Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAP6_LEIBR

TriTrypDb:

LbrM.20.1320 , LBRM2903_200022500

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4HAP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.560
CLV_NRD_NRD_1	121	123	PF00675	0.576
CLV_NRD_NRD_1	30	32	PF00675	0.543
CLV_NRD_NRD_1	410	412	PF00675	0.624
CLV_NRD_NRD_1	581	583	PF00675	0.751
CLV_NRD_NRD_1	625	627	PF00675	0.800
CLV_NRD_NRD_1	638	640	PF00675	0.589
CLV_NRD_NRD_1	7	9	PF00675	0.561
CLV_PCSK_FUR_1	4	8	PF00082	0.579
CLV_PCSK_KEX2_1	121	123	PF00082	0.534
CLV_PCSK_KEX2_1	30	32	PF00082	0.543
CLV_PCSK_KEX2_1	409	411	PF00082	0.626
CLV_PCSK_KEX2_1	581	583	PF00082	0.646
CLV_PCSK_KEX2_1	6	8	PF00082	0.539
CLV_PCSK_KEX2_1	625	627	PF00082	0.800
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.626
CLV_PCSK_PC7_1	2	8	PF00082	0.643
CLV_PCSK_PC7_1	405	411	PF00082	0.634
CLV_PCSK_SKI1_1	230	234	PF00082	0.547
CLV_PCSK_SKI1_1	488	492	PF00082	0.536
CLV_PCSK_SKI1_1	652	656	PF00082	0.629
CLV_PCSK_SKI1_1	689	693	PF00082	0.757
CLV_PCSK_SKI1_1	7	11	PF00082	0.537
DEG_APCC_DBOX_1	6	14	PF00400	0.555
DEG_APCC_DBOX_1	625	633	PF00400	0.633
DEG_COP1_1	585	595	PF00400	0.530
DEG_Nend_UBRbox_1	1	4	PF02207	0.600
DOC_CDC14_PxL_1	349	357	PF14671	0.483
DOC_CDC14_PxL_1	62	70	PF14671	0.507
DOC_CKS1_1	226	231	PF01111	0.521
DOC_CKS1_1	34	39	PF01111	0.639
DOC_CYCLIN_RxL_1	263	273	PF00134	0.491
DOC_CYCLIN_RxL_1	378	389	PF00134	0.289
DOC_MAPK_DCC_7	278	287	PF00069	0.627
DOC_PP1_RVXF_1	104	111	PF00149	0.295
DOC_PP1_RVXF_1	228	235	PF00149	0.556
DOC_PP2B_LxvP_1	321	324	PF13499	0.364
DOC_PP2B_LxvP_1	600	603	PF13499	0.647
DOC_PP4_FxxP_1	248	251	PF00568	0.319
DOC_USP7_MATH_1	149	153	PF00917	0.662
DOC_USP7_MATH_1	19	23	PF00917	0.676
DOC_USP7_MATH_1	536	540	PF00917	0.647
DOC_USP7_MATH_1	547	551	PF00917	0.652
DOC_USP7_MATH_1	603	607	PF00917	0.670
DOC_USP7_MATH_1	609	613	PF00917	0.685
DOC_USP7_MATH_1	628	632	PF00917	0.523
DOC_USP7_MATH_1	657	661	PF00917	0.755
DOC_USP7_UBL2_3	571	575	PF12436	0.557
DOC_WW_Pin1_4	225	230	PF00397	0.522
DOC_WW_Pin1_4	246	251	PF00397	0.515
DOC_WW_Pin1_4	33	38	PF00397	0.644
DOC_WW_Pin1_4	532	537	PF00397	0.519
DOC_WW_Pin1_4	624	629	PF00397	0.747
DOC_WW_Pin1_4	655	660	PF00397	0.663
DOC_WW_Pin1_4	670	675	PF00397	0.666
DOC_WW_Pin1_4	676	681	PF00397	0.521
LIG_14-3-3_CanoR_1	121	130	PF00244	0.553
LIG_14-3-3_CanoR_1	197	206	PF00244	0.645
LIG_14-3-3_CanoR_1	334	342	PF00244	0.491
LIG_14-3-3_CanoR_1	410	415	PF00244	0.662
LIG_14-3-3_CanoR_1	432	439	PF00244	0.574
LIG_14-3-3_CanoR_1	456	461	PF00244	0.447
LIG_14-3-3_CanoR_1	488	495	PF00244	0.546
LIG_14-3-3_CanoR_1	581	591	PF00244	0.670
LIG_14-3-3_CanoR_1	652	662	PF00244	0.639
LIG_14-3-3_CanoR_1	689	695	PF00244	0.752
LIG_Actin_WH2_2	73	88	PF00022	0.356
LIG_DLG_GKlike_1	456	463	PF00625	0.300
LIG_FHA_1	226	232	PF00498	0.515
LIG_FHA_1	296	302	PF00498	0.487
