Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAN7_LEIBR

TriTrypDb:

LbrM.20.1230 , LBRM2903_200021200

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.539
CLV_NRD_NRD_1	165	167	PF00675	0.494
CLV_NRD_NRD_1	178	180	PF00675	0.509
CLV_NRD_NRD_1	530	532	PF00675	0.555
CLV_PCSK_KEX2_1	164	166	PF00082	0.494
CLV_PCSK_KEX2_1	178	180	PF00082	0.507
CLV_PCSK_KEX2_1	327	329	PF00082	0.714
CLV_PCSK_KEX2_1	530	532	PF00082	0.555
CLV_PCSK_KEX2_1	73	75	PF00082	0.678
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.714
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.678
CLV_PCSK_SKI1_1	107	111	PF00082	0.633
CLV_PCSK_SKI1_1	231	235	PF00082	0.652
CLV_PCSK_SKI1_1	324	328	PF00082	0.625
CLV_PCSK_SKI1_1	330	334	PF00082	0.595
CLV_PCSK_SKI1_1	359	363	PF00082	0.480
CLV_PCSK_SKI1_1	399	403	PF00082	0.514
CLV_PCSK_SKI1_1	47	51	PF00082	0.569
CLV_PCSK_SKI1_1	512	516	PF00082	0.402
DEG_SPOP_SBC_1	135	139	PF00917	0.694
DEG_SPOP_SBC_1	257	261	PF00917	0.555
DOC_CKS1_1	48	53	PF01111	0.552
DOC_MAPK_gen_1	164	170	PF00069	0.505
DOC_MAPK_HePTP_8	209	221	PF00069	0.522
DOC_MAPK_MEF2A_6	212	221	PF00069	0.522
DOC_MAPK_MEF2A_6	468	477	PF00069	0.461
DOC_PP1_RVXF_1	510	516	PF00149	0.418
DOC_PP1_RVXF_1	583	590	PF00149	0.413
DOC_PP2B_LxvP_1	434	437	PF13499	0.681
DOC_PP4_FxxP_1	430	433	PF00568	0.512
DOC_PP4_FxxP_1	48	51	PF00568	0.545
DOC_USP7_MATH_1	136	140	PF00917	0.752
DOC_USP7_MATH_1	147	151	PF00917	0.477
DOC_USP7_MATH_1	256	260	PF00917	0.687
DOC_USP7_MATH_1	285	289	PF00917	0.509
DOC_USP7_MATH_1	377	381	PF00917	0.543
DOC_USP7_MATH_1	437	441	PF00917	0.523
DOC_USP7_MATH_1	561	565	PF00917	0.534
DOC_USP7_MATH_1	578	582	PF00917	0.590
DOC_USP7_MATH_1	95	99	PF00917	0.661
DOC_WW_Pin1_4	195	200	PF00397	0.618
DOC_WW_Pin1_4	261	266	PF00397	0.548
DOC_WW_Pin1_4	309	314	PF00397	0.546
DOC_WW_Pin1_4	394	399	PF00397	0.737
DOC_WW_Pin1_4	445	450	PF00397	0.599
DOC_WW_Pin1_4	47	52	PF00397	0.549
DOC_WW_Pin1_4	5	10	PF00397	0.605
DOC_WW_Pin1_4	619	624	PF00397	0.502
LIG_14-3-3_CanoR_1	120	130	PF00244	0.655
LIG_14-3-3_CanoR_1	169	177	PF00244	0.530
LIG_14-3-3_CanoR_1	284	292	PF00244	0.500
LIG_14-3-3_CanoR_1	399	409	PF00244	0.496
LIG_14-3-3_CanoR_1	530	537	PF00244	0.439
LIG_Actin_WH2_2	196	214	PF00022	0.469
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_deltaCOP1_diTrp_1	415	426	PF00928	0.588
LIG_eIF4E_1	237	243	PF01652	0.653
LIG_EVH1_2	92	96	PF00568	0.544
LIG_FHA_1	123	129	PF00498	0.547
LIG_FHA_1	136	142	PF00498	0.570
LIG_FHA_1	258	264	PF00498	0.555
LIG_FHA_1	303	309	PF00498	0.559
LIG_FHA_1	310	316	PF00498	0.504
LIG_FHA_1	420	426	PF00498	0.494
LIG_FHA_1	459	465	PF00498	0.521
LIG_FHA_1	516	522	PF00498	0.410
LIG_FHA_1	554	560	PF00498	0.510
LIG_FHA_1	577	583	PF00498	0.590
LIG_FHA_2	13	19	PF00498	0.529
LIG_FHA_2	360	366	PF00498	0.648
LIG_FHA_2	531	537	PF00498	0.432
LIG_FHA_2	636	642	PF00498	0.499
LIG_LIR_Apic_2	403	409	PF02991	0.497
LIG_LIR_Gen_1	247	257	PF02991	0.548
