Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAP9_LEIBR

TriTrypDb:

LbrM.20.1350 , LBRM2903_200022800

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.714
CLV_C14_Caspase3-7	578	582	PF00656	0.713
CLV_NRD_NRD_1	160	162	PF00675	0.621
CLV_NRD_NRD_1	164	166	PF00675	0.616
CLV_NRD_NRD_1	175	177	PF00675	0.637
CLV_NRD_NRD_1	463	465	PF00675	0.637
CLV_NRD_NRD_1	467	469	PF00675	0.640
CLV_NRD_NRD_1	512	514	PF00675	0.560
CLV_NRD_NRD_1	58	60	PF00675	0.709
CLV_NRD_NRD_1	651	653	PF00675	0.568
CLV_NRD_NRD_1	716	718	PF00675	0.632
CLV_NRD_NRD_1	8	10	PF00675	0.652
CLV_NRD_NRD_1	90	92	PF00675	0.701
CLV_PCSK_FUR_1	161	165	PF00082	0.676
CLV_PCSK_FUR_1	233	237	PF00082	0.635
CLV_PCSK_FUR_1	461	465	PF00082	0.685
CLV_PCSK_KEX2_1	160	162	PF00082	0.680
CLV_PCSK_KEX2_1	163	165	PF00082	0.671
CLV_PCSK_KEX2_1	175	177	PF00082	0.699
CLV_PCSK_KEX2_1	232	234	PF00082	0.702
CLV_PCSK_KEX2_1	235	237	PF00082	0.693
CLV_PCSK_KEX2_1	463	465	PF00082	0.643
CLV_PCSK_KEX2_1	466	468	PF00082	0.643
CLV_PCSK_KEX2_1	512	514	PF00082	0.560
CLV_PCSK_KEX2_1	570	572	PF00082	0.710
CLV_PCSK_KEX2_1	58	60	PF00082	0.717
CLV_PCSK_KEX2_1	651	653	PF00082	0.568
CLV_PCSK_KEX2_1	8	10	PF00082	0.652
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.608
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.608
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.520
CLV_PCSK_PC7_1	160	166	PF00082	0.531
CLV_PCSK_PC7_1	463	469	PF00082	0.654
CLV_PCSK_SKI1_1	390	394	PF00082	0.619
CLV_PCSK_SKI1_1	585	589	PF00082	0.548
CLV_PCSK_SKI1_1	630	634	PF00082	0.615
CLV_PCSK_SKI1_1	639	643	PF00082	0.527
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DEG_SCF_FBW7_2	290	297	PF00400	0.685
DEG_SPOP_SBC_1	125	129	PF00917	0.725
DEG_SPOP_SBC_1	17	21	PF00917	0.552
DOC_CKS1_1	477	482	PF01111	0.642
DOC_CYCLIN_RxL_1	636	643	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	419	422	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.643
DOC_MAPK_MEF2A_6	688	697	PF00069	0.543
DOC_PIKK_1	621	629	PF02985	0.518
DOC_PP1_RVXF_1	530	536	PF00149	0.534
DOC_PP1_RVXF_1	7	14	PF00149	0.506
DOC_PP2B_LxvP_1	207	210	PF13499	0.727
DOC_PP2B_LxvP_1	419	422	PF13499	0.500
DOC_PP2B_LxvP_1	425	428	PF13499	0.601
DOC_PP4_FxxP_1	277	280	PF00568	0.623
DOC_PP4_FxxP_1	535	538	PF00568	0.567
DOC_PP4_FxxP_1	603	606	PF00568	0.685
DOC_PP4_FxxP_1	766	769	PF00568	0.498
DOC_USP7_MATH_1	118	122	PF00917	0.761
