Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HAQ7_LEIBR

TriTrypDb:

LbrM.20.1440 , LBRM2903_250028700

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	3
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HAQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0016787	hydrolase activity	2	2
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.700
CLV_C14_Caspase3-7	212	216	PF00656	0.475
CLV_C14_Caspase3-7	475	479	PF00656	0.705
CLV_NRD_NRD_1	15	17	PF00675	0.722
CLV_NRD_NRD_1	169	171	PF00675	0.380
CLV_NRD_NRD_1	415	417	PF00675	0.475
CLV_NRD_NRD_1	496	498	PF00675	0.746
CLV_PCSK_FUR_1	275	279	PF00082	0.358
CLV_PCSK_FUR_1	494	498	PF00082	0.742
CLV_PCSK_KEX2_1	15	17	PF00082	0.822
CLV_PCSK_KEX2_1	277	279	PF00082	0.358
CLV_PCSK_KEX2_1	415	417	PF00082	0.475
CLV_PCSK_KEX2_1	496	498	PF00082	0.746
CLV_PCSK_KEX2_1	60	62	PF00082	0.652
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.358
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.475
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.668
CLV_PCSK_SKI1_1	312	316	PF00082	0.358
CLV_PCSK_SKI1_1	381	385	PF00082	0.451
CLV_PCSK_SKI1_1	398	402	PF00082	0.189
CLV_PCSK_SKI1_1	450	454	PF00082	0.371
DEG_SPOP_SBC_1	261	265	PF00917	0.475
DEG_SPOP_SBC_1	43	47	PF00917	0.771
DOC_MAPK_gen_1	200	208	PF00069	0.451
DOC_MAPK_gen_1	381	389	PF00069	0.475
DOC_MAPK_gen_1	441	449	PF00069	0.475
DOC_MAPK_gen_1	60	68	PF00069	0.617
DOC_MAPK_MEF2A_6	61	70	PF00069	0.592
DOC_PP1_RVXF_1	284	290	PF00149	0.358
DOC_USP7_MATH_1	261	265	PF00917	0.466
DOC_USP7_MATH_1	29	33	PF00917	0.736
DOC_USP7_MATH_1	43	47	PF00917	0.552
DOC_USP7_MATH_1	81	85	PF00917	0.384
DOC_USP7_MATH_2	103	109	PF00917	0.475
DOC_WW_Pin1_4	210	215	PF00397	0.475
DOC_WW_Pin1_4	304	309	PF00397	0.475
DOC_WW_Pin1_4	463	468	PF00397	0.466
DOC_WW_Pin1_4	7	12	PF00397	0.811
LIG_14-3-3_CanoR_1	229	233	PF00244	0.354
LIG_14-3-3_CanoR_1	331	339	PF00244	0.358
LIG_14-3-3_CanoR_1	36	44	PF00244	0.786
LIG_Actin_WH2_2	458	474	PF00022	0.475
LIG_APCC_ABBA_1	173	178	PF00400	0.475
LIG_APCC_ABBA_1	340	345	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.809
LIG_BIR_III_2	28	32	PF00653	0.781
LIG_BIR_III_4	273	277	PF00653	0.475
LIG_BRCT_BRCA1_1	107	111	PF00533	0.344
LIG_FHA_1	339	345	PF00498	0.317
LIG_FHA_1	389	395	PF00498	0.475
LIG_FHA_1	409	415	PF00498	0.125
LIG_FHA_1	444	450	PF00498	0.358
LIG_FHA_1	457	463	PF00498	0.358
LIG_FHA_1	51	57	PF00498	0.715
LIG_FHA_2	122	128	PF00498	0.371
LIG_FHA_2	15	21	PF00498	0.740
LIG_FHA_2	217	223	PF00498	0.475
LIG_FHA_2	53	59	PF00498	0.691
LIG_Integrin_RGD_1	508	510	PF01839	0.771
LIG_LIR_Gen_1	108	119	PF02991	0.475
LIG_LIR_Gen_1	124	132	PF02991	0.475
LIG_LIR_Nem_3	108	114	PF02991	0.475
LIG_LIR_Nem_3	124	128	PF02991	0.475
LIG_LIR_Nem_3	231	236	PF02991	0.304
LIG_NRBOX	444	450	PF00104	0.358
LIG_PCNA_PIPBox_1	321	330	PF02747	0.475
LIG_PCNA_yPIPBox_3	237	245	PF02747	0.475
LIG_Pex14_2	228	232	PF04695	0.475
LIG_Rb_pABgroove_1	190	198	PF01858	0.475
LIG_SH2_SRC	343	346	PF00017	0.475
LIG_SH2_STAT5	155	158	PF00017	0.405
LIG_SH2_STAT5	226	229	PF00017	0.475
LIG_SH2_STAT5	343	346	PF00017	0.337
LIG_SH2_STAT5	480	483	PF00017	0.594
