C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4HAP1_LEIBR

TriTrypDb:

LbrM.20.1270 , LBRM2903_200021800

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAP1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004527	exonuclease activity	5	7
GO:0005488	binding	1	7
GO:0008408	3'-5' exonuclease activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.388
CLV_NRD_NRD_1	244	246	PF00675	0.314
CLV_NRD_NRD_1	268	270	PF00675	0.508
CLV_NRD_NRD_1	285	287	PF00675	0.282
CLV_NRD_NRD_1	344	346	PF00675	0.362
CLV_NRD_NRD_1	380	382	PF00675	0.302
CLV_NRD_NRD_1	78	80	PF00675	0.196
CLV_PCSK_KEX2_1	204	206	PF00082	0.472
CLV_PCSK_KEX2_1	246	248	PF00082	0.306
CLV_PCSK_KEX2_1	285	287	PF00082	0.300
CLV_PCSK_KEX2_1	380	382	PF00082	0.459
CLV_PCSK_KEX2_1	431	433	PF00082	0.384
CLV_PCSK_KEX2_1	460	462	PF00082	0.298
CLV_PCSK_KEX2_1	492	494	PF00082	0.415
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.472
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.306
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.297
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.298
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.403
CLV_PCSK_PC7_1	427	433	PF00082	0.280
CLV_PCSK_SKI1_1	246	250	PF00082	0.365
CLV_PCSK_SKI1_1	332	336	PF00082	0.401
CLV_PCSK_SKI1_1	407	411	PF00082	0.349
CLV_PCSK_SKI1_1	414	418	PF00082	0.393
CLV_PCSK_SKI1_1	56	60	PF00082	0.254
DEG_APCC_DBOX_1	105	113	PF00400	0.396
DOC_CKS1_1	448	453	PF01111	0.324
DOC_CYCLIN_RxL_1	401	412	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.396
DOC_MAPK_gen_1	126	136	PF00069	0.396
DOC_MAPK_gen_1	269	276	PF00069	0.452
DOC_MAPK_gen_1	471	480	PF00069	0.420
DOC_MAPK_gen_1	77	86	PF00069	0.594
DOC_MAPK_MEF2A_6	269	276	PF00069	0.380
DOC_MAPK_MEF2A_6	471	480	PF00069	0.420
DOC_MAPK_RevD_3	272	286	PF00069	0.313
DOC_PP2B_LxvP_1	134	137	PF13499	0.396
DOC_PP4_FxxP_1	173	176	PF00568	0.330
DOC_USP7_MATH_1	137	141	PF00917	0.476
DOC_USP7_MATH_1	148	152	PF00917	0.444
DOC_USP7_MATH_1	253	257	PF00917	0.325
DOC_USP7_MATH_1	33	37	PF00917	0.454
DOC_USP7_MATH_1	386	390	PF00917	0.417
DOC_WW_Pin1_4	22	27	PF00397	0.402
DOC_WW_Pin1_4	337	342	PF00397	0.341
DOC_WW_Pin1_4	447	452	PF00397	0.337
LIG_14-3-3_CanoR_1	180	188	PF00244	0.491
LIG_14-3-3_CanoR_1	269	273	PF00244	0.309
LIG_14-3-3_CanoR_1	432	442	PF00244	0.290
LIG_14-3-3_CanoR_1	471	477	PF00244	0.420
LIG_14-3-3_CanoR_1	511	515	PF00244	0.323
LIG_Actin_WH2_2	146	163	PF00022	0.518
LIG_BRCT_BRCA1_1	18	22	PF00533	0.465
LIG_BRCT_BRCA1_1	35	39	PF00533	0.454
LIG_BRCT_BRCA1_1	390	394	PF00533	0.373
LIG_BRCT_BRCA1_1	435	439	PF00533	0.441
LIG_BRCT_BRCA1_1	95	99	PF00533	0.491
LIG_FHA_1	170	176	PF00498	0.318
LIG_FHA_1	180	186	PF00498	0.307
LIG_FHA_1	259	265	PF00498	0.350
LIG_FHA_1	269	275	PF00498	0.287
LIG_FHA_1	329	335	PF00498	0.361
LIG_FHA_1	410	416	PF00498	0.388
LIG_FHA_1	473	479	PF00498	0.428
LIG_FHA_2	382	388	PF00498	0.533
LIG_FHA_2	435	441	PF00498	0.451
LIG_FHA_2	448	454	PF00498	0.352
LIG_IRF3_LxIS_1	39	44	PF10401	0.508
LIG_LIR_Apic_2	130	135	PF02991	0.454
LIG_LIR_Apic_2	172	176	PF02991	0.296
LIG_LIR_Gen_1	404	410	PF02991	0.326
LIG_LIR_Gen_1	436	446	PF02991	0.457
LIG_LIR_Nem_3	342	347	PF02991	0.370
LIG_LIR_Nem_3	357	363	PF02991	0.393
LIG_LIR_Nem_3	404	408	PF02991	0.385
LIG_LIR_Nem_3	436	442	PF02991	0.376
