Putative NLI-interacting factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PTP1-interacting protein, 39 kDa, putative

Species:

Leishmania braziliensis

UniProt:

A4HAP2_LEIBR

TriTrypDb:

LbrM.20.1280 , LBRM2903_200022000

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HAP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0004725	protein tyrosine phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.391
CLV_NRD_NRD_1	228	230	PF00675	0.405
CLV_PCSK_KEX2_1	228	230	PF00082	0.405
CLV_PCSK_SKI1_1	260	264	PF00082	0.451
CLV_PCSK_SKI1_1	99	103	PF00082	0.296
DEG_APCC_DBOX_1	259	267	PF00400	0.438
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DOC_CDC14_PxL_1	177	185	PF14671	0.228
DOC_CDC14_PxL_1	263	271	PF14671	0.326
DOC_CKS1_1	201	206	PF01111	0.345
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.517
DOC_MAPK_gen_1	185	193	PF00069	0.371
DOC_MAPK_gen_1	255	265	PF00069	0.430
DOC_MAPK_gen_1	47	56	PF00069	0.286
DOC_MAPK_MEF2A_6	20	27	PF00069	0.445
DOC_MAPK_MEF2A_6	310	318	PF00069	0.545
DOC_MAPK_MEF2A_6	47	56	PF00069	0.247
DOC_MAPK_NFAT4_5	49	57	PF00069	0.275
DOC_PP1_RVXF_1	328	334	PF00149	0.631
DOC_PP2B_LxvP_1	37	40	PF13499	0.416
DOC_USP7_MATH_1	147	151	PF00917	0.421
DOC_USP7_MATH_1	18	22	PF00917	0.485
DOC_USP7_MATH_1	215	219	PF00917	0.147
DOC_USP7_MATH_1	353	357	PF00917	0.610
DOC_USP7_UBL2_3	148	152	PF12436	0.304
DOC_WW_Pin1_4	200	205	PF00397	0.311
DOC_WW_Pin1_4	321	326	PF00397	0.496
LIG_14-3-3_CanoR_1	138	144	PF00244	0.405
LIG_14-3-3_CanoR_1	167	172	PF00244	0.252
LIG_14-3-3_CanoR_1	185	193	PF00244	0.432
LIG_14-3-3_CanoR_1	2	7	PF00244	0.579
LIG_14-3-3_CanoR_1	228	235	PF00244	0.490
LIG_EVH1_1	37	41	PF00568	0.447
LIG_FHA_1	166	172	PF00498	0.326
LIG_FHA_1	280	286	PF00498	0.435
LIG_FHA_1	300	306	PF00498	0.271
LIG_FHA_1	49	55	PF00498	0.235
LIG_FHA_2	228	234	PF00498	0.319
LIG_GBD_Chelix_1	52	60	PF00786	0.236
LIG_LIR_Apic_2	32	38	PF02991	0.479
LIG_LIR_Gen_1	139	147	PF02991	0.304
LIG_LIR_Gen_1	89	98	PF02991	0.298
LIG_LIR_Nem_3	139	144	PF02991	0.357
LIG_LIR_Nem_3	160	165	PF02991	0.381
LIG_LIR_Nem_3	286	291	PF02991	0.395
LIG_LIR_Nem_3	89	94	PF02991	0.264
LIG_PDZ_Class_1	354	359	PF00595	0.543
LIG_Pex14_2	109	113	PF04695	0.405
LIG_Pex14_2	31	35	PF04695	0.487
LIG_PTB_Apo_2	332	339	PF02174	0.457
LIG_SH2_PTP2	143	146	PF00017	0.208
LIG_SH2_PTP2	91	94	PF00017	0.317
LIG_SH2_STAT5	121	124	PF00017	0.288
LIG_SH2_STAT5	143	146	PF00017	0.424
LIG_SH2_STAT5	179	182	PF00017	0.288
LIG_SH2_STAT5	293	296	PF00017	0.348
LIG_SH2_STAT5	91	94	PF00017	0.229
LIG_SH3_1	198	204	PF00018	0.236
LIG_SH3_3	198	204	PF00018	0.236
LIG_SH3_3	30	36	PF00018	0.354
LIG_SH3_3	313	319	PF00018	0.450
LIG_SH3_3	38	44	PF00018	0.356