LIG_SH2_STAT5	62	65	PF00017	0.627
LIG_SH3_1	71	77	PF00018	0.475
LIG_SH3_2	11	16	PF14604	0.812
LIG_SH3_2	467	472	PF14604	0.680
LIG_SH3_3	464	470	PF00018	0.475
LIG_SH3_3	71	77	PF00018	0.475
LIG_SH3_3	8	14	PF00018	0.806
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.475
LIG_TRAF2_1	17	20	PF00917	0.816
LIG_TRAF2_1	484	487	PF00917	0.708
LIG_UBA3_1	315	322	PF00899	0.475
LIG_UBA3_1	393	398	PF00899	0.358
LIG_WRC_WIRS_1	122	127	PF05994	0.475
LIG_WRC_WIRS_1	225	230	PF05994	0.358
LIG_WW_3	12	16	PF00397	0.811
MOD_CDC14_SPxK_1	12	15	PF00782	0.809
MOD_CDK_SPxK_1	9	15	PF00069	0.809
MOD_CDK_SPxxK_3	9	16	PF00069	0.810
MOD_CK1_1	151	157	PF00069	0.331
MOD_CK1_1	263	269	PF00069	0.475
MOD_CK1_1	304	310	PF00069	0.475
MOD_CK1_1	32	38	PF00069	0.787
MOD_CK1_1	333	339	PF00069	0.358
MOD_CK1_1	358	364	PF00069	0.389
MOD_CK1_1	443	449	PF00069	0.358
MOD_CK1_1	457	463	PF00069	0.358
MOD_CK2_1	121	127	PF00069	0.371
MOD_CK2_1	14	20	PF00069	0.742
MOD_CK2_1	304	310	PF00069	0.475
MOD_CK2_1	353	359	PF00069	0.475
MOD_CK2_1	481	487	PF00069	0.654
MOD_CK2_1	52	58	PF00069	0.704
MOD_Cter_Amidation	275	278	PF01082	0.358
MOD_GlcNHglycan	150	153	PF01048	0.319
MOD_GlcNHglycan	249	252	PF01048	0.475
MOD_GlcNHglycan	316	319	PF01048	0.358
MOD_GlcNHglycan	37	40	PF01048	0.705
MOD_GlcNHglycan	403	406	PF01048	0.394
MOD_GlcNHglycan	46	49	PF01048	0.596
MOD_GlcNHglycan	83	86	PF01048	0.371
MOD_GSK3_1	224	231	PF00069	0.423
MOD_GSK3_1	3	10	PF00069	0.756
MOD_GSK3_1	52	59	PF00069	0.671
MOD_N-GLC_1	389	394	PF02516	0.358
MOD_N-GLC_1	50	55	PF02516	0.728
MOD_NEK2_1	139	144	PF00069	0.351
MOD_NEK2_1	228	233	PF00069	0.358
MOD_NEK2_1	262	267	PF00069	0.475
MOD_NEK2_1	301	306	PF00069	0.475
MOD_NEK2_1	314	319	PF00069	0.247
MOD_NEK2_1	34	39	PF00069	0.789
MOD_NEK2_1	56	61	PF00069	0.561
MOD_NEK2_2	338	343	PF00069	0.475
MOD_NEK2_2	410	415	PF00069	0.475
MOD_NEK2_2	52	57	PF00069	0.710
MOD_PIKK_1	353	359	PF00454	0.475
MOD_PIKK_1	486	492	PF00454	0.696
MOD_PKA_2	14	20	PF00069	0.817
MOD_PKA_2	228	234	PF00069	0.354
MOD_PKA_2	330	336	PF00069	0.358
MOD_PKA_2	35	41	PF00069	0.786
MOD_PKA_2	440	446	PF00069	0.358
MOD_PKA_2	56	62	PF00069	0.554
MOD_Plk_1	358	364	PF00069	0.358
MOD_Plk_1	389	395	PF00069	0.358
MOD_Plk_4	139	145	PF00069	0.358
MOD_Plk_4	228	234	PF00069	0.358
MOD_Plk_4	358	364	PF00069	0.389
MOD_Plk_4	389	395	PF00069	0.475
MOD_Plk_4	443	449	PF00069	0.436
MOD_Plk_4	457	463	PF00069	0.223
MOD_ProDKin_1	210	216	PF00069	0.475
MOD_ProDKin_1	304	310	PF00069	0.475
MOD_ProDKin_1	463	469	PF00069	0.466
MOD_ProDKin_1	7	13	PF00069	0.808
MOD_SUMO_for_1	295	298	PF00179	0.475
TRG_DiLeu_BaEn_1	369	374	PF01217	0.475
TRG_ER_diArg_1	14	16	PF00400	0.819
TRG_ER_diArg_1	285	288	PF00400	0.375
TRG_ER_diArg_1	70	73	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	26%	77%
A0A0N1HY56	Leptomonas seymouri	27%	75%
A0A0N1I0Y5	Leptomonas seymouri	26%	84%
A0A0N1IH46	Leptomonas seymouri	30%	73%
A0A0N1PAZ2	Leptomonas seymouri	27%	68%
A0A0N1PDD6	Leptomonas seymouri	29%	67%
A0A0S4IJP8	Bodo saltans	25%	68%
A0A0S4J1I2	Bodo saltans	29%	78%
A0A0S4JBJ4	Bodo saltans	27%	94%
A0A0S4JEF6	Bodo saltans	26%	76%
A0A0S4JJ54	Bodo saltans	29%	73%
