Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAQ2_LEIBR

TriTrypDb:

LbrM.20.1380 , LBRM2903_200023100

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.742
CLV_C14_Caspase3-7	562	566	PF00656	0.747
CLV_PCSK_KEX2_1	34	36	PF00082	0.591
CLV_PCSK_KEX2_1	519	521	PF00082	0.606
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.591
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.628
CLV_PCSK_SKI1_1	192	196	PF00082	0.600
CLV_PCSK_SKI1_1	379	383	PF00082	0.653
CLV_PCSK_SKI1_1	51	55	PF00082	0.664
CLV_PCSK_SKI1_1	71	75	PF00082	0.318
DEG_APCC_DBOX_1	63	71	PF00400	0.385
DOC_ANK_TNKS_1	250	257	PF00023	0.596
DOC_CKS1_1	139	144	PF01111	0.779
DOC_CKS1_1	245	250	PF01111	0.737
DOC_CKS1_1	322	327	PF01111	0.837
DOC_CKS1_1	498	503	PF01111	0.684
DOC_CYCLIN_RxL_1	68	77	PF00134	0.391
DOC_MAPK_gen_1	484	493	PF00069	0.465
DOC_MAPK_gen_1	62	70	PF00069	0.384
DOC_MAPK_MEF2A_6	235	244	PF00069	0.564
DOC_MAPK_MEF2A_6	484	493	PF00069	0.432
DOC_MAPK_NFAT4_5	486	494	PF00069	0.430
DOC_PP1_RVXF_1	69	76	PF00149	0.390
DOC_PP2B_LxvP_1	541	544	PF13499	0.782
DOC_PP4_FxxP_1	237	240	PF00568	0.559
DOC_USP7_MATH_1	24	28	PF00917	0.508
DOC_USP7_MATH_1	240	244	PF00917	0.720
DOC_USP7_MATH_1	297	301	PF00917	0.620
DOC_USP7_MATH_1	337	341	PF00917	0.604
DOC_USP7_MATH_1	393	397	PF00917	0.589
DOC_USP7_MATH_1	480	484	PF00917	0.487
DOC_USP7_MATH_1	563	567	PF00917	0.531
DOC_WW_Pin1_4	138	143	PF00397	0.774
DOC_WW_Pin1_4	244	249	PF00397	0.676
DOC_WW_Pin1_4	258	263	PF00397	0.729
DOC_WW_Pin1_4	283	288	PF00397	0.692
DOC_WW_Pin1_4	298	303	PF00397	0.591
DOC_WW_Pin1_4	318	323	PF00397	0.525
DOC_WW_Pin1_4	36	41	PF00397	0.581
DOC_WW_Pin1_4	406	411	PF00397	0.788
DOC_WW_Pin1_4	413	418	PF00397	0.611
DOC_WW_Pin1_4	497	502	PF00397	0.689
DOC_WW_Pin1_4	91	96	PF00397	0.647
LIG_14-3-3_CanoR_1	113	119	PF00244	0.581
LIG_14-3-3_CanoR_1	151	159	PF00244	0.597
LIG_14-3-3_CanoR_1	213	217	PF00244	0.567
LIG_14-3-3_CanoR_1	309	319	PF00244	0.582
LIG_14-3-3_CanoR_1	364	372	PF00244	0.601
LIG_14-3-3_CanoR_1	405	410	PF00244	0.801
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.398
LIG_BIR_II_1	1	5	PF00653	0.735
LIG_BIR_III_3	1	5	PF00653	0.735
LIG_BRCT_BRCA1_1	233	237	PF00533	0.560
LIG_CtBP_PxDLS_1	147	151	PF00389	0.664
LIG_deltaCOP1_diTrp_1	508	517	PF00928	0.461
LIG_FHA_1	104	110	PF00498	0.641
LIG_FHA_1	139	145	PF00498	0.745
LIG_FHA_1	159	165	PF00498	0.329
LIG_FHA_1	168	174	PF00498	0.545
LIG_FHA_1	204	210	PF00498	0.534
