t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAP8_LEIBR

TriTrypDb:

LbrM.20.1340 , LBRM2903_200022700

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.697
CLV_C14_Caspase3-7	289	293	PF00656	0.443
CLV_C14_Caspase3-7	392	396	PF00656	0.402
CLV_NRD_NRD_1	24	26	PF00675	0.635
CLV_NRD_NRD_1	529	531	PF00675	0.444
CLV_NRD_NRD_1	669	671	PF00675	0.685
CLV_NRD_NRD_1	697	699	PF00675	0.619
CLV_NRD_NRD_1	724	726	PF00675	0.817
CLV_NRD_NRD_1	772	774	PF00675	0.623
CLV_NRD_NRD_1	862	864	PF00675	0.804
CLV_NRD_NRD_1	904	906	PF00675	0.577
CLV_PCSK_FUR_1	667	671	PF00082	0.681
CLV_PCSK_KEX2_1	162	164	PF00082	0.583
CLV_PCSK_KEX2_1	370	372	PF00082	0.687
CLV_PCSK_KEX2_1	64	66	PF00082	0.774
CLV_PCSK_KEX2_1	669	671	PF00082	0.685
CLV_PCSK_KEX2_1	697	699	PF00082	0.619
CLV_PCSK_KEX2_1	724	726	PF00082	0.743
CLV_PCSK_KEX2_1	904	906	PF00082	0.648
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.583
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.788
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.757
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.648
CLV_PCSK_PC7_1	366	372	PF00082	0.523
CLV_PCSK_SKI1_1	118	122	PF00082	0.592
CLV_PCSK_SKI1_1	159	163	PF00082	0.465
CLV_PCSK_SKI1_1	494	498	PF00082	0.486
CLV_PCSK_SKI1_1	570	574	PF00082	0.633
CLV_PCSK_SKI1_1	724	728	PF00082	0.566
CLV_PCSK_SKI1_1	8	12	PF00082	0.603
CLV_PCSK_SKI1_1	923	927	PF00082	0.684
DEG_APCC_DBOX_1	279	287	PF00400	0.689
DEG_APCC_KENBOX_2	506	510	PF00400	0.684
DEG_Nend_UBRbox_2	1	3	PF02207	0.727
DEG_SCF_FBW7_1	350	355	PF00400	0.541
DEG_SPOP_SBC_1	42	46	PF00917	0.613
DEG_SPOP_SBC_1	50	54	PF00917	0.591
DEG_SPOP_SBC_1	741	745	PF00917	0.561
DEG_SPOP_SBC_1	792	796	PF00917	0.618
DOC_CYCLIN_RxL_1	456	467	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	575	581	PF00134	0.729
DOC_CYCLIN_yCln2_LP_2	856	862	PF00134	0.546
DOC_MAPK_gen_1	724	731	PF00069	0.565
DOC_MAPK_gen_1	902	911	PF00069	0.799
DOC_MAPK_RevD_3	760	774	PF00069	0.492
DOC_MIT_MIM_1	662	671	PF04212	0.691
DOC_PP2B_LxvP_1	330	333	PF13499	0.578
DOC_PP2B_LxvP_1	575	578	PF13499	0.739
DOC_PP2B_LxvP_1	811	814	PF13499	0.582
DOC_PP2B_LxvP_1	856	859	PF13499	0.698
DOC_PP4_FxxP_1	221	224	PF00568	0.515
DOC_USP7_MATH_1	43	47	PF00917	0.732
DOC_USP7_MATH_1	50	54	PF00917	0.793
DOC_USP7_MATH_1	627	631	PF00917	0.556
DOC_USP7_MATH_1	741	745	PF00917	0.751
DOC_USP7_MATH_1	792	796	PF00917	0.521
DOC_USP7_MATH_1	821	825	PF00917	0.745
DOC_USP7_MATH_1	830	834	PF00917	0.670
DOC_USP7_UBL2_3	109	113	PF12436	0.488
DOC_USP7_UBL2_3	494	498	PF12436	0.486
DOC_USP7_UBL2_3	902	906	PF12436	0.577
DOC_WW_Pin1_4	152	157	PF00397	0.476
DOC_WW_Pin1_4	346	351	PF00397	0.809
DOC_WW_Pin1_4	570	575	PF00397	0.526