LIG_SH3_3	76	82	PF00018	0.147
LIG_SH3_5	86	90	PF00018	0.317
LIG_SUMO_SIM_par_1	188	195	PF11976	0.231
LIG_SUMO_SIM_par_1	50	55	PF11976	0.228
LIG_SxIP_EBH_1	319	330	PF03271	0.548
LIG_TRAF2_1	230	233	PF00917	0.322
LIG_TRFH_1	200	204	PF08558	0.228
LIG_TYR_ITIM	88	93	PF00017	0.304
LIG_WW_2	41	44	PF00397	0.550
MOD_CDK_SPK_2	200	205	PF00069	0.322
MOD_CK1_1	139	145	PF00069	0.396
MOD_CK1_1	155	161	PF00069	0.405
MOD_CK2_1	139	145	PF00069	0.396
MOD_CK2_1	227	233	PF00069	0.374
MOD_Cter_Amidation	183	186	PF01082	0.405
MOD_GlcNHglycan	12	15	PF01048	0.654
MOD_GlcNHglycan	335	338	PF01048	0.462
MOD_GlcNHglycan	340	343	PF01048	0.459
MOD_GSK3_1	153	160	PF00069	0.288
MOD_GSK3_1	163	170	PF00069	0.187
MOD_GSK3_1	196	203	PF00069	0.311
MOD_GSK3_1	329	336	PF00069	0.493
MOD_GSK3_1	56	63	PF00069	0.275
MOD_GSK3_1	69	76	PF00069	0.275
MOD_NEK2_1	1	6	PF00069	0.464
MOD_NEK2_1	153	158	PF00069	0.318
MOD_NEK2_1	165	170	PF00069	0.177
MOD_NEK2_1	299	304	PF00069	0.402
MOD_NEK2_1	314	319	PF00069	0.412
MOD_NEK2_1	333	338	PF00069	0.540
MOD_NEK2_1	60	65	PF00069	0.309
MOD_NEK2_2	344	349	PF00069	0.438
MOD_PIKK_1	165	171	PF00454	0.254
MOD_PIKK_1	227	233	PF00454	0.345
MOD_PK_1	186	192	PF00069	0.304
MOD_PKA_1	185	191	PF00069	0.405
MOD_PKA_2	1	7	PF00069	0.450
MOD_PKA_2	227	233	PF00069	0.439
MOD_Plk_1	215	221	PF00069	0.345
MOD_Plk_1	344	350	PF00069	0.562
MOD_Plk_1	56	62	PF00069	0.228
MOD_Plk_4	139	145	PF00069	0.327
MOD_Plk_4	186	192	PF00069	0.287
MOD_Plk_4	2	8	PF00069	0.559
MOD_Plk_4	215	221	PF00069	0.260
MOD_Plk_4	329	335	PF00069	0.400
MOD_Plk_4	48	54	PF00069	0.228
MOD_Plk_4	56	62	PF00069	0.228
MOD_ProDKin_1	200	206	PF00069	0.311
MOD_ProDKin_1	321	327	PF00069	0.487
TRG_ENDOCYTIC_2	141	144	PF00928	0.340
TRG_ENDOCYTIC_2	179	182	PF00928	0.263
TRG_ENDOCYTIC_2	90	93	PF00928	0.369
TRG_ER_diArg_1	227	229	PF00400	0.405
TRG_NES_CRM1_1	135	149	PF08389	0.304
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.443
TRG_PTS1	356	359	PF00515	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D2	Leptomonas seymouri	73%	100%
A0A0S4IR87	Bodo saltans	26%	80%
A0A0S4IXS3	Bodo saltans	32%	93%
A0A0S4J698	Bodo saltans	33%	77%
A0A0S4J952	Bodo saltans	36%	100%
A0A0S4JFL1	Bodo saltans	34%	100%
A0A0S4JJI6	Bodo saltans	39%	96%
A0A0S4JU68	Bodo saltans	35%	100%
A0A1X0NUJ8	Trypanosomatidae	51%	99%
A0A3S7X7S3	Leishmania donovani	87%	100%
A0A422N4T2	Trypanosoma rangeli	51%	100%
A4I9T8	Leishmania infantum	87%	100%
C9ZXU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZXU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B4U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q377	Leishmania major	86%	100%
Q8JIL9	Xenopus laevis	30%	100%
V5B4L5	Trypanosoma cruzi	52%	100%