Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAN5_LEIBR

TriTrypDb:

LbrM.20.1210 , LBRM2903_200021000

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.559
CLV_NRD_NRD_1	115	117	PF00675	0.337
CLV_NRD_NRD_1	259	261	PF00675	0.540
CLV_NRD_NRD_1	280	282	PF00675	0.505
CLV_NRD_NRD_1	298	300	PF00675	0.523
CLV_NRD_NRD_1	355	357	PF00675	0.532
CLV_NRD_NRD_1	365	367	PF00675	0.571
CLV_NRD_NRD_1	414	416	PF00675	0.550
CLV_PCSK_FUR_1	353	357	PF00082	0.440
CLV_PCSK_KEX2_1	115	117	PF00082	0.337
CLV_PCSK_KEX2_1	280	282	PF00082	0.575
CLV_PCSK_KEX2_1	298	300	PF00082	0.531
CLV_PCSK_KEX2_1	355	357	PF00082	0.540
CLV_PCSK_KEX2_1	365	367	PF00082	0.613
CLV_PCSK_KEX2_1	422	424	PF00082	0.552
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.536
CLV_PCSK_PC7_1	418	424	PF00082	0.421
CLV_PCSK_SKI1_1	133	137	PF00082	0.494
CLV_PCSK_SKI1_1	298	302	PF00082	0.480
CLV_PCSK_SKI1_1	331	335	PF00082	0.586
CLV_PCSK_SKI1_1	400	404	PF00082	0.541
CLV_PCSK_SKI1_1	422	426	PF00082	0.502
CLV_PCSK_SKI1_1	436	440	PF00082	0.489
DEG_APCC_DBOX_1	103	111	PF00400	0.527
DEG_APCC_DBOX_1	417	425	PF00400	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.499
DEG_SPOP_SBC_1	468	472	PF00917	0.580
DEG_SPOP_SBC_1	481	485	PF00917	0.509
DOC_CKS1_1	1	6	PF01111	0.629
DOC_CKS1_1	463	468	PF01111	0.563
DOC_MAPK_gen_1	413	421	PF00069	0.552
DOC_MAPK_MEF2A_6	413	421	PF00069	0.345
DOC_PP2B_LxvP_1	284	287	PF13499	0.598
DOC_USP7_MATH_1	146	150	PF00917	0.555
DOC_USP7_MATH_1	203	207	PF00917	0.521
DOC_USP7_MATH_1	246	250	PF00917	0.482
DOC_USP7_MATH_1	276	280	PF00917	0.477
DOC_USP7_MATH_1	300	304	PF00917	0.485
DOC_USP7_MATH_1	481	485	PF00917	0.561
DOC_USP7_UBL2_3	129	133	PF12436	0.411
DOC_USP7_UBL2_3	178	182	PF12436	0.473
DOC_WW_Pin1_4	448	453	PF00397	0.716
DOC_WW_Pin1_4	462	467	PF00397	0.615
LIG_14-3-3_CanoR_1	321	325	PF00244	0.392
LIG_14-3-3_CanoR_1	331	338	PF00244	0.449
LIG_14-3-3_CanoR_1	360	364	PF00244	0.551
LIG_14-3-3_CanoR_1	66	76	PF00244	0.451
LIG_14-3-3_CterR_2	493	498	PF00244	0.509
LIG_Actin_WH2_2	237	254	PF00022	0.541
LIG_CaM_IQ_9	181	196	PF13499	0.482
LIG_Clathr_ClatBox_1	45	49	PF01394	0.497
LIG_FHA_1	123	129	PF00498	0.435
LIG_FHA_1	299	305	PF00498	0.556
LIG_FHA_1	399	405	PF00498	0.553
LIG_FHA_1	41	47	PF00498	0.534
LIG_FHA_1	463	469	PF00498	0.700
LIG_FHA_2	164	170	PF00498	0.432
LIG_FHA_2	33	39	PF00498	0.425
LIG_FHA_2	393	399	PF00498	0.491
LIG_FHA_2	483	489	PF00498	0.759
LIG_LIR_Gen_1	84	93	PF02991	0.447
LIG_LIR_Nem_3	84	89	PF02991	0.452
LIG_LRP6_Inhibitor_1	254	260	PF00058	0.361
LIG_NRBOX	92	98	PF00104	0.557
LIG_PCNA_yPIPBox_3	238	252	PF02747	0.345
LIG_PCNA_yPIPBox_3	360	371	PF02747	0.524
LIG_SH2_GRB2like	24	27	PF00017	0.511
LIG_SH3_1	447	453	PF00018	0.493
LIG_SH3_3	1	7	PF00018	0.481
LIG_SH3_3	447	453	PF00018	0.493
LIG_SH3_3	460	466	PF00018	0.483
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.584
LIG_SUMO_SIM_anti_2	401	407	PF11976	0.550
LIG_SUMO_SIM_par_1	401	407	PF11976	0.457
LIG_TRAF2_1	166	169	PF00917	0.380
LIG_TRAF2_1	177	180	PF00917	0.458
LIG_TRAF2_1	339	342	PF00917	0.403
LIG_TRAF2_1	395	398	PF00917	0.484
LIG_UBA3_1	195	200	PF00899	0.415
LIG_UBA3_1	402	406	PF00899	0.554
LIG_UBA3_1	45	50	PF00899	0.336
