Putative ATP dependent DEAD-box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP dependent DEAD-box helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAQ8_LEIBR

TriTrypDb:

LbrM.20.1450 , LBRM2903_200019100

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005761	mitochondrial ribosome	7	1
GO:0005840	ribosome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	4
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.678
CLV_C14_Caspase3-7	225	229	PF00656	0.664
CLV_NRD_NRD_1	13	15	PF00675	0.644
CLV_NRD_NRD_1	221	223	PF00675	0.651
CLV_NRD_NRD_1	326	328	PF00675	0.594
CLV_NRD_NRD_1	361	363	PF00675	0.522
CLV_NRD_NRD_1	365	367	PF00675	0.564
CLV_NRD_NRD_1	399	401	PF00675	0.393
CLV_NRD_NRD_1	544	546	PF00675	0.686
CLV_NRD_NRD_1	62	64	PF00675	0.573
CLV_NRD_NRD_1	683	685	PF00675	0.654
CLV_NRD_NRD_1	710	712	PF00675	0.524
CLV_PCSK_FUR_1	541	545	PF00082	0.435
CLV_PCSK_FUR_1	60	64	PF00082	0.681
CLV_PCSK_KEX2_1	13	15	PF00082	0.644
CLV_PCSK_KEX2_1	221	223	PF00082	0.604
CLV_PCSK_KEX2_1	326	328	PF00082	0.594
CLV_PCSK_KEX2_1	361	363	PF00082	0.489
CLV_PCSK_KEX2_1	365	367	PF00082	0.530
CLV_PCSK_KEX2_1	399	401	PF00082	0.393
CLV_PCSK_KEX2_1	543	545	PF00082	0.690
CLV_PCSK_KEX2_1	62	64	PF00082	0.608
CLV_PCSK_KEX2_1	620	622	PF00082	0.455
CLV_PCSK_KEX2_1	685	687	PF00082	0.656
CLV_PCSK_KEX2_1	710	712	PF00082	0.524
CLV_PCSK_KEX2_1	749	751	PF00082	0.519
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.455
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.681
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.519
CLV_PCSK_PC7_1	361	367	PF00082	0.620
CLV_PCSK_SKI1_1	110	114	PF00082	0.697
CLV_PCSK_SKI1_1	178	182	PF00082	0.577
CLV_PCSK_SKI1_1	198	202	PF00082	0.681
CLV_PCSK_SKI1_1	448	452	PF00082	0.432
CLV_PCSK_SKI1_1	46	50	PF00082	0.611
CLV_PCSK_SKI1_1	686	690	PF00082	0.563
CLV_Separin_Metazoa	167	171	PF03568	0.530
CLV_Separin_Metazoa	420	424	PF03568	0.432
DEG_COP1_1	479	490	PF00400	0.470
DOC_CKS1_1	534	539	PF01111	0.400
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.554
DOC_MAPK_gen_1	326	334	PF00069	0.567
DOC_MAPK_gen_1	554	564	PF00069	0.596
DOC_MAPK_MEF2A_6	284	292	PF00069	0.420
DOC_MAPK_MEF2A_6	448	455	PF00069	0.423
DOC_MAPK_MEF2A_6	724	732	PF00069	0.487
DOC_MAPK_NFAT4_5	448	456	PF00069	0.420
DOC_PP2B_LxvP_1	239	242	PF13499	0.591
DOC_PP2B_LxvP_1	29	32	PF13499	0.548