LIG_LIR_Gen_1	469	479	PF02991	0.457
LIG_LIR_LC3C_4	266	270	PF02991	0.513
LIG_LIR_Nem_3	247	252	PF02991	0.541
LIG_LIR_Nem_3	423	429	PF02991	0.576
LIG_LIR_Nem_3	469	475	PF02991	0.464
LIG_LIR_Nem_3	581	587	PF02991	0.439
LIG_LIR_Nem_3	8	13	PF02991	0.529
LIG_NRBOX	638	644	PF00104	0.540
LIG_PDZ_Class_3	641	646	PF00595	0.387
LIG_Pex14_1	245	249	PF04695	0.524
LIG_Pex14_2	426	430	PF04695	0.577
LIG_SH2_CRK	376	380	PF00017	0.515
LIG_SH2_CRK	584	588	PF00017	0.419
LIG_SH2_NCK_1	376	380	PF00017	0.518
LIG_SH2_NCK_1	39	43	PF00017	0.503
LIG_SH2_PTP2	10	13	PF00017	0.553
LIG_SH2_STAP1	39	43	PF00017	0.529
LIG_SH2_STAT5	10	13	PF00017	0.553
LIG_SH2_STAT5	39	42	PF00017	0.649
LIG_SH2_STAT5	406	409	PF00017	0.478
LIG_SH3_3	141	147	PF00018	0.502
LIG_SH3_3	249	255	PF00018	0.585
LIG_SH3_3	422	428	PF00018	0.528
LIG_SH3_3	56	62	PF00018	0.553
LIG_SH3_3	78	84	PF00018	0.649
LIG_SH3_3	89	95	PF00018	0.566
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.502
LIG_SUMO_SIM_par_1	217	228	PF11976	0.476
LIG_SUMO_SIM_par_1	431	441	PF11976	0.473
LIG_SUMO_SIM_par_1	592	597	PF11976	0.357
LIG_TRAF2_1	564	567	PF00917	0.510
LIG_TRFH_1	309	313	PF08558	0.680
LIG_TYR_ITIM	374	379	PF00017	0.516
LIG_TYR_ITIM	582	587	PF00017	0.436
LIG_WRC_WIRS_1	474	479	PF05994	0.449
MOD_CDK_SPK_2	394	399	PF00069	0.509
MOD_CDK_SPK_2	49	54	PF00069	0.513
MOD_CDK_SPxxK_3	47	54	PF00069	0.510
MOD_CK1_1	124	130	PF00069	0.514
MOD_CK1_1	193	199	PF00069	0.632
MOD_CK1_1	224	230	PF00069	0.549
MOD_CK1_1	261	267	PF00069	0.590
MOD_CK1_1	34	40	PF00069	0.500
MOD_CK1_1	397	403	PF00069	0.603
MOD_CK1_1	459	465	PF00069	0.521
MOD_CK1_1	489	495	PF00069	0.548
MOD_CK1_1	576	582	PF00069	0.479
MOD_CK1_1	63	69	PF00069	0.629
MOD_CK2_1	359	365	PF00069	0.642
MOD_CK2_1	377	383	PF00069	0.417
MOD_CK2_1	499	505	PF00069	0.562
MOD_CK2_1	530	536	PF00069	0.449
MOD_CK2_1	561	567	PF00069	0.511
MOD_CK2_1	635	641	PF00069	0.402
MOD_GlcNHglycan	130	133	PF01048	0.745
MOD_GlcNHglycan	138	141	PF01048	0.597
MOD_GlcNHglycan	147	150	PF01048	0.447
MOD_GlcNHglycan	227	230	PF01048	0.538
MOD_GlcNHglycan	288	291	PF01048	0.601
MOD_GlcNHglycan	3	6	PF01048	0.530
MOD_GlcNHglycan	365	369	PF01048	0.507
MOD_GlcNHglycan	379	382	PF01048	0.651
MOD_GlcNHglycan	456	459	PF01048	0.562
MOD_GlcNHglycan	469	472	PF01048	0.433
MOD_GlcNHglycan	488	491	PF01048	0.339
MOD_GlcNHglycan	635	638	PF01048	0.508
MOD_GlcNHglycan	88	91	PF01048	0.698
MOD_GSK3_1	1	8	PF00069	0.539
MOD_GSK3_1	12	19	PF00069	0.477
MOD_GSK3_1	120	127	PF00069	0.562
MOD_GSK3_1	178	185	PF00069	0.658
MOD_GSK3_1	186	193	PF00069	0.546
MOD_GSK3_1	217	224	PF00069	0.531
MOD_GSK3_1	257	264	PF00069	0.584
MOD_GSK3_1	286	293	PF00069	0.636
MOD_GSK3_1	330	337	PF00069	0.606
MOD_GSK3_1	360	367	PF00069	0.510
MOD_GSK3_1	397	404	PF00069	0.680
MOD_GSK3_1	415	422	PF00069	0.539
MOD_GSK3_1	452	459	PF00069	0.608
MOD_GSK3_1	462	469	PF00069	0.502
MOD_GSK3_1	501	508	PF00069	0.602
MOD_GSK3_1	574	581	PF00069	0.493