LIG_FHA_1	328	334	PF00498	0.422
LIG_FHA_1	34	40	PF00498	0.579
LIG_FHA_1	342	348	PF00498	0.400
LIG_FHA_1	470	476	PF00498	0.510
LIG_FHA_1	633	639	PF00498	0.605
LIG_FHA_1	649	655	PF00498	0.640
LIG_FHA_1	679	685	PF00498	0.755
LIG_FHA_2	294	300	PF00498	0.568
LIG_FHA_2	419	425	PF00498	0.713
LIG_FHA_2	487	493	PF00498	0.581
LIG_FHA_2	710	716	PF00498	0.640
LIG_IRF3_LxIS_1	466	471	PF10401	0.319
LIG_LIR_Gen_1	179	188	PF02991	0.539
LIG_LIR_Gen_1	417	425	PF02991	0.610
LIG_LIR_Gen_1	688	699	PF02991	0.534
LIG_LIR_Gen_1	89	100	PF02991	0.491
LIG_LIR_Nem_3	179	183	PF02991	0.531
LIG_LIR_Nem_3	417	423	PF02991	0.615
LIG_LIR_Nem_3	531	537	PF02991	0.666
LIG_LIR_Nem_3	688	694	PF02991	0.720
LIG_NRP_CendR_1	714	716	PF00754	0.538
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.435
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.575
LIG_Pex14_1	29	33	PF04695	0.522
LIG_PTB_Apo_2	104	111	PF02174	0.493
LIG_SH2_CRK	534	538	PF00017	0.688
LIG_SH2_NCK_1	495	499	PF00017	0.563
LIG_SH2_STAT3	224	227	PF00017	0.303
LIG_SH2_STAT5	130	133	PF00017	0.378
LIG_SH2_STAT5	224	227	PF00017	0.502
LIG_SH2_STAT5	270	273	PF00017	0.422
LIG_SH2_STAT5	33	36	PF00017	0.582
LIG_SH2_STAT5	420	423	PF00017	0.715
LIG_SH2_STAT5	495	498	PF00017	0.476
LIG_SH3_3	440	446	PF00018	0.564
LIG_SH3_3	55	61	PF00018	0.582
LIG_SH3_3	596	602	PF00018	0.724
LIG_Sin3_3	369	376	PF02671	0.283
LIG_SUMO_SIM_anti_2	298	309	PF11976	0.420
LIG_SUMO_SIM_par_1	163	169	PF11976	0.529
LIG_SUMO_SIM_par_1	384	389	PF11976	0.440
LIG_UBA3_1	400	409	PF00899	0.633
LIG_WRC_WIRS_1	177	182	PF05994	0.531
LIG_WRC_WIRS_1	231	236	PF05994	0.402
MOD_CDK_SPK_2	225	230	PF00069	0.576
MOD_CDK_SPxxK_3	670	677	PF00069	0.532
MOD_CK1_1	154	160	PF00069	0.555
MOD_CK1_1	200	206	PF00069	0.660
MOD_CK1_1	326	332	PF00069	0.454
MOD_CK1_1	389	395	PF00069	0.464
MOD_CK1_1	413	419	PF00069	0.635
MOD_CK1_1	469	475	PF00069	0.425
MOD_CK1_1	550	556	PF00069	0.684
MOD_CK1_1	563	569	PF00069	0.630
MOD_CK1_1	631	637	PF00069	0.759
MOD_CK1_1	670	676	PF00069	0.630
MOD_CK1_1	690	696	PF00069	0.792
MOD_CK2_1	486	492	PF00069	0.550
MOD_CK2_1	510	516	PF00069	0.339
MOD_CK2_1	627	633	PF00069	0.801
MOD_CK2_1	709	715	PF00069	0.547
MOD_GlcNHglycan	140	143	PF01048	0.650
MOD_GlcNHglycan	199	202	PF01048	0.629
MOD_GlcNHglycan	213	216	PF01048	0.375
MOD_GlcNHglycan	221	224	PF01048	0.485
MOD_GlcNHglycan	263	266	PF01048	0.495
MOD_GlcNHglycan	40	43	PF01048	0.580
MOD_GlcNHglycan	44	47	PF01048	0.531
MOD_GlcNHglycan	483	487	PF01048	0.406
MOD_GlcNHglycan	523	526	PF01048	0.668
MOD_GlcNHglycan	545	548	PF01048	0.708
MOD_GlcNHglycan	613	616	PF01048	0.583
MOD_GlcNHglycan	655	658	PF01048	0.745
MOD_GlcNHglycan	695	698	PF01048	0.794
MOD_GlcNHglycan	96	99	PF01048	0.530
MOD_GSK3_1	19	26	PF00069	0.599
MOD_GSK3_1	306	313	PF00069	0.537
MOD_GSK3_1	322	329	PF00069	0.458
MOD_GSK3_1	38	45	PF00069	0.282