LIG_FHA_1	228	234	PF00498	0.597
LIG_FHA_1	351	357	PF00498	0.688
LIG_FHA_1	493	499	PF00498	0.634
LIG_FHA_1	565	571	PF00498	0.744
LIG_FHA_1	83	89	PF00498	0.597
LIG_FHA_2	202	208	PF00498	0.513
LIG_FHA_2	355	361	PF00498	0.708
LIG_FHA_2	414	420	PF00498	0.672
LIG_FHA_2	470	476	PF00498	0.737
LIG_FHA_2	498	504	PF00498	0.580
LIG_FHA_2	52	58	PF00498	0.659
LIG_FHA_2	546	552	PF00498	0.705
LIG_LIR_Apic_2	182	186	PF02991	0.563
LIG_LIR_Apic_2	234	240	PF02991	0.559
LIG_LIR_Gen_1	72	82	PF02991	0.407
LIG_LIR_LC3C_4	360	363	PF02991	0.435
LIG_LIR_Nem_3	522	527	PF02991	0.634
LIG_LIR_Nem_3	72	78	PF02991	0.398
LIG_NRBOX	69	75	PF00104	0.640
LIG_PALB2_WD40_1	185	193	PF16756	0.522
LIG_SH2_CRK	183	187	PF00017	0.549
LIG_SH2_STAT3	460	463	PF00017	0.534
LIG_SH2_STAT3	81	84	PF00017	0.709
LIG_SH2_STAT5	166	169	PF00017	0.534
LIG_SH2_STAT5	371	374	PF00017	0.625
LIG_SH2_STAT5	376	379	PF00017	0.648
LIG_SH2_STAT5	525	528	PF00017	0.628
LIG_SH2_STAT5	66	69	PF00017	0.643
LIG_SH2_STAT5	81	84	PF00017	0.461
LIG_SH3_2	255	260	PF14604	0.588
LIG_SH3_3	133	139	PF00018	0.651
LIG_SH3_3	239	245	PF00018	0.781
LIG_SH3_3	249	255	PF00018	0.687
LIG_SH3_3	256	262	PF00018	0.703
LIG_SH3_3	275	281	PF00018	0.796
LIG_SH3_3	319	325	PF00018	0.717
LIG_SH3_3	353	359	PF00018	0.639
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.446
LIG_TRAF2_1	4	7	PF00917	0.597
LIG_TRAF2_1	500	503	PF00917	0.581
LIG_UBA3_1	515	519	PF00899	0.594
LIG_UBA3_1	67	71	PF00899	0.385
LIG_WRPW_2	63	66	PF00400	0.617
MOD_CDK_SPxxK_3	244	251	PF00069	0.738
MOD_CDK_SPxxK_3	283	290	PF00069	0.578
MOD_CDK_SPxxK_3	413	420	PF00069	0.760
MOD_CK1_1	103	109	PF00069	0.760
MOD_CK1_1	121	127	PF00069	0.632
MOD_CK1_1	231	237	PF00069	0.616
MOD_CK1_1	268	274	PF00069	0.666
MOD_CK1_1	293	299	PF00069	0.822
MOD_CK1_1	310	316	PF00069	0.715
MOD_CK1_1	321	327	PF00069	0.694
MOD_CK1_1	332	338	PF00069	0.604
MOD_CK1_1	345	351	PF00069	0.581
MOD_CK1_1	395	401	PF00069	0.745
MOD_CK1_1	408	414	PF00069	0.822
MOD_CK1_1	529	535	PF00069	0.710
MOD_CK2_1	201	207	PF00069	0.500
MOD_CK2_1	497	503	PF00069	0.582
MOD_CK2_1	51	57	PF00069	0.662
MOD_CK2_1	545	551	PF00069	0.659
MOD_GlcNHglycan	218	221	PF01048	0.641
MOD_GlcNHglycan	230	233	PF01048	0.517
MOD_GlcNHglycan	26	29	PF01048	0.503
MOD_GlcNHglycan	267	270	PF01048	0.603
MOD_GlcNHglycan	292	295	PF01048	0.802
MOD_GlcNHglycan	309	312	PF01048	0.662
MOD_GlcNHglycan	331	334	PF01048	0.623
MOD_GlcNHglycan	335	338	PF01048	0.844
MOD_GlcNHglycan	366	369	PF01048	0.493
