Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAP5_LEIBR

TriTrypDb:

LbrM.20.1310 , LBRM2903_200022400

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.698
CLV_C14_Caspase3-7	335	339	PF00656	0.517
CLV_NRD_NRD_1	220	222	PF00675	0.567
CLV_NRD_NRD_1	303	305	PF00675	0.575
CLV_PCSK_KEX2_1	169	171	PF00082	0.489
CLV_PCSK_KEX2_1	220	222	PF00082	0.559
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.489
CLV_PCSK_SKI1_1	116	120	PF00082	0.312
CLV_PCSK_SKI1_1	169	173	PF00082	0.490
CLV_PCSK_SKI1_1	191	195	PF00082	0.325
CLV_PCSK_SKI1_1	324	328	PF00082	0.431
CLV_PCSK_SKI1_1	61	65	PF00082	0.404
CLV_PCSK_SKI1_1	75	79	PF00082	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DEG_ODPH_VHL_1	243	254	PF01847	0.305
DEG_SPOP_SBC_1	262	266	PF00917	0.540
DOC_CKS1_1	172	177	PF01111	0.414
DOC_MAPK_gen_1	40	48	PF00069	0.444
DOC_MAPK_HePTP_8	321	333	PF00069	0.470
DOC_MAPK_MEF2A_6	324	333	PF00069	0.465
DOC_PP1_RVXF_1	251	257	PF00149	0.370
DOC_PP2B_LxvP_1	18	21	PF13499	0.472
DOC_PP2B_LxvP_1	314	317	PF13499	0.274
DOC_PP4_FxxP_1	93	96	PF00568	0.522
DOC_USP7_MATH_1	105	109	PF00917	0.460
DOC_USP7_MATH_1	219	223	PF00917	0.537
DOC_USP7_MATH_1	232	236	PF00917	0.570
DOC_USP7_MATH_1	262	266	PF00917	0.631
DOC_USP7_MATH_1	83	87	PF00917	0.508
DOC_USP7_MATH_1	89	93	PF00917	0.543
DOC_WW_Pin1_4	11	16	PF00397	0.445
DOC_WW_Pin1_4	171	176	PF00397	0.447
DOC_WW_Pin1_4	226	231	PF00397	0.758
LIG_14-3-3_CanoR_1	104	110	PF00244	0.515
LIG_14-3-3_CanoR_1	116	125	PF00244	0.510
LIG_14-3-3_CanoR_1	152	156	PF00244	0.461
LIG_14-3-3_CanoR_1	253	259	PF00244	0.339
LIG_14-3-3_CanoR_1	328	334	PF00244	0.463
LIG_AP2alpha_2	231	233	PF02296	0.472
LIG_BIR_III_4	49	53	PF00653	0.513
LIG_BRCT_BRCA1_1	109	113	PF00533	0.440
LIG_deltaCOP1_diTrp_1	100	109	PF00928	0.454
LIG_deltaCOP1_diTrp_1	198	203	PF00928	0.388
LIG_FHA_1	172	178	PF00498	0.451
LIG_FHA_1	188	194	PF00498	0.433
LIG_FHA_1	276	282	PF00498	0.527
LIG_FHA_1	295	301	PF00498	0.579
LIG_FHA_1	83	89	PF00498	0.496
LIG_FHA_2	117	123	PF00498	0.460
LIG_FHA_2	244	250	PF00498	0.316
LIG_FHA_2	330	336	PF00498	0.368
LIG_LIR_Apic_2	92	96	PF02991	0.533
LIG_LIR_Gen_1	306	316	PF02991	0.441
LIG_LIR_Nem_3	100	106	PF02991	0.452
LIG_LIR_Nem_3	197	203	PF02991	0.381
LIG_LIR_Nem_3	306	311	PF02991	0.515
LIG_Pex14_1	109	113	PF04695	0.333
LIG_Pex14_1	178	182	PF04695	0.496
LIG_SH2_PTP2	330	333	PF00017	0.369
LIG_SH2_STAP1	182	186	PF00017	0.445
LIG_SH2_STAP1	248	252	PF00017	0.456
LIG_SH2_STAT5	133	136	PF00017	0.460
LIG_SH2_STAT5	330	333	PF00017	0.401
LIG_SH3_3	153	159	PF00018	0.503
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.328
LIG_SUMO_SIM_par_1	276	282	PF11976	0.407
LIG_SUMO_SIM_par_1	310	315	PF11976	0.502
LIG_SUMO_SIM_par_1	341	346	PF11976	0.350
LIG_TRAF2_1	160	163	PF00917	0.457
LIG_TRAF2_1	26	29	PF00917	0.576
LIG_WRPW_2	327	330	PF00400	0.415
LIG_WW_3	33	37	PF00397	0.546
MOD_CDK_SPxK_1	11	17	PF00069	0.379
MOD_CK1_1	266	272	PF00069	0.553
MOD_CK2_1	116	122	PF00069	0.463
MOD_CK2_1	157	163	PF00069	0.455
MOD_CK2_1	329	335	PF00069	0.420
MOD_Cter_Amidation	203	206	PF01082	0.487
MOD_GlcNHglycan	138	141	PF01048	0.613
MOD_GlcNHglycan	221	224	PF01048	0.638
MOD_GlcNHglycan	235	238	PF01048	0.501
MOD_GlcNHglycan	268	271	PF01048	0.602
MOD_GlcNHglycan	275	278	PF01048	0.436
MOD_GlcNHglycan	286	289	PF01048	0.586
MOD_GlcNHglycan	61	64	PF01048	0.628
MOD_GlcNHglycan	72	75	PF01048	0.431
MOD_GlcNHglycan	85	88	PF01048	0.556
MOD_GSK3_1	182	189	PF00069	0.326
MOD_GSK3_1	254	261	PF00069	0.503
MOD_GSK3_1	262	269	PF00069	0.628
MOD_GSK3_1	273	280	PF00069	0.372
MOD_GSK3_1	6	13	PF00069	0.376
MOD_GSK3_1	61	68	PF00069	0.489
MOD_LATS_1	114	120	PF00433	0.373
MOD_N-GLC_1	262	267	PF02516	0.470
MOD_NEK2_1	254	259	PF00069	0.412
MOD_NEK2_1	82	87	PF00069	0.419
MOD_PKA_2	151	157	PF00069	0.353
MOD_PKA_2	219	225	PF00069	0.679
MOD_PKA_2	254	260	PF00069	0.374
MOD_Plk_1	312	318	PF00069	0.272
MOD_Plk_4	329	335	PF00069	0.361
MOD_Plk_4	61	67	PF00069	0.559
MOD_ProDKin_1	11	17	PF00069	0.462
MOD_ProDKin_1	171	177	PF00069	0.440
MOD_ProDKin_1	226	232	PF00069	0.752
MOD_SUMO_rev_2	235	244	PF00179	0.459
MOD_SUMO_rev_2	276	286	PF00179	0.401
TRG_DiLeu_BaEn_1	122	127	PF01217	0.353
TRG_DiLeu_BaEn_4	179	185	PF01217	0.354
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.420
TRG_ENDOCYTIC_2	330	333	PF00928	0.391
TRG_ER_diArg_1	252	255	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C8	Leptomonas seymouri	47%	100%
A0A1X0P9I6	Trypanosomatidae	36%	82%
A0A3Q8IKX0	Leishmania donovani	76%	100%
A4I9U1	Leishmania infantum	77%	100%
C9ZMU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q374	Leishmania major	76%	100%
V5BIU6	Trypanosoma cruzi	33%	99%