DOC_USP7_MATH_1	125	129	PF00917	0.707
DOC_USP7_MATH_1	152	156	PF00917	0.601
DOC_USP7_MATH_1	169	173	PF00917	0.749
DOC_USP7_MATH_1	174	178	PF00917	0.819
DOC_USP7_MATH_1	210	214	PF00917	0.721
DOC_USP7_MATH_1	225	229	PF00917	0.674
DOC_USP7_MATH_1	242	246	PF00917	0.740
DOC_USP7_MATH_1	247	251	PF00917	0.791
DOC_USP7_MATH_1	271	275	PF00917	0.537
DOC_USP7_MATH_1	363	367	PF00917	0.751
DOC_USP7_MATH_1	444	448	PF00917	0.769
DOC_USP7_MATH_1	546	550	PF00917	0.665
DOC_USP7_MATH_1	606	610	PF00917	0.728
DOC_USP7_MATH_1	661	665	PF00917	0.664
DOC_USP7_MATH_1	716	720	PF00917	0.541
DOC_USP7_MATH_1	754	758	PF00917	0.602
DOC_USP7_MATH_1	80	84	PF00917	0.759
DOC_USP7_UBL2_3	231	235	PF12436	0.586
DOC_USP7_UBL2_3	332	336	PF12436	0.653
DOC_WW_Pin1_4	176	181	PF00397	0.803
DOC_WW_Pin1_4	185	190	PF00397	0.676
DOC_WW_Pin1_4	238	243	PF00397	0.559
DOC_WW_Pin1_4	269	274	PF00397	0.728
DOC_WW_Pin1_4	276	281	PF00397	0.627
DOC_WW_Pin1_4	290	295	PF00397	0.524
DOC_WW_Pin1_4	378	383	PF00397	0.589
DOC_WW_Pin1_4	476	481	PF00397	0.653
DOC_WW_Pin1_4	482	487	PF00397	0.672
DOC_WW_Pin1_4	492	497	PF00397	0.508
DOC_WW_Pin1_4	597	602	PF00397	0.563
DOC_WW_Pin1_4	631	636	PF00397	0.574
DOC_WW_Pin1_4	673	678	PF00397	0.608
DOC_WW_Pin1_4	717	722	PF00397	0.587
DOC_WW_Pin1_4	727	732	PF00397	0.562
LIG_14-3-3_CanoR_1	175	180	PF00244	0.640
LIG_14-3-3_CanoR_1	2	11	PF00244	0.565
LIG_14-3-3_CanoR_1	26	32	PF00244	0.658
LIG_14-3-3_CanoR_1	33	40	PF00244	0.662
LIG_14-3-3_CanoR_1	475	480	PF00244	0.595
LIG_14-3-3_CanoR_1	630	635	PF00244	0.509
LIG_14-3-3_CanoR_1	688	696	PF00244	0.541
LIG_14-3-3_CanoR_1	717	721	PF00244	0.738
LIG_BRCT_BRCA1_1	187	191	PF00533	0.562
LIG_BRCT_BRCA1_1	273	277	PF00533	0.630
LIG_BRCT_BRCA1_1	315	319	PF00533	0.566
LIG_BRCT_BRCA1_1	47	51	PF00533	0.752
LIG_BRCT_BRCA1_1	599	603	PF00533	0.548
LIG_CaM_IQ_9	500	515	PF13499	0.562
LIG_eIF4E_1	636	642	PF01652	0.591
LIG_FHA_1	138	144	PF00498	0.541
LIG_FHA_1	17	23	PF00498	0.551
LIG_FHA_1	256	262	PF00498	0.690
LIG_FHA_1	306	312	PF00498	0.552
LIG_FHA_1	35	41	PF00498	0.483
LIG_FHA_1	379	385	PF00498	0.654
LIG_FHA_1	404	410	PF00498	0.595
LIG_FHA_1	486	492	PF00498	0.744
LIG_FHA_1	61	67	PF00498	0.676
LIG_FHA_1	692	698	PF00498	0.567
LIG_FHA_2	365	371	PF00498	0.702
LIG_FHA_2	429	435	PF00498	0.743
LIG_FHA_2	667	673	PF00498	0.504
LIG_LIR_Apic_2	274	280	PF02991	0.630
LIG_LIR_Apic_2	600	606	PF02991	0.539