LIG_WW_3	451	455	PF00397	0.496
MOD_CDC14_SPxK_1	451	454	PF00782	0.492
MOD_CDK_SPxK_1	448	454	PF00069	0.497
MOD_CK1_1	14	20	PF00069	0.533
MOD_CK1_1	320	326	PF00069	0.590
MOD_CK1_1	329	335	PF00069	0.652
MOD_CK1_1	461	467	PF00069	0.649
MOD_CK1_1	483	489	PF00069	0.525
MOD_CK2_1	163	169	PF00069	0.372
MOD_CK2_1	174	180	PF00069	0.496
MOD_CK2_1	219	225	PF00069	0.389
MOD_CK2_1	32	38	PF00069	0.512
MOD_CK2_1	336	342	PF00069	0.554
MOD_CK2_1	392	398	PF00069	0.493
MOD_CK2_1	461	467	PF00069	0.666
MOD_CK2_1	482	488	PF00069	0.671
MOD_CK2_1	89	95	PF00069	0.514
MOD_GlcNHglycan	148	151	PF01048	0.574
MOD_GSK3_1	140	147	PF00069	0.586
MOD_GSK3_1	332	339	PF00069	0.571
MOD_GSK3_1	457	464	PF00069	0.630
MOD_GSK3_1	67	74	PF00069	0.463
MOD_N-GLC_1	163	168	PF02516	0.347
MOD_N-GLC_1	25	30	PF02516	0.369
MOD_N-GLC_1	314	319	PF02516	0.662
MOD_N-GLC_1	398	403	PF02516	0.552
MOD_N-GLC_1	427	432	PF02516	0.525
MOD_NEK2_1	110	115	PF00069	0.567
MOD_NEK2_1	173	178	PF00069	0.437
MOD_NEK2_1	40	45	PF00069	0.530
MOD_PIKK_1	144	150	PF00454	0.445
MOD_PIKK_1	158	164	PF00454	0.600
MOD_PIKK_1	17	23	PF00454	0.475
MOD_PIKK_1	212	218	PF00454	0.508
MOD_PIKK_1	246	252	PF00454	0.644
MOD_PIKK_1	336	342	PF00454	0.513
MOD_PIKK_1	71	77	PF00454	0.382
MOD_PIKK_1	99	105	PF00454	0.523
MOD_PKA_1	298	304	PF00069	0.418
MOD_PKA_2	225	231	PF00069	0.616
MOD_PKA_2	298	304	PF00069	0.610
MOD_PKA_2	320	326	PF00069	0.441
MOD_PKA_2	359	365	PF00069	0.495
MOD_PKA_2	439	445	PF00069	0.413
MOD_PKA_2	492	498	PF00069	0.680
MOD_PKA_2	71	77	PF00069	0.572
MOD_PKA_2	79	85	PF00069	0.568
MOD_Plk_1	246	252	PF00069	0.540
MOD_Plk_1	25	31	PF00069	0.428
MOD_Plk_1	314	320	PF00069	0.507
MOD_Plk_1	329	335	PF00069	0.506
MOD_Plk_1	398	404	PF00069	0.558
MOD_Plk_1	427	433	PF00069	0.530
MOD_Plk_1	89	95	PF00069	0.522
MOD_Plk_2-3	219	225	PF00069	0.468
MOD_Plk_2-3	32	38	PF00069	0.468
MOD_Plk_2-3	407	413	PF00069	0.475
MOD_Plk_4	14	20	PF00069	0.466
MOD_Plk_4	314	320	PF00069	0.540
MOD_Plk_4	380	386	PF00069	0.410
MOD_Plk_4	427	433	PF00069	0.530
MOD_ProDKin_1	448	454	PF00069	0.722
MOD_ProDKin_1	462	468	PF00069	0.615
MOD_SUMO_for_1	198	201	PF00179	0.435
MOD_SUMO_for_1	29	32	PF00179	0.529
MOD_SUMO_for_1	424	427	PF00179	0.506
MOD_SUMO_for_1	58	61	PF00179	0.462
MOD_SUMO_rev_2	106	113	PF00179	0.548
MOD_SUMO_rev_2	175	184	PF00179	0.408
MOD_SUMO_rev_2	222	230	PF00179	0.466
MOD_SUMO_rev_2	409	417	PF00179	0.428
TRG_DiLeu_BaEn_1	398	403	PF01217	0.552
TRG_DiLeu_BaEn_1	41	46	PF01217	0.484
TRG_DiLeu_BaEn_1	427	432	PF01217	0.477
TRG_DiLeu_BaEn_4	168	174	PF01217	0.412
TRG_ER_diArg_1	280	282	PF00400	0.492
TRG_ER_diArg_1	297	299	PF00400	0.555
TRG_ER_diArg_1	352	355	PF00400	0.578
TRG_ER_diArg_1	365	367	PF00400	0.633
TRG_NES_CRM1_1	56	71	PF08389	0.521
TRG_NLS_MonoExtC_3	421	427	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	436	441	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H0	Leptomonas seymouri	56%	79%
A0A1X0P9M9	Trypanosomatidae	23%	88%
A0A3R7KMJ4	Trypanosoma rangeli	25%	88%
A0A3S7X7R3	Leishmania donovani	59%	75%
A4I9S8	Leishmania infantum	59%	75%
E9B4T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	75%
Q4Q387	Leishmania major	57%	100%
V5B3B6	Trypanosoma cruzi	28%	87%