Mitochondrial chaperone BCS1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BCS1 N terminal/ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania braziliensis

UniProt:

A4HAQ0_LEIBR

TriTrypDb:

LbrM.20.1360 , LBRM2903_200022900

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HAQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.374
CLV_C14_Caspase3-7	290	294	PF00656	0.374
CLV_NRD_NRD_1	153	155	PF00675	0.228
CLV_NRD_NRD_1	191	193	PF00675	0.310
CLV_NRD_NRD_1	320	322	PF00675	0.362
CLV_NRD_NRD_1	7	9	PF00675	0.255
CLV_NRD_NRD_1	87	89	PF00675	0.284
CLV_PCSK_FUR_1	151	155	PF00082	0.228
CLV_PCSK_FUR_1	85	89	PF00082	0.408
CLV_PCSK_KEX2_1	153	155	PF00082	0.234
CLV_PCSK_KEX2_1	191	193	PF00082	0.297
CLV_PCSK_KEX2_1	7	9	PF00082	0.228
CLV_PCSK_KEX2_1	85	87	PF00082	0.278
CLV_PCSK_PC7_1	149	155	PF00082	0.254
CLV_PCSK_SKI1_1	174	178	PF00082	0.323
CLV_PCSK_SKI1_1	280	284	PF00082	0.228
CLV_PCSK_SKI1_1	321	325	PF00082	0.368
CLV_PCSK_SKI1_1	34	38	PF00082	0.324
CLV_PCSK_SKI1_1	71	75	PF00082	0.348
CLV_PCSK_SKI1_1	79	83	PF00082	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DEG_SCF_FBW7_2	44	51	PF00400	0.156
DOC_CDC14_PxL_1	395	403	PF14671	0.474
DOC_MAPK_gen_1	151	161	PF00069	0.228
DOC_MAPK_gen_1	298	308	PF00069	0.228
DOC_MAPK_gen_1	34	43	PF00069	0.374
DOC_MAPK_gen_1	7	16	PF00069	0.243
DOC_MAPK_MEF2A_6	301	310	PF00069	0.228
DOC_MAPK_MEF2A_6	7	16	PF00069	0.322
DOC_PP1_RVXF_1	278	284	PF00149	0.246
DOC_PP2B_LxvP_1	186	189	PF13499	0.333
DOC_USP7_MATH_1	155	159	PF00917	0.243
DOC_USP7_UBL2_3	322	326	PF12436	0.498
DOC_WW_Pin1_4	44	49	PF00397	0.156
DOC_WW_Pin1_4	62	67	PF00397	0.114
DOC_WW_Pin1_4	89	94	PF00397	0.352
LIG_14-3-3_CanoR_1	154	160	PF00244	0.193
LIG_14-3-3_CanoR_1	216	222	PF00244	0.293
LIG_14-3-3_CanoR_1	28	36	PF00244	0.355
LIG_14-3-3_CanoR_1	390	396	PF00244	0.543
LIG_14-3-3_CanoR_1	79	84	PF00244	0.378
LIG_BRCT_BRCA1_1	178	182	PF00533	0.374
LIG_BRCT_BRCA1_1	350	354	PF00533	0.299
LIG_BRCT_BRCA1_1	373	377	PF00533	0.363
LIG_BRCT_BRCA1_2	178	184	PF00533	0.272
LIG_Clathr_ClatBox_1	310	314	PF01394	0.327
LIG_Clathr_ClatBox_1	400	404	PF01394	0.612
LIG_deltaCOP1_diTrp_1	24	29	PF00928	0.322
LIG_eIF4E_1	190	196	PF01652	0.284
LIG_FHA_1	203	209	PF00498	0.401
LIG_FHA_1	233	239	PF00498	0.357
LIG_FHA_1	243	249	PF00498	0.303
LIG_FHA_1	284	290	PF00498	0.228
LIG_FHA_1	33	39	PF00498	0.322
LIG_FHA_1	362	368	PF00498	0.367
LIG_FHA_2	56	62	PF00498	0.287
LIG_FXI_DFP_1	400	404	PF00024	0.393
LIG_HOMEOBOX	23	26	PF00046	0.374
LIG_IRF3_LxIS_1	215	220	PF10401	0.374
LIG_LIR_Gen_1	20	30	PF02991	0.243
LIG_LIR_Gen_1	97	108	PF02991	0.377
LIG_LIR_Nem_3	104	108	PF02991	0.326
LIG_LIR_Nem_3	180	186	PF02991	0.397
LIG_LIR_Nem_3	97	103	PF02991	0.377
LIG_NRBOX	233	239	PF00104	0.228
LIG_PCNA_yPIPBox_3	254	268	PF02747	0.374
LIG_Pex14_2	335	339	PF04695	0.370
LIG_REV1ctd_RIR_1	352	361	PF16727	0.364
LIG_SH2_CRK	183	187	PF00017	0.485
LIG_SH2_GRB2like	137	140	PF00017	0.228
LIG_SH2_STAP1	23	27	PF00017	0.322
LIG_SH2_STAP1	95	99	PF00017	0.257
LIG_SH2_STAT5	194	197	PF00017	0.243
LIG_SH3_1	393	399	PF00018	0.686
LIG_SH3_3	156	162	PF00018	0.424
LIG_SH3_3	362	368	PF00018	0.363
LIG_SH3_3	393	399	PF00018	0.616
LIG_SUMO_SIM_anti_2	218	223	PF11976	0.374
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.231
LIG_SUMO_SIM_par_1	10	15	PF11976	0.322
LIG_SUMO_SIM_par_1	244	251	PF11976	0.246
LIG_SUMO_SIM_par_1	309	314	PF11976	0.329
LIG_SUMO_SIM_par_1	363	369	PF11976	0.225
LIG_SUMO_SIM_par_1	79	84	PF11976	0.374
LIG_TRAF2_1	126	129	PF00917	0.448