DOC_WW_Pin1_4	69	74	PF00397	0.658
DOC_WW_Pin1_4	709	714	PF00397	0.704
DOC_WW_Pin1_4	724	729	PF00397	0.710
LIG_14-3-3_CanoR_1	199	207	PF00244	0.518
LIG_14-3-3_CanoR_1	285	291	PF00244	0.692
LIG_14-3-3_CanoR_1	343	350	PF00244	0.621
LIG_14-3-3_CanoR_1	441	445	PF00244	0.416
LIG_14-3-3_CanoR_1	49	56	PF00244	0.696
LIG_14-3-3_CanoR_1	503	511	PF00244	0.430
LIG_14-3-3_CanoR_1	588	592	PF00244	0.562
LIG_14-3-3_CanoR_1	597	601	PF00244	0.643
LIG_14-3-3_CanoR_1	65	74	PF00244	0.751
LIG_BIR_III_4	395	399	PF00653	0.635
LIG_BRCT_BRCA1_1	283	287	PF00533	0.442
LIG_BRCT_BRCA1_1	67	71	PF00533	0.578
LIG_CaM_IQ_9	399	415	PF13499	0.657
LIG_CaM_IQ_9	638	654	PF13499	0.705
LIG_deltaCOP1_diTrp_1	537	546	PF00928	0.549
LIG_FHA_1	166	172	PF00498	0.435
LIG_FHA_1	209	215	PF00498	0.616
LIG_FHA_1	242	248	PF00498	0.563
LIG_FHA_1	382	388	PF00498	0.592
LIG_FHA_1	604	610	PF00498	0.574
LIG_FHA_1	635	641	PF00498	0.608
LIG_FHA_2	503	509	PF00498	0.577
LIG_FHA_2	514	520	PF00498	0.552
LIG_FHA_2	731	737	PF00498	0.576
LIG_FHA_2	83	89	PF00498	0.574
LIG_LIR_Apic_2	219	224	PF02991	0.519
LIG_LIR_Gen_1	140	150	PF02991	0.444
LIG_LIR_Gen_1	184	193	PF02991	0.430
LIG_LIR_Gen_1	284	294	PF02991	0.501
LIG_LIR_Gen_1	676	686	PF02991	0.588
LIG_LIR_Gen_1	826	832	PF02991	0.553
LIG_LIR_Nem_3	140	145	PF02991	0.487
LIG_LIR_Nem_3	184	190	PF02991	0.432
LIG_LIR_Nem_3	284	290	PF02991	0.496
LIG_LIR_Nem_3	308	314	PF02991	0.558
LIG_LIR_Nem_3	676	681	PF02991	0.604
LIG_LIR_Nem_3	68	74	PF02991	0.578
LIG_LIR_Nem_3	826	831	PF02991	0.556
LIG_PCNA_yPIPBox_3	474	484	PF02747	0.614
LIG_Pex14_1	138	142	PF04695	0.449
LIG_REV1ctd_RIR_1	705	712	PF16727	0.648
LIG_SH2_CRK	187	191	PF00017	0.403
LIG_SH2_CRK	311	315	PF00017	0.560
LIG_SH2_NCK_1	750	754	PF00017	0.533
LIG_SH2_SRC	869	872	PF00017	0.541
LIG_SH2_STAP1	685	689	PF00017	0.635
LIG_SH2_STAT3	154	157	PF00017	0.483
LIG_SH2_STAT5	123	126	PF00017	0.705
LIG_SH2_STAT5	154	157	PF00017	0.582
LIG_SH2_STAT5	187	190	PF00017	0.406
LIG_SH2_STAT5	386	389	PF00017	0.676
LIG_SH2_STAT5	767	770	PF00017	0.628
LIG_SH2_STAT5	803	806	PF00017	0.682
LIG_SH2_STAT5	869	872	PF00017	0.687
LIG_SH3_2	858	863	PF14604	0.691
LIG_SH3_3	347	353	PF00018	0.765
LIG_SH3_3	36	42	PF00018	0.669
LIG_SH3_3	571	577	PF00018	0.673
LIG_SH3_3	757	763	PF00018	0.676
LIG_SH3_3	817	823	PF00018	0.601
LIG_SH3_3	855	861	PF00018	0.703
LIG_Sin3_3	686	693	PF02671	0.557
LIG_Sin3_3	785	792	PF02671	0.520
LIG_SUMO_SIM_par_1	168	174	PF11976	0.435
LIG_TYR_ITIM	185	190	PF00017	0.406
LIG_WW_1	576	579	PF00397	0.744
LIG_WW_3	860	864	PF00397	0.685
MOD_CDC14_SPxK_1	72	75	PF00782	0.617
MOD_CDK_SPxK_1	69	75	PF00069	0.639
MOD_CDK_SPxK_1	724	730	PF00069	0.565
MOD_CDK_SPxxK_3	152	159	PF00069	0.477
MOD_CK1_1	103	109	PF00069	0.681