DOC_PP2B_LxvP_1	504	507	PF13499	0.406
DOC_PP4_FxxP_1	689	692	PF00568	0.553
DOC_USP7_MATH_1	134	138	PF00917	0.749
DOC_USP7_MATH_1	171	175	PF00917	0.629
DOC_USP7_MATH_1	212	216	PF00917	0.665
DOC_USP7_MATH_1	223	227	PF00917	0.659
DOC_USP7_MATH_1	242	246	PF00917	0.344
DOC_USP7_MATH_1	32	36	PF00917	0.757
DOC_USP7_MATH_1	454	458	PF00917	0.348
DOC_USP7_MATH_1	521	525	PF00917	0.335
DOC_USP7_UBL2_3	616	620	PF12436	0.526
DOC_USP7_UBL2_3	743	747	PF12436	0.557
DOC_WW_Pin1_4	137	142	PF00397	0.767
DOC_WW_Pin1_4	533	538	PF00397	0.393
DOC_WW_Pin1_4	675	680	PF00397	0.504
DOC_WW_Pin1_4	90	95	PF00397	0.611
LIG_14-3-3_CanoR_1	132	141	PF00244	0.780
LIG_14-3-3_CanoR_1	14	23	PF00244	0.694
LIG_14-3-3_CanoR_1	150	157	PF00244	0.491
LIG_14-3-3_CanoR_1	365	373	PF00244	0.448
LIG_14-3-3_CanoR_1	520	526	PF00244	0.421
LIG_14-3-3_CanoR_1	669	675	PF00244	0.679
LIG_Actin_WH2_2	383	401	PF00022	0.422
LIG_BIR_III_4	228	232	PF00653	0.623
LIG_BRCT_BRCA1_1	160	164	PF00533	0.752
LIG_BRCT_BRCA1_1	341	345	PF00533	0.501
LIG_BRCT_BRCA1_1	629	633	PF00533	0.596
LIG_deltaCOP1_diTrp_1	339	345	PF00928	0.438
LIG_FHA_1	18	24	PF00498	0.651
LIG_FHA_1	258	264	PF00498	0.301
LIG_FHA_1	283	289	PF00498	0.428
LIG_FHA_1	31	37	PF00498	0.671
LIG_FHA_1	375	381	PF00498	0.476
LIG_FHA_1	477	483	PF00498	0.493
LIG_FHA_1	52	58	PF00498	0.574
LIG_FHA_1	743	749	PF00498	0.504
LIG_FHA_2	179	185	PF00498	0.562
LIG_FHA_2	186	192	PF00498	0.577
LIG_FHA_2	346	352	PF00498	0.480
LIG_LIR_Apic_2	687	692	PF02991	0.556
LIG_LIR_Gen_1	233	242	PF02991	0.554
LIG_LIR_Gen_1	24	32	PF02991	0.722
LIG_LIR_Gen_1	339	349	PF02991	0.412
LIG_LIR_Gen_1	391	398	PF02991	0.420
LIG_LIR_Gen_1	700	707	PF02991	0.580
LIG_LIR_Nem_3	233	237	PF02991	0.560
LIG_LIR_Nem_3	24	29	PF02991	0.724
LIG_LIR_Nem_3	248	254	PF02991	0.570
LIG_LIR_Nem_3	273	279	PF02991	0.440
LIG_LIR_Nem_3	339	344	PF02991	0.417
LIG_LIR_Nem_3	354	360	PF02991	0.439
LIG_LIR_Nem_3	391	395	PF02991	0.425
LIG_LIR_Nem_3	700	705	PF02991	0.570
LIG_LIR_Nem_3	89	95	PF02991	0.662
LIG_NRBOX	262	268	PF00104	0.480
LIG_PCNA_PIPBox_1	665	674	PF02747	0.535
LIG_REV1ctd_RIR_1	686	691	PF16727	0.586
LIG_SH2_CRK	251	255	PF00017	0.599
LIG_SH2_CRK	357	361	PF00017	0.380
LIG_SH2_CRK	702	706	PF00017	0.552
LIG_SH2_NCK_1	702	706	PF00017	0.552
LIG_SH2_NCK_1	92	96	PF00017	0.736
LIG_SH2_STAP1	341	345	PF00017	0.451