LIG_LIR_Apic_2	765	769	PF02991	0.503
LIG_LIR_Gen_1	29	39	PF02991	0.694
LIG_LIR_Gen_1	318	325	PF02991	0.443
LIG_LIR_Gen_1	345	352	PF02991	0.544
LIG_LIR_Gen_1	389	399	PF02991	0.582
LIG_LIR_Gen_1	408	416	PF02991	0.571
LIG_LIR_Nem_3	29	34	PF02991	0.665
LIG_LIR_Nem_3	318	324	PF02991	0.442
LIG_LIR_Nem_3	345	349	PF02991	0.543
LIG_LIR_Nem_3	389	395	PF02991	0.577
LIG_LIR_Nem_3	408	413	PF02991	0.573
LIG_LIR_Nem_3	672	678	PF02991	0.682
LIG_MYND_1	205	209	PF01753	0.655
LIG_MYND_1	492	496	PF01753	0.573
LIG_MYND_3	204	208	PF01753	0.575
LIG_SH2_CRK	346	350	PF00017	0.545
LIG_SH2_CRK	527	531	PF00017	0.580
LIG_SH2_CRK	776	780	PF00017	0.578
LIG_SH2_STAP1	285	289	PF00017	0.684
LIG_SH2_STAP1	611	615	PF00017	0.711
LIG_SH2_STAP1	689	693	PF00017	0.552
LIG_SH2_STAT5	285	288	PF00017	0.709
LIG_SH2_STAT5	334	337	PF00017	0.554
LIG_SH2_STAT5	636	639	PF00017	0.637
LIG_SH2_STAT5	678	681	PF00017	0.577
LIG_SH2_STAT5	776	779	PF00017	0.598
LIG_SH3_1	681	687	PF00018	0.550
LIG_SH3_3	183	189	PF00018	0.715
LIG_SH3_3	203	209	PF00018	0.675
LIG_SH3_3	241	247	PF00018	0.543
LIG_SH3_3	470	476	PF00018	0.625
LIG_SH3_3	598	604	PF00018	0.667
LIG_SH3_3	681	687	PF00018	0.550
LIG_SH3_3	748	754	PF00018	0.551
LIG_SH3_3	766	772	PF00018	0.704
LIG_Sin3_3	105	112	PF02671	0.520
LIG_SUMO_SIM_anti_2	690	698	PF11976	0.551
LIG_SUMO_SIM_par_1	308	314	PF11976	0.552
LIG_SUMO_SIM_par_1	383	389	PF11976	0.460
LIG_SUMO_SIM_par_1	693	698	PF11976	0.558
LIG_SUMO_SIM_par_1	705	712	PF11976	0.542
LIG_UBA3_1	384	390	PF00899	0.455
LIG_UBA3_1	500	508	PF00899	0.546
LIG_WRC_WIRS_1	1	6	PF05994	0.512
LIG_WRC_WIRS_1	28	33	PF05994	0.704
MOD_CDC14_SPxK_1	730	733	PF00782	0.532
MOD_CDK_SPK_2	290	295	PF00069	0.698
MOD_CDK_SPxK_1	727	733	PF00069	0.543
MOD_CDK_SPxxK_3	492	499	PF00069	0.560
MOD_CK1_1	134	140	PF00069	0.566
MOD_CK1_1	141	147	PF00069	0.539
MOD_CK1_1	178	184	PF00069	0.720
MOD_CK1_1	187	193	PF00069	0.760
MOD_CK1_1	238	244	PF00069	0.799
MOD_CK1_1	3	9	PF00069	0.505
MOD_CK1_1	345	351	PF00069	0.470
MOD_CK1_1	443	449	PF00069	0.713
MOD_CK1_1	45	51	PF00069	0.760
MOD_CK1_1	549	555	PF00069	0.453
MOD_CK1_1	575	581	PF00069	0.647
MOD_CK1_1	596	602	PF00069	0.703
MOD_CK1_1	609	615	PF00069	0.697
MOD_CK1_1	634	640	PF00069	0.648
MOD_CK1_1	673	679	PF00069	0.617
MOD_CK1_1	720	726	PF00069	0.663
MOD_CK1_1	79	85	PF00069	0.717
MOD_CK2_1	124	130	PF00069	0.710
MOD_CK2_1	364	370	PF00069	0.766