MOD_GSK3_1	410	417	PF00069	0.626
MOD_GSK3_1	428	435	PF00069	0.403
MOD_GSK3_1	482	489	PF00069	0.481
MOD_GSK3_1	493	500	PF00069	0.419
MOD_GSK3_1	528	535	PF00069	0.664
MOD_GSK3_1	537	544	PF00069	0.686
MOD_GSK3_1	558	565	PF00069	0.807
MOD_GSK3_1	56	63	PF00069	0.459
MOD_GSK3_1	567	574	PF00069	0.705
MOD_GSK3_1	603	610	PF00069	0.704
MOD_GSK3_1	624	631	PF00069	0.714
MOD_GSK3_1	648	655	PF00069	0.678
MOD_GSK3_1	664	671	PF00069	0.627
MOD_GSK3_1	683	690	PF00069	0.735
MOD_GSK3_1	693	700	PF00069	0.770
MOD_N-GLC_1	456	461	PF02516	0.420
MOD_N-GLC_1	486	491	PF02516	0.560
MOD_N-GLC_1	583	588	PF02516	0.651
MOD_N-GLC_2	357	359	PF02516	0.275
MOD_NEK2_1	100	105	PF00069	0.452
MOD_NEK2_1	13	18	PF00069	0.555
MOD_NEK2_1	386	391	PF00069	0.392
MOD_NEK2_1	404	409	PF00069	0.546
MOD_NEK2_1	414	419	PF00069	0.624
MOD_NEK2_1	423	428	PF00069	0.529
MOD_NEK2_1	466	471	PF00069	0.437
MOD_NEK2_1	510	515	PF00069	0.581
MOD_NEK2_1	537	542	PF00069	0.725
MOD_NEK2_1	576	581	PF00069	0.681
MOD_NEK2_1	632	637	PF00069	0.720
MOD_NEK2_1	653	658	PF00069	0.670
MOD_PIKK_1	122	128	PF00454	0.322
MOD_PIKK_1	151	157	PF00454	0.642
MOD_PIKK_1	632	638	PF00454	0.804
MOD_PIKK_1	657	663	PF00454	0.727
MOD_PKA_1	410	416	PF00069	0.638
MOD_PKA_2	128	134	PF00069	0.384
MOD_PKA_2	209	215	PF00069	0.537
MOD_PKA_2	404	410	PF00069	0.532
MOD_PKB_1	456	464	PF00069	0.299
MOD_Plk_1	306	312	PF00069	0.551
MOD_Plk_1	386	392	PF00069	0.429
MOD_Plk_1	456	462	PF00069	0.401
MOD_Plk_1	486	492	PF00069	0.517
MOD_Plk_1	583	589	PF00069	0.528
MOD_Plk_1	687	693	PF00069	0.665
MOD_Plk_2-3	293	299	PF00069	0.503
MOD_Plk_2-3	558	564	PF00069	0.557
MOD_Plk_4	100	106	PF00069	0.475
MOD_Plk_4	160	166	PF00069	0.327
MOD_Plk_4	230	236	PF00069	0.403
MOD_Plk_4	591	597	PF00069	0.758
MOD_ProDKin_1	225	231	PF00069	0.514
MOD_ProDKin_1	246	252	PF00069	0.511
MOD_ProDKin_1	33	39	PF00069	0.635
MOD_ProDKin_1	532	538	PF00069	0.520
MOD_ProDKin_1	624	630	PF00069	0.748
MOD_ProDKin_1	655	661	PF00069	0.663
MOD_ProDKin_1	670	676	PF00069	0.667
MOD_SUMO_for_1	505	508	PF00179	0.461
MOD_SUMO_rev_2	500	507	PF00179	0.498
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.296
TRG_ENDOCYTIC_2	130	133	PF00928	0.378
TRG_ENDOCYTIC_2	420	423	PF00928	0.463
TRG_ENDOCYTIC_2	534	537	PF00928	0.688
TRG_ER_diArg_1	1	4	PF00400	0.633
TRG_ER_diArg_1	120	122	PF00400	0.574
TRG_ER_diArg_1	242	245	PF00400	0.388
TRG_ER_diArg_1	29	31	PF00400	0.520
TRG_ER_diArg_1	410	412	PF00400	0.647
TRG_ER_diArg_1	5	8	PF00400	0.566
TRG_ER_diArg_1	580	582	PF00400	0.756
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T2	Leptomonas seymouri	50%	94%
A0A3Q8IHF2	Leishmania donovani	73%	100%
A0A3R7MW53	Trypanosoma rangeli	28%	100%
A4I9U2	Leishmania infantum	72%	100%
E9B4V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q373	Leishmania major	70%	100%
V5B3D0	Trypanosoma cruzi	28%	100%