Enriched in surface-labeled proteome protein 11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 11, putative

Species:

Leishmania braziliensis

UniProt:

A4HAN6_LEIBR

TriTrypDb:

LbrM.20.1220 , LBRM2903_200021100

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4HAN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.404
CLV_PCSK_KEX2_1	113	115	PF00082	0.492
CLV_PCSK_KEX2_1	174	176	PF00082	0.404
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.492
CLV_PCSK_SKI1_1	53	57	PF00082	0.683
DEG_SCF_FBW7_1	165	170	PF00400	0.528
DOC_CKS1_1	164	169	PF01111	0.524
DOC_MAPK_gen_1	12	20	PF00069	0.434
DOC_MAPK_gen_1	51	60	PF00069	0.356
DOC_MAPK_MEF2A_6	12	20	PF00069	0.434
DOC_MAPK_MEF2A_6	70	78	PF00069	0.319
DOC_PP1_RVXF_1	49	55	PF00149	0.357
DOC_PP2B_LxvP_1	78	81	PF13499	0.431
DOC_USP7_MATH_1	167	171	PF00917	0.567
DOC_USP7_MATH_1	177	181	PF00917	0.609
DOC_USP7_MATH_1	216	220	PF00917	0.630
DOC_USP7_MATH_1	240	244	PF00917	0.608
DOC_WW_Pin1_4	163	168	PF00397	0.647
DOC_WW_Pin1_4	221	226	PF00397	0.792
LIG_14-3-3_CanoR_1	53	60	PF00244	0.393
LIG_AP2alpha_2	115	117	PF02296	0.353
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	196	200	PF00533	0.645
LIG_BRCT_BRCA1_1	87	91	PF00533	0.300
LIG_FHA_1	107	113	PF00498	0.378
LIG_FHA_1	43	49	PF00498	0.383
LIG_FHA_1	81	87	PF00498	0.418
LIG_FHA_2	199	205	PF00498	0.675
LIG_FHA_2	54	60	PF00498	0.355
LIG_GBD_Chelix_1	16	24	PF00786	0.500
LIG_LIR_Apic_2	162	167	PF02991	0.530
LIG_LIR_Apic_2	45	50	PF02991	0.363
LIG_LIR_Nem_3	189	195	PF02991	0.546
LIG_MLH1_MIPbox_1	87	91	PF16413	0.300
LIG_NRBOX	19	25	PF00104	0.493
LIG_PCNA_yPIPBox_3	41	53	PF02747	0.365
LIG_PDZ_Class_1	242	247	PF00595	0.675
LIG_Pex14_1	160	164	PF04695	0.574
LIG_PTB_Apo_2	84	91	PF02174	0.383
LIG_PTB_Phospho_1	84	90	PF10480	0.415
LIG_SH2_GRB2like	85	88	PF00017	0.434
LIG_SH2_NCK_1	195	199	PF00017	0.629
LIG_SH2_PTP2	164	167	PF00017	0.623
LIG_SH2_SRC	85	88	PF00017	0.434
LIG_SH2_STAT5	151	154	PF00017	0.317
LIG_SH2_STAT5	164	167	PF00017	0.580
LIG_SH2_STAT5	47	50	PF00017	0.510
LIG_SH2_STAT5	85	88	PF00017	0.392
LIG_SH2_STAT5	90	93	PF00017	0.357
LIG_SH3_3	176	182	PF00018	0.731
LIG_SH3_3	219	225	PF00018	0.789
LIG_SUMO_SIM_par_1	136	142	PF11976	0.276
LIG_SxIP_EBH_1	165	175	PF03271	0.538
LIG_WRC_WIRS_1	143	148	PF05994	0.312
MOD_CDK_SPK_2	163	168	PF00069	0.525
MOD_CK1_1	142	148	PF00069	0.398
MOD_CK1_1	203	209	PF00069	0.653
MOD_CK1_1	36	42	PF00069	0.459
MOD_CK2_1	198	204	PF00069	0.672
MOD_CK2_1	235	241	PF00069	0.755
MOD_CK2_1	53	59	PF00069	0.357
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	196	199	PF01048	0.460
MOD_GlcNHglycan	216	219	PF01048	0.384
MOD_GlcNHglycan	38	41	PF01048	0.657
MOD_GlcNHglycan	94	97	PF01048	0.629
MOD_GSK3_1	163	170	PF00069	0.694
MOD_GSK3_1	177	184	PF00069	0.684
MOD_GSK3_1	194	201	PF00069	0.626
MOD_GSK3_1	203	210	PF00069	0.652
MOD_GSK3_1	212	219	PF00069	0.650
MOD_GSK3_1	35	42	PF00069	0.471
MOD_NEK2_1	106	111	PF00069	0.343
MOD_NEK2_1	207	212	PF00069	0.613
MOD_NEK2_1	22	27	PF00069	0.534
MOD_NEK2_1	33	38	PF00069	0.571
MOD_OFUCOSY	104	110	PF10250	0.634
MOD_PKB_1	51	59	PF00069	0.357
MOD_Plk_1	203	209	PF00069	0.562
MOD_Plk_4	126	132	PF00069	0.429
MOD_Plk_4	167	173	PF00069	0.571
MOD_Plk_4	22	28	PF00069	0.468
MOD_Plk_4	80	86	PF00069	0.461
MOD_ProDKin_1	163	169	PF00069	0.647
MOD_ProDKin_1	221	227	PF00069	0.791
TRG_ER_diArg_1	12	15	PF00400	0.584
TRG_ER_diArg_1	173	175	PF00400	0.673
TRG_ER_diArg_1	50	53	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W2	Leptomonas seymouri	46%	100%
A0A3S7X7R5	Leishmania donovani	64%	89%
A0A422NGS8	Trypanosoma rangeli	39%	100%
A4I9S9	Leishmania infantum	64%	89%
C9ZMV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B4U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	89%
Q4Q386	Leishmania major	62%	100%