LIG_UBA3_1	1	9	PF00899	0.374
LIG_UBA3_1	26	34	PF00899	0.287
LIG_WRC_WIRS_1	367	372	PF05994	0.264
MOD_CK1_1	131	137	PF00069	0.252
MOD_CK1_1	142	148	PF00069	0.314
MOD_CK1_1	178	184	PF00069	0.243
MOD_CK1_1	233	239	PF00069	0.272
MOD_CK1_1	386	392	PF00069	0.448
MOD_CK1_1	42	48	PF00069	0.252
MOD_CK1_1	55	61	PF00069	0.252
MOD_CK2_1	55	61	PF00069	0.342
MOD_GlcNHglycan	110	113	PF01048	0.310
MOD_GlcNHglycan	264	267	PF01048	0.306
MOD_GlcNHglycan	344	347	PF01048	0.372
MOD_GSK3_1	10	17	PF00069	0.284
MOD_GSK3_1	145	152	PF00069	0.426
MOD_GSK3_1	28	35	PF00069	0.334
MOD_GSK3_1	366	373	PF00069	0.458
MOD_GSK3_1	42	49	PF00069	0.270
MOD_GSK3_1	51	58	PF00069	0.313
MOD_GSK3_1	89	96	PF00069	0.377
MOD_GSK3_1	99	106	PF00069	0.231
MOD_N-GLC_1	222	227	PF02516	0.374
MOD_N-GLC_1	260	265	PF02516	0.374
MOD_N-GLC_1	89	94	PF02516	0.287
MOD_N-GLC_2	258	260	PF02516	0.374
MOD_NEK2_1	103	108	PF00069	0.243
MOD_NEK2_1	14	19	PF00069	0.261
MOD_NEK2_1	176	181	PF00069	0.302
MOD_NEK2_1	215	220	PF00069	0.238
MOD_NEK2_1	222	227	PF00069	0.216
MOD_NEK2_1	283	288	PF00069	0.228
MOD_NEK2_1	370	375	PF00069	0.331
MOD_NEK2_1	391	396	PF00069	0.533
MOD_NEK2_1	50	55	PF00069	0.363
MOD_NEK2_1	81	86	PF00069	0.338
MOD_PIKK_1	313	319	PF00454	0.384
MOD_PKA_2	145	151	PF00069	0.283
MOD_PKA_2	215	221	PF00069	0.262
MOD_Plk_1	103	109	PF00069	0.322
MOD_Plk_1	131	137	PF00069	0.234
MOD_Plk_1	230	236	PF00069	0.287
MOD_Plk_1	260	266	PF00069	0.374
MOD_Plk_1	377	383	PF00069	0.419
MOD_Plk_4	110	116	PF00069	0.283
MOD_Plk_4	131	137	PF00069	0.259
MOD_Plk_4	155	161	PF00069	0.243
MOD_Plk_4	178	184	PF00069	0.462
MOD_Plk_4	203	209	PF00069	0.243
MOD_Plk_4	233	239	PF00069	0.319
MOD_Plk_4	242	248	PF00069	0.321
MOD_Plk_4	366	372	PF00069	0.243
MOD_Plk_4	39	45	PF00069	0.310
MOD_ProDKin_1	44	50	PF00069	0.156
MOD_ProDKin_1	62	68	PF00069	0.114
MOD_ProDKin_1	89	95	PF00069	0.352
MOD_SUMO_for_1	304	307	PF00179	0.228
MOD_SUMO_rev_2	166	176	PF00179	0.384
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.512
TRG_ENDOCYTIC_2	183	186	PF00928	0.337
TRG_ENDOCYTIC_2	23	26	PF00928	0.243
TRG_ENDOCYTIC_2	320	323	PF00928	0.410
TRG_ER_diArg_1	150	153	PF00400	0.228
TRG_ER_diArg_1	190	192	PF00400	0.298
TRG_ER_diArg_1	6	8	PF00400	0.243
TRG_ER_diArg_1	85	88	PF00400	0.280
TRG_NLS_MonoExtN_4	385	391	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.228
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXY0	Leptomonas seymouri	78%	83%
A0A0S4IXV8	Bodo saltans	52%	88%
A0A1X0NQP6	Trypanosomatidae	54%	86%
A0A1X0P1R2	Trypanosomatidae	28%	74%
A0A3Q8IUI9	Leishmania donovani	91%	100%
A0A3R7RKG3	Trypanosoma rangeli	28%	100%
A0A3S7XBS4	Leishmania donovani	27%	92%
A0A422MTV6	Trypanosoma rangeli	57%	86%
A4IDV4	Leishmania infantum	27%	70%
C9ZVE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	85%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	76%
E9ATX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B4V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P32839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	89%
Q4Q0M1	Leishmania major	29%	100%
Q4Q369	Leishmania major	92%	100%
Q54DY9	Dictyostelium discoideum	39%	89%
Q54HY8	Dictyostelium discoideum	35%	96%
Q5E9H5	Bos taurus	40%	97%
Q7ZTL7	Xenopus laevis	42%	97%
Q7ZV60	Danio rerio	38%	97%
Q9CZP5	Mus musculus	40%	97%
Q9LH83	Arabidopsis thaliana	28%	83%
Q9P6Q3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	90%
Q9Y276	Homo sapiens	41%	97%
V5BA71	Trypanosoma cruzi	55%	87%
V5BUW7	Trypanosoma cruzi	31%	73%