Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAQ3_LEIBR

TriTrypDb:

LbrM.20.1400 , LBRM2903_200023300

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.517
CLV_C14_Caspase3-7	200	204	PF00656	0.436
CLV_NRD_NRD_1	26	28	PF00675	0.621
CLV_NRD_NRD_1	260	262	PF00675	0.450
CLV_NRD_NRD_1	287	289	PF00675	0.497
CLV_NRD_NRD_1	299	301	PF00675	0.448
CLV_NRD_NRD_1	314	316	PF00675	0.390
CLV_NRD_NRD_1	321	323	PF00675	0.512
CLV_NRD_NRD_1	5	7	PF00675	0.515
CLV_NRD_NRD_1	53	55	PF00675	0.430
CLV_PCSK_FUR_1	3	7	PF00082	0.521
CLV_PCSK_FUR_1	34	38	PF00082	0.516
CLV_PCSK_KEX2_1	26	28	PF00082	0.651
CLV_PCSK_KEX2_1	287	289	PF00082	0.500
CLV_PCSK_KEX2_1	299	301	PF00082	0.361
CLV_PCSK_KEX2_1	313	315	PF00082	0.471
CLV_PCSK_KEX2_1	319	321	PF00082	0.378
CLV_PCSK_KEX2_1	36	38	PF00082	0.548
CLV_PCSK_KEX2_1	5	7	PF00082	0.515
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.337
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.531
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.535
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.581
CLV_PCSK_PC7_1	315	321	PF00082	0.462
DEG_APCC_DBOX_1	11	19	PF00400	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_ANK_TNKS_1	5	12	PF00023	0.518
DOC_CKS1_1	95	100	PF01111	0.490
DOC_CYCLIN_RxL_1	49	60	PF00134	0.372
DOC_CYCLIN_yClb1_LxF_4	74	80	PF00134	0.449
DOC_MAPK_gen_1	61	68	PF00069	0.454
DOC_PP1_RVXF_1	220	227	PF00149	0.332
DOC_PP4_FxxP_1	95	98	PF00568	0.532
DOC_USP7_MATH_1	106	110	PF00917	0.588
DOC_USP7_MATH_1	35	39	PF00917	0.525
DOC_USP7_UBL2_3	249	253	PF12436	0.361
DOC_USP7_UBL2_3	319	323	PF12436	0.597
DOC_WW_Pin1_4	37	42	PF00397	0.573
DOC_WW_Pin1_4	94	99	PF00397	0.628
LIG_Actin_WH2_2	110	127	PF00022	0.468
LIG_APCC_ABBA_1	166	171	PF00400	0.426
LIG_CtBP_PxDLS_1	138	142	PF00389	0.478
LIG_eIF4E_1	160	166	PF01652	0.445
LIG_EVH1_1	95	99	PF00568	0.485
LIG_FHA_1	125	131	PF00498	0.712
LIG_FHA_1	185	191	PF00498	0.350
LIG_FHA_1	80	86	PF00498	0.493
LIG_FHA_2	261	267	PF00498	0.578
LIG_FHA_2	293	299	PF00498	0.366
LIG_LIR_Apic_2	92	98	PF02991	0.518
LIG_LIR_Gen_1	78	89	PF02991	0.548
LIG_LIR_Nem_3	118	124	PF02991	0.537
LIG_LIR_Nem_3	45	51	PF02991	0.461
LIG_NRBOX	219	225	PF00104	0.330
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.376
LIG_PCNA_yPIPBox_3	211	224	PF02747	0.472
LIG_SH2_CRK	237	241	PF00017	0.337
LIG_SH2_GRB2like	160	163	PF00017	0.382
LIG_SH2_STAP1	81	85	PF00017	0.464
LIG_SH2_STAT5	81	84	PF00017	0.468
LIG_SH3_2	7	12	PF14604	0.517
LIG_SH3_3	144	150	PF00018	0.576
LIG_SH3_3	4	10	PF00018	0.662
LIG_SH3_3	93	99	PF00018	0.475
LIG_TRAF2_1	173	176	PF00917	0.392
MOD_CK1_1	100	106	PF00069	0.611
MOD_CK1_1	16	22	PF00069	0.760
MOD_CK2_1	260	266	PF00069	0.577
MOD_CK2_1	292	298	PF00069	0.348
MOD_CK2_1	67	73	PF00069	0.516
MOD_DYRK1A_RPxSP_1	37	41	PF00069	0.473
MOD_GlcNHglycan	162	165	PF01048	0.413
MOD_GlcNHglycan	69	72	PF01048	0.510
MOD_GlcNHglycan	99	102	PF01048	0.602
MOD_GSK3_1	100	107	PF00069	0.648
MOD_GSK3_1	13	20	PF00069	0.721
MOD_GSK3_1	67	74	PF00069	0.516
MOD_GSK3_1	90	97	PF00069	0.513
MOD_N-GLC_1	303	308	PF02516	0.435
MOD_NEK2_1	124	129	PF00069	0.624
MOD_NEK2_1	79	84	PF00069	0.485
MOD_NEK2_1	90	95	PF00069	0.567
MOD_PKA_2	260	266	PF00069	0.499
MOD_Plk_1	193	199	PF00069	0.509
MOD_Plk_1	303	309	PF00069	0.465
MOD_Plk_4	90	96	PF00069	0.451
MOD_ProDKin_1	37	43	PF00069	0.570
MOD_ProDKin_1	94	100	PF00069	0.634
MOD_SUMO_for_1	279	282	PF00179	0.430
MOD_SUMO_rev_2	119	127	PF00179	0.538
TRG_DiLeu_BaEn_1	298	303	PF01217	0.440
TRG_DiLeu_BaEn_4	215	221	PF01217	0.488
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.552
TRG_ENDOCYTIC_2	169	172	PF00928	0.340
TRG_ENDOCYTIC_2	237	240	PF00928	0.337
TRG_ENDOCYTIC_2	81	84	PF00928	0.491
TRG_ER_diArg_1	2	5	PF00400	0.556
TRG_ER_diArg_1	286	288	PF00400	0.567
TRG_ER_diArg_1	320	322	PF00400	0.502
TRG_NES_CRM1_1	200	216	PF08389	0.350
TRG_NLS_Bipartite_1	26	40	PF00514	0.605
TRG_NLS_MonoCore_2	318	323	PF00514	0.589
TRG_NLS_MonoExtC_3	318	323	PF00514	0.589
TRG_NLS_MonoExtN_4	34	40	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R6	Leptomonas seymouri	47%	100%
A0A3Q8IIE4	Leishmania donovani	68%	100%
A4I9V0	Leishmania infantum	70%	100%
E9B4W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q365	Leishmania major	68%	100%