MOD_CK2_1	428	434	PF00069	0.596
MOD_CK2_1	443	449	PF00069	0.715
MOD_CK2_1	492	498	PF00069	0.523
MOD_CK2_1	666	672	PF00069	0.725
MOD_CK2_1	706	712	PF00069	0.541
MOD_CK2_1	720	726	PF00069	0.638
MOD_Cter_Amidation	161	164	PF01082	0.620
MOD_Cter_Amidation	229	232	PF01082	0.748
MOD_Cter_Amidation	233	236	PF01082	0.675
MOD_Cter_Amidation	461	464	PF01082	0.689
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.613
MOD_GlcNHglycan	147	150	PF01048	0.656
MOD_GlcNHglycan	154	157	PF01048	0.665
MOD_GlcNHglycan	171	174	PF01048	0.713
MOD_GlcNHglycan	249	252	PF01048	0.615
MOD_GlcNHglycan	313	316	PF01048	0.557
MOD_GlcNHglycan	376	379	PF01048	0.563
MOD_GlcNHglycan	437	440	PF01048	0.726
MOD_GlcNHglycan	442	445	PF01048	0.775
MOD_GlcNHglycan	446	449	PF01048	0.819
MOD_GlcNHglycan	548	551	PF01048	0.723
MOD_GlcNHglycan	574	577	PF01048	0.666
MOD_GlcNHglycan	672	675	PF01048	0.619
MOD_GlcNHglycan	722	725	PF01048	0.663
MOD_GlcNHglycan	78	81	PF01048	0.709
MOD_GlcNHglycan	85	88	PF01048	0.720
MOD_GSK3_1	114	121	PF00069	0.660
MOD_GSK3_1	132	139	PF00069	0.590
MOD_GSK3_1	141	148	PF00069	0.640
MOD_GSK3_1	174	181	PF00069	0.738
MOD_GSK3_1	221	228	PF00069	0.580
MOD_GSK3_1	236	243	PF00069	0.759
MOD_GSK3_1	265	272	PF00069	0.738
MOD_GSK3_1	289	296	PF00069	0.650
MOD_GSK3_1	311	318	PF00069	0.551
MOD_GSK3_1	320	327	PF00069	0.593
MOD_GSK3_1	374	381	PF00069	0.573
MOD_GSK3_1	41	48	PF00069	0.593
MOD_GSK3_1	428	435	PF00069	0.594
MOD_GSK3_1	440	447	PF00069	0.691
MOD_GSK3_1	481	488	PF00069	0.801
MOD_GSK3_1	575	582	PF00069	0.639
MOD_GSK3_1	593	600	PF00069	0.652
MOD_GSK3_1	606	613	PF00069	0.662
MOD_GSK3_1	630	637	PF00069	0.636
MOD_GSK3_1	640	647	PF00069	0.461
MOD_GSK3_1	666	673	PF00069	0.661
MOD_GSK3_1	687	694	PF00069	0.544
MOD_GSK3_1	702	709	PF00069	0.635
MOD_GSK3_1	712	719	PF00069	0.559
MOD_GSK3_1	76	83	PF00069	0.750
MOD_GSK3_1	87	94	PF00069	0.607
MOD_LATS_1	7	13	PF00433	0.507
MOD_N-GLC_1	114	119	PF02516	0.521
MOD_N-GLC_1	145	150	PF02516	0.536
MOD_NEK2_1	124	129	PF00069	0.707
MOD_NEK2_1	255	260	PF00069	0.571
MOD_NEK2_1	289	294	PF00069	0.744
MOD_NEK2_1	319	324	PF00069	0.595
MOD_NEK2_1	34	39	PF00069	0.539
MOD_NEK2_2	27	32	PF00069	0.671
MOD_NEK2_2	405	410	PF00069	0.553
MOD_PIKK_1	225	231	PF00454	0.596
MOD_PIKK_1	514	520	PF00454	0.525
MOD_PK_1	467	473	PF00069	0.536
MOD_PKA_1	175	181	PF00069	0.543
MOD_PKA_1	235	241	PF00069	0.729
