	51	PF02991	0.471
LIG_Pex14_2	135	139	PF04695	0.572
LIG_SH2_CRK	215	219	PF00017	0.377
LIG_SH2_STAP1	229	233	PF00017	0.471
LIG_SH2_STAT5	208	211	PF00017	0.370
LIG_SH2_STAT5	48	51	PF00017	0.451
LIG_SH2_STAT5	61	64	PF00017	0.260
LIG_SH3_3	232	238	PF00018	0.406
LIG_SUMO_SIM_par_1	121	129	PF11976	0.249
LIG_SUMO_SIM_par_1	270	276	PF11976	0.530
LIG_TYR_ITIM	46	51	PF00017	0.363
MOD_CK1_1	172	178	PF00069	0.623
MOD_CK1_1	54	60	PF00069	0.459
MOD_CK2_1	240	246	PF00069	0.614
MOD_GlcNHglycan	180	183	PF01048	0.718
MOD_GlcNHglycan	184	187	PF01048	0.730
MOD_GlcNHglycan	53	56	PF01048	0.342
MOD_GSK3_1	162	169	PF00069	0.568
MOD_GSK3_1	178	185	PF00069	0.495
MOD_GSK3_1	236	243	PF00069	0.317
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	120	125	PF00069	0.289
MOD_NEK2_1	135	140	PF00069	0.558
MOD_NEK2_1	170	175	PF00069	0.633
MOD_NEK2_1	51	56	PF00069	0.482
MOD_NEK2_2	17	22	PF00069	0.477
MOD_PKA_2	46	52	PF00069	0.461
MOD_PKA_2	91	97	PF00069	0.249
MOD_Plk_1	120	126	PF00069	0.532
MOD_Plk_4	120	126	PF00069	0.249
MOD_Plk_4	135	141	PF00069	0.485
MOD_Plk_4	253	259	PF00069	0.486
MOD_Plk_4	270	276	PF00069	0.461
MOD_ProDKin_1	142	148	PF00069	0.567
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.480
TRG_ENDOCYTIC_2	105	108	PF00928	0.373
TRG_ENDOCYTIC_2	15	18	PF00928	0.431
TRG_ENDOCYTIC_2	215	218	PF00928	0.372
TRG_ENDOCYTIC_2	229	232	PF00928	0.404
TRG_ENDOCYTIC_2	48	51	PF00928	0.398
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X3	Leptomonas seymouri	56%	99%
A0A0S4JYF2	Bodo saltans	30%	95%
A0A1X0P9S4	Trypanosomatidae	34%	100%
A0A3R7R5B2	Trypanosoma rangeli	31%	100%
A0A3S5H7W7	Leishmania donovani	73%	100%
A4I9X7	Leishmania infantum	72%	100%
C9ZMR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B4Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q301	Leishmania major	71%	100%
V5BNH8	Trypanosoma cruzi	33%	100%