MOD_GlcNHglycan	397	400	PF01048	0.697
MOD_GlcNHglycan	413	416	PF01048	0.498
MOD_GlcNHglycan	440	443	PF01048	0.661
MOD_GlcNHglycan	469	472	PF01048	0.520
MOD_GlcNHglycan	528	531	PF01048	0.764
MOD_GlcNHglycan	538	541	PF01048	0.615
MOD_GSK3_1	112	119	PF00069	0.658
MOD_GSK3_1	208	215	PF00069	0.654
MOD_GSK3_1	227	234	PF00069	0.626
MOD_GSK3_1	240	247	PF00069	0.686
MOD_GSK3_1	289	296	PF00069	0.794
MOD_GSK3_1	307	314	PF00069	0.547
MOD_GSK3_1	329	336	PF00069	0.792
MOD_GSK3_1	350	357	PF00069	0.773
MOD_GSK3_1	389	396	PF00069	0.661
MOD_GSK3_1	401	408	PF00069	0.770
MOD_GSK3_1	51	58	PF00069	0.580
MOD_GSK3_1	526	533	PF00069	0.615
MOD_N-GLC_1	273	278	PF02516	0.562
MOD_N-GLC_1	307	312	PF02516	0.666
MOD_N-GLC_1	406	411	PF02516	0.802
MOD_NEK2_1	114	119	PF00069	0.559
MOD_NEK2_1	150	155	PF00069	0.622
MOD_NEK2_1	167	172	PF00069	0.552
MOD_NEK2_1	212	217	PF00069	0.683
MOD_NEK2_1	233	238	PF00069	0.589
MOD_NEK2_1	267	272	PF00069	0.736
MOD_NEK2_1	489	494	PF00069	0.686
MOD_NEK2_1	564	569	PF00069	0.642
MOD_NEK2_1	82	87	PF00069	0.487
MOD_NEK2_2	208	213	PF00069	0.558
MOD_PIKK_1	150	156	PF00454	0.493
MOD_PIKK_1	337	343	PF00454	0.804
MOD_PIKK_1	436	442	PF00454	0.669
MOD_PK_1	55	61	PF00069	0.651
MOD_PKA_1	519	525	PF00069	0.632
MOD_PKA_2	103	109	PF00069	0.766
MOD_PKA_2	112	118	PF00069	0.681
MOD_PKA_2	150	156	PF00069	0.603
MOD_PKA_2	212	218	PF00069	0.563
MOD_PKA_2	329	335	PF00069	0.808
MOD_PKA_2	519	525	PF00069	0.632
MOD_Plk_1	382	388	PF00069	0.615
MOD_Plk_2-3	469	475	PF00069	0.483
MOD_Plk_4	314	320	PF00069	0.593
MOD_Plk_4	494	500	PF00069	0.603
MOD_ProDKin_1	138	144	PF00069	0.777
MOD_ProDKin_1	244	250	PF00069	0.679
MOD_ProDKin_1	258	264	PF00069	0.730
MOD_ProDKin_1	283	289	PF00069	0.691
MOD_ProDKin_1	298	304	PF00069	0.664
MOD_ProDKin_1	318	324	PF00069	0.524
MOD_ProDKin_1	36	42	PF00069	0.585
MOD_ProDKin_1	406	412	PF00069	0.785
MOD_ProDKin_1	413	419	PF00069	0.607
MOD_ProDKin_1	497	503	PF00069	0.684
MOD_ProDKin_1	91	97	PF00069	0.652
MOD_SUMO_for_1	372	375	PF00179	0.725
TRG_DiLeu_BaEn_1	7	12	PF01217	0.563
TRG_DiLeu_BaEn_2	512	518	PF01217	0.475
TRG_ER_diArg_1	157	160	PF00400	0.571
TRG_ER_diArg_1	198	201	PF00400	0.466
TRG_ER_diArg_1	544	547	PF00400	0.768
TRG_NES_CRM1_1	21	33	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C9	Leptomonas seymouri	53%	98%
A0A3S7X7T6	Leishmania donovani	78%	100%
A4I9U8	Leishmania infantum	77%	99%
E9B4V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q367	Leishmania major	78%	100%