MOD_GSK3_1	633	640	PF00069	0.405
MOD_N-GLC_1	394	399	PF02516	0.509
MOD_N-GLC_1	607	612	PF02516	0.475
MOD_N-GLC_1	633	638	PF02516	0.410
MOD_N-GLC_2	454	456	PF02516	0.497
MOD_NEK2_1	182	187	PF00069	0.600
MOD_NEK2_1	194	199	PF00069	0.557
MOD_NEK2_1	217	222	PF00069	0.526
MOD_NEK2_1	268	273	PF00069	0.482
MOD_NEK2_1	303	308	PF00069	0.582
MOD_NEK2_1	351	356	PF00069	0.568
MOD_NEK2_1	401	406	PF00069	0.503
MOD_NEK2_1	466	471	PF00069	0.477
MOD_NEK2_1	473	478	PF00069	0.443
MOD_NEK2_1	513	518	PF00069	0.656
MOD_NEK2_1	55	60	PF00069	0.519
MOD_NEK2_1	573	578	PF00069	0.504
MOD_NEK2_1	594	599	PF00069	0.438
MOD_NEK2_1	606	611	PF00069	0.519
MOD_NEK2_1	633	638	PF00069	0.567
MOD_NEK2_2	578	583	PF00069	0.508
MOD_PIKK_1	12	18	PF00454	0.592
MOD_PIKK_1	22	28	PF00454	0.490
MOD_PIKK_1	330	336	PF00454	0.628
MOD_PIKK_1	489	495	PF00454	0.621
MOD_PIKK_1	530	536	PF00454	0.449
MOD_PKA_1	178	184	PF00069	0.537
MOD_PKA_1	530	536	PF00069	0.449
MOD_PKA_2	121	127	PF00069	0.653
MOD_PKA_2	178	184	PF00069	0.537
MOD_PKA_2	285	291	PF00069	0.493
MOD_PKA_2	334	340	PF00069	0.555
MOD_PKA_2	499	505	PF00069	0.515
MOD_PKA_2	529	535	PF00069	0.454
MOD_PKA_2	60	66	PF00069	0.609
MOD_PKB_1	120	128	PF00069	0.509
MOD_PKB_1	284	292	PF00069	0.500
MOD_PKB_1	328	336	PF00069	0.560
MOD_Plk_1	182	188	PF00069	0.654
MOD_Plk_1	303	309	PF00069	0.488
MOD_Plk_1	34	40	PF00069	0.504
MOD_Plk_1	415	421	PF00069	0.599
MOD_Plk_1	438	444	PF00069	0.502
MOD_Plk_1	607	613	PF00069	0.443
MOD_Plk_4	124	130	PF00069	0.542
MOD_Plk_4	147	153	PF00069	0.583
MOD_Plk_4	16	22	PF00069	0.647
MOD_Plk_4	205	211	PF00069	0.446
MOD_Plk_4	268	274	PF00069	0.723
MOD_Plk_4	304	310	PF00069	0.644
MOD_Plk_4	34	40	PF00069	0.542
MOD_Plk_4	351	357	PF00069	0.452
MOD_Plk_4	408	414	PF00069	0.611
MOD_Plk_4	416	422	PF00069	0.512
MOD_Plk_4	438	444	PF00069	0.502
MOD_Plk_4	462	468	PF00069	0.512
MOD_Plk_4	473	479	PF00069	0.457
MOD_ProDKin_1	195	201	PF00069	0.617
MOD_ProDKin_1	261	267	PF00069	0.546
MOD_ProDKin_1	309	315	PF00069	0.549
MOD_ProDKin_1	394	400	PF00069	0.736
MOD_ProDKin_1	445	451	PF00069	0.599
MOD_ProDKin_1	47	53	PF00069	0.550
MOD_ProDKin_1	5	11	PF00069	0.603
MOD_ProDKin_1	619	625	PF00069	0.502
MOD_SUMO_for_1	110	113	PF00179	0.482
MOD_SUMO_for_1	326	329	PF00179	0.555
MOD_SUMO_rev_2	532	539	PF00179	0.415
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.509
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.385
TRG_ENDOCYTIC_2	10	13	PF00928	0.553
TRG_ENDOCYTIC_2	376	379	PF00928	0.513
TRG_ENDOCYTIC_2	584	587	PF00928	0.424
TRG_ER_diArg_1	119	122	PF00400	0.553
TRG_ER_diArg_1	164	166	PF00400	0.494
TRG_ER_diArg_1	177	179	PF00400	0.508
TRG_ER_diArg_1	284	287	PF00400	0.549
TRG_ER_diArg_1	529	531	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6C8	Leptomonas seymouri	34%	97%
A0A3Q8IE95	Leishmania donovani	60%	100%
A4I9T0	Leishmania infantum	60%	100%
E9B4U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	98%
Q4Q385	Leishmania major	60%	100%