MOD_PKA_1	467	473	PF00069	0.697
MOD_PKA_1	91	97	PF00069	0.602
MOD_PKA_2	174	180	PF00069	0.598
MOD_PKA_2	195	201	PF00069	0.557
MOD_PKA_2	235	241	PF00069	0.712
MOD_PKA_2	303	309	PF00069	0.504
MOD_PKA_2	32	38	PF00069	0.672
MOD_PKA_2	467	473	PF00069	0.630
MOD_PKA_2	687	693	PF00069	0.528
MOD_PKA_2	716	722	PF00069	0.658
MOD_PKA_2	83	89	PF00069	0.756
MOD_Plk_1	541	547	PF00069	0.556
MOD_Plk_1	613	619	PF00069	0.557
MOD_Plk_1	735	741	PF00069	0.682
MOD_Plk_1	764	770	PF00069	0.500
MOD_Plk_2-3	593	599	PF00069	0.653
MOD_Plk_2-3	706	712	PF00069	0.541
MOD_Plk_4	210	216	PF00069	0.565
MOD_Plk_4	272	278	PF00069	0.720
MOD_Plk_4	315	321	PF00069	0.583
MOD_Plk_4	380	386	PF00069	0.483
MOD_Plk_4	405	411	PF00069	0.566
MOD_Plk_4	554	560	PF00069	0.570
MOD_Plk_4	606	612	PF00069	0.699
MOD_Plk_4	755	761	PF00069	0.524
MOD_ProDKin_1	176	182	PF00069	0.802
MOD_ProDKin_1	185	191	PF00069	0.676
MOD_ProDKin_1	238	244	PF00069	0.553
MOD_ProDKin_1	269	275	PF00069	0.728
MOD_ProDKin_1	276	282	PF00069	0.625
MOD_ProDKin_1	290	296	PF00069	0.517
MOD_ProDKin_1	378	384	PF00069	0.585
MOD_ProDKin_1	476	482	PF00069	0.654
MOD_ProDKin_1	492	498	PF00069	0.503
MOD_ProDKin_1	597	603	PF00069	0.564
MOD_ProDKin_1	631	637	PF00069	0.573
MOD_ProDKin_1	673	679	PF00069	0.608
MOD_ProDKin_1	717	723	PF00069	0.591
MOD_ProDKin_1	727	733	PF00069	0.560
MOD_SUMO_rev_2	577	587	PF00179	0.535
TRG_DiLeu_BaEn_1	415	420	PF01217	0.570
TRG_DiLeu_BaEn_2	626	632	PF01217	0.668
TRG_DiLeu_BaEn_4	627	633	PF01217	0.521
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.430
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.534
TRG_ENDOCYTIC_2	346	349	PF00928	0.544
TRG_ENDOCYTIC_2	527	530	PF00928	0.581
TRG_ENDOCYTIC_2	776	779	PF00928	0.598
TRG_ER_diArg_1	159	161	PF00400	0.686
TRG_ER_diArg_1	163	165	PF00400	0.669
TRG_ER_diArg_1	395	398	PF00400	0.501
TRG_ER_diArg_1	461	464	PF00400	0.630
TRG_ER_diArg_1	466	468	PF00400	0.627
TRG_ER_diArg_1	532	535	PF00400	0.534
TRG_ER_diArg_1	57	59	PF00400	0.530
TRG_ER_diArg_1	650	652	PF00400	0.560
TRG_NLS_MonoExtC_3	230	235	PF00514	0.579
TRG_NLS_MonoExtN_4	231	236	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL05	Leptomonas seymouri	44%	100%
A0A1X0P9E8	Trypanosomatidae	30%	100%
A0A3S7X7P6	Leishmania donovani	74%	100%
A4I9U5	Leishmania infantum	74%	100%
E9B4V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q370	Leishmania major	73%	100%