D-isomer specific 2-hydroxyacid dehydrogenase-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

d-isomer specific 2-hydroxyacid dehydrogenase- protein

Species:

Leishmania braziliensis

UniProt:

A4HAQ6_LEIBR

TriTrypDb:

LbrM.20.1430 , LBRM2903_200023800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0036094	small molecule binding	2	8
GO:0051287	NAD binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.220
CLV_NRD_NRD_1	59	61	PF00675	0.218
CLV_PCSK_KEX2_1	174	176	PF00082	0.532
CLV_PCSK_KEX2_1	28	30	PF00082	0.220
CLV_PCSK_KEX2_1	59	61	PF00082	0.218
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.453
CLV_PCSK_SKI1_1	100	104	PF00082	0.225
CLV_PCSK_SKI1_1	105	109	PF00082	0.217
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DOC_MAPK_gen_1	110	118	PF00069	0.495
DOC_MAPK_gen_1	17	27	PF00069	0.389
DOC_MAPK_gen_1	28	35	PF00069	0.420
DOC_MAPK_gen_1	65	73	PF00069	0.569
DOC_MAPK_HePTP_8	155	167	PF00069	0.389
DOC_MAPK_MEF2A_6	112	120	PF00069	0.410
DOC_MAPK_MEF2A_6	158	167	PF00069	0.389
DOC_SPAK_OSR1_1	68	72	PF12202	0.389
DOC_USP7_UBL2_3	14	18	PF12436	0.252
LIG_14-3-3_CanoR_1	122	131	PF00244	0.454
LIG_14-3-3_CanoR_1	181	189	PF00244	0.464
LIG_BRCT_BRCA1_1	113	117	PF00533	0.452
LIG_deltaCOP1_diTrp_1	16	22	PF00928	0.438
LIG_LIR_Gen_1	106	116	PF02991	0.433
LIG_LIR_Gen_1	16	27	PF02991	0.465
LIG_LIR_Nem_3	114	120	PF02991	0.435
LIG_LIR_Nem_3	16	22	PF02991	0.473
LIG_LIR_Nem_3	186	191	PF02991	0.652
LIG_LIR_Nem_3	5	11	PF02991	0.466
LIG_Pex14_2	103	107	PF04695	0.420
LIG_PTB_Apo_2	101	108	PF02174	0.389
LIG_REV1ctd_RIR_1	100	109	PF16727	0.434
LIG_TYR_ITIM	35	40	PF00017	0.410
MOD_CK2_1	10	16	PF00069	0.388
MOD_CK2_1	122	128	PF00069	0.420
MOD_CK2_1	79	85	PF00069	0.452
MOD_GlcNHglycan	113	116	PF01048	0.218
MOD_GlcNHglycan	60	63	PF01048	0.262
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	10	15	PF00069	0.384
MOD_NEK2_1	167	172	PF00069	0.595
MOD_NEK2_1	180	185	PF00069	0.521
MOD_NEK2_1	53	58	PF00069	0.448
MOD_NEK2_1	79	84	PF00069	0.501
MOD_PIKK_1	122	128	PF00454	0.506
MOD_PKA_2	180	186	PF00069	0.468
MOD_PKA_2	58	64	PF00069	0.462
MOD_Plk_1	79	85	PF00069	0.452
MOD_Plk_4	183	189	PF00069	0.454
MOD_SUMO_rev_2	61	66	PF00179	0.452
TRG_ENDOCYTIC_2	37	40	PF00928	0.450
TRG_ER_diArg_1	157	160	PF00400	0.389
TRG_ER_diArg_1	27	29	PF00400	0.420
TRG_ER_diArg_1	58	60	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JA38	Bodo saltans	41%	69%
A0A3R7MNZ9	Trypanosoma rangeli	51%	92%
A0A422MS45	Trypanosoma rangeli	56%	92%
A0A422MS54	Trypanosoma rangeli	59%	71%
A4I9V3	Leishmania infantum	68%	94%
E9B4W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%