LIG_SH2_STAP1	672	676	PF00017	0.642
LIG_SH2_STAT3	356	359	PF00017	0.397
LIG_SH2_STAT3	672	675	PF00017	0.538
LIG_SH2_STAT5	15	18	PF00017	0.704
LIG_SH2_STAT5	397	400	PF00017	0.396
LIG_SH2_STAT5	402	405	PF00017	0.364
LIG_SH2_STAT5	611	614	PF00017	0.494
LIG_SH2_STAT5	672	675	PF00017	0.562
LIG_SH2_STAT5	702	705	PF00017	0.538
LIG_SH3_3	331	337	PF00018	0.436
LIG_SH3_3	408	414	PF00018	0.491
LIG_SH3_3	482	488	PF00018	0.533
LIG_SH3_3	534	540	PF00018	0.405
LIG_SH3_4	474	481	PF00018	0.600
LIG_SH3_4	743	750	PF00018	0.457
LIG_SH3_5	337	341	PF00018	0.539
LIG_TRAF2_1	78	81	PF00917	0.610
LIG_TRFH_1	660	664	PF08558	0.557
MOD_CDK_SPK_2	536	541	PF00069	0.412
MOD_CDK_SPxxK_3	536	543	PF00069	0.413
MOD_CK1_1	137	143	PF00069	0.736
MOD_CK1_1	174	180	PF00069	0.645
MOD_CK1_1	192	198	PF00069	0.538
MOD_CK1_1	213	219	PF00069	0.641
MOD_CK1_1	24	30	PF00069	0.660
MOD_CK1_1	282	288	PF00069	0.413
MOD_CK1_1	39	45	PF00069	0.667
MOD_CK1_1	524	530	PF00069	0.345
MOD_CK2_1	148	154	PF00069	0.705
MOD_CK2_1	185	191	PF00069	0.576
MOD_CK2_1	242	248	PF00069	0.497
MOD_CK2_1	345	351	PF00069	0.483
MOD_CK2_1	562	568	PF00069	0.397
MOD_CK2_1	90	96	PF00069	0.654
MOD_GlcNHglycan	134	137	PF01048	0.819
MOD_GlcNHglycan	154	157	PF01048	0.450
MOD_GlcNHglycan	191	194	PF01048	0.601
MOD_GlcNHglycan	23	26	PF01048	0.602
MOD_GlcNHglycan	234	237	PF01048	0.494
MOD_GlcNHglycan	244	247	PF01048	0.520
MOD_GlcNHglycan	263	266	PF01048	0.373
MOD_GlcNHglycan	281	284	PF01048	0.416
MOD_GlcNHglycan	285	288	PF01048	0.402
MOD_GlcNHglycan	456	459	PF01048	0.415
MOD_GlcNHglycan	482	485	PF01048	0.474
MOD_GlcNHglycan	488	491	PF01048	0.432
MOD_GlcNHglycan	563	567	PF01048	0.390
MOD_GSK3_1	13	20	PF00069	0.629
MOD_GSK3_1	132	139	PF00069	0.771
MOD_GSK3_1	148	155	PF00069	0.594
MOD_GSK3_1	174	181	PF00069	0.599
MOD_GSK3_1	185	192	PF00069	0.546
MOD_GSK3_1	208	215	PF00069	0.644
MOD_GSK3_1	253	260	PF00069	0.400
MOD_GSK3_1	279	286	PF00069	0.460
MOD_GSK3_1	32	39	PF00069	0.690
MOD_GSK3_1	476	483	PF00069	0.494
MOD_GSK3_1	627	634	PF00069	0.358
MOD_GSK3_1	84	91	PF00069	0.549
MOD_LATS_1	714	720	PF00433	0.644
MOD_N-GLC_1	39	44	PF02516	0.767
MOD_NEK2_1	148	153	PF00069	0.603
MOD_NEK2_1	306	311	PF00069	0.487
MOD_NEK2_1	317	322	PF00069	0.432
MOD_NEK2_1	345	350	PF00069	0.501
MOD_NEK2_1	364	369	PF00069	0.327
MOD_NEK2_1	373	378	PF00069	0.415
MOD_NEK2_1	4	9	PF00069	0.745
