Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HAQ7_LEIBR

TriTrypDb:

LbrM.20.1440 , LBRM2903_250028700

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

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Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	3
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

A4HAQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ7

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.700
CLV_C14_Caspase3-7	212	216	PF00656	0.475
CLV_C14_Caspase3-7	475	479	PF00656	0.705
CLV_NRD_NRD_1	15	17	PF00675	0.722
CLV_NRD_NRD_1	169	171	PF00675	0.380
CLV_NRD_NRD_1	415	417	PF00675	0.475
CLV_NRD_NRD_1	496	498	PF00675	0.746
CLV_PCSK_FUR_1	275	279	PF00082	0.358
CLV_PCSK_FUR_1	494	498	PF00082	0.742
CLV_PCSK_KEX2_1	15	17	PF00082	0.822

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	26%	77%
A0A0N1HY56	Leptomonas seymouri	27%	75%
A0A0N1I0Y5	Leptomonas seymouri	26%	84%
A0A0N1IH46	Leptomonas seymouri	30%	73%
A0A0N1PAZ2	Leptomonas seymouri	27%	68%
A0A0N1PDD6	Leptomonas seymouri	29%	67%
A0A0S4IJP8	Bodo saltans	25%	68%
A0A0S4J1I2	Bodo saltans	29%	78%
A0A0S4JBJ4	Bodo saltans	27%	94%
A0A0S4JEF6	Bodo saltans	26%	76%

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