MOD_CK1_1	239	245	PF00069	0.795
MOD_CK1_1	306	312	PF00069	0.706
MOD_CK1_1	348	354	PF00069	0.711
MOD_CK1_1	37	43	PF00069	0.590
MOD_CK1_1	428	434	PF00069	0.430
MOD_CK1_1	502	508	PF00069	0.675
MOD_CK1_1	69	75	PF00069	0.786
MOD_CK1_1	720	726	PF00069	0.703
MOD_CK1_1	739	745	PF00069	0.485
MOD_CK1_1	769	775	PF00069	0.655
MOD_CK1_1	793	799	PF00069	0.562
MOD_CK1_1	834	840	PF00069	0.704
MOD_CK1_1	846	852	PF00069	0.612
MOD_CK1_1	884	890	PF00069	0.607
MOD_CK1_1	90	96	PF00069	0.649
MOD_CK2_1	188	194	PF00069	0.390
MOD_CK2_1	332	338	PF00069	0.676
MOD_CK2_1	502	508	PF00069	0.546
MOD_CK2_1	513	519	PF00069	0.460
MOD_CK2_1	730	736	PF00069	0.688
MOD_CK2_1	748	754	PF00069	0.650
MOD_CK2_1	82	88	PF00069	0.587
MOD_CK2_1	873	879	PF00069	0.702
MOD_Cter_Amidation	62	65	PF01082	0.668
MOD_GlcNHglycan	127	130	PF01048	0.656
MOD_GlcNHglycan	190	193	PF01048	0.418
MOD_GlcNHglycan	238	241	PF01048	0.703
MOD_GlcNHglycan	317	320	PF01048	0.642
MOD_GlcNHglycan	340	343	PF01048	0.777
MOD_GlcNHglycan	36	39	PF01048	0.763
MOD_GlcNHglycan	45	48	PF01048	0.700
MOD_GlcNHglycan	452	455	PF01048	0.565
MOD_GlcNHglycan	485	489	PF01048	0.564
MOD_GlcNHglycan	551	554	PF01048	0.596
MOD_GlcNHglycan	610	613	PF01048	0.478
MOD_GlcNHglycan	655	658	PF01048	0.749
MOD_GlcNHglycan	738	741	PF01048	0.604
MOD_GlcNHglycan	744	747	PF01048	0.660
MOD_GlcNHglycan	750	753	PF01048	0.697
MOD_GlcNHglycan	823	826	PF01048	0.719
MOD_GlcNHglycan	843	846	PF01048	0.584
MOD_GlcNHglycan	851	854	PF01048	0.721
MOD_GlcNHglycan	882	886	PF01048	0.832
MOD_GSK3_1	10	17	PF00069	0.692
MOD_GSK3_1	141	148	PF00069	0.674
MOD_GSK3_1	198	205	PF00069	0.613
MOD_GSK3_1	2	9	PF00069	0.791
MOD_GSK3_1	286	293	PF00069	0.695
MOD_GSK3_1	295	302	PF00069	0.666
MOD_GSK3_1	306	313	PF00069	0.536
MOD_GSK3_1	315	322	PF00069	0.699
MOD_GSK3_1	33	40	PF00069	0.681
MOD_GSK3_1	338	345	PF00069	0.832
MOD_GSK3_1	348	355	PF00069	0.630
MOD_GSK3_1	41	48	PF00069	0.566
MOD_GSK3_1	51	58	PF00069	0.680
MOD_GSK3_1	549	556	PF00069	0.606
MOD_GSK3_1	604	611	PF00069	0.506
MOD_GSK3_1	65	72	PF00069	0.626
MOD_GSK3_1	653	660	PF00069	0.660
MOD_GSK3_1	716	723	PF00069	0.703
MOD_GSK3_1	736	743	PF00069	0.486
MOD_GSK3_1	830	837	PF00069	0.638
MOD_GSK3_1	865	872	PF00069	0.678
MOD_GSK3_1	874	881	PF00069	0.728
MOD_GSK3_1	96	103	PF00069	0.745
MOD_N-GLC_1	100	105	PF02516	0.605
MOD_N-GLC_1	208	213	PF02516	0.463
MOD_N-GLC_1	236	241	PF02516	0.530
MOD_N-GLC_1	570	575	PF02516	0.564
MOD_N-GLC_1	681	686	PF02516	0.475
MOD_N-GLC_1	736	741	PF02516	0.570
MOD_N-GLC_1	81	86	PF02516	0.797
MOD_NEK2_1	150	155	PF00069	0.501
MOD_NEK2_1	165	170	PF00069	0.622
MOD_NEK2_1	270	275	PF00069	0.748
MOD_NEK2_1	286	291	PF00069	0.426
MOD_NEK2_1	310	315	PF00069	0.560