MOD_NEK2_1	435	440	PF00069	0.429
MOD_NEK2_1	494	499	PF00069	0.326
MOD_NEK2_1	562	567	PF00069	0.397
MOD_NEK2_1	752	757	PF00069	0.578
MOD_PIKK_1	134	140	PF00454	0.738
MOD_PIKK_1	148	154	PF00454	0.804
MOD_PIKK_1	496	502	PF00454	0.365
MOD_PIKK_1	716	722	PF00454	0.641
MOD_PIKK_1	76	82	PF00454	0.654
MOD_PKA_1	13	19	PF00069	0.656
MOD_PKA_1	365	371	PF00069	0.607
MOD_PKA_2	13	19	PF00069	0.658
MOD_PKA_2	185	191	PF00069	0.581
MOD_PKA_2	21	27	PF00069	0.520
MOD_PKA_2	364	370	PF00069	0.577
MOD_PKA_2	521	527	PF00069	0.416
MOD_PKA_2	651	657	PF00069	0.514
MOD_Plk_1	171	177	PF00069	0.636
MOD_Plk_1	339	345	PF00069	0.414
MOD_Plk_1	562	568	PF00069	0.397
MOD_Plk_1	700	706	PF00069	0.588
MOD_Plk_2-3	158	164	PF00069	0.664
MOD_Plk_2-3	627	633	PF00069	0.561
MOD_Plk_4	118	124	PF00069	0.765
MOD_Plk_4	185	191	PF00069	0.571
MOD_Plk_4	214	220	PF00069	0.717
MOD_Plk_4	339	345	PF00069	0.463
MOD_Plk_4	352	358	PF00069	0.388
MOD_Plk_4	477	483	PF00069	0.499
MOD_Plk_4	724	730	PF00069	0.553
MOD_ProDKin_1	137	143	PF00069	0.764
MOD_ProDKin_1	533	539	PF00069	0.395
MOD_ProDKin_1	675	681	PF00069	0.499
MOD_ProDKin_1	90	96	PF00069	0.612
MOD_SUMO_rev_2	457	464	PF00179	0.540
MOD_SUMO_rev_2	614	622	PF00179	0.519
TRG_DiLeu_BaEn_1	53	58	PF01217	0.604
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.605
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.388
TRG_ENDOCYTIC_2	251	254	PF00928	0.609
TRG_ENDOCYTIC_2	341	344	PF00928	0.472
TRG_ENDOCYTIC_2	357	360	PF00928	0.346
TRG_ENDOCYTIC_2	69	72	PF00928	0.643
TRG_ENDOCYTIC_2	702	705	PF00928	0.529
TRG_ENDOCYTIC_2	92	95	PF00928	0.688
TRG_ER_diArg_1	12	14	PF00400	0.644
TRG_ER_diArg_1	220	222	PF00400	0.667
TRG_ER_diArg_1	360	362	PF00400	0.522
TRG_ER_diArg_1	364	366	PF00400	0.541
TRG_ER_diArg_1	398	400	PF00400	0.398
TRG_ER_diArg_1	540	543	PF00400	0.690
TRG_ER_diArg_1	573	576	PF00400	0.406
TRG_ER_diArg_1	60	63	PF00400	0.645
TRG_ER_diArg_1	683	686	PF00400	0.581
TRG_ER_diArg_1	710	712	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC11	Leptomonas seymouri	62%	100%
A0A1X0P9H1	Trypanosomatidae	49%	100%
A0A3R7MZ37	Trypanosoma rangeli	48%	100%
A0A3S7X7R6	Leishmania donovani	72%	99%
A4HAM5	Leishmania braziliensis	86%	98%
E9AHT4	Leishmania infantum	73%	99%
E9B4X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q347	Leishmania major	72%	99%
V5BT32	Trypanosoma cruzi	49%	100%