DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial DNA polymerase I protein A, putative

Species:

Leishmania braziliensis

UniProt:

A4HAP3_LEIBR

TriTrypDb:

LbrM.20.1290 , LBRM2903_200022100

Length:

1264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP3

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006260	DNA replication	5	8
GO:0006261	DNA-templated DNA replication	6	8
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.501
CLV_C14_Caspase3-7	256	260	PF00656	0.585
CLV_C14_Caspase3-7	350	354	PF00656	0.642
CLV_C14_Caspase3-7	627	631	PF00656	0.531
CLV_NRD_NRD_1	1015	1017	PF00675	0.268
CLV_NRD_NRD_1	1126	1128	PF00675	0.268
CLV_NRD_NRD_1	1158	1160	PF00675	0.311
CLV_NRD_NRD_1	1213	1215	PF00675	0.311
CLV_NRD_NRD_1	158	160	PF00675	0.516
CLV_NRD_NRD_1	314	316	PF00675	0.579

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I668	Leptomonas seymouri	60%	99%
A0A3Q8IH45	Leishmania donovani	78%	100%
A0A3R7L752	Trypanosoma rangeli	40%	100%
A4I9T9	Leishmania infantum	72%	100%
E9B4V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q8IS90	Leishmania major	78%	100%

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