A0A0S4JMJ1	Bodo saltans	25%	84%
A0A0S4JRN9	Bodo saltans	31%	78%
A0A0S4KL43	Bodo saltans	30%	100%
A0A0S4KLZ8	Bodo saltans	27%	70%
A0A1X0NCS4	Trypanosomatidae	26%	100%
A0A1X0NJN6	Trypanosomatidae	29%	100%
A0A1X0NL76	Trypanosomatidae	27%	71%
A0A1X0NNY0	Trypanosomatidae	26%	78%
A0A1X0NP27	Trypanosomatidae	28%	69%
A0A1X0NQX5	Trypanosomatidae	27%	73%
A0A1X0NWZ8	Trypanosomatidae	32%	69%
A0A1X0NY69	Trypanosomatidae	28%	67%
A0A1X0P2B6	Trypanosomatidae	24%	83%
A0A1X0P5Y8	Trypanosomatidae	25%	76%
A0A1X0P9E3	Trypanosomatidae	26%	86%
A0A1X0P9T0	Trypanosomatidae	45%	100%
A0A1X0PAG9	Trypanosomatidae	26%	86%
A0A3Q8IAZ2	Leishmania donovani	32%	78%
A0A3Q8IBS7	Leishmania donovani	25%	84%
A0A3Q8IEL2	Leishmania donovani	27%	87%
A0A3Q8IG88	Leishmania donovani	26%	73%
A0A3Q8IHG6	Leishmania donovani	27%	87%
A0A3R7KHX7	Trypanosoma rangeli	29%	69%
A0A3R7KSK0	Trypanosoma rangeli	28%	69%
A0A3R7MC35	Trypanosoma rangeli	27%	100%
A0A3R7MDH9	Trypanosoma rangeli	27%	72%
A0A3R7R330	Trypanosoma rangeli	26%	98%
A0A3S5H4S8	Leishmania donovani	26%	76%
A0A3S5H5N6	Leishmania donovani	26%	77%
A0A3S5IRH3	Trypanosoma rangeli	23%	84%
A0A3S7WST0	Leishmania donovani	27%	70%
A0A3S7X2P9	Leishmania donovani	27%	87%
A0A422MZ05	Trypanosoma rangeli	26%	76%
A0A422NEQ8	Trypanosoma rangeli	32%	68%
A0A422NYZ6	Trypanosoma rangeli	30%	76%
A0A422P4C5	Trypanosoma rangeli	27%	71%
A3BFT0	Oryza sativa subsp. japonica	28%	67%
A4H337	Leishmania braziliensis	26%	77%
A4H4I4	Leishmania braziliensis	28%	78%
A4H7F1	Leishmania braziliensis	27%	70%
A4HCT2	Leishmania braziliensis	32%	71%
A4HDC2	Leishmania braziliensis	26%	89%
A4HHN8	Leishmania braziliensis	27%	87%
A4HHY2	Leishmania braziliensis	26%	85%
A4HRC5	Leishmania infantum	26%	76%
A4HSA6	Leishmania infantum	26%	100%
A4HSQ9	Leishmania infantum	26%	77%
A4HVT9	Leishmania infantum	27%	70%
A4I0A6	Leishmania infantum	32%	78%
A4I4V2	Leishmania infantum	27%	87%
A4I4V3	Leishmania infantum	27%	87%
A4I562	Leishmania infantum	25%	84%
A4IBA7	Leishmania infantum	27%	73%
A6QPL4	Bos taurus	28%	77%
A8WFU8	Danio rerio	29%	81%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	69%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	87%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
C9ZTA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
C9ZTM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	68%
D0A6E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	71%
D0A898	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
E9ABZ2	Leishmania major	26%	77%
E9AEA0	Leishmania major	27%	100%
E9AEA1	Leishmania major	27%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	77%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	87%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	87%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	71%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	78%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	89%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	84%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
F1QN54	Danio rerio	31%	66%
F4ICA0	Arabidopsis thaliana	30%	71%