LIG_LIR_Nem_3	515	520	PF02991	0.445
LIG_LIR_Nem_3	96	101	PF02991	0.396
LIG_MLH1_MIPbox_1	435	439	PF16413	0.283
LIG_MLH1_MIPbox_1	95	99	PF16413	0.396
LIG_Pex14_1	434	438	PF04695	0.283
LIG_Pex14_2	438	442	PF04695	0.384
LIG_Pex14_2	490	494	PF04695	0.344
LIG_PTB_Apo_2	440	447	PF02174	0.361
LIG_Rb_pABgroove_1	272	280	PF01858	0.377
LIG_REV1ctd_RIR_1	43	51	PF16727	0.508
LIG_SH2_CRK	405	409	PF00017	0.409
LIG_SH2_NCK_1	383	387	PF00017	0.459
LIG_SH2_SRC	152	155	PF00017	0.396
LIG_SH2_SRC	360	363	PF00017	0.409
LIG_SH2_STAP1	375	379	PF00017	0.401
LIG_SH2_STAP1	405	409	PF00017	0.333
LIG_SH2_STAP1	95	99	PF00017	0.508
LIG_SH2_STAT5	11	14	PF00017	0.258
LIG_SH2_STAT5	152	155	PF00017	0.508
LIG_SH2_STAT5	166	169	PF00017	0.322
LIG_SH2_STAT5	251	254	PF00017	0.413
LIG_SH2_STAT5	360	363	PF00017	0.494
LIG_SH2_STAT5	383	386	PF00017	0.450
LIG_SH2_STAT5	429	432	PF00017	0.296
LIG_SH2_STAT5	497	500	PF00017	0.347
LIG_SH3_3	367	373	PF00018	0.302
LIG_SUMO_SIM_anti_2	24	31	PF11976	0.392
LIG_SUMO_SIM_anti_2	256	261	PF11976	0.298
MOD_CK1_1	169	175	PF00069	0.437
MOD_CK1_1	389	395	PF00069	0.383
MOD_CK2_1	127	133	PF00069	0.454
MOD_CK2_1	381	387	PF00069	0.456
MOD_CK2_1	434	440	PF00069	0.440
MOD_CK2_1	447	453	PF00069	0.352
MOD_GlcNHglycan	168	171	PF01048	0.509
MOD_GlcNHglycan	95	98	PF01048	0.280
MOD_GSK3_1	317	324	PF00069	0.366
MOD_GSK3_1	386	393	PF00069	0.358
MOD_GSK3_1	397	404	PF00069	0.300
MOD_GSK3_1	506	513	PF00069	0.386
MOD_N-GLC_1	117	122	PF02516	0.308
MOD_N-GLC_1	389	394	PF02516	0.364
MOD_N-GLC_2	421	423	PF02516	0.300
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	112	117	PF00069	0.454
MOD_NEK2_1	179	184	PF00069	0.405
MOD_NEK2_1	241	246	PF00069	0.374
MOD_NEK2_1	32	37	PF00069	0.564
MOD_NEK2_1	409	414	PF00069	0.413
MOD_NEK2_1	41	46	PF00069	0.459
MOD_NEK2_2	434	439	PF00069	0.358
MOD_PKA_2	179	185	PF00069	0.409
MOD_PKA_2	268	274	PF00069	0.336
MOD_PKA_2	434	440	PF00069	0.283
MOD_PKA_2	510	516	PF00069	0.318
MOD_Plk_1	117	123	PF00069	0.508
MOD_Plk_1	137	143	PF00069	0.435
MOD_Plk_1	253	259	PF00069	0.310
MOD_Plk_1	389	395	PF00069	0.397
MOD_Plk_1	73	79	PF00069	0.542
MOD_Plk_1	82	88	PF00069	0.468
MOD_Plk_4	117	123	PF00069	0.396
MOD_Plk_4	148	154	PF00069	0.469
MOD_Plk_4	366	372	PF00069	0.399
MOD_Plk_4	434	440	PF00069	0.482
MOD_Plk_4	85	91	PF00069	0.454
MOD_ProDKin_1	22	28	PF00069	0.402
MOD_ProDKin_1	337	343	PF00069	0.344
MOD_ProDKin_1	447	453	PF00069	0.329
MOD_SUMO_rev_2	120	128	PF00179	0.396
MOD_SUMO_rev_2	273	282	PF00179	0.473
MOD_SUMO_rev_2	500	509	PF00179	0.393
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.413
TRG_ENDOCYTIC_2	11	14	PF00928	0.258
TRG_ENDOCYTIC_2	289	292	PF00928	0.402
TRG_ENDOCYTIC_2	360	363	PF00928	0.530
TRG_ENDOCYTIC_2	396	399	PF00928	0.504
TRG_ENDOCYTIC_2	405	408	PF00928	0.316
TRG_ENDOCYTIC_2	95	98	PF00928	0.508
TRG_ER_diArg_1	379	381	PF00400	0.309
TRG_NLS_MonoExtC_3	244	249	PF00514	0.304
TRG_NLS_MonoExtN_4	245	250	PF00514	0.302
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.196
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV0	Leptomonas seymouri	54%	94%
A0A3S7X7Q1	Leishmania donovani	72%	96%
A4I9T6	Leishmania infantum	72%	96%
E9B4U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	96%
Q4Q379	Leishmania major	73%	100%
Q8VEG4	Mus musculus	23%	81%
Q9NVH0	Homo sapiens	22%	85%