MOD_NEK2_1	440	445	PF00069	0.566
MOD_NEK2_1	548	553	PF00069	0.488
MOD_NEK2_1	56	61	PF00069	0.643
MOD_NEK2_1	634	639	PF00069	0.513
MOD_NEK2_1	653	658	PF00069	0.431
MOD_NEK2_1	681	686	PF00069	0.475
MOD_NEK2_1	707	712	PF00069	0.721
MOD_NEK2_1	87	92	PF00069	0.605
MOD_NEK2_2	241	246	PF00069	0.558
MOD_PIKK_1	103	109	PF00454	0.494
MOD_PIKK_1	165	171	PF00454	0.436
MOD_PIKK_1	270	276	PF00454	0.694
MOD_PIKK_1	319	325	PF00454	0.720
MOD_PIKK_1	381	387	PF00454	0.597
MOD_PIKK_1	389	395	PF00454	0.576
MOD_PIKK_1	418	424	PF00454	0.441
MOD_PIKK_1	425	431	PF00454	0.396
MOD_PIKK_1	56	62	PF00454	0.653
MOD_PKA_2	198	204	PF00069	0.562
MOD_PKA_2	281	287	PF00069	0.535
MOD_PKA_2	342	348	PF00069	0.635
MOD_PKA_2	440	446	PF00069	0.564
MOD_PKA_2	502	508	PF00069	0.427
MOD_PKA_2	56	62	PF00069	0.674
MOD_PKA_2	587	593	PF00069	0.564
MOD_PKA_2	596	602	PF00069	0.641
MOD_PKA_2	76	82	PF00069	0.622
MOD_PKB_1	836	844	PF00069	0.546
MOD_Plk_1	100	106	PF00069	0.630
MOD_Plk_1	150	156	PF00069	0.720
MOD_Plk_1	299	305	PF00069	0.586
MOD_Plk_1	371	377	PF00069	0.785
MOD_Plk_1	381	387	PF00069	0.535
MOD_Plk_1	681	687	PF00069	0.476
MOD_Plk_1	896	902	PF00069	0.592
MOD_Plk_4	100	106	PF00069	0.657
MOD_Plk_4	141	147	PF00069	0.641
MOD_Plk_4	286	292	PF00069	0.550
MOD_Plk_4	306	312	PF00069	0.480
MOD_Plk_4	587	593	PF00069	0.554
MOD_Plk_4	766	772	PF00069	0.714
MOD_Plk_4	82	88	PF00069	0.570
MOD_Plk_4	865	871	PF00069	0.679
MOD_ProDKin_1	152	158	PF00069	0.476
MOD_ProDKin_1	346	352	PF00069	0.807
MOD_ProDKin_1	570	576	PF00069	0.521
MOD_ProDKin_1	69	75	PF00069	0.659
MOD_ProDKin_1	709	715	PF00069	0.706
MOD_ProDKin_1	724	730	PF00069	0.712
MOD_SUMO_rev_2	158	164	PF00179	0.461
MOD_SUMO_rev_2	751	757	PF00179	0.525
TRG_DiLeu_BaEn_1	160	165	PF01217	0.600
TRG_DiLeu_BaEn_2	921	927	PF01217	0.639
TRG_DiLeu_BaEn_4	537	543	PF01217	0.441
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.455
TRG_DiLeu_LyEn_5	160	165	PF01217	0.453
TRG_ENDOCYTIC_2	142	145	PF00928	0.504
TRG_ENDOCYTIC_2	187	190	PF00928	0.569
TRG_ENDOCYTIC_2	311	314	PF00928	0.558
TRG_ENDOCYTIC_2	678	681	PF00928	0.506
TRG_ENDOCYTIC_2	767	770	PF00928	0.628
TRG_ER_diArg_1	115	118	PF00400	0.451
TRG_ER_diArg_1	666	669	PF00400	0.687
TRG_ER_diArg_1	724	726	PF00400	0.817
TRG_ER_diArg_1	74	77	PF00400	0.729
TRG_ER_diArg_1	836	839	PF00400	0.614
TRG_NES_CRM1_1	389	403	PF08389	0.501
TRG_NES_CRM1_1	460	473	PF08389	0.651
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	687	692	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC52	Leptomonas seymouri	38%	100%
A0A3S7X7P7	Leishmania donovani	62%	97%
A4I9U4	Leishmania infantum	62%	97%
E9B4V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	83%
Q4Q371	Leishmania major	65%	99%