F4K4C5	Arabidopsis thaliana	29%	67%
F9W301	Oryza sativa subsp. japonica	25%	100%
O00139	Homo sapiens	27%	73%
O15066	Homo sapiens	31%	69%
P17119	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	70%
P18105	Drosophila melanogaster	29%	77%
P20480	Drosophila melanogaster	29%	73%
P28739	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	67%
P28740	Mus musculus	27%	73%
P28741	Mus musculus	29%	73%
P28743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	73%
P32364	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	78%
P45962	Caenorhabditis elegans	28%	86%
P46864	Arabidopsis thaliana	30%	69%
P46870	Chlamydomonas reinhardtii	29%	66%
P46871	Strongylocentrotus purpuratus	29%	69%
P46872	Strongylocentrotus purpuratus	29%	73%
P46873	Caenorhabditis elegans	30%	73%
P46874	Bombyx mori	32%	100%
P46875	Arabidopsis thaliana	30%	68%
P70096	Cricetulus griseus	29%	71%
P79955	Xenopus laevis	31%	80%
Q0JLE4	Oryza sativa subsp. japonica	30%	66%
Q10E64	Oryza sativa subsp. japonica	28%	70%
Q14807	Homo sapiens	27%	77%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
Q1MTQ7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	81%
Q2NL05	Bos taurus	28%	78%
Q2R2P7	Oryza sativa subsp. japonica	30%	80%
Q3V300	Mus musculus	29%	78%
Q4Q7S4	Leishmania major	26%	100%
Q4QFZ3	Leishmania major	27%	70%
Q4QJ61	Leishmania major	28%	76%
Q4R628	Macaca fascicularis	29%	73%
Q4R918	Macaca fascicularis	29%	88%
Q5E913	Arabidopsis thaliana	26%	82%
Q5I0E8	Rattus norvegicus	29%	78%
Q5R4H3	Pongo abelii	29%	73%
Q5R9Y9	Pongo abelii	27%	69%
Q5REP4	Pongo abelii	27%	77%
Q5XI51	Rattus norvegicus	29%	77%
Q5XI63	Rattus norvegicus	31%	74%
Q5ZKV8	Gallus gallus	27%	73%
Q60443	Cricetulus griseus	30%	82%
Q61771	Mus musculus	30%	69%
Q62909	Rattus norvegicus	28%	76%
Q6P3R1	Xenopus tropicalis	28%	80%
Q6S001	Dictyostelium discoideum	28%	75%
Q7Y1C8	Oryza sativa subsp. japonica	29%	71%
Q7ZYL5	Xenopus laevis	28%	79%
Q8GW44	Arabidopsis thaliana	26%	100%
Q8J1G1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	75%
Q8N4N8	Homo sapiens	26%	76%
Q8W0Y9	Arabidopsis thaliana	29%	82%
Q91636	Xenopus laevis	26%	70%
Q91637	Xenopus laevis	27%	75%
Q922S8	Mus musculus	28%	71%
Q95LP1	Macaca fascicularis	28%	76%
Q95LT1	Macaca fascicularis	27%	77%
Q965T6	Caenorhabditis elegans	31%	79%
Q96FN5	Homo sapiens	31%	79%
Q99661	Homo sapiens	28%	71%
Q9BW19	Homo sapiens	31%	76%
Q9D2Z8	Mus musculus	31%	80%
Q9I869	Xenopus laevis	28%	79%
Q9NF78	Leishmania major	32%	78%
Q9QWT9	Mus musculus	31%	76%
Q9UIL4	Homo sapiens	27%	100%
Q9US60	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	93%
Q9V877	Drosophila melanogaster	28%	82%
Q9W1U4	Drosophila melanogaster	29%	82%
Q9WV63	Rattus norvegicus	27%	73%
Q9Y496	Homo sapiens	29%	73%
V5AV84	Trypanosoma cruzi	28%	97%
V5B8M1	Trypanosoma cruzi	28%	84%
V5B8X9	Trypanosoma cruzi	25%	73%
V5BAR9	Trypanosoma cruzi	30%	80%
V5BCN9	Trypanosoma cruzi	27%	72%
V5BHI2	Trypanosoma cruzi	27%	71%
V5BHY4	Trypanosoma cruzi	29%	69%
V5BK25	Trypanosoma cruzi	28%	71%
V5D733	Trypanosoma cruzi	32%	68%
V5DFA7	Trypanosoma cruzi	31%	91%
V5DMS2	Trypanosoma cruzi	31%	96%
V5DTU1	Trypanosoma cruzi	25%	89%